Abstract: The present technology provides, in one aspect, an edible or inhalable composition including an isolated “antagonist ligand” or an isolated “antagonist antibody” or an antigen-binding fragment thereof, which specifically binds a taste receptor ligand or an olfactory receptor ligand. Foods and intranasal formulations containing the above-described compositions are described, as are methods of use.

Abstract: The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.

Abstract: The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.

Abstract: A thermal interface material includes a mechanically compliant vertically aligned nanofiber film and a binder material for joining the nanofibers of the film to the surfaces of two substrates. Preferably, the binder material comprises a non-hydrocarbon-based material such as a metallic eutectic with a melting temperature below a nanofiber thermal damage threshold temperature of the film. The film is grown on a substrate which is then bonded to another substrate by the binder material in an adhesion process that may include pressure and heat. Alternatively, the film may be released from the substrate to produce a stand-alone thermal tape which may later be placed between two substrates and bonded.

Abstract: An apparatus for enhancing audio comprising a first interface and a harmonizing module is disclosed. The first interface receive a first audio segment from a first source. The harmonizing module is coupled to the first interface. The harmonizing module is configured to identify at least one musical property of the first audio segment; calculate a subset of notes that are harmonious with the first audio segment based on the at least one musical property; and select from the subset of notes to generate an audio track to be played substantially synchronously with the first audio segment. A second interface may also be provided to receive a second audio segment from a second source. In this case, the harmonizing module may be configured to generate the audio track by transforming one or more notes of the second audio segment. A method is also provided.

Abstract: The present invention provides single-walled carbon nanotubes and systems and methods for their preparation.

Abstract: The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.

Abstract: The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.

Abstract: A cross-port analysis method is provided to analyze multichannel traces in a network. More particularly, cross-port analysis is a method allowing for aggregate network analysis capabilities from a multi-channel analyzer. This can be performed as traces of network traffic generated by each port on two or more analyzers. Precise timestamps are recorded for each trace and the topology of devices on the network is determined. An expert analysis is then performed on the captured data traces.

Abstract: The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.

Abstract: A network monitoring architecture and methodology enabling performance detection and diagnostics in storage area networks or other networks. The network monitoring is performed using a three-tiered distributed computing system architecture, including a data source tier, a portal tier and a client tier. The data source tier monitors the physical data on the network medium using multiple data collection sources, or data probes, connected to the network. The probes analyze network data and generate metrics that describe attributes of the network data. The metrics are synchronized in time by virtue of time stamps associated with the data monitored by the data probes. The time-synchronized metrics are used by the data portal tier, which is the second tier of the system. The portal tier encapsulates the metrics into data containers. The data containers may be requested by the client tier, which is the third tier in the network monitoring system.

Abstract: One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.

Abstract: An apparatus for enhancing audio comprising a first interface and a harmonizing module is disclosed. The first interface receive a first audio segment from a first source. The harmonizing module is coupled to the first interface. The harmonizing module is configured to identify at least one musical property of the first audio segment; calculate a subset of notes that are harmonious with the first audio segment based on the at least one musical property; and select from the subset of notes to generate an audio track to be played substantially synchronously with the first audio segment. A second interface may also be provided to receive a second audio segment from a second source. In this case, the harmonizing module may be configured to generate the audio track by transforming one or more notes of the second audio segment. A method is also provided.

Abstract: Methods are disclosed for sterilizing biological materials to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing biological materials containing one or more non-aqueous solvents with irradiation.

Abstract: The present invention provides single-walled carbon nanotubes and systems and methods for their preparation.

Abstract: Provided are deglycosylation methods designed to optimize the yield of Veratrum alkaloid from Veratrum plant material and/or from an extract of Veratrum plant material.

Abstract: Methods are disclosed for sterilizing biological materials to reduce the level of one or more biological contaminants or pathogens therein, such as viruses, bacterial (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, single or multicellular parasites, and/or prions or similar agents responsible. These methods involve the use of alpha-keto acids in methods of sterilizing biological materials with irradiation.

Abstract: Methods are disclosed for sterilizing biological materials to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing biological materials containing one or more non-aqueous solvents with irradiation.

Abstract: Pet toys configured to accept an edible or chewable treat which can be readily replaced. The pet toys have a first portion and a second portion which releaseably engage to retain the edible treat with the toy until the treat is consumed or otherwise removed from the toy by the pet. When desired, the toy can be disassembled by removing the first portion from the second portion, new treats can be added to the toy, and the two portions reassembled.

Abstract: A thermal interface material includes a mechanically compliant vertically aligned nanofiber film and a binder material for joining the nanofibers of the film to the surfaces of two substrates. Preferably, the binder material comprises a non-hydrocarbon-based material such as a metallic eutectic with a melting temperature below a nanofiber thermal damage threshold temperature of the film. The film is grown on a substrate which is then bonded to another substrate by the binder material in an adhesion process that may include pressure and heat. Alternatively, the film may be released from the substrate to produce a stand-alone thermal tape which may later be placed between two substrates and bonded.