Patents by Inventor David R. Holmes, Jr.
David R. Holmes, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100121188Abstract: This document provides methods and materials that can be used to reduce or prevent contrast agent-induced toxicity. For example, devices for capturing contrast agents from blood are provided.Type: ApplicationFiled: October 10, 2007Publication date: May 13, 2010Inventors: Gurpreet S. Sandhu, David R. Holmes, III, David R. Holmes, JR., Nicole P. Sandhu, Robert D. Simari
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Publication number: 20090210050Abstract: An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise depressions, pores, projections, pleats, channels or grooves in the stent body and are designed to increase turbulence or stagnation in the flow of a liquid, such as blood through the stent, and/or to promote the growth of infiltrating cells in an organized pattern. Alternatively, the invention stent can be populated with living cells prior to implant and can be heatable from an external source of energy, thereby inducing production of therapeutic bioactive agents from ingrowing cells. The invention also provides an implantable heatable stent for transcutaneously monitoring the flow of fluid through a lumen into which the stent is implanted by measuring the rate at which the heated stent cools in response to blood flow when the source of heat is removed.Type: ApplicationFiled: April 24, 2009Publication date: August 20, 2009Inventors: Robert A. Van Tassel, David R. Holmes, JR., Robert S. Schwartz
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Publication number: 20080312715Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.Type: ApplicationFiled: November 21, 2006Publication date: December 18, 2008Inventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes, JR.
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Patent number: 7252654Abstract: The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue.Type: GrantFiled: September 2, 2005Date of Patent: August 7, 2007Assignee: TriCardia, LLCInventors: Robert A. VanTassel, David R. Holmes, Jr., Robert S. Schwartz
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Patent number: 7235096Abstract: An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise depressions, pores, projections, pleats, channels or grooves in the stent body and are designed to increase turbulence or stagnation in the flow of a liquid, such as blood through the stent, and/or to promote the growth of infiltrating cells in an organized pattern. Alternatively, the invention stent can be populated with living cells prior to implant and can be heatable from an external source of energy, thereby inducing production of therapeutic bioactive agents from ingrowing cells. The invention also provides an implantable heatable stent for transcutaneously monitoring the flow of fluid through a lumen into which the stent is implanted by measuring the rate at which the heated stent cools in response to blood flow when the source of heat is removed.Type: GrantFiled: August 25, 1999Date of Patent: June 26, 2007Assignee: TriCardia, LLCInventors: Robert A. Van Tassel, David R. Holmes, Jr., Robert S. Schwartz
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Patent number: 6949087Abstract: The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue.Type: GrantFiled: May 26, 2004Date of Patent: September 27, 2005Assignee: Tricardia, LLCInventors: Robert A. VanTassel, David R. Holmes, Jr., Robert S. Schwartz
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Patent number: 6913762Abstract: Implantable medical devices that include a non-woven framework are described, as well as methods of using such devices to deliver therapeutic compounds to a patient.Type: GrantFiled: April 25, 2001Date of Patent: July 5, 2005Assignee: Mayo Foundation for Medical Education and ResearchInventors: Noel Caplice, David Berry, Robert S. Schwartz, David R. Holmes, Jr., Robert D. Simari
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Patent number: 6855132Abstract: The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue.Type: GrantFiled: January 14, 2003Date of Patent: February 15, 2005Assignee: TriCardia, LLCInventors: Robert A. VanTassel, David R. Holmes, Jr., Robert S. Schwartz
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Patent number: 6699280Abstract: A stent includes a first stent section, a second stent section, and at least one connecting member. The connecting member has a first end attached to the first stent section, a second end attached to the second stent section and a physically separable portion.Type: GrantFiled: October 29, 2002Date of Patent: March 2, 2004Assignee: Mayo Foundation for Medical Education and ResearchInventors: Allan R. Camrud, David R. Holmes, Jr., Robert S. Schwartz, Timothy D. Argo
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Patent number: 6569129Abstract: A catheter delivery system for delivering a treatment substance to an occlusion in a lumen of a tubular vessel includes a tubular catheter and a treatment substance. The tubular catheter includes a central lumen passing between a proximal end and a distal end adjacent to an inflatable balloon. The treatment substance is in a form that is configured to be deliverable through the central lumen of the catheter into the lumen of the tubular vessel and to solidify in the vessel.Type: GrantFiled: September 13, 2000Date of Patent: May 27, 2003Assignee: Mayo Foundation for Medical Education and ResearchInventors: David R. Holmes, Jr., Robert S. Schwartz
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Patent number: 6547769Abstract: The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue.Type: GrantFiled: April 9, 2001Date of Patent: April 15, 2003Assignee: Tricardia LLCInventors: Robert A. VanTassel, David R. Holmes, Jr., Robert S. Schwartz
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Patent number: 6485510Abstract: A stent includes a first stent section, a second stent section, and at least one connecting member. The connecting member has a first end attached to the first stent section, a second end attached to the second stent section and a physically separable portion.Type: GrantFiled: April 14, 2000Date of Patent: November 26, 2002Assignee: Mayo Foundation for Medical Education and ResearchInventors: Allan R. Camrud, David R. Holmes, Jr., Robert S. Schwartz
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Patent number: 6258117Abstract: A multi-section stent includes a connecting structure that allows the stent sections to move and flex relative to one another. For deployment and positioning, the connecting structure connects the multiple stent sections and holds the stent sections substantially stationary relative to one another. Following deployment, the connecting structure allows the multiple stent sections to move relative to one another. Movable stent sections enable flexure of the stent upon deployment within a body lumen. This flexing structure allows better conformance of the stent to the shape of the body lumen, and exerts less overall pressure against the lumen wall, reducing the potential for trauma. Upon deployment, the multiple stent sections may be completely detached from one another. Alternatively, the stent sections may remain partially connected in a manner that allows substantial independent movement.Type: GrantFiled: April 15, 1999Date of Patent: July 10, 2001Assignee: Mayo Foundation for Medical Education and ResearchInventors: Allen R. Camrud, Robert S. Schwartz, David R. Holmes, Jr., Timothy D. Argo, David Berry
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Patent number: 6241710Abstract: The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue.Type: GrantFiled: December 20, 1999Date of Patent: June 5, 2001Assignee: Tricardia LLCInventors: Robert A. VanTassel, David R. Holmes, Jr., Robert S. Schwartz