Patents by Inventor Fei Wei

Fei Wei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HUMAN MutY
    Publication number: 20090029380
    Abstract: A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
    Type: Application
    Filed: September 4, 2008
    Publication date: January 29, 2009
    Applicant: Human Genome Sciences, Inc.
    Inventor: Ying-Fei Wei
  • 207 Human Secreted Proteins
    Publication number: 20090005301
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: June 7, 2007
    Publication date: January 1, 2009
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reinhard Ebner, David W. LaFleur, Paul A. Moore, Henrik S. Olsen, Craig A. Rosen, Steven M. Ruben, Daniel R. Soppet, Paul E. Young, Yanggu Shi, Kimberly A. Florence, Ying-Fei Wei, Charles Florence, Jing-Shan Hu, Yi Li, Hla Kyaw, Carrie L. Fischer, Ann M. Ferrie, Ping Fan, Ping Feng, Gregory A. Endress, Patrick J. Dillon, Kenneth C. Carter, Laurie A. Brewer, Guo-Liang Yu, Zhizhen Zeng, John M. Greene
  • Methods for diagnosing cancer and determining a susceptibility for developing cancer
    Patent number: 7470510
    Abstract: A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutations in nucleic acid sequence endcoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, area also disclosed.
    Type: Grant
    Filed: February 12, 2003
    Date of Patent: December 30, 2008
    Assignee: Human Genome Sciences, Inc.
    Inventor: Ying-Fei Wei
  • Antibodies to Chemokine Alpha-5
    Publication number: 20080317756
    Abstract: The present invention relates to a novel CK?-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK?-5 protein. CK?-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CK?-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CK?-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Application
    Filed: January 22, 2008
    Publication date: December 25, 2008
    Inventors: Ying-Fei Wei, Yi Li, Jian Ni, Craig A. Rosen, Steven M. Ruben
  • Chemokine Beta-15
    Publication number: 20080226586
    Abstract: The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine ?-15 protein. Chemokine ?-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.
    Type: Application
    Filed: October 2, 2006
    Publication date: September 18, 2008
    Applicant: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Brent Kreider, Craig Rosen
  • 98 Human Secreted Proteins
    Publication number: 20080051338
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: July 12, 2007
    Publication date: February 28, 2008
    Applicant: Human Genome Sciences, Inc.
    Inventors: George Komatsoulis, Craig Rosen, Steven Ruben, Roxanne Duan, Paul Moore, Yanggu Shi, David LaFleur, Ying-Fei Wei, Jian Ni, Kimberly Florence, Paul Young, Laurie Brewer, Daniel Soppet, Gregory Endress, Reinhard Ebner, Henrik Olsen, Michael Mucenski
  • Antibodies to Chemokine Alpha-5
    Patent number: 7320869
    Abstract: The present invention relates to a novel CK?-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK?-5 protein. CK?-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CK?-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CK?-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Grant
    Filed: September 13, 2005
    Date of Patent: January 22, 2008
    Assignee: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Yi Li, Jian Ni, Craig A. Rosen, Steven M. Ruben
  • 28 HUMAN SECRETED PROTEINS
    Publication number: 20070203070
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: May 4, 2007
    Publication date: August 30, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Craig Rosen, Steven Ruben, Yi Li, Zhizhen Zeng, Hla Kyaw, Carrie Fischer, Haodong Li, Daniel Soppet, Reiner Gentz, Ying-Fei Wei, Paul Moore, Paul Young, John Greene, Ann Ferrie, Gregg Hastings
  • ANTIBODIES TO HHPEN62 POLYPEPTIDE
    Publication number: 20070172830
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: May 21, 2004
    Publication date: July 26, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Kimberly Florence, Jian Ni, Craig Rosen, Kenneth Carter, Paul Moore, Henrik Olsen, Yanggu Shi, Paul Young, Ying-Fei Wei, Laurie Brewer, Daniel Soppet, David LaFleur, Gregory Endress, Reinhard Ebner, Charles Birse
  • Antibodies to HHPEN62 polypeptide
    Patent number: 7247442
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Grant
    Filed: May 21, 2004
    Date of Patent: July 24, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Kimberly A. Florence, Jian Ni, Craig A. Rosen, Kenneth C. Carter, Paul A. Moore, Henrik S. Olsen, Yanggu Shi, Paul E. Young, Ying-Fei Wei, Laurie A. Brewer, Daniel R. Soppet, David W. LaFleur, Gregory A. Endress, Reinhard Ebner, Charles E. Birse
  • 44 Human Secreted Proteins
    Publication number: 20070154918
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: December 11, 2006
    Publication date: July 5, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: David LaFleur, Steven Ruben, Craig Rosen, Paul Moore, Yanggu Shi, Hla Kyaw, Ying-Fei Wei
  • Antibodies to chemokine Alpha-6
    Patent number: 7217529
    Abstract: The present invention relates to a novel CK?-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK?-6 protein. CK?-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK?-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: May 15, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Steven M. Ruben, Craig A. Rosen
  • Chemokine Beta-15
    Publication number: 20070048256
    Abstract: The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine ?-15 protein. Chemokine ?-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.
    Type: Application
    Filed: October 2, 2006
    Publication date: March 1, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Brent Kreider, Craig Rosen
  • 94 human secreted proteins
    Publication number: 20070020724
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: July 9, 2004
    Publication date: January 25, 2007
    Inventors: Steven Ruben, Jian Ni, Craig Rosen, Ying-Fei Wei, Paul Young, Kimberly Florence, Daniel Soppet, Laurie Brewer, Gregory Endress, Kenneth Carter, Michael Mucenski, Reinhard Ebner, David LaFleur, Henrik Olsen, Yanggu Shi, Paul Moore, George Komatsoulis
  • Transforming Growth Factor Alpha HI
    Publication number: 20060286593
    Abstract: The present invention discloses transforming growth factor alpha HI polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
    Type: Application
    Filed: August 14, 2006
    Publication date: December 21, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Paul Meissner, Rebecca Fuldner, Ying Fei-Wei, Mark Adams
  • 44 human secreted proteins
    Publication number: 20060281095
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: December 3, 2004
    Publication date: December 14, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: David LaFleur, Steven Ruben, Craig Rosen, Paul Moore, Yanggu Shi, Hla Kyaw, Ying-Fei Wei
  • Chemokine ?-15
    Patent number: 7135551
    Abstract: The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine ?-15 protein. Chemokine ?-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: November 14, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Brent L Kreider, Craig A Rosen
  • Human DNA topoisomerase I alpha
    Publication number: 20060234342
    Abstract: Disclosed is a human is a hTopI-? polypeptide and DNA (RNA) encoding such hTopI-? polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-? for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
    Type: Application
    Filed: June 24, 2003
    Publication date: October 19, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Mark Adams, Robert Fleischmann
  • 207 human secreted proteins
    Publication number: 20060223077
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: September 20, 2005
    Publication date: October 5, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reinhard Ebner, David LaFleur, Paul Moore, Henrik Olsen, Craig Rosen, Steven Ruben, Daniel Soppet, Paul Young, Yanggu Shi, Kimberly Florence, Ying-Fei Wei, Charles Florence, Jing-Shan Hu, Yi Li, Hla Kyaw, Carrie Fischer, Ann Ferrie, Ping Fan, Ping Feng, Gregory Endress, Patrick Dillon, Kenneth Carter, Laurie Brewer, Guo-Liang Yu, Zhizhen Zeng, John Greene
  • Chemokine ?-5
    Patent number: 7060261
    Abstract: The present invention relates to a novel CK?-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK?-5 protein. CK?-5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK?-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: June 13, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Yi Li, Jian Ni, Craig A. Rosen, Steven M. Ruben