Abstract: The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

Abstract: A configuration control transfer (“CCT”) system controls the transferring of control of configuration information of a device from a current configuration source to a target configuration source. A CCT server of the CCT system may send a request for the configuration information of the device where the configuration information of the device currently under control of the at least one first configuration source. The CCT server may also receive the requested configuration information, determine whether the second configuration source is able to support the configuration information of the first configuration source, and based at least on a determination that the second configuration source is able to support the configuration information, request that the device transfer control of the configuration information from the first configuration source to the second configuration source to unenroll the device with the first configuration source and enroll the device with the second configuration source.

Abstract: The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylam ides and analogues thereof, having the structure: or a pharmaceutically acceptable salt thereof, as set forth in the Description. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

Abstract: A configuration control transfer (“CCT”) system controls the transferring of control of configuration information of a device from a current configuration source to a target configuration source. A CCT server of the CCT system may send a request for the configuration information of the device where the configuration information of the device currently under control of the at least one first configuration source. The CCT server may also receive the requested configuration information, determine whether the second configuration source is able to support the configuration information of the first configuration source, and based at least on a determination that the second configuration source is able to support the configuration information, request that the device transfer control of the configuration information from the first configuration source to the second configuration source to unenroll the device with the first configuration source and enroll the device with the second configuration source.

Abstract: A sensor device includes: a probe body having a first end and a second end, the probe body defining a probe cavity within the probe body; a sensor located at the first end of the probe body, the sensor having a sensor surface in sensory communication with the probe cavity defined within the probe body; a permanent magnet located adjacent the second end of the probe body and at least partially circumscribing the probe cavity defined within the probe body; an isolating boundary portion located between the permanent magnet and a surface of the object of interest and having a passage formed therethrough, the passage in communication with the probe cavity defined within the probe body.

Abstract: The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, and pyrrolo[2,3-b]pyridinyl acrylamides, epoxides, and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

Abstract: A configuration control transfer (“CCT”) system controls the transferring of control of configuration information of a device from a current configuration source to a target configuration source. A CCT server of the CCT system may send to the device a message requesting the configuration information of the device. In response, a CCT client of the CCT system collects the configuration information of the device and sends the collected configuration information to the CCT server. If the second configuration source can support the configuration information of the current configuration source, the CCT server requests that the device transfer control of the configuration information from the current configuration source to the target configuration source. The CCT client then transfers control of the configuration information to the target configuration source as the new current configuration source and un-enrolls the device from the former current configuration source.

Abstract: A sensor device includes: a probe body having a first end and a second end, the probe body defining a probe cavity within the probe body; a sensor located at the first end of the probe body, the sensor having a sensor surface in sensory communication with the probe cavity defined within the probe body; a permanent magnet located adjacent the second end of the probe body and at least partially circumscribing the probe cavity defined within the probe body; an isolating boundary portion located between the permanent magnet and a surface of the object of interest and having a passage formed therethrough, the passage in communication with the probe cavity defined within the probe body.

Abstract: A flexible, scalable hardware input device for interacting with a variety of devices ranging from a phone, to a media playback device to a steering wheel or a tablet PC is provided. The input device includes a set of mechanical input controls, each mapping to one or more independent functions and a set of touch sensitive input control areas (e.g., capacitive), where each touch sensitive input control area receives touch input independently. In addition, one or more of the touch sensitive input control areas interchangeably overlay one or more of the mechanical input controls, whereby interaction with the touch sensitive input control areas is processed together to determine a corresponding function for controlling the application, service or computing device.

Abstract: The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, and pyrrolo[2,3-b]pyridinyl acrylamides, epoxides, and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

Abstract: The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

Abstract: A configuration control transfer (“CCT”) system controls the transferring of control of configuration information of a device from a current configuration source to a target configuration source. A CCT server of the CCT system may send to the device a message requesting the configuration information of the device. In response, a CCT client of the CCT system collects the configuration information of the device and sends the collected configuration information to the CCT server. If the second configuration source can support the configuration information of the current configuration source, the CCT server requests that the device transfer control of the configuration information from the current configuration source to the target configuration source. The CCT client then transfers control of the configuration information to the target configuration source as the new current configuration source and un-enrolls the device from the former current configuration source.

Abstract: The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof, having the structure: or a pharmaceutically acceptable salt or solvate thereof, or an enantiomer or diastereomer thereof, as set forth in the Description. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.

Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.

Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.

Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.

Abstract: The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.

Abstract: A flexible, scalable hardware input device for interacting with a variety of devices ranging from a phone, to a media playback device to a steering wheel or a tablet PC is provided. The input device includes a set of mechanical input controls, each mapping to one or more independent functions and a set of touch sensitive input control areas (e.g., capacitive), where each touch sensitive input control area receives touch input independently. In addition, one or more of the touch sensitive input control areas interchangeably overlay one or more of the mechanical input controls, whereby interaction with the touch sensitive input control areas is processed together to determine a corresponding function for controlling the application, service or computing device.