Patents by Inventor David M. Hoganson
David M. Hoganson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230225703Abstract: Methods, systems, and coaptation measurement devices as described herein include an elongate sensor body at the end of a proximal connecting member, and a plurality of sensors in an array across a face of the sensor body, wherein each sensor of the plurality of sensors is configured to detect if a portion of a heart valve is in contact with the sensor.Type: ApplicationFiled: December 16, 2022Publication date: July 20, 2023Inventors: David M. Hoganson, Peter E. Hammer
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Patent number: 11160956Abstract: A dilator system for arterial and venous cannulas, where there is a smooth transition between the dilator and the outer wall of the cannula. One aspect of the subject technology provides a blunt-tip cannula that is used as a dilator for insertion of an arterial or venous cannula. The balloon might either be a single diameter or may have a larger diameter at the distal portion such that the diameter of the distal portion of the balloon dilator matches the diameter of the cannula at the tip. Another aspect of the subject technology is a balloon dilator for cannulae that may be positioned over a guidewire, for guidewire-directed placement of a cannula within a vessel, duct, lumen or heart structure of the body. Another aspect of the subject technology is an inflation system for the balloon dilator, such that the balloon dilator may be deflated and quickly removed from the cannula after the cannula has been positioned and secured within the vessel, duct, lumen or heart structure.Type: GrantFiled: February 6, 2016Date of Patent: November 2, 2021Inventor: David M. Hoganson
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Patent number: 10939989Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: GrantFiled: November 1, 2017Date of Patent: March 9, 2021Assignees: The General Hospital Corporation, The Charles Stark Draper Laboratory, Inc.Inventors: David M. Hoganson, Howard I. Pryor, Ira Spool, Joseph P. Vacanti, Jeffrey T. Borenstein
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Patent number: 10670585Abstract: The present invention provides an in vitro blood vessel model for investigation of drug induced vascular injury and other vascular pathologies. The in vitro blood vessel model provides two channels separated by a porous membrane that is coated on one side by an endothelial cell layer and is coated on the other side by a smooth muscle cell layer, wherein said model is susceptible to the extravasation of red blood cells across said porous membrane due to drug induced vascular injury.Type: GrantFiled: February 23, 2017Date of Patent: June 2, 2020Inventors: David M. Hoganson, Joseph P. Vacanti, Jeffrey T. Borenstein
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Patent number: 10327885Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: GrantFiled: February 6, 2015Date of Patent: June 25, 2019Assignees: The General Hospital Corporation, The Charles Stark Draper LaboratoryInventors: David M. Hoganson, Howard I. Pryor, Ira Spool, Joseph P. Vacanti, Jeffrey T. Borenstein
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Publication number: 20180256312Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: ApplicationFiled: November 1, 2017Publication date: September 13, 2018Inventors: David M. Hoganson, Howard I. Pryor, Ira Spool, Joseph P. Vacanti, Jeffrey T. Borenstein
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Patent number: 9814563Abstract: The imperfect hemodymamics and non-endothelialized surface of the BT shunt and RV-PA conduit can be improved by utilizing a shape that has more uniform flow and lower shear stress. Accordingly, the shunt will have an acute takeoff angle with a fluted inlet portion that eliminates fluid separation and maintains the shear stress within or near the physiologic range. The distal aspect of the shunt may be fluted in one or both directions along the pulmonary artery to improve the flow transition and reduce the shear forces on the posterior wall the pulmonary artery. An autologous umbilical vein may be used as the shunt with fluted proximal and distal portions with an autologous endothelialized surface to minimize platelet deposition and thrombus formation. The umbilical vein shunt may have an external support for diameter constraint and maintaining the hemodynamically optimized fluted design.Type: GrantFiled: April 25, 2015Date of Patent: November 14, 2017Inventor: David M. Hoganson
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Publication number: 20170241991Abstract: The present invention provides an in vitro blood vessel model for investigation of drug induced vascular injury and other vascular pathologies. The in vitro blood vessel model provides two channels separated by a porous membrane that is coated on one side by an endothelial cell layer and is coated on the other side by a smooth muscle cell layer, wherein said model is susceptible to the extravasation of red blood cells across said porous membrane due to drug induced vascular injury.Type: ApplicationFiled: February 23, 2017Publication date: August 24, 2017Applicants: The General Hospital Corporation, The Charles Stark Draper Laboratory, Inc.Inventors: David M. Hoganson, Joseph P. Vacanti, Jeffrey T. Borenstein
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Patent number: 9595206Abstract: The present invention provides an in vitro blood vessel model for investigation of drug induced vascular injury and other vascular pathologies. The in vitro blood vessel model provides two channels separated by a porous membrane that is coated on one side by an endothelial cell layer and is coated on the other side by a smooth muscle cell layer, wherein said model is susceptible to the extravasation of red blood cells across said porous membrane due to drug induced vascular injury.Type: GrantFiled: February 11, 2009Date of Patent: March 14, 2017Assignees: The General Hospital, The Charles Stark Draper Laboratory, Inc.Inventors: David M. Hoganson, Joseph P. Vacanti, Jeffrey T. Borenstein
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Patent number: 9498320Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: GrantFiled: November 15, 2013Date of Patent: November 22, 2016Assignees: THE GENERAL HOSPITAL CORPORATION, THE CHARLES STARK DRAPER LABORATORY, INC.Inventors: David M. Hoganson, Jeffrey T. Borenstein
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Publication number: 20150366651Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: ApplicationFiled: February 6, 2015Publication date: December 24, 2015Applicants: THE CHARLES STARK DRAPER LABORATORY, THE GENERAL HOSPITAL CORPORATIONInventors: David M. Hoganson, Howard I. Pryor, Ira Spool, Joseph P. Vacanti, Jeffrey T. Borenstein
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Patent number: 9162039Abstract: A device for accessing a vessel, duct or lumen, comprising a guidewire having a proximal end and a distal end, and at least one projection that extends from said guidewire at or near the distal end of the guidewire. When the guidewire is placed into the vessel, duct or lumen containing a flowing fluid, the drag on the guidewire is greater when the fluid is flowing from the proximal to distal end of the guidewire than it is when it is flowing distally-to-proximally, thereby helping to direct the guidewire. The device is particularly useful in crossing a narrowing in the vessel, duct or lumen, such as may occur in blood vessels containing a stenosis, such as due to atherosclerosis.Type: GrantFiled: August 18, 2006Date of Patent: October 20, 2015Inventors: David M. Hoganson, Ravi K. Veeraswamy
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Patent number: 8951302Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: GrantFiled: October 9, 2009Date of Patent: February 10, 2015Assignees: The General Hospital Corporation, The Charles Stark Draper LaboratoryInventors: Howard I. Pryor, Ira Spool, David M. Hoganson, Joseph P. Vacanti, Jeffrey T. Borenstein
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Patent number: 8795242Abstract: An implantable device for facilitating the healing of voids in bone, cartilage and soft tissue is disclosed. In one embodiment, the device is arranged for the local delivery of therapeutic agent. A preferred embodiment is a porous resorbable implant, wherein the therapy delivery may be localized in nature, rather than systemic, such that higher doses at the target site may be allowed than would be tolerable by the body systemically.Type: GrantFiled: February 12, 2005Date of Patent: August 5, 2014Assignee: Kensey Nash CorporationInventors: David M. Hoganson, Gino Bradica, Scott M. Goldman, John H. Brekke
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Publication number: 20140081384Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: ApplicationFiled: November 15, 2013Publication date: March 20, 2014Applicant: THE GENERAL HOSPITAL CORPORATIONInventor: David M. Hoganson
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Patent number: 8591597Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: GrantFiled: March 22, 2010Date of Patent: November 26, 2013Assignee: The General Hospital CorporationInventors: David M. Hoganson, Joseph P. Vacanti, Howard I. Pryor
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Patent number: 8377080Abstract: A system and method of use for effecting the bypass or other anastomosis, connection, or port in a portion of a native blood vessel, duct, lumen or other tubular organ within the body of a living being. The system includes a connector assembly and a deployment instrument for carrying the device to the desired position within the vessel, duct, lumen or tubular organ. The system includes a piercer-dilator instrument to form an opening in the wall of the vessel, duct, lumen or tubular organ into which a connector assembly may be deployed by the deployment instrument. The connector assembly may be at least partially formed of a resorbable material and includes movable members for securing it to the tissue of the vessel, duct, lumen or tubular organ contiguous with the opening. Other components may be included in the device for expediting the procedure, with or without the use of sutures.Type: GrantFiled: April 13, 2010Date of Patent: February 19, 2013Assignee: Kensey Nash CorporationInventors: John E. Nash, Douglas G. Evans, David M. Hoganson
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Patent number: 8361164Abstract: The construct described herein allows opposing tissues to form adhesions with either side of the construct, as part of the natural healing process. The construct however is multi-layered, wherein the space between the layers provides the protection from unwanted adhesions forming between and bonding separate tissues. In one embodiment, this space between layers of the construct may be developed spontaneously, that is the multiple layers are released by design after a finite time and the opposing tissues are free to move independent of each other, free of adhesions.Type: GrantFiled: July 19, 2010Date of Patent: January 29, 2013Assignee: Kensey Nash CorporationInventor: David M. Hoganson
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Publication number: 20110053207Abstract: The present invention provides an in vitro blood vessel model for investigation of drug induced vascular injury and other vascular pathologies. The in vitro blood vessel model provides two channels separated by a porous membrane that is coated on one side by an endothelial cell layer and is coated on the other side by a smooth muscle cell layer, wherein said model is susceptible to the extravasation of red blood cells across said porous membrane due to drug induced vascular injury.Type: ApplicationFiled: February 11, 2009Publication date: March 3, 2011Inventors: David M. Hoganson, Joseph P. Vacanti
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Publication number: 20110035026Abstract: The construct described herein allows opposing tissues to form adhesions with either side of the construct, as part of the natural healing process. The construct however is multi-layered, wherein the space between the layers provides the protection from unwanted adhesions forming between and bonding separate tissues. In one embodiment, this space between layers of the construct may be developed spontaneously, that is the multiple layers are released by design after a finite time and the opposing tissues are free to move independent of each other, free of adhesions.Type: ApplicationFiled: July 19, 2010Publication date: February 10, 2011Inventor: David M. Hoganson