Patents by Inventor Fei Wei

Fei Wei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tumor necrosis factor receptor-5
    Patent number: 7049402
    Abstract: The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: May 23, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Reiner Gentz, Jian Ni, Steven M Ruben
  • 12 human secreted proteins
    Publication number: 20060099622
    Abstract: The present invention relates to 12 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: October 11, 2005
    Publication date: May 11, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Paul Young, Joseph Kenny, Henrik Olsen, Paul Moore, Ying-Fei Wei, John Greene, Steven Ruben, Ding Liu, Paul Crocker
  • 98 human secreted proteins
    Publication number: 20060079670
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: September 20, 2005
    Publication date: April 13, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: George Komatsoulis, Craig Rosen, Steven Ruben, Roxanne Duan, Paul Moore, Yanggu Shi, David LaFleur, Ying-Fei Wei, Jian Ni, Kimberly Florence, Paul Young, Laurie Brewer, Daniel Soppet, Gregory Endress, Reinhard Ebner, Henrik Olsen, Michael Mucenski
  • Antibodies to Chemokine Alpha-5
    Publication number: 20060008882
    Abstract: The present invention relates to a novel CK?-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK?-5 protein. CK?-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CK?-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CK?-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Application
    Filed: September 13, 2005
    Publication date: January 12, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Yi Li, Jian Ni, Craig Rosen, Steven Ruben
  • Method and apparatus to measure gas amounts adsorbed on a powder sample
    Patent number: 6981426
    Abstract: A method and apparatus for measuring the gas amounts adsorbed on a powder which directly measures pressure changes in a gas supply chamber with the use of differential pressure sensors between the gas supply chamber and a reference chamber which gas amount is maintained constant. Calculations of the gas amounts adsorbed are based on the pressure changes in a sample cell and the pressure changes in the gas supply chamber or a gas reference chamber. The method and apparatus of this invention measures the adsorption or desorption isotherm or gas uptake at constant pressure curve of a powder with, as compared with presently available measurement techniques, increased accuracy and resolution. The experimental data can be analyzed to obtain information on the surface area, pore size distribution, pore volume, pore structure and diffusion coefficient of the powder.
    Type: Grant
    Filed: December 15, 2003
    Date of Patent: January 3, 2006
    Assignee: Tsinghua University
    Inventors: Dezheng Wang, Fei Wei, Jinfu Wang
  • Chemokine ?-6
    Patent number: 6979443
    Abstract: The present invention relates to a novel CK?-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK?-6 protein. CK?-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK?-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.
    Type: Grant
    Filed: March 4, 2002
    Date of Patent: December 27, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Steven M. Ruben, Craig A. Rosen
  • Antibodies to tumor necrosis factor receptor 5
    Publication number: 20050255100
    Abstract: The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
    Type: Application
    Filed: July 18, 2005
    Publication date: November 17, 2005
    Applicant: HUMAN GENOME SCIENCES, INC.
    Inventors: Ying-Fei Wei, Jian Ni, Reiner Gentz, Steven Ruben
  • Antibodies to chemokine alpha-6
    Publication number: 20050208591
    Abstract: The present invention relates to a novel CK?-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK?-6 protein. CK?-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK?-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.
    Type: Application
    Filed: March 16, 2005
    Publication date: September 22, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Steven Ruben, Craig Rosen
  • 28 human secreted proteins
    Publication number: 20050208621
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: September 29, 2004
    Publication date: September 22, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Craig Rosen, Steven Ruben, Yi Li, ZhiZhen Zeng, Hla Kyaw, Carrie Fishcher, Haodong Li, Daniel Soppet, Reiner Gentz, Ying-Fei Wei, Paul Moore, Paul Young, John Greene, Ann Ferrie, Gregg Hastings
  • Antibody which binds human blue-light photoreceptor hCRY2
    Patent number: 6929921
    Abstract: The present invention relates to a novel member of the blue-light photoreceptor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human hCRY2 receptor. hCRY2 polypeptides are also provided as are vectors, host cells, antibodies, and recombinant methods for producing the same.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: August 16, 2005
    Assignees: Human Genome Sciences, Inc., The University of North Carolina at Chapel Hill
    Inventors: Ying-Fei Wei, Steven M. Ruben, Aziz Sancar, Shiao-Wen D. Hsu, Aleksey G. Kazantsev
  • Antibodies to protein HPMBQ91
    Patent number: 6919433
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: July 19, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Yi Li, Zhizhen Zeng, Hla Kyaw, Carrie L. Fischer, Haodong Li, Daniel R. Soppet, Reiner L. Gentz, Ying-Fei Wei, Paul A. Moore, Paul E. Young, John M. Greene, Ann M. Ferrie, Gregg A. Hastings
  • 44 human secreted proteins
    Publication number: 20050153335
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: December 3, 2004
    Publication date: July 14, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: David LaFleur, Steven Ruben, Craig Rosen, Paul Moore, Yanggu Shi, Hla Kyaw, Ying-Fei Wei
  • 44 human secreted proteins
    Publication number: 20050079537
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: December 3, 2004
    Publication date: April 14, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: David LaFleur, Steven Ruben, Craig Rosen, Paul Moore, Yanggu Shi, Hla Kyaw, Ying-Fei Wei
  • Methods for diagnosing cancer and determining a susceptibility for developing cancer
    Publication number: 20050074755
    Abstract: A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutations in nucleic acid sequence endcoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, area also disclosed.
    Type: Application
    Filed: February 12, 2003
    Publication date: April 7, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventor: Ying-Fei Wei
  • 83 human secreted proteins
    Publication number: 20050037467
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: September 9, 2004
    Publication date: February 17, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Ping Feng, David LaFleur, Paul Moore, Yanggu Shi, Hla Kyaw, Yi Li, ZhiZhen Zeng, Kenneth Carter, Gregory Endress, Ying-Fei Wei, Ping Fan, Craig Rosen
  • 44 Human secreted proteins
    Publication number: 20050009085
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: August 16, 2004
    Publication date: January 13, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: David LaFleur, Steven Ruben, Craig Rosen, Paul Moore, Yanggu Shi, Hla Kyaw, Ying-Fei Wei
  • Transforming growth factor alpha Hlll
    Publication number: 20040229787
    Abstract: The present invention discloses transforming growth factor alpha HIII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
    Type: Application
    Filed: November 21, 2003
    Publication date: November 18, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventor: Ying-Fei Wei
  • 125 human secreted proteins
    Publication number: 20040185440
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: March 28, 2001
    Publication date: September 23, 2004
    Inventors: Ping Feng, Steven M. Ruben, Craig A. Rosen, Reinhard Ebner, Henrik S. Olsen, Jian Ni, Ying-Fei Wei, Daniel R. Soppet, Paul A. Moore, Hla Kyaw, David W. LaFleur, Yanggu Shi, Fouad Janat, Gregory A. Endress, Kenneth C. Carter
  • Continuous mass production of carbon nanotubes in a nano-agglomerate fluidized-bed and the reactor
    Publication number: 20040151654
    Abstract: The present invention relates to a method for continuous production of carbon nanotubes in a nano-agglomerate fluidized bed, which comprises the following steps: loading transition metal compounds on a support, obtaining supported nanosized metal catalysts by reducing or dissociating, catalytically decomposing a carbon-source gas, and growing carbon nanotubes on the catalyst support by chemical vapor deposition of carbon atoms. The carbon nanotubes are 4˜100 nm in diameter and 0.5˜1000 &mgr;m in length. The carbon nanotube agglomerates, ranged between 1˜1000 &mgr;m, are smoothly fluidized under 0.005 to 2 m/s superficial gas velocity and 20˜800 kg/m3 bed density in the fluidized-bed reactor. The apparatus is simple and easy to operate, has a high reaction rate, and it can be used to produce carbon nanotubes with high degree of crystallization, high purity, and high yield.
    Type: Application
    Filed: November 24, 2003
    Publication date: August 5, 2004
    Inventors: Fei Wei, Yao Wang, Guohua Luo, Hao Yu, Zhifei Li, Weizhong Qian, Zhanwen Wang, Yong Jin
  • Transforming growth factor alpha HII
    Publication number: 20040146510
    Abstract: The present invention discloses transforming growth factor alpha HII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders, and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptides and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
    Type: Application
    Filed: August 21, 2003
    Publication date: July 29, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Paul S. Meissner, Jian Ni