Patents by Inventor David R. Holmes, Jr.
David R. Holmes, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240058057Abstract: Devices and methods can be used to treat of heart conditions, hypertension, and other medical disorders. For example, devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation are described herein. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.Type: ApplicationFiled: November 3, 2023Publication date: February 22, 2024Inventors: Samuel J. Asirvatham, David R. Holmes, JR.
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Patent number: 11844565Abstract: This document provides devices and methods for the treatment of heart conditions, hypertension, and other medical disorders. For example, this document provides devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.Type: GrantFiled: July 12, 2019Date of Patent: December 19, 2023Assignee: Mayo Foundation for Medical Education and ResearchInventors: Samuel J. Asirvatham, David R. Holmes, Jr.
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Publication number: 20220346870Abstract: Devices and methods for the treatment of heart conditions, hypertension, and other medical disorders are described. For example, this document describes devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation. Additionally, in some embodiments, particulate matter, such as thrombus or crystalline drug compounds, created during the ablation is captured and removed from the patient using devices and methods provided herein. Further, devices and methods for non-thermal methods of causing cell death, such as tissue suction and tissue stretching, are also described.Type: ApplicationFiled: July 18, 2022Publication date: November 3, 2022Applicant: Mayo Foundation for Medical Education and ResearchInventors: David R. Holmes, JR., Samuel J. Asirvatham, Christopher V. DeSimone
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Publication number: 20190336208Abstract: This document provides devices and methods for the treatment of heart conditions, hypertension, and other medical disorders. For example, this document provides devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.Type: ApplicationFiled: July 12, 2019Publication date: November 7, 2019Inventors: Samuel J. Asirvatham, David R. Holmes, JR.
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Patent number: 10390879Abstract: This document provides devices and methods for the treatment of heart conditions, hypertension, and other medical disorders. For example, this document provides devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.Type: GrantFiled: May 20, 2014Date of Patent: August 27, 2019Assignee: Mayo Foundation for Medical Education and ResearchInventors: Samuel J. Asirvatham, David R. Holmes, Jr.
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Publication number: 20180360531Abstract: Devices and methods for the treatment of heart conditions, hypertension, and other medical disorders are described. For example, this document describes devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation. Additionally, in some embodiments, particulate matter, such as thrombus or crystalline drug compounds, created during the ablation is captured and removed from the patient using devices and methods provided herein. Further, devices and methods for non-thermal methods of causing cell death, such as tissue suction and tissue stretching, are also described.Type: ApplicationFiled: October 25, 2016Publication date: December 20, 2018Applicant: Mayo Foundation for Medical Education and ResearchInventors: David R. Holmes, Jr., Samuel J. Asirvatham, Christopher V. DeSimone
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Publication number: 20170281193Abstract: Devices and methods can be used to treat heart conditions. Some such devices include endocardial occlusion and ablation devices. For example, such devices can be used for closing and ablating the left atrial appendage to treat atrial fibrillation and to reduce the potential for embolic stroke. In addition, this document provides devices and methods for closing and ablating other body viscera, conduits, valves, and the like.Type: ApplicationFiled: August 26, 2015Publication date: October 5, 2017Applicant: Mayo Foundation for Medical Education and ResearchInventors: Samuel J. Asirvatham, David R. Holmes, Jr.
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Publication number: 20160374754Abstract: This document provides devices and methods for the treatment of heart conditions, hypertension, and other medical disorders. For example, this document provides devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.Type: ApplicationFiled: May 20, 2014Publication date: December 29, 2016Inventors: Samuel J. Asirvatham, David R. Holmes, Jr.
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Patent number: 9414762Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.Type: GrantFiled: June 13, 2014Date of Patent: August 16, 2016Assignee: Mayo Foundation for Medical Education and ResearchInventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes, Jr.
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Publication number: 20160082234Abstract: An apparatus and method of use are disclosed for treating, preventing and terminating arrhythmias. In particular, the apparatus is implantable within or on various tissues and structures and is used to prevent or block conduction of aberrant impulses. A variety of methods of the present invention may be used to attack arrhythmias by short-circuiting impulses, inducing fibrosis, ablating tissue or inducing inflammation. In addition, the device and methods may also be used to treat aneurysms. The device may also be used to treat hypertension, and to function as a blood pressure regulator.Type: ApplicationFiled: December 4, 2015Publication date: March 24, 2016Applicant: Syntach AGInventors: Robert S. Schwartz, Robert A. Van Tassel, David R. Holmes, JR.
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Publication number: 20140296680Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.Type: ApplicationFiled: June 13, 2014Publication date: October 2, 2014Inventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes, JR.
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Publication number: 20140052169Abstract: An apparatus and method of use are disclosed for treating, preventing and terminating arrhythmias. In particular, the apparatus is implantable within or on various tissues and structures and is used to prevent or block conduction of aberrant impulses. A variety of methods of the present invention may be used to attack arrhythmias by short-circuiting impulses, inducing fibrosis, ablating tissue or inducing inflammation. In addition, the device and methods may also be used to treat aneurysms. The device may also be used to treat hypertension, and to function as a blood pressure regulator.Type: ApplicationFiled: October 28, 2013Publication date: February 20, 2014Applicant: Syntach AGInventors: Robert S. Schwartz, Robert A. Van Tassel, David R. Holmes, JR.
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Patent number: 8579955Abstract: An apparatus and method of use are disclosed for treating, preventing and terminating arrhythmias. In particular, the apparatus is implantable within or on various tissues and structures and is used to prevent or block conduction of aberrant impulses. A variety of methods of the present invention may be used to attack arrhythmias by short-circuiting impulses, inducing fibrosis, ablating tissue or inducing inflammation. In addition, the device and methods may also be used to treat aneurysms. The device may also be used to treat hypertension, and to function as a blood pressure regulator.Type: GrantFiled: October 20, 2006Date of Patent: November 12, 2013Assignee: Syntach AGInventors: Robert S. Schwartz, Robert A. Van Tassel, David R. Holmes, Jr.
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Patent number: 8544474Abstract: Systems and methods that provide magnetically-enhanced delivery of therapeutic agents to selected tissue are disclosed. The systems and methods involve the use of carrier devices and release devices and two different magnetic fields to move magnetic particles into selected tissue. Movement of the magnetic particles (and any associated therapeutic agent) into the tissue may be assisted by both magnetic attractive forces as well as magnetic repulsive forces.Type: GrantFiled: December 19, 2008Date of Patent: October 1, 2013Assignee: Mayo Foundation for Medical Education and ResearchInventors: Gurpreet S. Sandhu, David R. Holmes, Jr., Robert D. Simari, Nicole P. Sandhu, David R. Holmes, III
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Publication number: 20130211537Abstract: Medical devices, such as endoprostheses, and methods of making the devices are disclosed. The endoprostheses comprise a tubular member capable of maintaining patency of a bodily vessel. The tubular member includes a duplex stainless steel (e.g., 2205 stainless steel), which may be magnetized.Type: ApplicationFiled: May 24, 2011Publication date: August 15, 2013Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Gurpreet S. Sandhu, Robert D. Simari, David R. Holmes, JR., Dan Dragomir-Daescu, Anthony P. Parakka
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Publication number: 20120220890Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.Type: ApplicationFiled: May 10, 2012Publication date: August 30, 2012Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes, JR.
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Patent number: 8204600Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.Type: GrantFiled: November 21, 2006Date of Patent: June 19, 2012Assignee: Mayo Foundation for Medical Education and ResearchInventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes, Jr.
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Publication number: 20110178539Abstract: This document provides methods and materials related to minimally invasive techniques for reducing the volume of and/or occluding left atrial appendages.Type: ApplicationFiled: July 8, 2009Publication date: July 21, 2011Inventors: David R. Holmes, Jr., David R. Holmes, III, Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Susan B. Johnson, Rebecca B. Fountain
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Publication number: 20110144411Abstract: Systems and methods that provide magnetically-enhanced delivery of therapeutic agents to selected tissue are disclosed. The systems and methods involve the use of carrier devices and release devices and two different magnetic fields to move magnetic particles into selected tissue. Movement of the magnetic particles (and any associated therapeutic agent) into the tissue may be assisted by both magnetic attractive forces as well as magnetic repulsive forces.Type: ApplicationFiled: December 19, 2008Publication date: June 16, 2011Applicant: Mayo Foundation for Medical Education and ResearchInventors: Gurpreet S. Sandhu, David R. Holmes, JR., Robert D. Simari, Nicole P. Sandhu
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Patent number: 7727184Abstract: A catheter delivery system for delivering a treatment substance to an occlusion in a lumen of a tubular vessel includes a tubular catheter and a treatment substance. The tubular catheter includes a central lumen passing between a proximal end and a distal end adjacent to an inflatable balloon. The treatment substance is in a form that is configured to be deliverable through the central lumen of the catheter into the lumen of the tubular vessel and to solidify in the vessel.Type: GrantFiled: May 17, 2007Date of Patent: June 1, 2010Assignee: Mayo Foundation for Medical Education and ResearchInventors: David R. Holmes, Jr., Robert S. Schwartz