Patents by Inventor Elisabeth Perzborn

Elisabeth Perzborn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-Phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
    Publication number: 20050070541
    Abstract: The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
    Type: Application
    Filed: August 20, 2004
    Publication date: March 31, 2005
    Applicant: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewohner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Karl-Heinz Schlemmer, Jorg Keldenich, Erwin Bischoff, Elisabeth Perzborn, Klaus Dembowsky, Peter Serno, Marc Nowakowski
  • Stents
    Publication number: 20050064006
    Abstract: The invention concerns stents containing compounds of formula (I) and methods for making said stents as well as their use.
    Type: Application
    Filed: October 11, 2002
    Publication date: March 24, 2005
    Applicant: Bayer Aktiengesellschaft
    Inventors: Elisabeth Perzborn, Jochen Kalbe, Wolfram Ledwoch, Didier Meulien
  • Derivatives of dicarboxylic acid having pharmaceutical properties
    Patent number: 6864287
    Abstract: The present invention relates to the compounds of the general formula (I) and their salts and stereoisomers for the production of medicaments for the treatment of cardiovascular disorders.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: March 8, 2005
    Assignee: Bayer Aktiengesellschaft
    Inventors: Cristina Alonso-Alija, Markus Heil, Dietmar Flubacher, Paul Naab, Johannes-Peter Stasch, Frank Wunder, Klaus Dembowsky, Elisabeth Perzborn, Elke Stahl
  • 7-Aikyl and cycloalkyl-substituted imidazotriazinones
    Publication number: 20050049250
    Abstract: The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.
    Type: Application
    Filed: May 20, 2004
    Publication date: March 3, 2005
    Applicant: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewohner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Gunter Schmidt, Karl-Heinz Schlemmer, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn
  • Novel imidazo[1,3,5]triazinones and their use
    Publication number: 20050043303
    Abstract: The invention relates to imidazo[1,3,5]triazinones, a method for their production and methods of use, in particular as inhibitors of cyclic GMP metabolizing phosphodiesterases.
    Type: Application
    Filed: July 15, 2004
    Publication date: February 24, 2005
    Applicant: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewohner, Helmut Haning, Thomas Lampe, Mazen Es-Sayed, Gunter Schmidt, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • Substituted isoindoles and the use thereof
    Publication number: 20050004207
    Abstract: The invention relates to the field of blood clotting, to novel compounds of formula (I), to a method for their production and to the use of these compounds as active ingredients in medicaments for preventing and/or treating diseases. The compounds are factor Xa inhibitors.
    Type: Application
    Filed: July 3, 2002
    Publication date: January 6, 2005
    Inventors: Alexander Straub, Thomas Lampe, Jens Pohlmann, Susanne Rohrig, Stephan Jordan, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • 7-alkyl-and cycloalkyl-substituted imidazotriazinones
    Patent number: 6838459
    Abstract: The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: January 4, 2005
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewöhner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Gunter Schmidt, Karl-Heinz Schlemmer, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn
  • Substituted pyrazole derivatives
    Patent number: 6833364
    Abstract: The present invention relates to novel substituted pyrazole derivatives of the general formula (I) in which the substituents R1, R2, R3, A, X and Y are each as defined, and to processes for their preparation and to their use as medicaments, in particular as medicaments for the treatment of cardiovascular disorders.
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: December 21, 2004
    Assignee: Bayer HealthCare AG
    Inventors: Alexander Straub, Achim Feurer, Cristina Alonso-Alija, Elke Stahl, Johannes-Peter Stasch, Elisabeth Perzborn, Joachim Hütter, Klaus Dembowsky
  • Substituted oxazolidinones for combinational therapy
    Publication number: 20040242660
    Abstract: The invention relates to combinations of A) oxazolidinones of formula (I) and B) other active ingredients, to a method for producing said combinations and to the use thereof as medicaments, in particular for the treatment and/or prophylaxis of thrombo-embolic diseases.
    Type: Application
    Filed: June 28, 2004
    Publication date: December 2, 2004
    Inventors: Alexander Straub, Thomas Lampe, Josef Pernerstorfer, Elisabeth Perzborn, Jens Pohlmann, Susanne Rohrig, Karl-Heinz Schlemmer
  • Morpholine-bridged pyrazolopyridine derivatives
    Publication number: 20040235863
    Abstract: The invention relates to novel pyrazolopyridine derivatives of formula (I), wherein R1 represents (a) or (b) and n represents 1 or 2 and R2 represents H NH2. The invention also relates to salts, isomers and hydrates thereof as stimulators for soluble guanylate cyclase and to their use as agents in the treatment of cardiovascular diseases, hypertonicity, thrombo-embolic diseases and ischemia, sexual dysfunction or inflammations and for the treatment of diseases of the central nervous system.
    Type: Application
    Filed: June 28, 2004
    Publication date: November 25, 2004
    Inventors: Achim Feurer, Dietmar Flubacher, Stefan Weigand, Johannes-Peter Stasch, Elke Stahl, Thomas Schenke, Cristina Alonso-Alija, Frank Wunder, Dieter Lang, Klaus Dembowsky, Alexander Straub, Elisabeth Perzborn
  • Novel substituted pyrazole derivatives
    Publication number: 20040224945
    Abstract: The present invention relates to novel substituted pyrazole derivatives of the general formula (I) 1
    Type: Application
    Filed: May 28, 2004
    Publication date: November 11, 2004
    Applicant: Bayer HealthCare AG
    Inventors: Alexander Straub, Achim Feurer, Cristina Alonso-Alija, Johannes-Peter Stasch, Elisabeth Perzborn, Joachim Hutter, Klaus Dembowsky, Elke Stahl
  • Substituted isoindoles and the e use thereof
    Publication number: 20040215019
    Abstract: The invention relates to coagulation of the blood.
    Type: Application
    Filed: January 30, 2004
    Publication date: October 28, 2004
    Inventors: Alexander Straub, Thomas Lampe, Jens Pohlmann, Susanne Rohrig, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • Imidazo[1,3,5]triazinones and the use thereof
    Patent number: 6803365
    Abstract: The invention relates to imidazo[1.3.5]triazinones, a method for their production and methods of use, in particular as inhibitors of cyclic GMP metabolizing phosphodiesterases.
    Type: Grant
    Filed: November 4, 2002
    Date of Patent: October 12, 2004
    Assignee: Bayer Aktlengesellschaft
    Inventors: Ulrich Niewöhner, Helmut Haning, Thomas Lampe, Mazen Es-Sayed, Gunter Schmidt, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • Novel sulfonate substituted pyrazol pyridine derivatives
    Publication number: 20040171832
    Abstract: The invention relates to novel pyrazol pyridine derivatives of formula (I), wherein R1 signifies a radical of formula —O—SO2—R3, R3 represents a radical from the group consisting of optionally substituted C1-6-alkyl, optionally substituted C3-8-cycloalkyl, or optionally substituted phenyl, R2 represents H or optionally substituted C1-6-alkyl-SO2—; in addition to the salts, isomers and hydrates thereof, as stimulators of soluble guanylate cyclase, and to the use thereof as agents for treating cardio-vascular diseases, hypertonia, thromboembolic diseases and ischaemia, sexual dysfunction or inflammations and for treating diseases of the central nervous system 1
    Type: Application
    Filed: April 22, 2004
    Publication date: September 2, 2004
    Inventors: Johannes- Peter Stasch, Achim Feurer, Stefan Weigand, Elke Stahl, Dietmar Flubacher, Cristina Alonso-Alija, Frank Wunder, Dieter Lang, Klaus Dembowsky, Alexander Straub, Elisabeth Perzborn
  • Isoxazolo pyrimidinones and the use thereof
    Patent number: 6777416
    Abstract: The invention relates to novel isoxazolo pyrimidinones of general formula (I), a method for producing the same and the pharmaceutical use thereof.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: August 17, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewöhner, Helmut Haning, Thomas Lampe, Mazen Es-Sayed, Gunter Schmidt, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • Substituted pyrazole derivatives condensed with six-membered heterocyclic rings
    Patent number: 6743798
    Abstract: The present invention relates to novel substituted pyrazole derivatives of the general formula (I) in which R1, R2, R3 and A are each as defined, and to processes for their preparation and to their use as medicaments, in particular as medicaments for the treatment of cardiovascular disorders.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: June 1, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Achim Feurer, Cristina Alonso-Alija, Johannes-Peter Stasch, Elisabeth Perzborn, Joachim Hütter, Klaus Dembowsky, Elke Stahl
  • Novel imidazotriazinones and the use thereof
    Publication number: 20040097498
    Abstract: Novel imidazotrizinones of general formula (I), a method for the production and the pharmaceutical use thereof are disclosed.
    Type: Application
    Filed: February 6, 2003
    Publication date: May 20, 2004
    Inventors: Ulrich Niewohner, Maria Niewohner, Mazen Es-Sayed, Thomas Lampe, Helmut Haning, Gunter Schmidt, Karl-Heinz Schlemmer, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn
  • Novel carbamate-substituted pyrazolopyridine derivatives
    Publication number: 20040082596
    Abstract: The invention relates to novel pyrazolopyridine derivatives of the formula (I), wherein R1 represents hydrogen or a di-C1-6-alkylaminocarbonyl group, R2 represents a rest of the formula —O—CO—NR3R4, wherein R3 and R4 are the same or different and represent a rest of the group comprising optionally substituted C1-6 alkyl, optionally substituted C2-6 ?alkenyl, or optionally substituted C3-8 ? cycloalkyl: or which, together with the nitrogen atom to which they are bound, form a five- to seven-membered saturated heterocycle that may optionally contain an additional hetero atom from the group N, O, S and/or that may be optionally substituted, and to the salts, isomers and hydrates of said derivatives, as stimulants of the soluble guanylate cyclase and for use as agents for treating cardiovascular diseases, hypertonia, thromboembolic diseases and ischemia, sexual dysfunction or inflammations, and for treating diseases of the central nervous system.
    Type: Application
    Filed: October 23, 2003
    Publication date: April 29, 2004
    Inventors: Johannes-Peter Stasch, Achim Feurer, Stefan Weigand, Elke Stahl, Dietmar Flubacher, Cristina Alonso-Alija, Frank Wunder, Dieter Lang, Klaus Dembowsky, Alexander Straub, Elisabeth Perzborn
  • Novel sulfonamide-substituted pyrazolopyridine derivatives
    Publication number: 20040067937
    Abstract: The invention relates to novel pyrazolopyridine derivatives of formula (I) wherein R1 represents H, Cl or NH2, and R2 and R3 form; together with the heteroatoms to which they are bonded, a five to six-membered heterocycle which can be saturated or partially unsaturated, can optionally contain at least one other heteroatom from the group N, O, S and can be optionally substituted. The invention also relates to salts, isomers and hydrates of said derivatives, in the form of stimulators of soluble guanylate cyclase and as agents for treating cardiovascular diseases, hypertonia, thrombo-embolic diseases and ischaemia, sexual dysfunction, inflammations, and diseases of the central nervous system.
    Type: Application
    Filed: October 23, 2003
    Publication date: April 8, 2004
    Inventors: Johannes-Peter Stasch, Achim Feurer, Stefan Weigand, Elke Stahl, Dietmar Flubacher, Cristina Alonso-Alija, Frank Wunder, Dieter Lang, Klaus Dembowsky, Alexander Straub, Elisabeth Perzborn
  • 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
    Publication number: 20040067945
    Abstract: The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
    Type: Application
    Filed: February 12, 2003
    Publication date: April 8, 2004
    Inventors: Ulrich Niewohner, Maria Niewohner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Karl-Heinz Schlemmer, Jorg Keldenich, Erwin Bischoff, Elisabeth Perzborn, Klaus Dembowsky, Peter Serno, Marc Nowakowski