Abstract: A system may include an implantable device having at least a first sensor configured to collect first data regarding one or more characteristics of a bone of a patient, wherein the implantable device is configured for implantation in a medullary canal of the tibia. The system may include an attachment member configured to couple with the implantable device when the implantable device is implanted in the medullary canal of the tibia. The system may further include a targeting device moveably coupled to the attachment member, wherein the targeting device is configured to reference a distal anatomy of a leg, and wherein the targeting device has at least a second sensor configured to collect second data regarding at least a position of the targeting device.

Abstract: A product includes a three-dimensional structure having a plurality of sequentially-formed layers comprised of liquid crystal elastomers. The liquid crystal elastomers in at least a predefined portion of a first of the layers are substantially aligned in a first orientation, and the liquid crystal elastomers in at least a predefined portion of a second of the layers are substantially aligned in a second orientation. In addition, each of the portions of the three-dimensional structure is characterized as exhibiting a shape change in response to a stimulus, where the shape change is reversible.

Abstract: Magnetic particle actuating systems may include a magnet system configured to generate a magnetic field that includes a field-free region. A corresponding control system can be configured to control the magnet system to create a field-free region at least partially matching a target region. An excitation system can be configured to generate an excitation field to cause actuation of magnetic nanoparticles in an actuation region.

Abstract: Compositions comprising silica particles having a mean size by standard particle sizing of between 0.5 nm and 20 nm are described for used in activating lymphocytes in culture or in whole blood.

Abstract: An exemplary embodiment of the present disclosure provides a detector configured to output a signal associated with one or more interactions with subatomic particles. The detector comprises a sensor comprising a first diode comprising first semiconductor material abutting a first metal and forming a first junction, wherein the sensor is configured to be exposed to subatomic particles and a voltage reference member configured to generate a reference measurement. The sensor and the voltage reference member form a bandgap reference circuit. The present disclosure also provides methods for detecting subatomic particles from a solid-state detector comprising a first Schottky diode in electrical communication with a reference voltage member comprising a parallel circuit of two or more second Schottky diodes, wherein the first Schottky diode is configured to be exposed to subatomic particles and the second Schottky diodes of the reference voltage member are configured to generate a reference measurement.

Abstract: The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of hydrobromide salts of Compound 1, and, optionally, a pharmaceutically acceptable carrier; c) methods of treating tumors or cancers by administering one or more solid state forms of hydrobromide salts of Compound 1 to a subject in need thereof; and d) methods for the preparation of solid state forms of Compound 1.

Abstract: Disclosed herein are compositions comprising fixed doses of ETC-1002 and one or more statins. Also disclosed herein are methods for using fixed doses of ETC-1002 and one or more statins. Uses include methods of treating cardiovascular disease or reducing the risk of cardiovascular disease in a subject. Uses also include methods of treating hypercholesterolemia in a subject.

Abstract: A compact valve block for a chemical container wherein the coaxial valve block has a housing that can accommodate three valve control mechanisms thus allowing for quick and effective purging without the need for an additional external conduit, valves, and coaxial injector. The advantage is a greatly reduced amount of wetted surface area inside the valve block leading to a significant decrease in the time it takes to purge a system thus allowing for quicker times to change chemical containers.

Abstract: Motorcycle riders may be exposed to cold weather. Herein, an electrical heating system in a garment is inductively powered from the motorcycle. Primary induction coils may be in the handlebar grips, tank area or other areas of the motorcycle. Garments may have a battery that is recharged inductively and powers heating elements in the garment. Rider accessories may also be wirelessly powered or charged. Rider comfort and convenience may contribute to improved rider response and safety.

Abstract: An apparatus for correcting a defect in an object using three-dimensional (3D) printing. The apparatus includes a flexible wrapper-shaped printing module including an array of port openings adapted to allow a 3D printable material to move therethrough. The flexible wrapper-shaped printing module is configured to wrap around an object to allow the 3D printable material to move through a first set of selected port openings of the array of port openings and be injected into the defect in order to correct the defect.

Abstract: The present disclosure relates to compositions comprising preparations of uncultured fecal bacteria, methods of manufacturing the compositions, and methods of using the compositions to treat a disorder related to a gut dysbiosis.

Abstract: The present application relates to particular anti-PAD4 (peptidyl arginine deiminase 4) antibodies, nucleic acids encoding the antibodies, vectors and host cells comprising the nucleic acids, and methods of making and using the antibodies.

Abstract: An example of a system for post-case analysis of cardiopulmonary resuscitation (CPR) performance trends includes a ventilation metrics device with sensors configured to generate signals indicative of ventilation treatment data during a medical treatment of a patient, and a patient monitor/defibrillator configured to receive the signals, calculate the ventilation treatment data based on the received signals, and transmit the ventilation treatment data, and a remote computing device configured to communicatively couple with the treatment monitoring system and with an output display device, the computing device including at least one memory and at least one processor communicatively coupled to the memory, the at least one processor configured to receive treatment data from the treatment monitoring system, the treatment data including the ventilation treatment data, and provide case review information at a case review dashboard at the output device, the case review information including time trend plots of the ve

Abstract: A damping control system for a vehicle having a suspension located between a plurality of ground engaging members and a vehicle frame includes at least one adjustable shock absorber having an adjustable damping profile.

Abstract: The present invention relates to RNA constructs, and particularly, although not exclusively, to mRNA constructs and saRNA replicons and to nucleic acids and expression vectors encoding such RNA constructs. The invention extends to the use of such RNA constructs in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.

Abstract: A cleaning wipe including a first nonwoven having a plurality of first nonwoven strips and a second nonwoven having a plurality of second nonwoven strips. The first nonwoven and the second nonwoven are each gate folded. More than about 10% of the second nonwoven strips are bent so that the free ends of the second nonwoven strips are bent out of plane relative to the fixed ends of the second nonwoven strips.

Abstract: A process for packaging a product including the steps of providing a cleaning wipe that includes nonwoven strips and moving the cleaning wipe in a direction aligned with the longitudinal axis of the cleaning wipe. A gas is moved from positions on opposite sides of the longitudinal axis and beyond the longitudinal edges of the cleaning wipe to bend the free ends of the nonwoven strips out of plane relative to the fixed ends of the strips.

Abstract: A product including a previously unopened closed container and a plurality of cleaning wipes contained in the container. The cleaning wipes include a first nonwoven having a plurality of first nonwoven strips and a second nonwoven having a plurality of second nonwoven strips. More than about 10% of the second nonwoven strips are bent so that the free ends of the second nonwoven strips are bent out of plane relative to the fixed ends of the second nonwoven strips.