Abstract: Systems and methods are disclosed. A digitized human vocal expression of a user and digital images are received over a network from a remote device. The digitized human vocal expression is processed to determine characteristics of the human vocal expression, including: pitch, volume, rapidity, a magnitude spectrum identify, and/or pauses in speech. Digital images are received and processed to detect characteristics of the user face, including detecting if any of the following is present: a sagging lip, a crooked smile, uneven eyebrows, and/or facial droop. Using the human vocal expression characteristics and face characteristics, a determination is made as to what action is to be taken. A cepstrum pitch may be determined using an inverse Fourier transform of a logarithm of a spectrum of a human vocal expression signal. The volume may be determined using peak heights in a power spectrum of the human vocal expression.

Abstract: Aspect pre-selection techniques using machine learning are described. In one example, an artificial assistant system is configured to implement a chat bot. A user then engages in a first natural-language conversation. As part of this first natural-language conversation, a communication is generated by the chat bot to prompt the user to specify an aspect of a category that is a subject of a first natural-language conversation and user data is received in response. Data that describes this first natural-language conversation is used to train a model using machine learning. Data, is then be received by the chat bot as part of a second natural-language conversation. This data, from the second natural-language conversation, is processed using the model as part of machine learning to generate the second search query to include the aspect of the category automatically and without user intervention.

Abstract: Systems and methods for determining whether to enable color blind accessibility settings within the course of a user interactive narrative are described herein. Virtual color blindness indication objects containing colors that are visibly distinguishable within a single dichromatic visual spectrum can be utilized in objectives to determine a user's dichromatic visual deficiency type.

Abstract: A pipe support assembly comprising: a body having a clamp device adapted to clamp the pipe within an aperture in the body, having first and second clamp arms and a fastening mechanism; a spacer adapted to be received within the aperture in the body having an inner face adapted to engage the pipe and an outer face adapted to engage at least one of the first and second clamp arms, to space at least one of the first and second clamp arms from the pipe. The spacer comprises at least two segments and the aperture is non-circular. Each spacer segment has a first circumferential end and a second circumferential end, and in at least two spacer segments in the spacer, the first circumferential end has a larger radial dimension than the second circumferential end. At least two spacer segments have a tapered arcuate profile between the first and second circumferential ends.

Abstract: Systems and methods for detecting and classifying premature ventricular contractions (PVCs) are discussed. An exemplary system includes a sensor circuit to sense a cardiac signal of a subject, and a processor circuit to detect heartbeats from the cardiac signal and detect a PVC under a first detection mode or a different second detection mode. The first detection mode includes identifying a PVC candidate of a particular type using cardiac intervals or signal amplitudes of the detected heartbeats, and classifying the identified PVC candidate as a PVC singleton or a pattern of multiple consecutive PVCs using signal features including morphology features of the sensed cardiac signal. The second detection mode includes detecting PVC of the particular type using the cardiac intervals or the signal amplitudes of the detected heartbeats. The first detection mode can be transitioned to the second detection mode in response to a mode-switching trigger event.

Abstract: A metering pump for a medical injector includes a housing, a sleeve at least partially received within the housing, a piston at least partially received within the sleeve, and an interlock. The piston has a first position where the chamber has a first volume and a second position where the chamber has a second volume, with the first volume larger than the second volume. The sleeve has a first rotational position where an inlet is in fluid communication with the chamber, a second rotational position where an outlet is in fluid communication with the chamber, and a third rotational position where the inlet and outlet are isolated from the chamber. The interlock includes an elastomeric member and a protrusion, where engagement between the elastomeric member and the protrusion is configured to restrict movement of the sleeve until the sleeve overcomes a predetermined torque value.

Abstract: The systems and methods described herein provide, in accordance with different embodiments, different examples of unified systems and methods that allow to automate or streamline, at least partially, a plurality of tasks related to one or more water-related services or functions provided by or under the authority of a water-related entity.

Abstract: A method and apparatus of a device that grows and/or shrinks a table that is shared between a writer and a plurality of readers is described. In an exemplary embodiment, a device receives an entry to be added to the shared table. In response to receiving the entry, the device remaps shared table to add a new storage segment to the shared table. The device further adds the entry to the shared table, where the entry is stored in the new storage segment. In addition, the device updates a shared table characteristic to indicate that the shared table has changed. The device further shrinks the shared table by remapping the table to remove a segment of the table.

Abstract: Methods and systems for implementing a Jupiter aerospace mission can enable delivery of a science payload to a Jupiter orbit on a direct Earth-to-Jupiter trajectory. Solar power and use of avionics also allow a fast assembly, integration, and test process compared to past outer Solar System missions. The spacecraft can include an aerodynamic forebody, a shell, and a thermal protection system. The spacecraft can manage the radiation environment, generate solar power, and return data to Earth with a robust radio-frequency (RF) amplification and antenna gain.

Abstract: A formulation for forming a styrene-based scintillator using light-directed additive manufacturing techniques includes a base monomer, a primary dye, a secondary dye, and a cationic photoinitiator. The base monomer includes one or more styrene-derivative monomers.

Abstract: A product includes a three-dimensional structure having a plurality of sequentially-formed layers comprised of liquid crystal elastomers. The liquid crystal elastomers in a portion of a first of the layers are substantially aligned in a predefined first orientation and the liquid crystal elastomers in a portion of a second of the layers are substantially aligned in a predefined second orientation that is different than the first orientation. Each of the portions of the three-dimensional structure is characterized as exhibiting a shape change in response to a stimulus, wherein the shape change is reversible. The product includes a contiguous region of aligned liquid crystal elastomers in one of the portions having a maximum dimension of less than 60 microns.

Abstract: The present invention relates to the treatment of elderly subjects (e.g., subjects aged 65 years or older) having relapsed and/or refractory (R/R) non-Hodgkin's lymphoma (NHL). More specifically, the invention pertains to the treatment of subjects having an R/R NHL by intravenous administration of mosunetuzumab.

Abstract: At a rule processing unit of an evolving, self-organized machine learning-based resource management service, a rule of a first rule set is applied to a value of a first collected metric, resulting in the initiation of a first corrective action. A set of metadata indicating the metric value and the corrective action is transmitted to a repository, and is used as part of an input data set for a machine learning model trained to generate rule modification recommendations. In response to determining that the corrective actions did not meet a success criterion, an escalation message is transmitted to another rule processing unit.

Abstract: A microfluidic device for detection of an analyte in a fluid is described. The microfluidic device comprises a substrate having a first surface defining entrances to one or more chambers defined in the substrate, surfaces of the chambers defining a second surface of the substrate, the first surface being modified for selective targeting and capture of at least one analyte to operably effect a blocking of the entrance to at least one of the chambers, and wherein a response characteristic of the microfluidic device is operably varied by the blocking of the entrance to the at least one of the chambers, thereby providing an indication of the presence of the analyte within the fluid.

Abstract: The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of hydrobromide salts of Compound 1, and, optionally, a pharmaceutically acceptable carrier; c) methods of treating tumors or cancers by administering one or more solid state forms of hydrobromide salts of Compound 1 to a subject in need thereof; and d) methods for the preparation of solid state forms of Compound 1.

Abstract: The present disclosure is directed to human GDF-15-binding antibodies and antigen-binding fragments thereof. The antibodies and fragments can be used, for example, to detect human GDF-15 and/or in methods of treating cancer or body weight loss, including cachexia, associated with over-expression of human GDF-15.

Abstract: The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of hydrobromide salts of Compound 1, and, optionally, a pharmaceutically acceptable carrier; c) methods of treating tumors or cancers by administering one or more solid state forms of hydrobromide salts of Compound 1 to a subject in need thereof; and d) methods for the preparation of solid state forms of Compound 1.

Abstract: An IoT hub comprising one or more servers and databases is configured to automatically assign Internet of Things (IoT) enabled devices to IoT solutions based on a subnet to which the IoT devices are connected. A user interface is configured to enable a user to define subnets within the customer's network environment and assign each subnet to an IoT solution. Upon the user setting up an IoT device's network connection to a network device, such as a router, the IoT device transmits its network information to the IoT hub. The IoT hub can then automatically assign the IoT device to a specific IoT solution without further user input or predict which IoT solution to utilize for that IoT device based on known parameters.

Abstract: The present disclosure relates to the modulation of glucagon-like peptide 1 (GLP-1) with inhibitors of lysophosphatidic acid (LPA). LPAR antagonists such as Ki16425, BMS-986020, SAR 100842, AM966, AM095, H2L5186303, LPA2-antagonist 1 and combinations thereof are used in the treatment or prevention of diseases characterized by reduced GLP-1 activity such as: diabetes, Alzheimer's disease, Parkinson's disease, kidney disease (including chronic kidney disease), diabetic nephropathy, a serious renal event, cardiovascular disease, stroke, depression, metal health, pulmonary fibrosis, obesity, aging, or non-alcoholic fatty liver disease.