Abstract: A method, system, apparatus, and/or device with a miniaturized impedance sensor. The method, system, apparatus, and/or device may include a substrate with locally non-flexible regions interconnected by a flexible material and a miniaturized impedance sensor disposed on the substrate. The miniaturized impedance sensor may include: an array of electrical contacts; an array of miniaturized electrodes disposed on the array of electrical contacts; and an interstitial filler disposed within the array of miniaturized electrodes. The locally non-flexible regions may correspond to subsets of the array of miniaturized electrodes. The locally non-flexible regions may retain shape as the flexible material changes shape.

Abstract: The present invention relates to compounds of formula (1): wherein Q is selected from O or S; R1 is a 5-membered nitrogen-containing heteroaryl group substituted with R6 and optionally further substituted; R2 is an alpha, alpha?-substituted cyclic group which may optionally be further substituted; R3 and R4 are each independently hydrogen, halogen, —OH, —NH2, —CN, —R5, —OR5, —NHR5 or —N(R5)2; or R3 and R4 together with the carbon atom to which they are attached may form a 3 to 7 membered saturated or unsaturated, optionally substituted cyclic group; R5 is independently an optionally substituted C1-C4 alkyl group; and R6 is any group comprising a nitrogen atom. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Abstract: A method, system, apparatus, and/or device with interdigitated miniaturized electrodes. The method, system, apparatus, and/or device may include: a band configured to extend at least partially around a body part of a user, the body part including a dermal layer; a user interface coupled to the band; a processing device coupled to the band; a miniaturized impedance sensor integrated into the band and positioned in the band to be pressed against the dermal layer, the miniaturized impedance sensor comprising a row of interdigitated miniaturized electrodes alternating between a miniaturized electrode of a first set of miniaturized electrodes and another miniaturized electrode of a second set of miniaturized electrodes; and an electrical circuit embedded in the band interconnecting the user interface, the processing device, or the miniaturized impedance sensor.

Abstract: A method, system, device, or apparatus for notifying a device of a greater number of safety events associated with the first user. The method includes retrieving safety events associated with a first user of a first electronic device and determining a frequency of safety events. The method includes retrieving safety events associated with a second user of a second electronic device and determining a frequency of safety events. The method includes comparing the frequency of safety events associated with the first user and the number of safety events associated with the second user and determining that there is a greater frequency of safety events associated with the first user than with the second user for the period of time. The method includes determining a cause of the greater frequency of safety events associated with the first user.

Abstract: A method, system, apparatus, and/or device to select a depth within a body part to measure an impedance. The method, system, apparatus, and/or device may include: a band configured to extend at least partially around a body part of a user; a user interface coupled to the band; a miniaturized impedance sensor embedded in the band and positioned in the band to be pressed against the body part when the user wears the band, the miniaturized impedance sensor including an array of miniaturized electrodes, where the array of miniaturized electrodes is configured to measure an impedance at a depth within the body part and the depth corresponds to a subdermal feature within the body part; a processing device coupled to the band, where the processing device is configured to select the depth within the body part to measure an impedance; and an electrical circuit embedded in the band.

Abstract: A method, system, apparatus, and/or device to determine a condition of a user using a spectrometer with a collimator on a glass substrate. The method, system, apparatus, and/or device may include: a band comprising a shape, size, and flexibility designed for attaching the band to a body part of a user; a light source embedded in the band that emits light comprising a constituent wavelength that provides an indication of a feature of the body part; an optical sensor positioned in the band to receive the constituent wavelength; and a glass substrate oriented in the band to receive the light, the glass substrate comprising: an optical filter that comprises a passband to isolate the constituent wavelength from other wavelengths of the light; and a carbon nanotube grid structure comprising walls and through-channels, the carbon nanotube grid structure adhered to the glass substrate.

Abstract: The disclosed tunable laser array may include multiple lasers including at least first and second lasers having center emission wavelengths that are separated by at least a specified minimum wavelength. The tunable laser array may also include at least one coupler/splitter. In the tunable laser array, emitted light from the first laser at a first wavelength and emitted light from the second laser at a second, different wavelength may be combined and then split at the coupler/splitter. Moreover, the lasers may have at least a minimum amount of thermal resistance. Various other systems, apparatuses, and methods of manufacturing are also disclosed.

Abstract: Provided are mechanisms and processes for inserting a visual element into a multi-view digital media representation (MVIDMR). In one example, a process includes analyzing an MVIDMR to determine if there is an appropriate location to insert a visual element. Once a location is found, the type of visual element appropriate for the location is determined, where the type of visual element includes either a three-dimensional object to be inserted in the MVIDMR or a two-dimensional image to be inserted as or projected onto a background or object in the MVIDMR. A visual element that is appropriate for the location is then retrieved and inserted into the MVIDMR, such that the visual element is integrated into the MVIDMR and navigable by a user.

Abstract: The present invention relates to compounds of formula (I): comprising a 5-membered nitrogen-containing heteroaryl ring A, wherein the heteroaryl ring A is substituted with at least one group containing an oxygen atom, and wherein said oxygen atom is attached to the heteroaryl ring A via at least two other atoms. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Abstract: Systems and methods for fulfilling travel requests are described herein. A method for fulfilling travel requests may commence with receiving a travel request from a user and determining itinerary components based on the travel request. The method may further include generating an itinerary network based on the itinerary components. The itinerary network may be generated by creating a plurality of nodes and creating a plurality of edges within the itinerary network. Each of the plurality of nodes may represent information associated with the travel request. The plurality of edges may represent an order of the plurality of nodes in time based on dependencies between the plurality of nodes. The method may further include generating a travel itinerary responsive to the travel request. The method may continue with presenting the generated travel itinerary to the user on a user interface of a computing device associated with the user.

Abstract: One aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, (I) wherein: ring A is a 5 or 6 membered aromatic or heteroaromatic ring, wherein said aromatic or heteroaromatic ring is optionally substituted with one or more substituents selected from F, Cl, Br, I, CN, alkoxy, NR11R11?, OH, alkyl, haloalkyl, aralkyl, aryl, and heteroaryl, and wherein said aryl and heteroaryl substituents are in turn optionally substituted with one or more substituents each independently selected from F, Cl, Br, I, CN, alkoxy, NR11R11?, OH, alkyl, haloalkyl, and aralkyl; Y is selected from C?N—OH and CR10R10?, wherein R10 and R10?, are each independently selected from H, F, alkyl, and haloalkyl; R1, R4, and R5 are each independently selected from H, F, Cl, Br, and I; R2 and R3 are each independently selected from H, F, Cl, Br, I, CN, methoxy, and haloalkyl; and R11 and R11? wherein R12 and R13 are both alkyl; for use as a medicament.

Abstract: A tissue visualization system comprises a flexible elongate shaft through which a lumen extends. The system also comprises a pliable visualization device coupled to a distal portion of the flexible elongate shaft. The pliable visualization device includes a chamber configured to receive a fluid. The system also comprises a piercing instrument configured to extend through the lumen and to penetrate a surface of the pliable visualization device.

Abstract: An assembly and method for using weather sensors with enhanced modular capability is disclosed. The weather sensor assembly generally comprises a cap module, middle module, and a base module, where the cap module, middle module(s) and the base module are stacked adjacently to provide environmental sealing, weather sensing, and electrical connectivity to the weather sensor assembly. One or more ring mechanisms may be included that interlock the cap module, middle module(s), base module to form the weather sensor assembly into an integrated unit. Moreover, the ring mechanisms enable further modules to be added to the weather sensor assembly for additional capabilities. By doing so, each of the modules in the weather sensor assembly may be independent units that can be removed, reordered, swapped, and added for desired sensing modalities and environments.

Abstract: The invention provides a (drug-containing) lipid nanoparticle with: (i) at least one phospholipid; (ii) at least one lysolipid; and (iii) at least one phospholipid comprising a hydrophilic polymer; and (iv) at least one structural lipid of formula (I) which has the following general structure: wherein R and R? are long hydrocarbyl hydrophobic chains, Y is a linker element, and PHG is a polar head group described as large according to its van der Waals radius, and which is different from the phospholipid (i). The lipid nanoparticle can release a drug (or API) from within the lipid nanoparticle as a result of focused ultrasound (FUS) applied continuously, at least twice, to a desired part of the body to induce hyperthermia (an increase in temperature). FUS is applied after the lipid nanoparticle containing the drug has been administered to the live subject, and causes controlled release of the drug at the desired site of the body.

Abstract: A controller for a plasma generation system includes a model evaluation module receives a sensed value that varies in accordance with a state of a plasma controlled by a RF power generator. The model evaluation module generates a plasma parameter that varies in accordance with the sensed value. A model integration module receives the plasma parameter, integrates the plasma parameter, and outputs an integrated model parameter. An IEDF evaluation module receives the integrated model parameter and generates an ion energy distribution function (IEDF) in accordance with the integrated model parameter. An IEDF controller module receives the IEDF and generates a signal for controlling a RF generator. A RF generator control module receives the signal and generates an RF generator control signal to control at least one of power, frequency, or phase of the RF power generator.

Abstract: A method, system, apparatus, and/or device to align a miniaturized impedance sensor over the muscular-walled tube of a user. The method, system, apparatus, and/or device may include: a band comprising a shape, size, and flexibility designed for attaching the band to a body part of a user, where the body part includes a dermal layer and a muscular-walled tube; a miniaturized impedance sensor embedded in the band and positioned in the band to be pressed against a portion of the body part adjacent to the muscular-walled tube as the user wears the band, where the miniaturized impedance sensor may include two or more miniaturized electrode strips or an array of miniaturized electrode pillars; and an alignment device embedded in the band and configured in the band to align the miniaturized impedance sensor over the muscular-walled tube as the user wears the band.

Abstract: The present invention relates to compounds of formula (I): Formula (I) wherein Q is selected from O or S; L is a saturated or unsaturated, optionally substituted C1-C12 hydrocarbylene group optionally including one or more heteroatoms N, O or S; R1 is —NR3R4, —OR5, —(C?NR6)R7, —(CO)R8, —CN, —N3, a quaternary ammonium group or an optionally substituted heterocycle; R3, R4, R5, R6, R7 and R8 are each independently hydrogen or a saturated or unsaturated, optionally substituted C1-C10 hydrocarbyl group optionally including one or more heteroatoms N, O or S; wherein optionally L and R3, or L and R4, or R3 and R4, or L and R5, or L and R6, or L and R7, or R6 and R7, or L and R8 together with the atom(s) to which they are attached may form a 3- to 12-membered, saturated or unsaturated, optionally substituted cyclic group; and R2 is a cyclic group substituted at the a-position, wherein R2 may optionally be further substituted; provided that the atom of L which is attached to the sulfur atom of the sulfonylurea group

Abstract: Various embodiments of the present disclosure relate generally to systems and methods for generating multi-view interactive digital media representations in a virtual reality environment. According to particular embodiments, a plurality of images is fused into a first content model and a first context model, both of which include multi-view interactive digital media representations of objects. Next, a virtual reality environment is generated using the first content model and the first context model. The virtual reality environment includes a first layer and a second layer. The user can navigate through and within the virtual reality environment to switch between multiple viewpoints of the content model via corresponding physical movements. The first layer includes the first content model and the second layer includes a second content model and wherein selection of the first layer provides access to the second layer with the second content model.

Abstract: Provided are mechanisms and processes for inserting a visual element into a multi-view digital media representation (MVIDMR). In one example, a process includes analyzing an MVIDMR to determine if there is an appropriate location to insert a visual element. Once a location is found, the type of visual element appropriate for the location is determined, where the type of visual element includes either a three-dimensional object to be inserted in the MVIDMR or a two-dimensional image to be inserted as or projected onto a background or object in the MVIDMR. A visual element that is appropriate for the location is then retrieved and inserted into the MVIDMR, such that the visual element is integrated into the MVIDMR and navigable by a user.

Abstract: A novel food station comprises a plurality of cubbies, each cubby sized to enclose a food portion container, and an externally accessible collection hatch large enough for the food portion container to pass therethrough. A heating system can controllably heat the food portion container within a selected one of the cubbies, independently of an operation of the heating system the other cubbies. A cooling system can perform cooling within a subset of cubbies that includes at least the selected cubby. An internal transport system includes an end effector that temporarily couples to the portion container carrier of the selected cubby and controllably moves the food portion container carrier within the food station to the collection hatch. A control system includes a memory that controls the heating and controls the movement of the internal transport system.