Abstract: Disclosed herein are rouging methods and devices for a flip-chip package. The flip chip includes several outer pads and several inner pads. The routing method includes: setting an outer sequence based on the arrangement order of the outer pads; setting several inner sequences based on the connection relationships between inner pads and the outer pads; calculating the longest common subsequence of each inner sequence and the outer sequence, defining the connection relationships between the inner pads and the outer pads corresponding to the longest common subsequence as direct connections, and defining the connection relationships between the inner pads and the outer pads that do not correspond to the longest common subsequence as detour connections; establishing the routing scheme of the flip chip based on the connection relationships between the inner pads and the outer pads.

Abstract: Aspects of the invention relate to techniques for determining edge fragment correlation information. With various implementations of the invention, image intensity slope information for edge fragments in a layout design is determined. The image intensity slope information comprises information describing how image intensity for each of the edge fragments changes with its position. Image amplitude sensitivity information for the edge fragments is also determined. The image amplitude sensitivity information comprises information describing how image amplitude for each of the edge fragments changes with positions of neighboring edge fragments. Based on the image intensity slope information and the image amplitude sensitivity information, edge fragment correlation information for the edge fragments is determined. Using the edge fragment correlation information, the layout design may be processed by using, for example, OPC techniques.

Abstract: Aspects of the invention relate to techniques for determining edge fragment correlation information. With various implementations of the invention, image intensity slope information for edge fragments in a layout design is determined. The image intensity slope information comprises information describing how image intensity for each of the edge fragments changes with its position. Image amplitude sensitivity information for the edge fragments is also determined. The image amplitude sensitivity information comprises information describing how image amplitude for each of the edge fragments changes with positions of neighboring edge fragments. Based on the image intensity slope information and the image amplitude sensitivity information, edge fragment correlation information for the edge fragments is determined. Using the edge fragment correlation information, the layout design may be processed by using, for example, OPC techniques.

Abstract: The invention provides isolated Pre-Ligand Assembly Domain (PLAD) polypeptides comprising an amino acid sequence of a domain (e.g., a Fibronectin Ill-like domain) of an IL-17 Receptor (IL-17R) family member, wherein the PLAD polypeptide inhibits multimerization of a receptor complex comprising an IL-17R family member. Also provided are isolated PLAD-binding polypeptides, e.g., antibodies and avimers, which specifically bind to a PLAD polypeptide described herein. Related chimeric proteins, conjugates, nucleic acids, vectors, and host cells are provided herein. Further provided are methods of treating an inflammatory or autoimmune disease, methods of inhibiting IL-17-mediated signal transduction, methods of inhibiting IL-17 ligand binding, methods of inhibiting multimerization of IL-17R complexes, and methods of inhibiting the production of at least one cytokine, chemokine, matrix metalloproteinase, or other molecule associated with IL-17 signal transduction are provided.

Abstract: Methods for identifying agents capable of disrupting a salt bridge in an influenza A virus nucleoprotein corresponding to the E339 . . . R416 salt bridge in SEQ ID NO:1, and thus the trimerization of the NP protein; and uses of such agents, e.g., small molecules and peptides, for inhibiting influenza virus replication and treating infection caused by influenza virus.

Abstract: Disclosed herein are rouging methods and devices for a flip-chip package. The flip chip includes several outer pads and several inner pads. The routing method includes: setting an outer sequence based on the arrangement order of the outer pads; setting several inner sequences based on the connection relationships between inner pads and the outer pads; calculating the longest common subsequence of each inner sequence and the outer sequence, defining the connection relationships between the inner pads and the outer pads corresponding to the longest common subsequence as direct connections, and defining the connection relationships between the inner pads and the outer pads that do not correspond to the longest common subsequence as detour connections; establishing the routing scheme of the flip chip based on the connection relationships between the inner pads and the outer pads.

Abstract: A punching system for singulating IC units comprising: a punching assembly arranged to receive a substrate and singulate said substrate into the IC units; a rotary carrier rotatable from a first position to a second position said rotary carrier arranged to receive said units at the first position and carry said units to the second position through rotation; wherein said rotary carrier includes recesses for receiving at least a portion of the units. A punching assembly comprising a die block having recesses for receiving selectively replaceable inserts wherein said inserts correspond to a punch pattern specific to a predetermined IC package arrangement.

Abstract: The invention provides isolated Pre-Ligand Assembly Domain (PLAD) polypeptides comprising an amino acid sequence of a domain (e.g., a Fibronectin Ill-like domain) of an IL-17 Receptor (IL-17R) family member, wherein the PLAD polypeptide inhibits multimerization of a receptor complex comprising an IL-17R family member. Also provided are isolated PLAD-binding polypeptides, e.g., antibodies and avimers, which specifically bind to a PLAD polypeptide described herein. Related chimeric proteins, conjugates, nucleic acids, vectors, and host cells are provided herein. Further provided are methods of treating an inflammatory or autoimmune disease, methods of inhibiting IL-17-mediated signal transduction, methods of inhibiting IL-17 ligand binding, methods of inhibiting multimerization of IL-17R complexes, and methods of inhibiting the production of at least one cytokine, chemokine, matrix metalloproteinase, or other molecule associated with IL-17 signal transduction are provided.

Abstract: A punch and die assembly for singulating an IC unit from a substrate, the assembly comprising an array of punches a guide block having opposed first and second faces with a plurality of elongate channels corresponding to each punch extending from said first to second face; a die block for supporting said substrate, said die block having an array of punching zones at which the punches bear so as to singulate all or a portion of a peripheral edge of said IC units from the substrate.

Abstract: A method to systematically analyze a next generation telecommunications network to result in creating a provisioning plan for provisioning the network to provide services for one or more subscribers. In one specific embodiment, the method involves creating and storing information that represents a logical decomposition of the next generation network into a plurality of discrete functional areas. The information representing the functional areas is analyzed to identify one or more provisioning requirements for each of the functional areas. One or more provisioning procedures are determined, and one or more required provisioning tools are identified for each of the functional areas, based on the provisioning requirements. A sequence of execution of the procedures and tools is created and stored as a provisioning plan.

Abstract: A method of automation of subscriber customer premises equipment provisioning for use in a next generation telecommunications network. In one specific embodiment, the method involves receiving a service request from a network service provider that specifies a service to be provided to the customer premises equipment. A configuration template for a configuration appropriate for the customer premises equipment is retrieved. Configuration data is automatically generated for the customer premises equipment based on the configuration template and stored system configuration information. The completed configuration data is automatically delivered over the network to the customer premises equipment to result in configuring the customer premises equipment to provide the service. Embodiments are useful for configuring ADSL and T1 CPE devices in a voice-over-ATM network that uses Internet Protocol.

Abstract: The invention relates to sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones compounds having formula (I) wherein R1 is selected from the group consisting of 4-methylsulfonyl, 4-aminosulfonyl, hydrogen, 2-, 3-, or 4-halogen, C1–C6-alkyl, cyclopentyl, cyclohexyl, C1–C4-alkoxy, hydroxy, cyano, nitro, amino or trifluoromethyl; R2 is selected from the group consisting of 4-methylsulfonyl, 4-aminosulfonyl, hydrogen, 2-, 3-, or 4-halogen, C1–C6-alkyl, cyclopentyl, cyclohexyl, C1–C4-alkoxy, hydroxy, cyano, nitro, amino or trifluoromethyl; and R3 is selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, i-propyl, c-propyl, n-butyl, isobutyl; provided that when R1 is a methylsulfonyl or aminosulfonyl group, R2 is any group as defined above except a methylsulfonyl or aminosulfonyl group; and when R2 is a methylsulfonyl or aminosulfonyl group, R1 is any group as defined above except a methylsulfonyl or aminosulfonyl group, also to processes for the preparation of such compounds, to pharmaceutical co

Abstract: A process for obtaining a compound from buckwheat and its use as a pharmaceutical treatment are disclosed. Methods of treatment using extracts of buckwheat are also disclosed.

Abstract: A method and system for synchronizing a reference signal and an output signal produced by an electrical circuit, the electrical circuit comprising an analog portion and a digital portion, is disclosed. The method comprises the steps of utilizing the digital portion to produce a phase-adjusted signal and utilizing the analog portion to produce an output signal in substantially the same phase as the phase-adjusted signal. Through the use of the method and system in accordance with the present invention, the large bi-direction shift register of conventional hybrid DLLs is no longer necessary and high speed DLLs will be capable of providing high resolution deskewed clocks in a shorter amount of time. The use of the present invention also facilitates the coverage of a wider range of clock frequencies.

Abstract: A golf trolley has a wheel device, a wheel support frame, and a golf trolley wheel connection assembly disposed between the wheel device and the wheel support frame. The golf trolley wheel connection assembly has a fixed seat, a pressing block, a spring, and a blocking seat. The fixed seat has a sleeve, a shaft hole, and a through hole. The pressing block has a head, a bevel, and two legs. Each leg has a blocking end. The blocking seat has two arms and a through aperture. The pressing block is inserted in the sleeve. The spring is disposed between the legs. A rivet passes through the through hole and the through aperture.

Abstract: Method and circuit aspects for improving lock-in time following power-up in a phase-locked loop are provided. The circuit and method for providing same includes a phase-locked loop, the phase-locked loop comprising a low pass filter, and a pulse generation circuit coupled to the low pass filter. The pulse generation circuit provides a control pulse of predetermined duration to increase a voltage across the low pass filter and reduce lock-in time in the phase-locked loop following power-up. The pulse generation circuit further includes a plurality of logic gates, the plurality of logic gates including a plurality of inverters coupled to a NAND gate.