Abstract: A wearable drug delivery device and related methods are described. The wearable drug delivery device can include: a housing; a flexible bag disposed within the housing; a cannula in fluid communication with the flexible bag; and a pumping mechanism for forcing a drug from the flexible bag and into the cannula, wherein the pumping mechanism is proximate the flexible bag and includes a spring-loaded paddle or a driving bag.

Abstract: A drug delivery assembly is used for delivering a medicament to a patient. The assembly includes a main body having a housing and defining a recess, with an actuator associated with the housing. An adhesive pad, configured to attach to a human body surface, is associated with a lower surface of the housing. The assembly also includes a cartridge configured to be at least partially inserted into the recess and having: a cartridge housing, a drug reservoir positioned within the cartridge housing, a stopper movably associated with the drug reservoir, and a needle movably associated with the drug reservoir. The actuator is manipulated to deploy the needle, with the actuator also engaging the cartridge to prevent removal of the cartridge from the recess during drug delivery. A rod of the body engages the stopper to move the stopper and dispense a medicament from the drug reservoir during drug delivery.

Abstract: A drug delivery device has a housing with an adhesive pad associated with the lower surface of the housing and configured to removably attach to a human body surface. A drug reservoir is positioned within the housing and includes an outlet with a valve, with a needle fluidically connected to the reservoir and configured to define at least a portion of a fluid flow path between the reservoir and the human body surface. A controller is configured to control the components of the drug delivery device to execute a drug delivery routine. The drug delivery device also includes pressurized fluid positioned to apply a force to the reservoir. The controller moves the valve from a closed condition to an open condition during a drug delivery routine to allow the pressurized fluid to deform the reservoir or move a plunger to convey the drug out of the reservoir via the outlet.

Abstract: An on-body injector includes a drug reservoir with an associated temperature sensor. A piston having an associated force sensor is driven to convey a drug out of the drug reservoir during a drug delivery routine. The temperature and force sensors are electrically coupled to a controller that controls the components of the on-body injector to execute a drug delivery routine. The controller receives signals from the temperature sensor indicative of a temperature of the drug within the reservoir and from the force sensor indicative of a force experienced by the piston during the drug delivery routine. The controller analyzes the signals to determine whether the measured force is different from an expected force at the measured temperature. The controller generates an error signal when the measured force is different from the expected force at the measured temperature.

Abstract: A magazine assembly (1) that stores a plurality of needles (56) configured to engage a medication pen (2) via an adapter (4) for medication delivery, the magazine assembly (1) comprising a magazine housing (20) enclosing a plurality of hub chambers (22) each enclosing one of a plurality of needle hubs (50), a connector (28) in each of the plurality of hub chambers (22), each connector (28) engages one of the plurality of needle hubs (50), and a plurality of enclosures (30) each sealing the plurality of hub chambers (22), wherein a selected enclosure of the plurality of enclosures (30) is removed to expose a selected needle hub (52) of the plurality of needle hubs (50), the adapter (4) attaches to the medication pen (2) to engage the selected needle hub (52) while disengaging the selected needle hub (52) from the hub chamber (22), and the selected needle hub (52) is removed from the magazine housing (20) to prepare the medication pen (2) for medication delivery.

Abstract: A drug dispensing system with replaceable cartridges wherein the system indicates whether the cartridge is suitable for use.

Abstract: The representative examples are intended to help illustrate the invention, and are not intended to, nor should they be construed to, limit the scope of the invention. Indeed, various modifications of the invention and many further embodiments thereof, in addition to those shown and described herein, will become apparent to those skilled in the art from the full contents of this document, including the examples and the references to the scientific and patent literature included herein. The examples contain important additional information, exemplification and guidance that can be adapted to the practice of this invention in its various embodiments and equivalents thereof.

Abstract: Devices are provided for applying an indicator composition and, optionally, a disinfectant composition to an article being dispensed through the device. The device includes a housing at least partially surrounding an interior volume and having a wall defining a dispensing aperture extending through the wall, a reservoir having at least one chamber sized to contain an indicator composition, and an application mechanism positioned within the housing relative to the dispensing aperture. The reservoir optionally has a second chamber sized to contain a disinfectant composition. The application mechanism is configured to be in fluid communication with the reservoir to apply an amount of the indicator composition and the optional disinfectant composition from the reservoir to an article dispensed through the dispensing aperture. Related compositions, articles, and methods are provided.

Abstract: Provided are devices, compositions, and methods for surface disinfection and decontamination; the devices generally adapted to contain a single or multi-component indicator composition, and optionally a disinfectant composition, and to dispense the indicator composition and optional disinfectant composition to a disinfectant solution, a surface, or a disinfectant article upon actuation of the device; also provided is an article of manufacture in the form of a removable cartridge adapted to fit a device described here, which may be pre-filled with a single or multi-component indicator composition as described here, and/or with a disinfectant composition, and one or more optional additives.

Abstract: An electronic smoking article includes a heater in communication with a liquid supply reservoir including liquid material and operable to heat the liquid material to a temperature sufficient to volatilize the liquid material contained therein and form an aerosol. The volatilized material flows through a sheath flow and aerosol promoter insert that is operable to cool the aerosol, reduce the particle size of the aerosol and increase the delivery rate of the aerosol.

Abstract: An electronic smoking article includes an outer housing extending in the longitudinal direction, a liquid aerosol formulation, a heater operable to at least partially volatilize at least a portion of the liquid aerosol formulation and form an aerosol, a power supply operable to apply voltage across the heater, at least one light emitting diode, a charging button assembly including a conductive post operable to form a first external, electrical contact at the upstream end of the electronic smoking article, and a second external, electrical contact including a portion of an outer surface of the outer housing at the upstream end of the electronic smoking article. The first and second external, electrical contacts charge the power supply.

Abstract: An electronic smoking article includes a heater in communication with a liquid supply reservoir including liquid material and operable to heat the liquid material to a temperature sufficient to volatilize the liquid material contained therein and form an aerosol. The volatilized material flows through a sheath flow and aerosol promoter insert that is operable to cool the aerosol, reduce the particle size of the aerosol and increase the delivery rate of the aerosol.

Abstract: A magazine assembly (1) that stores a plurality of needles (56) configured to engage a medication pen (2) via an adapter (4) for medication delivery, the magazine assembly (1) comprising a magazine housing (20) enclosing a plurality of hub chambers (22) each enclosing one of a plurality of needle hubs (50), a connector (28) in each of the plurality of hub chambers (22), each connector (28) engages one of the plurality of needle hubs (50), and a plurality of enclosures (30) each sealing the plurality of hub chambers (22), wherein a selected enclosure of the plurality of enclosures (30) is removed to expose a selected needle hub (52) of the plurality of needle hubs (50), the adapter (4) attaches to the medication pen (2) to engage the selected needle hub (52) while disengaging the selected needle hub (52) from the hub chamber (22), and the selected needle hub (52) is removed from the magazine housing (20) to prepare the medication pen (2) for medication delivery.

Abstract: An electronic smoking article includes an outer housing extending in the longitudinal direction, a liquid aerosol formulation, a heater operable to at least partially volatilize at least a portion of the liquid aerosol formulation and form an aerosol, a power supply operable to apply voltage across the heater, at least one light emitting diode, a charging button assembly including a conductive post operable to form a first external, electrical contact at the upstream end of the electronic smoking article, and a second external, electrical contact including a portion of an outer surface of the outer housing at the upstream end of the electronic smoking article. The first and second external, electrical contacts charge the power supply.

Abstract: An electronic smoking article or electronic vaping article includes a reservoir containing a liquid material and having an outlet, a capillary having a capillary inlet and a capillary outlet, the capillary inlet of the capillary in communication with the outlet of the reservoir, a heater operable to heat the capillary to a temperature sufficient to at least initially volatilize liquid material contained within the capillary, and a shuttle valve between the outlet of the reservoir and the capillary inlet. The shuttle valve is operable to prevent release of liquid material from the reservoir when the shuttle valve is in a closed position and is operable to release liquid material from the reservoir when the shuttle valve is in an open position.

Abstract: A magazine assembly (1) that stores a plurality of needles (56) configured to engage a medication pen (2) via an adapter (4) for medication delivery, the magazine assembly (1) comprising a magazine housing (20) enclosing a plurality of hub chambers (22) each enclosing one of a plurality of needle hubs (50), a connector (28) in each of the plurality of hub chambers (22), each connector (28) engages one of the plurality of needle hubs (50), and a plurality of enclosures (30) each sealing the plurality of hub chambers (22), wherein a selected enclosure of the plurality of enclosures (30) is removed to expose a selected needle hub (52) of the plurality of needle hubs (50), the adapter (4) attaches to the medication pen (2) to engage the selected needle hub (52) while disengaging the selected needle hub (52) from the hub chamber (22), and the selected needle hub (52) is removed from the magazine housing (20) to prepare the medication pen (2) for medication delivery.

Abstract: An electronic smoking article or electronic vaping article includes a reservoir containing a liquid material and having an outlet, a capillary having a capillary inlet and a capillary outlet, the capillary inlet of the capillary in communication with the outlet of the reservoir, a heater operable to heat the capillary to a temperature sufficient to at least initially volatilize liquid material contained within the capillary, and a shuttle valve between the outlet of the reservoir and the capillary inlet. The shuttle valve is operable to prevent release of liquid material from the reservoir when the shuttle valve is in a closed position and is operable to release liquid material from the reservoir when the shuttle valve is in an open position.

Abstract: Devices are provided for applying an indicator composition and, optionally, a disinfectant composition to an article being dispensed through the device. The device includes a housing at least partially surrounding an interior volume and having a wall defining a dispensing aperture extending through the wall, a reservoir having at least one chamber sized to contain an indicator composition, and an application mechanism positioned within the housing relative to the dispensing aperture. The reservoir optionally has a second chamber sized to contain a disinfectant composition. The application mechanism is configured to be in fluid communication with the reservoir to apply an amount of the indicator composition and the optional disinfectant composition from the reservoir to an article dispensed through the dispensing aperture. Related compositions, articles, and methods are provided.