Abstract: Disclosed are compositions and methods useful for delivering targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to effect a beneficial therapeutic result. The disclosed targeting is useful for delivering therapeutic and detectable agents to diseased tissue in an animal.

Abstract: This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a promoter from a Zea mays KN1 gene. Some embodiments relate to a promoter from a Zea mays KN1 gene that functions in plants to promote transcription of operably linked nucleotide sequences.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for obtaining a translation of a previous version of a display item to present on a graphical user interface when a translation of a current version of the display item is unavailable. A client device can request a translation of a display item in a graphical user interface invoked by the client device. The client device can send a server a first key corresponding to the current version of the display item, a second key corresponding to a previous version of the display item, and locale information describing the current location and/or language preferences of the client device. If the server cannot obtain a translation corresponding to the first key, the server can obtain a translation of the previous version of the display item in the language associated with the locale based on the second key.

Abstract: Compositions and methods useful for delivery of targeted therapies for pulmonary arterial hypertension, sepsis, cancer and cachexia. The compositions and methods are based on peptide pharmacophores that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. Peptide pharmacophores may selectively target tumor vasculature, regenerating tissue, wounded tissue, inflamed tissue, fibrotic tissue, remodeled tissue, tissue characterized by elevated heparanase levels, and have the ability to internalize into such diseased cells.

Abstract: Provided herein are methods of producing three-dimensional (3-D) microtissue from a starting cell suspension of pluripotent stem cell (PSC)-derived hepatocytes. Such a method may comprise supplementing the cell suspension with cell adhesion-promoting components and culturing the PSC-derived hepatocytes on a non-adhesive surface to produce the microtissue.

Abstract: Disclosed are compositions and methods useful for delivering targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to effect a beneficial therapeutic result. The disclosed targeting is useful for delivering therapeutic and detectable agents to diseased tissue in an animal.

Abstract: A method and system for adaptively powering down cells within a cluster are disclosed. According to one aspect, a method includes detecting when a load on a first cell falls below a first predetermined threshold, the load being based at least in part on a number of wireless devices in communication with a first radio unit serving the first cell. Upon detecting when a load on the first cell falls below the first predetermined threshold, a transmitter of the first radio unit is powered down over a period of time to allow time for handoff of wireless devices in the first cell to a second radio unit serving an adjacent cell.

Abstract: Disclosed are compositions and methods useful for oral delivery of targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. The disclosed targeting is useful for oral delivery of therapeutic and detectable agents to diseased tissue in an animal.

Abstract: Disclosed are compositions and methods for triggering disease selective macropinocytosis. The compositions can serve as a marker of disease activity and as a trigger of enhanced macropinocytosis in tissues undergoing disease remodeling such as wound healing, cancer, PAH, inflammation, diabetes, Crohn's disease, ulcerative colitis, ankylosing spondylitis, diseases of the endometrium, psoriasis, irritable bowel syndrome, arthritis, fibrotic disorders, interstitial cystitis, autoimmune diseases, asthma, acute lung injury, and adult respiratory distress syndrome. The compositions can also serve as a receptor for disease selective cell penetrating peptides in the cells and extracellular matrix of diseased tissues.

Abstract: Pet toys configured to accept an edible or chewable treat which can be readily replaced. The pet toys have a first portion and a second portion which releasably engage to retain the edible treat with the toy until the treat is consumed or otherwise removed from the toy by the pet. When desired, the toy can be disassembled by removing the first portion from the second portion, new treats can be added to the toy, and the two portions reassembled.

Abstract: This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a promoter from a Zea mays ZAG1 gene. Some embodiments relate to a promoter from a Zea mays ZAG1 gene that functions in plants to promote transcription of operably linked nucleotide sequences.

Abstract: This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a promoter from a Zea mays KN1 gene. Some embodiments relate to a promoter from a Zea mays KN1 gene that functions in plants to promote transcription of operably linked nucleotide sequences.

Abstract: Disclosed are compositions and methods for triggering disease selective macropinocytosis. The compositions can serve as a marker of disease activity and as a trigger of enhanced macropinocytosis in tissues undergoing disease remodeling such as wound healing, cancer, PAH, inflammation, diabetes, Crohn's disease, ulcerative colitis, ankylosing spondylitis, diseases of the endometrium, psoriasis, irritable bowel syndrome, arthritis, fibrotic disorders, interstitial cystitis, autoimmune diseases, asthma, acute lung injury, and adult respiratory distress syndrome. The compositions can also serve as a receptor for disease selective cell penetrating peptides in the cells and extracellular matrix of diseased tissues.

Abstract: This disclosure concerns compositions and methods for promoting transcription and translation of a nucleotide sequence in a plant or plant cell, employing a promoter and/or a 3?UTR from Zea mays Zrp2 gene. Some embodiments relate to a promoter from a Zea mays Zrp2 gene that is operably linked to a Zea mays Ubiquitin 1 intron and functions in plants to promote transcription of operably linked nucleotide sequences. Other embodiments relate to a 3? UTR from a Zea mays Zrp2 gene that functions in plants to terminate transcription of operably linked nucleotide sequences.

Abstract: Disclosed are compositions and methods useful for delivering targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to effect a beneficial therapeutic result. The disclosed targeting is useful for delivering therapeutic and detectable agents to diseased tissue in an animal.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for obtaining a translation of a previous version of a display item to present on a graphical user interface when a translation of a current version of the display item is unavailable. A client device can request a translation of a display item in a graphical user interface invoked by the client device. The client device can send a server a first key corresponding to the current version of the display item, a second key corresponding to a previous version of the display item, and locale information describing the current location and/or language preferences of the client device. If the server cannot obtain a translation corresponding to the first key, the server can obtain a translation of the previous version of the display item in the language associated with the locale based on the second key.

Abstract: Provided are deglycosylation methods designed to optimize the yield of a Veratrum alkaloid from Veratrum plant material and/or from an extract of Veratrum plant material.

Abstract: Disclosed are compositions and methods for triggering disease selective macropinocytosis. The compositions can serve as a marker of disease activity and as a trigger of enhanced macropinocytosis in tissues undergoing disease remodeling such as wound healing, cancer, PAH, inflammation, diabetes, Crohn's disease, ulcerative colitis, ankylosing spondylitis, diseases of the endometrium, psoriasis, irritable bowel syndrome, arthritis, fibrotic disorders, interstitial cystitis, autoimmune diseases, asthma, acute lung injury, and adult respiratory distress syndrome. The compositions can also serve as a receptor for disease selective cell penetrating peptides in the cells and extracellular matrix of diseased tissues.

Abstract: A TETRA communications system, comprising a first TETRA communication device, connected to a first communication means by means of a first data link to transport TETRA message data and control information between said first communication means and said first TETRA communication device, a second TETRA communication device connected to a second communication means by means of a second data link to transport TETRA message data and control information between said second communication means and said second TETRA communication device, wherein said first communication means and said second communication means are further operable to establish a communications link with each other over a communications network to allow said message data and control information to be transported between said first and second TETRA communication device via said first communication means and said second communication means.

Abstract: The present technology provides an edible composition including a plurality of dietary strands coated with a flavored coating; where the interior of each dietary strand comprises a fat, protein, carbohydrate, or a combination thereof; where the dietary strands are braided or woven together; and where the flavor of the interior of the dietary strand is distinct from the flavor of the flavored coating. Also provided are methods of providing an animal with nourishment, including providing the animal with any one of the edible compositions described herein. The animal may or may not be a human.