Abstract: The invention relates to antisense molecules and methods for modulating splicing of polyomavirus T antigen pre-mRNA. In one aspect the invention relates to an antisense oligonucleotide 12 to 30, preferably 17, 18, 19 or 20 to 30 nucleobases in length which comprises a sequence that is the reverse complement of a contiguous stretch of at least 12 nucleobases of a polyomavirus T-antigen pre-mRNA and which antisense oligonucleotide can modulate splicing of said T-antigen pre-mRNA in a cell.

Abstract: The problem of limited throughput in three-dimensional (3D) printing processes is addressed by systems and methods that employ mirrors to receive energy reflected by the melt pool and to redirect such light back to the melt pool, where it may further heat the melt pool. Multiple such passes of reflection from the melt pool and redirection back to the melt pool may substantially increase the efficiency at which the melt pool absorbs the energy, thereby substantially increasing the throughput of the 3D printing process.

Abstract: A warehouse storage and retrieval system including an array of multilevel storage racks having at least one transfer deck, picking isles and storage areas disposed along picking isles, the storage areas being configured to hold differing loads, and a controller including a management module configured to variably size the storage areas of the array of multilevel storage rack modules and assign each of the variably sized storage areas to a corresponding one of the differing loads, wherein the storage and retrieval system is arranged to transport the differing loads for placement in the variably sized storage areas assigned by the controller.

Abstract: A system for enhancing personnel safety on a railroad track is presented. The system can receive data from sensors and/or a PTC system to determine positions of clients/worker and/or vehicles, and further utilize such data to determine if a vehicle is within a certain proximity of the client/worker location. The system can further generate geofences around clients/vehicles to and determine when such geofences intersect one another. Additionally, the present disclosure can assign severity levels and generate alerts with the assigned severity levels, and such severity levels can indicate how close a vehicle is to a particular location. It is an object of the invention to provide a system for generating alerts to notify personnel when they much retreat to a place of safety.

Abstract: The present disclosure relates to a coherent aperture array system for steering an optical source beam. The system may have a plurality of spaced apart, steerable emitters each being able to be mechanically aimed at a remote target location to steer portions of the source beam toward the target location. Each steerable emitter has a subaperture controllable independently of a remaining reflective surface of its associated steerable emitter, to receive and reflect a subportion of the source beam portion. The subportion forms a sense beam which is reflected toward a phase imaging system. A separate reference beam is created from the portion of the source beam travelling toward each steerable emitter. Each sense beam and each reference beam are thus associated uniquely with one of the steerable emitters. A phase imaging system is responsive to each of the reference beams and the sense beams, and determines phase differences between the portions of the source beam being transmitted from each steerable emitter.

Abstract: Systems and methods for file system management are provided. According to one embodiment, a non-transitory computer-readable medium comprises instructions that when executed by the processing resource cause the processing resource to implement, in a storage node, a multi-tiered file system comprising a read-only layer that contains a base configuration for the storage node and a read-write layer that contains modifications to the base configuration; and combine the read-only layer and the read-write layer into an overlay file system to be presented to an operating system.

Abstract: The problem of measuring the temperature of a 3D printing process is addressed by systems and methods that apply imaging spectrometry to measure blackbody radiation emitted before, during, or after a 3D printing process. The systems and methods utilize a pair of lenses, a field stop, and a wavelength separator to direct a plurality of wavelengths corresponding to the blackbody radiation to pixels of an optical detector. The plurality of wavelengths are analyzed by a controller to determine the temperature of the 3D printed component.

Abstract: A system for enhancing personnel safety on a railroad track is presented. The system can receive data from sensors and/or a PTC system to determine positions of clients/worker and/or vehicles, and further utilize such data to determine if a vehicle is within a certain proximity of the client/worker location. The system can further generate geofences around clients/vehicles to and determine when such geofences intersect one another. Additionally, the present disclosure can assign severity levels and generate alerts with the assigned severity levels, and such severity levels can indicate how close a vehicle is to a particular location. It is an object of the invention to provide a system for generating alerts to notify personnel when they much retreat to a place of safety.

Abstract: 3D metrology techniques are disclosed for determining a changing topography of a substrate processed in an additive manufacturing system. Techniques include fringe scanning, simultaneous fringe projections, interferometry, and x-ray imaging. The techniques can be applied to 3D printing systems to enable rapid topographical measurements of a 3D printer powder bed, or other rapidly moving, nearly continuous surface to be tested. The techniques act in parallel to the system being measured to provide information about system operation and the topography of the product being processed. A tool is provided for achieving higher precision, increasing throughput, and reducing the cost of operation through early detection and diagnosis of operating problems and printing defects. These techniques work well with any powder bed 3D printing system, providing real-time metrology of the powder bed, the most recently printed layer, or both without reducing throughput.

Abstract: To improve the operation of 3D printing systems, techniques are disclosed for a rotary 3D printer comprising: a main rotating support table rotating about a first axis and one or more secondary support tables rotating around a non-coaxial secondary axis; a powder supply assembly for distributing powder onto the tables; and an energy system for directing an energy beam at the powder to form a part. The main support table and secondary support tables can rotate in the same or opposite directions. Disclosed techniques include: grooved support table surfaces for improving stability of applied powder; reciprocating bellows for controlling a differential load on actuators that move the support tables; high temperature bearings or bushings for supporting rotary motion at high temperatures; and a mechanism for counterbalancing a weight of the part being built.

Abstract: Traditional home-automation systems utilize a single hub for controlling secondary devices within a home. The techniques described herein, meanwhile, utilize multiple hubs within the environment and/or located remotely from the environment. For instance, an environment may include multiple electronic devices, each configured to control one or more secondary devices within the environment. In addition, a remote service may be configured to control one or more secondary devices within the environment. As such, each controlling device stores and executes an instance of a control engine, rather than relying on a single instance of a control engine located at a single controlling hub.

Abstract: A sensing system includes a sensor including a flexible substrate and a graphene oxide sensing element deposited on the flexible substrate. The graphene oxide sensing element has first and second sides. First and second electrical connectors coupled to the first and second sides of the graphene oxide sensing element, respectively. A power source is coupled to the first and second electrical connectors of the sensor and is adapted to apply a constant voltage to the sensor. The sensing system also includes a measurement element measuring a current in the graphene oxide sensing element due to the constant voltage and a calculation element calculating an electrical resistance of the graphene oxide sensing element based on the electrical current and the constant voltage and calculating a condition at a location of the sensor based on a relationship between the electrical resistance and the condition for the graphene oxide sensing element.

Abstract: A robotic assistant comprises a plurality of sensors on a mobile chassis. An occupancy map includes obstacle cost values for particular areas or cells of the map. These obstacle cost values may be based on whether an obstacle is detected and the confidence value of that detection, estimated precision of the location of the detected object, and so forth. A set of rules for preferred locations of robot movement is used to assess the occupancy map and to determine constraint cost value for the particular areas. For example, the area in a center of a hallway may be associated with a relatively high constraint cost value. An aggregate cost value may be calculated by summing the obstacle cost value and the constraint cost value for the particular area. The aggregate cost value may be used to determine a maximum permissible speed for the robot while traversing the particular area.

Abstract: Method of tracking a plurality of objects comprising: focusing an image of the objects on an imaging element using an optical system; capturing the image of the objects using an imaging element comprising a plurality of pixels; measuring at least one characteristic of the objects from the captured image using an image processor; wherein the field of view is set be the widest field of view for which the image processor is able to measure the at least one characteristic.

Abstract: Surface changes are estimated using multiple speckle interferograms acquired using beams incident at different angles. Beam irradiation conditions can be changed to increase signal to noise ratio with averaging, such as weighted averaging. Irradiation conditions can be varied with a tilt plate, a wedge, or by changing beam wavelengths.

Abstract: Object interference in biological samples generated by lateral shearing interference microscopes is addressed by a shearing microscope slide comprising a periodic structure having alternating reference and sample regions. In some embodiments, the reference regions are configured to provide references that remove sample overlap in a sheared microscopic measurement. A system for generating sheared microscopic measurements is also provided that comprises an inlet configured to receive a sample material, an outlet configured to release a portion of the sample material, and a periodic structure having a plurality of interleaved reference and sample channels. In some cases, the sample channels are configured to accommodate a flow of sample material from the inlet to the outlet and the reference channels are configured to provide references that remove sample overlap in a sheared microscopic measurement.

Abstract: A device and a method is provided for profiling particles such as proteins. The device comprises: a liquid chromatography column (16) in a mixture separation module (10); a fractionation device (22, 24) and a plurality of microfluidic analysis modules (26, 28) in a microfluidic network (14). The microfluidic analysis modules are configured to provide multi-dimensional analysis of the particles. Furthermore, a fluidic flow adaptor (20) allows for controlled flow between separator (16) and the microfluidic network to provide a continuous fluid flow.

Abstract: Systems and techniques that facilitate uniform qubit chip gaps via injection-molded solder pillars are provided. In various embodiments, a device can comprise one or more injection-molded solder interconnects. In various aspects, the one or more injection-molded solder interconnects can couple at least one qubit chip to an interposer chip. In various embodiments, the device can further comprise one or more injection-molded solder pillars. In various instances, the one or more injection-molded solder pillars can be between the at least one quit chip and the interposer chip. In various cases, the one or more injection-molded solder pillars can be in parallel with the one or more injection-molded solder interconnects. In various embodiments, the one or more injection-molded solder pillars can facilitate and/or maintain a uniform gap between the at least one qubit chip and the interposer chip.

Abstract: A flow apparatus for detecting a component on a surface is provided. The flow apparatus, comprising an inlet for receiving a solution of the components to be detected; a detection chamber in fluid connection with and downstream from the inlet, and in fluid connection with a downstream outlet, wherein the internal surface of the detection chamber comprises a plurality of detection zones and the detection zones are configured to adhere to the component to be detected such that the component is immobilised in the detection zones; a detector for detecting components immobilised on each of the detection zones; and a director for directing the flow of the solution of the components to each of the detection zones in sequence, wherein the director is provided by flow rates.

Abstract: Techniques regarding selectively tuning the operating frequency of superconducting Josephson junction resonators are provided. For example, one or more embodiments described herein can comprise a method that can include chemically altering a Josephson junction of a Josephson junction resonator via a plasma treatment. The method can also comprise selectively tuning an operating frequency of the Josephson junction resonator based on a property of the plasma treatment.