Abstract: In some embodiments, methods of inhibiting, ameliorating, reducing the severity of, treating, reducing the likelihood of, or preventing social isolation stress or symptoms thereof in a subject in need thereof are described. In some embodiments, methods of determining a risk of social isolation stress in a subject are described.

Abstract: According to some embodiments herein, expression systems and methods for activity-dependent transcription of nucleic acids are provided. In some embodiments, adeno-associated viral vector systems comprise an immediate early gene promoter operably linked to a transcriptional activator. The transcription activator can be fused to an N-terminal portion of an immediate early gene, for example fos.

Abstract: A bone plate is dimensioned for securing the rotated cut segment of an upper tibia to the lower portion of the tibia as part of a tibial leveling osteotomy procedure for an animal. The bone plate includes an elongated shaft, a head portion pre-bent with respect to the elongated shaft, and a transition between the elongated shaft and head portion including opposing concave sidewalls. The elongated shaft has a centerline and the pre-bent head portion has a centerline angled with respect to the centerline of the elongated shaft to dispose the elongated shaft collinear or approximately collinear with respect to the lower portion of the tibia and to better fit the head portion to the rotated cut segment of the upper tibia.

Abstract: A water treatment system having a water treatment engine including a pressure vessel, electronics module and optionally replaceable shrouds. The water treatment engine may include a tether and a single connection point for water and power lines. The tether may have a release that is accessible only when the electronic module is removed. The water treatment engine may be circular and the water and power lines may be arranged within a region bounded by tangent lines that square the circular shape. The electronics module may be configured to receive one of a variety of alternative interchangeable displays. The electronics module may have a single display port that provides power and data that can be utilized by a plurality of different types of displays. The system may include a replaceable cartridge with soft end caps that include an integral seal and are shaped to self-center within the pressure vessel.

Abstract: The present disclosure relates to a telecommunications connection device. The device including a housing, a plurality of single-fiber connectorized pigtails that extend outwardly from the housing and a multi-fiber connectorized pigtail that extends outwardly from the housing. The multi-fiber connectorized pigtail can be optically coupled with the single fiber connectorized pigtails. The device can include optical fibers routed from the multi-fiber connectorized pigtail through the housing to the single-fiber connectorized pigtails. The single-fiber connectorized pigtails can be more flexible than the multi-fiber connectorized pigtail.

Abstract: Systems and methods for performing behavioral detection using three-dimensional tracking and machine learning in accordance with various embodiments of the invention are disclosed. One embodiment of the invention involves a the classification application that directs a microprocessor to: identify at least a primary subject interacting with a secondary subject within a sequence of frames of image data including depth information; determine poses of the subjects; extract a set of parameters describing the poses and movement of at least the primary and secondary subjects; and detect a social behavior performed by at least the primary subject and involving at least the second subject using a classifier trained to discriminate between a plurality of social behaviors based upon the set of parameters describing poses and movement.

Abstract: A thick-game client device includes all of the game data processing on-board while a thin-game client device includes only a small portion of game data processing such as to render visual displays while the majority of the game data processing is network based. A thick-voice client devices includes all of the voice processing on-board while a thin-voice client device includes only a small portion of the voice processing such as to generate acoustic parameter data discussed below while the remainder of the voice processing occurs at a voice services node. It will be appreciated that a client device may be thick with respect to both game processing and voice processing, may be thick with respect to one type of processing and thin with respect to the other, or may be thin with respect to both types of processing.

Abstract: The present disclosure relates to a telecommunications connection device. The device including a housing, a plurality of single-fiber connectorized pigtails that extend outwardly from the housing and a multi-fiber connectorized pigtail that extends outwardly from the housing. The multi-fiber connectorized pigtail can be optically coupled with the single fiber connectorized pigtails. The device can include optical fibers routed from the multi-fiber connectorized pigtail through the housing to the single-fiber connectorized pigtails. The single-fiber connectorized pigtails can be more flexible than the multi-fiber connectorized pigtail.

Abstract: Disclosed are various embodiments for transmitting a plurality of files of a plurality of file systems associated with a corresponding plurality of users to each one of the users. In one embodiment, a jukebox service identifies files from file systems associated with each user requesting to consume the transmitted content. In one embodiment, the jukebox service identifies the files based in part on a plurality of disc jockey preferences provided by a disc jockey. The jukebox service then generates a jukebox playlist of the identified files having an order that is generated based at least in part on a playback profile associated with each one of the files. For instance, the playback profile may describe a playback frequency of the respective file. The jukebox service may then transmit the files over a network to clients of requesting users according to the order established by the jukebox playlist.

Abstract: Disclosed are various embodiments for generating a network page having a data density that corresponds to a network page load time for a client in communication with an electronic commerce system. In one embodiment, the electronic commerce system determines a network page load time for a client and draws an association between the client and a data density based at least in part on the network page load time. The electronic commerce system generates a network page having the data density and serves the network page for the client.

Abstract: Embodiments are provided for utilizing speech analytics for automatically managing messages in a communications network. A message from a calling party to an unavailable called party is recorded in a messaging management module. The messaging management module automatically identifies a category for assigning to the content of the message based on information associated with the unavailable called party or a calling party and associates a language model with the message content based on the category. An analysis module utilizes the language model to identify grammar making up the message content. The messaging management module automatically performs a messaging management function on the message content based on a set of rules. The messaging management function may include automatically determining a priority for the message (enabling the message to be retrieved out of order) or automatically triggering an action in response to the message which is directed to the unavailable called party.

Abstract: The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.

Abstract: Embodiments are provided for utilizing speech analytics for automatically managing messages in a communications network. A message from a calling party to an unavailable called party is recorded in a messaging management module. The messaging management module automatically identifies a category for assigning to the content of the message based on information associated with the unavailable called party or a calling party and associates a language model with the message content based on the category. An analysis module utilizes the language model to identify grammar making up the message content. The messaging management module automatically performs a messaging management function on the message content based on a set of rules. The messaging management function may include automatically determining a priority for the message (enabling the message to be retrieved out of order) or automatically triggering an action in response to the message which is directed to the unavailable called party.

Abstract: The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.

Abstract: An implantable electrode system of is disclosed that includes a conductive electrode layer, an interconnect coupled to the electrode layer, an insulator that insulates the interconnect, and an anchor that more securely fixes the electrode layer in place. This structure is particularly useful with the electrode layer being a neural interface that is configured to provide either a recording or stimulating function. A method for forming such an implantable electrode system includes forming an interconnect over a base layer, forming an anchoring structure over the base layer, depositing an insulating material layer over the interconnect structure and over the anchoring structure, exposing a portion of the interconnect structure, forming an electrode layer over the insulating layer, the electrode layer contacting the exposed portion of the interconnect structure.

Abstract: The neural interface system of the preferred embodiments includes an electrode array having a plurality of electrode sites and a carrier that supports the electrode array. The electrode array is coupled to the carrier such that the electrode sites are arranged both circumferentially around the carrier and axially along the carrier. A group of the electrode sites may be simultaneously activated to create an activation pattern. The system of the preferred embodiment is preferably designed for deep brain stimulation, and, more specifically, for deep brain stimulation with fine electrode site positioning, selectivity, tunability, and precise activation patterning. The system of the preferred embodiments, however, may be alternatively used in any suitable environment (such as the spinal cord, peripheral nerve, muscle, or any other suitable anatomical location) and for any suitable reason.

Abstract: Systems and methods for performing behavioral detection using three-dimensional tracking and machine learning in accordance with various embodiments of the invention are disclosed. One embodiment of the invention involves a the classification application that directs a microprocessor to: identify at least a primary subject interacting with a secondary subject within a sequence of frames of image data including depth information; determine poses of the subjects; extract a set of parameters describing the poses and movement of at least the primary and secondary subjects; and detect a social behavior performed by at least the primary subject and involving at least the second subject using a classifier trained to discriminate between a plurality of social behaviors based upon the set of parameters describing poses and movement.

Abstract: The implantable electrode system of the preferred embodiments includes a conductor, an interconnect coupled to the conductor, an insulator that insulates the interconnect, and an anchor that overlaps a peripheral edge of the electrode layer. The anchor is mechanically interlocked with the insulator. This structure is particularly useful with the electrode layer being a neural interface that is configured to provide either a recording and stimulating function.

Abstract: A communications connection system includes an SC fiber optic connector including a storage device having memory configured to store physical layer information. The storage device also includes electrical contacts or an RFID antenna coil connected to the memory for transmitting information to a management system. The communications connection system also includes a fiber optic adapter module having one or more media reading interfaces. Each media reading interface is configured to read physical layer information stored on one of the fiber optic connectors received at the adapter module. Example media reading interfaces include electrical contacts and RFID readers.