Abstract: A manual release valve is provided for a electro-hydraulic actuator of the type including a piston movable in a cylinder and defining a piston side chamber and a rod side chamber, the valve threadedly attached to the housing of the actuator and extending at least partially within the fluid housing conduits, the valve moveable from a closed position fully seated in the housing to an open position for fluidly connecting both the piston side chamber and the rod side chamber to the reservoir, the valve further including a pressure relief portion that is operable when the valve is in the closed position for relieving pressure from at least one of the piston side chamber or the rod side chamber.

Abstract: A tibial tuberosity advancement implant and method includes a spacer body made of biocompatible, biodegradable material and having a main section with at least one bony growth orifice therethrough and at least one fin extending from the main section by at least one connector. A metal clip is engageable with of the spacer body main section and includes spaced screw holes for securing the spacer body to the advanced tibial tuberosity and the tibia when the implant is placed in the space between the advanced tibial tuberosity and the tibia.

Abstract: The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.

Abstract: Disclosed are various embodiments for generating a network page having a data density that corresponds to a network page load time for a client in communication with an electronic commerce system. In one embodiment, the electronic commerce system determines a network page load time for a client and draws an association between the client and a data density based at least in part on the network page load time. The electronic commerce system generates a network page having the data density and serves the network page for the client.

Abstract: Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous cells. Targeted disruption of the EphrinB2 gene prevents the remodeling of veins from a capillary plexus into properly branched structures. Moreover, it also disrupts the remodeling of arteries, suggesting that reciprocal interactions between pre-specified arterial and venous endothelial cells are necessary for angiogenesis. This distinction can be used to advantage in methods to alter angiogenesis, methods to assess the effect of drugs on artery cells and vein cells, and methods to identify and isolate artery cells and vein cells, for example.

Abstract: The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.

Abstract: The neural interface system of the preferred embodiments includes an electrode array having a plurality of electrode sites and a carrier that supports the electrode array. The electrode array is coupled to the carrier such that the electrode sites are arranged both circumferentially around the carrier and axially along the carrier. A group of the electrode sites may be simultaneously activated to create an activation pattern. The system of the preferred embodiment is preferably designed for deep brain stimulation, and, more specifically, for deep brain stimulation with fine electrode site positioning, selectivity, tunability, and precise activation patterning. The system of the preferred embodiments, however, may be alternatively used in any suitable environment (such as the spinal cord, peripheral nerve, muscle, or any other suitable anatomical location) and for any suitable reason.

Abstract: A tibial tuberosity advancement implant and method includes a spacer body made of biocompatible, biodegradable material and having a main section with at least one bony growth orifice therethrough and a proximal slot and at least one fin extending from the main section by at least one connector. A metal clip is slideable into the proximal slot of the spacer body main section and includes spaced screw holes for securing the spacer body to the advanced tibial tuberosity and the tibia when the implant is placed in the space between the advanced tibial tuberosity and the tibia.

Abstract: Some embodiments of the invention comprise a customizable multichannel microelectrode array with a modular planar microfabricated electrode array attached to a carrier and a high density of recording and/or stimulation electrode sites disposed thereon. Novel methods of making and using same are also disclosed.

Abstract: A tibial tuberosity advancement implant and method includes a spacer body made of biocompatible, biodegradable material and having a main section with at least one bony growth orifice therethrough and a proximal slot and at least one fin extending from the main section by at least one connector. A metal clip is slideable into the proximal slot of the spacer body main section and includes spaced screw holes for securing the spacer body to the advanced tibial tuberosity and the tibia when the implant is placed in the space between the advanced tibial tuberosity and the tibia.

Abstract: The invention relates to novel neurogenin proteins, nucleic acids and antibodies.

Abstract: The present disclosure provides methods and compositions that can be used to identify anxiolytic compounds, and to treat anxiety in a subject. Methods and compositions for identifying activating stimuli for sensory neurons, for example MrgprB4+ neurons, are also disclosed herein.

Abstract: Disclosed are various embodiments for replicating service requests. A service request is obtained from a client. A primary service and a secondary service are determined based at least in part on the service request and a routing configuration. The secondary service corresponds to another version of the primary service. The service request is routed to the primary service and potentially replicated to the secondary service. A service response to the service request is obtained from the primary service and then sent to the client.

Abstract: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of ?7 nicotinic acetylcholine receptors.

Abstract: A surface impedance sensor and method are provided. The surface impedance sensor generally includes first and second electrodes, a driver circuit to drive the electrodes at a plurality of driving frequencies, and a detection circuit to measure the impedance across the first and second electrodes for comparison against a plurality of reference profiles. The method generally includes measuring the localized surface impedance for each of a plurality of driving frequencies to generate a measured profile, and correlating the measured profile with a reference profile. The system and method can verify contact with a particular surface and can be used with a variety of host devices, including for example ultrasound delivery devices.

Abstract: A pivotable cable connection device for a pair of fiber optic connectors includes a carriage and a housing. The carriage includes a body defining a hub pin receiver and an actuator pin slot. A face is connected to the body and defines an opening. The housing is received within the carriage so as to extend through the opening. The housing includes a housing axis and a hub pin. The hub pin is received within the hub pin receiver. Additionally, the housing includes an actuator pin that is received within the actuator pin slot. The housing axis is substantially orthogonal to the face when the actuator pin is positioned in a first end of the actuator pin slot, and is positioned oblique to the face when the actuator pin is positioned in a second end of the actuator pin slot.

Abstract: A tibial tuberosity advancement implant and method includes a spacer body made of biocompatible, biodegradable material and having a main section with at least one bony growth orifice therethrough and a proximal slot and at least one fin extending from the main section by at least one connector. A metal clip is slideable into the proximal slot of the spacer body main section and includes spaced screw holes for securing the spacer body to the advanced tibial tuberosity and the tibia when the implant is placed in the space between the advanced tibial tuberosity and the tibia.

Abstract: A communications connection system includes an SC fiber optic connector including a storage device having memory configured to store physical layer information. The storage device also includes electrical contacts or an RFID antenna coil connected to the memory for transmitting information to a management system. The communications connection system also includes a fiber optic adapter module having one or more media reading interfaces. Each media reading interface is configured to read physical layer information stored on one of the fiber optic connectors received at the adapter module. Example media reading interfaces include electrical contacts and RFID readers.

Abstract: A method and system for searching an information retrieval system for items of interest that are in proximity to geographical locations provided by the user. The information retrieval system can perform a search for specified types of businesses or items of interest that surround or are in close proximity to the user's present geographical location, or a geographical location that the user has pre-configured in a database. The system receives geographical location information concerning the user's position from the wireless network carrier, which tracks the location of the user's mobile communications device. When the user desires to store a geographical location and geographical name for a future search, the information is entered into the pre-configured database. When conducting an information search at a later time, the user can narrow a search request to a geographical area in the vicinity of the stored geographical location.

Abstract: The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. Radiolabelled compounds useful for evaluating the binding affinity to ?7 nicotinic acetylcholine receptors also are described.