Abstract: A method, according to some implementations, includes determining, via at least one processor, a plurality of possible sites for recruiting patients from for a trial and determining, via the at least one processor and for each of one or more subgroupings of the plurality of possible sites, a predicted patient recruitment value. The method may include determining, via the at least one processor, a candidate subgrouping of the plurality of possible sites having a predicted patient recruitment value that globally optimizes a desired site selection criteria, and transmitting, via the at least one processor, data corresponding to the candidate subgrouping.

Abstract: A method, according to some implementations, includes obtaining trial design simulation results for a set of trial designs and determining a score for each trial design based on a performance criteria. The method may further include evaluating the designs in the set of trial designs to determine a convex hull for the set of trial designs, filtering designs based on the convex hull, and communicating the convex hull designs.

Abstract: A method, according to some implementations, includes receiving, via at least one processor, output data of a plurality of trial design simulations for a plurality of scenarios and evaluating, via the at least one processor, the output data to determine changes in performance over the plurality of scenarios. The method may further include generating, via the at least one processor, visual tornado diagram data structured to generate a visual tornado diagram on an electronic display of an electronic device and transmitting, via the at least one processor, the visual tornado diagram data to the electronic device.

Abstract: A method, according to some implementations, includes providing inputs to a plurality of trial design simulation engines, receiving first outputs of the plurality of trial design simulation engines in response to the inputs, and providing variations of the inputs to the plurality of trial design simulation engines. The method may further include receiving second outputs of the plurality of trial design simulation engines in response to the variations evaluating the first and the second outputs to determine delta values, and determining, based in part on the delta values, a plurality of normalization factors for the plurality of trial design simulation engines.

Abstract: A method, according to some implementations, includes displaying an interface structured to evaluate design data by a group of users and identifying user parameters for each user in the group. The method ma further include configuring the interface for each user in the group based at least in part on the user parameters, receiving, via the interface, user input data from one or more users in the group, and scoring designs based on the user input and user parameters.

Abstract: A method for trial design with simulated annealing includes obtaining, via at least one processor of a trial design platform, initial trial design simulation results data for a set of trial designs. The method may further include identifying an initial design from the design simulation results data, predicting, performance data of designs for variations of parameters corresponding to the set of trial designs, and identifying a new design for simulation by varying parameters of the initial simulated design based on the predicting. The method may also include simulating the new design, determining performance data of the new design, and identifying a second new design for simulation by varying parameters of the new design based on the simulated performance of the new design.

Abstract: A powder dispensing assembly for an additive manufacturing machine includes a hopper defining a powder reservoir for receiving additive powder and a plurality of powder distribution modules operably coupled with the hopper. The powder distribution modules include a powder distribution body defining a discharge orifice and a supply gate that fluidly couples the powder reservoir to the discharge orifice. A plunger valve is movably mounted over the discharge orifice and an actuator moves the plunger valve between an open position and a closed position to selectively dispense a flow of additive powder.

Abstract: The present disclosure relates to a composition that includes a metal chalcogenide having a surface and a ligand, where the ligand is covalently bound to the surface. In some embodiments of the present disclosure, the metal chalcogenide may be defined by MXz, where Z is between 1 and 3, inclusively, M (a metal) includes at least one of Sc, Zr, Hf, Zr, Ti, Nb, Ta, V, Mo, Cr, Re, W, S, Pt, Fe, Cu, Sb, In, Zn, Cd, P, and/or Mn, and X (a chalcogenide) includes at least one of S, Se, and/or Te.

Abstract: A cutting device includes a housing formed with a handle portion and an accommodation portion, a cutting portion connected to the housing and at least partially disposed in the accommodation portion, a motor disposed in the accommodation portion and extending in a first linear direction, and a bottom plate extending in a plane of the bottom plate and formed with an opening through which at least part of the cutting portion passes. The cutting device further includes a worm gear and worm structure disposed in the accommodation portion. The cutting portion includes a chain and a guide plate connected to the housing and used for supporting the chain. The motor includes an output shaft, the cutting portion is connected to a driving shaft, the output shaft transmits power to the driving shaft through a worm gear and a worm, and the driving shaft is capable of driving the chain.

Abstract: Disclosed herein are thermal interface materials (TIMs) including memory foam cores. In an exemplary embodiment, a thermal interface material generally includes a memory foam core including a plurality of sides defining a perimeter. A heat spreader is disposed at least partially around the perimeter defined the plurality of sides of the memory foam core.

Abstract: A gas dispersion system may include a drive mechanism, a drive shaft having a proximal end operably coupled to the drive mechanism, extending to a distal end, and configured to transfer rotational motion and torque, a mixing element arranged at or near the distal end of the drive shaft including a hub and multiple blade pairs, each blade pair including an upper blade and a lower blade secured to the hub and cantilevering freely and generally radially away from the hub.

Abstract: In some embodiments, a negative pressure wound therapy device includes a negative pressure source and a controller configured to, in response to determining that the negative pressure source is directly fluidically connected to a wound dressing without a canister between the two, operate the negative pressure source in a first mode; otherwise, operate the negative pressure source in a second, different mode. The controller can be further configured to, in response to determining that a level of activity of the negative pressure source over a first time duration satisfies at least one of a leak or blockage condition, provide an indication of at least one of a leak or blockage and, in response to determining that the level of activity does not satisfy the at least one of the leak or blockage condition over a second time duration subsequent to the first time duration, discontinue providing the indication.

Abstract: A method of aligning at least one laser beam of an additive manufacturing arrangement. The method includes measuring a surface of the calibration plate at a plurality of measurement points using the coordinate measuring machine. The method further includes generating a correction field based on the plurality of measurement points using the coordinate measuring machine. The method further includes writing at least one fiducial mark on the surface of the calibration plate using the at least one laser beam. The method further includes generating calibration data for the surface of the calibration plate using the calibration system. The method also includes aligning the laser beam within the additive manufacturing system based on the calibration data and the correction field using the computing device by comparing a position of the fiducial mark from the calibration data with the correction field to determine a corrected position of the laser beam.

Abstract: A cutting device includes a housing formed with a handle portion and an accommodation portion, a cutting portion connected to the housing and at least partially disposed in the accommodation portion, a motor disposed in the accommodation portion and extending in a first linear direction, and a bottom plate extending in a plane of the bottom plate and formed with an opening through which at least part of the cutting portion passes. The cutting device further includes a worm gear and worm structure disposed in the accommodation portion. The cutting portion includes a chain and a guide plate connected to the housing and used for supporting the chain. The motor includes an output shaft, the cutting portion is connected to a driving shaft, the output shaft transmits power to the driving shaft through a worm gear and a worm, and the driving shaft is capable of driving the chain.

Abstract: A water recycling system embodying a tank used for collecting and recycling bathroom shower warm up water for other household needs. The collection tank is fluidly connected to the shower head via an engaged diverter valve by way of a first conduit. The collection tank may provide a second conduit and valve system operatively associated with the collected warm up water to the toilet or other household water needs.

Abstract: A process of operating a spark-ignited internal combustion engine (SI-ICE) with improved fuel efficiency and reduced emissions including under steady state and under lean-operating conditions at high overall air to fuel (AFR) ratios. A first supply of high octane hydrocarbon fuel, such as gasoline or natural gas, and a first supply of oxidant are fed to a fuel reformer to produce a gaseous reformate with a reforming efficiency of greater than 75 percent relative to equilibrium. The gaseous reformate is mixed with a second supply of oxidant, after which the resulting reformate blended oxidant is fed with a second supply of high octane hydrocarbon fuel to the SI-ICE for combustion. Steady state fuel efficiency is improved by more than 3 percent, when the reformate comprises from greater than about 1 to less than about 18 percent of the total volume of reformate blended oxidant fed to the engine.

Abstract: A merchandising system includes a deck adjustable to various angles to accommodate merchandise for display on a shelf at such various angles. The system may include a front stop and dividers.

Abstract: A powder dispensing assembly for an additive manufacturing machine includes a hopper defining a powder reservoir for receiving additive powder and a plurality of powder distribution modules operably coupled with the hopper. The powder distribution modules include a powder distribution body defining a discharge orifice and a supply gate that fluidly couples the powder reservoir to the discharge orifice. A plunger valve is movably mounted over the discharge orifice and an actuator moves the plunger valve between an open position and a closed position to selectively dispense a flow of additive powder.

Abstract: This disclosure is generally drawn to systems, devices, apparatuses, and/or methods, related to monitoring a shaker and monitoring a room in which shaker(s) operate. Specifically, the disclosed systems, devices, apparatuses, and/or methods relate to controlling an actuated arm to inspect, remove, replace, repair, clean the shaker and/or screen assemblies based on monitoring the shaker and its screen assemblies, and to adjust or maintain shaker(s) in a defined area such as the room in which shaker(s) operate. While the examples disclosed herein generally describe shakers for separating solids from fluids, the present disclosure contemplates that other separation equipment (e.g., machines for separating solids from other solids) may also be monitored and controlled by the systems and methods described herein.

Abstract: A process of operating a spark-ignited internal combustion engine (SI-ICE) with improved fuel efficiency and reduced emissions including under steady state and under lean-operating conditions at high overall air to fuel (AFR) ratios. A first supply of high octane hydrocarbon fuel, such as gasoline or natural gas, and a first supply of oxidant are fed to a fuel reformer to produce a gaseous reformate with a reforming efficiency of greater than 75 percent relative to equilibrium. The gaseous reformate is mixed with a second supply of oxidant, after which the resulting reformate blended oxidant is fed with a second supply of high octane hydrocarbon fuel to the SI-ICE for combustion. Steady state fuel efficiency is improved by more than 3 percent, when the reformate comprises from greater than about 1 to less than about 18 percent of the total volume of reformate blended oxidant fed to the engine.