Abstract: A system according to certain aspects of the disclosure provides drug pricing information from multiple PBMs to users. For example, the system may obtain, calculate, and/or estimate drug prices that are available under contracts or agreements between PBMs and various pharmacies. These prices may be prices of drugs for purchase at the various pharmacies. In response to requests for prices of particular drugs, the system can display relevant prices. For example, the system displays a price for each pharmacy chain and/or displays prices for a particular geographical area. The users can compare the prices for a particular drug and determine which pharmacy they would like to purchase the drug from. The system can provide a discount coupon that allows the users to purchase the drug at the price listed by the system at the selected pharmacy.

Abstract: Systems and methods for optimizing routes and water usage are disclosed herein. An example method includes determining calendar data for a traveler, the calendar data including trip information for a trip, determining a current water supply for the traveler, determining water generation capability of a vehicle used by the traveler for the trip, predictively determining a water estimate for the trip, determining when the water supply and the water generation capability substantially correspond to the water estimate, and providing an alert to the traveler when the water supply and the water generation capability are insufficient relative to the water estimate.

Abstract: A belt mountable holder and methods of making and using a belt mountable holder including an arcuate member suspendable from a belt disposed about the waist of a wearer and having mateable fasteners disposed on an exterior face of the arcuate member to releasably couple one or more containers to carry articles or tool retainers to retain tools and optionally including a holder support to transfer a holder weight normally applied to the waist of a wearer to a ground engaging surface to remove weight bearing stress from the wearer's waist.

Abstract: A container including a clip attached at a clip first end to the container body and having a downwardly extending clip arm terminating in a clip second end for securing the container to a substrate disposed between the downwardly extending clip arm and the container body. In particular embodiments, the clip arm can include a clip aperture configured as the first of a pair of mateable fastener removably mateable to a second of the pair of mateable fasteners to removably affix the container to another surface or device.

Abstract: Gonioscope devices are disclosed herein that are configured to enable a medical professional to view structure inside the eye that is ordinarily hidden from normal view. The gonioscope can be an integrally molded single piece that includes both a handle and a gonioscopic optical element. The proximal surface can have a viewing area and a light diffusing area. A recess can provide access to a wound site on the eye while the gonioscope is used for viewing. The handle can be configured to encourage proper alignment of the gonioscope with the eye. The gonioscope can provide an optical fixation point for the subject to focus on to facilitate proper alignment of the eye. The gonioscope can have one or more retention elements configured to engage the tissue of the eye around the contact surface to stabilize the gonioscope. The gonioscope can couple to a lid speculum.

Abstract: A belt mountable holder and methods of making and using a belt mountable holder including an arcuate member suspendable from a belt disposed about the waist of a wearer and having mateable fasteners disposed on an exterior face of the arcuate member to releasably couple one or more containers to carry articles or tool retainers to retain tools and optionally including a holder support to transfer a holder weight normally applied to the waist of a wearer to a ground engaging surface to remove weight bearing stress from the wearer's waist.

Abstract: A system according to certain aspects of the disclosure provides drug pricing information from multiple PBMs to users. For example, the system may obtain, calculate, and/or estimate drug prices that are available under contracts or agreements between PBMs and various pharmacies. These prices may be prices of drugs for purchase at the various pharmacies. In response to requests for prices of particular drugs, the system can display relevant prices. For example, the system displays a price for each pharmacy chain and/or displays prices for a particular geographical area. The users can compare the prices for a particular drug and determine which pharmacy they would like to purchase the drug from. The system can provide a discount coupon that allows the users to purchase the drug at the price listed by the system at the selected pharmacy.

Abstract: Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.

Abstract: An intervertebral fusion device comprising inferior and superior fusion cage devices that provide an ability to correct spondylolisthesis via in-situ adjustment.

Abstract: A vehicle comprises: a dispenser for a liquid, the dispenser comprising an outlet for the liquid; and a source of ultraviolet light disposed to emit the ultraviolet light onto the outlet of the dispenser. The dispenser further comprises a first position and a second position that is different than the first position. The outlet of the dispenser is disposed closer to the source of ultraviolet light when the dispenser is in the second position than when the dispenser is in the first position. The vehicle comprises a controller in communication with the source of the ultraviolet light. The controller causes the source of ultraviolet light to emit the ultraviolet light when the dispenser is in the second position but not when the dispenser is in the first position.

Abstract: A system for a water generation apparatus of a vehicle includes a sensing device that detects an environmental condition of a geographical area associated with the vehicle. A display device is configured to present a depiction of the geographical area. A controller is in communication with the sensing device and the display device. The controller is configured to determine at least one water generation estimate for the water generation apparatus based on the environmental condition and the geographical area. The controller is further configured to generate a modified representation of the geographical area based on the at least one water generation estimate and the depiction of the geographical area. The controller is further configured to communicate an instruction to present the modified representation at the display device.

Abstract: Procedural world generation using tertiary data is described. In an example, a computing device can receive road network data associated with the real environment and a road mesh associated with a real environment. The computing device can associate the road network data with the road mesh to generate a simulated environment. Additionally, the computing device can associate supplemental data with the road network data and the road mesh to enhance the simulated environment (e.g., supplementing information otherwise unavailable to the sensor data due to an occlusion). The computing device can output the simulated environment for at least one of testing, validating, or training an algorithm used by an autonomous robotic computing device for at least one of navigating, planning, or decision making.

Abstract: A separate nub component between the plate and an intervertebral fusion cage, wherein the nub is attached to the plate. The nub lessens the undesired pivotal movement of the plate. It is believed that when the nub fits snugly between the endplates of the adjacent vertebral bodies, it acts as a stop against the undesired pivotal movement of the plate.

Abstract: Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.

Abstract: Various systems and methods are provided for surgical and interventional planning, support, post-operative follow-up, and functional recovery tracking. In general, a patient can be tracked throughout medical treatment including through initial onset of symptoms, diagnosis, non-surgical treatment, surgical treatment, and recovery from the surgical treatment. In one embodiment, a patient and one or more medical professionals involved with treating the patient can electronically access a comprehensive treatment planning, support, and review system. The system can provide recommendations regarding diagnosis, non-surgical treatment, surgical treatment, and recovery from the surgical treatment based on data gathered from the patient and the medical professional(s).

Abstract: A system includes a processor configured to detect a vehicle condition associated with a warning light. The processor is also configured to obtain explanatory information explaining the cause of the warning light. The processor is further configured to present the explanatory information via a vehicle display. Also, the processor is configured to present a plurality of options for further action with the explanatory information and, upon selection of one of the options, take further steps in accordance with the selection option.

Abstract: A vehicle including: (a) a water generator configured to generate water; (b) a water storage container configured to store the water that the water generator generates; (c) an ultraviolet light emitter configured to emit ultraviolet light into the water storage container; (d) a sensor configured to detect the ultraviolet light that the ultraviolet light emitter has emitted; and (e) a human-machine interface configured to issue a notification to a user of the vehicle regarding the ultraviolet light emitter. The sensor can detect a wavelength range of the ultraviolet light that the ultraviolet light emitter has emitted. The sensor can detect an intensity of the ultraviolet light at a predetermined wavelength or wavelength range that the ultraviolet light emitter has emitted. The vehicle further comprises a controller in communication with the ultraviolet light emitter, the sensor, and the human-machine interface.

Abstract: A wood grinding machine may have a vibration detection system including one or more vibration sensors. The vibration detection system may include a trip point representative of a maximum allowable level of vibration. If a vibration signal from the one or more vibration sensors exceeds the trip point, a trip protocol may be executed to automatically stop the grinding process. Related methods are also disclosed.

Abstract: There is provided a method which includes placing a component on a substrate and extending an alignment member through an opening in the substrate. Once the alignment member is extended through the opening, the component is moved to abut against the alignment member to align the component relative to the substrate. After the component is aligned relative to the substrate, the component is secured to the substrate and the alignment member is retracted through the opening.

Abstract: Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.