Patents by Inventor Ferdinando F. Bruno

Ferdinando F. Bruno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11123590
    Abstract: The disclosed subject matter relates to a method of treating of asbestos or asbestos-containing material, comprising applying to the asbestos or asbestos-containing material a composition including a treatment compound comprising at least one of hexafluoro titanium di-ammonium, potassium hexafluoro zirconate. ammonium hexafluoro phosphate. ammonium hexafluoro stannate, ammonium hexafluoro germanate, ammonium tetrafluoro borate or ammonium heptafluoro tantalite; and a fluorine scavenger compound.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: September 21, 2021
    Assignee: U.S. Government as Represented by the Secretary of the Army
    Inventors: Ferdinando F Bruno, Manuele Bernabei, LTC Andrea Chiappa, David Ziegler, Nicole F Farhadi
  • Patent number: 8932468
    Abstract: Disclosed is a process for the separation of one or more fractions from a resulting reaction mixture of an enzymatically catalyzed polymerization of flavonoid using HPLC with a varying concentration of organic solvent in the mobile phase. The isolated fractions can be used in numerous applications including as an antioxidant.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: January 13, 2015
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Nicole Favreau, Ferdinando F. Bruno
  • Patent number: 8143308
    Abstract: A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: March 27, 2012
    Assignees: University of Massachusetts Lowell, The United States of America, as represented by the Secretary of the Army
    Inventors: Ferdinando F. Bruno, Jayant Kumar, Subhalakshmi Nagarajan, Susan J. Braunhut, Ramaswamy Nagarajan, Lynne A. Samuelson, Donna McIntosh, Klaudia Foley
  • Patent number: 8134020
    Abstract: The present invention provides a method of producing polyhydroxytyrosol comprising the step of reacting hydroxytyrosol monomers or derivative thereof in a mixed solution comprising an enzyme, hydrogen peroxide, and an aqueous solvent.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: March 13, 2012
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Ferdinando F. Bruno, Nicole Favreau
  • Patent number: 8030432
    Abstract: The present invention provides a method of producing a copolymer of hydroxytyrosol, or its derivative, and at least one flavonoid comprising reacting hydroxytyrosol monomers or derivative with at least one flavonoid in the presence of an enzyme and hydrogen peroxide in an aqueous solution.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: October 4, 2011
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Ferdinando F. Bruno, Nicole Favreau
  • Publication number: 20110218252
    Abstract: Disclosed is a separated fraction of a reaction product of an enzymatically catalyzed polymerization of a flavonoid. The separated fraction is highly resistant to oxidation and is useful in numerous applications such as an antioxidant in food products and medical applications.
    Type: Application
    Filed: March 8, 2010
    Publication date: September 8, 2011
    Applicant: USA as represented by the Secretary of the Army
    Inventors: Nicole Favreau, Ferdinando F. Bruno
  • Publication number: 20110172389
    Abstract: Disclosed is a process for the separation of one or more fractions from a resulting reaction mixture of an enzymatically catalyzed polymerization of flavonoid using HPLC with a varying concentration of organic solvent in the mobile phase. The isolated fractions can be used in numerous applications including as an antioxidant.
    Type: Application
    Filed: January 12, 2010
    Publication date: July 14, 2011
    Applicant: USA as represented by the Secretary of the Army
    Inventors: Nicole Favreau, Ferdinando F. Bruno
  • Publication number: 20110144370
    Abstract: The present invention provides a method of producing polyhydroxytyrosol comprising the step of reacting hydroxytyrosol monomers or derivative thereof in a mixed solution comprising an enzyme, hydrogen peroxide, and an aqueous solvent.
    Type: Application
    Filed: December 10, 2009
    Publication date: June 16, 2011
    Applicant: USA as represented by the Secretary of the Army
    Inventors: Ferdinando F. Bruno, Nicole Favreau
  • Publication number: 20110144298
    Abstract: The present invention provides a method of producing a copolymer of hydroxytyrosol, or its derivative, and at least one flavonoid comprising reacting hydroxytyrosol monomers or derivative with at least one flavonoid in the presence of an enzyme and hydrogen peroxide in an aqueous solution.
    Type: Application
    Filed: December 10, 2009
    Publication date: June 16, 2011
    Applicant: USA as represented by the Secretary of the Army
    Inventors: Ferdinando F. Bruno, Nicole Favreau
  • Patent number: 7754267
    Abstract: Antioxidant polymers of the present invention comprise repeat units that include one or both of Structural Formulas (I) and (II): wherein: R is —H or a substituted or unsubstituted alkyl, acyl or aryl group; Ring A is substituted with at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Ring B is substituted with at least one —H and at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Rings A and B are each optionally substituted with one or more groups selected from the group consisting of —OH, —NH, —SH, a substituted or unsubstituted alkyl or aryl group, and a substituted or unsubstituted alkoxycarbonyl group; n is an integer equal to or greater than 2; and p is an integer equal to or greater than 0. The invention also includes methods of using and preparing these polymers.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: July 13, 2010
    Assignees: The United States of America as represented by the Secretary of the Army, University of Massachusetts Lowell
    Inventors: Ashok L. Cholli, Vijayendra Kumar, Javant Kumar, Virinder Singh Parmar, Lynne Ann Samuelson, Ferdinando F. Bruno
  • Patent number: 7727571
    Abstract: Antioxidant polymers of the present invention comprise repeat units that include one or both of Structural Formulas (I) and (II): wherein: R is —H or a substituted or unsubstituted alkyl, acyl or aryl group; Ring A is substituted with at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Ring B is substituted with at least one —H and at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Rings A and B are each optionally substituted with one or more groups selected from the group consisting of —OH, —NH, —SH, a substituted or unsubstituted alkyl or aryl group, and a substituted or unsubstituted alkoxycarbonyl group; n is an integer equal to or greater than 2; and p is an integer equal to or greater than 0. The invention also includes methods of using and preparing these polymers.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: June 1, 2010
    Assignees: University of Massachusetts Lowell, The United States of America as represented by the Secretary of the Army
    Inventors: Ashok L. Cholli, Vijayendra Kumar, Javant Kumar, Virinder Singh Parmar, Lynne Ann Samuelson, Ferdinando F. Bruno
  • Patent number: 7601378
    Abstract: The following is an examiner's statement of reasons for allowance: an antioxidant polymer and method of preparing, the antioxidant comprising repeat units that include one or both of Structural Formulas (I) and (II) wherein R is —H or a substituted or unsubstituted alkyl, acyl or aryl group; Ring A is substituted with at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Ring B is substituted with at least one —H and at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group is not taught nor fairly suggested by the prior art or any combination thereof.
    Type: Grant
    Filed: September 26, 2005
    Date of Patent: October 13, 2009
    Assignees: University of Massachusetts Lowell, The United States of America as represented by the Secretary of the Army
    Inventors: Ashok L. Cholli, Vijayendra Kumar, Jayant Kumar, Virinder Singh Parmar, Lynne Ann Samuelson, Ferdinando F. Bruno
  • Patent number: 7595074
    Abstract: A method of preparing a phenolic polymer comprising: a) protecting at least one hydroxyl group of a substituted or unsubstituted phenol represented by Structural Formula (XXIX), wherein: R11, R12, R13, R14 and R15 are independently —H, —OH, —NH, —SH, a substituted or unsubstituted alkyl or aryl group, a substituted or unsubstituted alkoxycarbonyl or aryloxycarbonyl group, a substituted or unsubstituted alkoxy group or a saturated or unsaturated carboxylic acid group; or R11, R12, R13, R14 or R15, in conjunction with an adjacent R11, R12, R13, R14 or R15, forms a substituted or unsubstituted alkylene dioxy group; provided that at least one of R11, R12, R13, R14 or R15 is a tert-butyl group 1-ethenyl-2-carboxylic acid or ester thereof, a substituted or unsubstituted alkylene dioxy group or a substituted or unsubstituted n-alkoxycarbonyl group, at least one of R11, R12, R13, R14 or R15 is a hydroxyl group, and at least one of R11, R12, R13, R14 and R15 is —H; with a protecting group, wherein thereby obtaining on
    Type: Grant
    Filed: January 21, 2004
    Date of Patent: September 29, 2009
    Assignees: University of Massachusetts Lowell, The United States of America as represented by the Secretary of the Army
    Inventors: Ashok L. Cholli, Vijayendra Kumar, Ashish Dhawan, Jayant Kumar, Virinder Singh Parmar, Lynne Ann Samuelson, Ferdinando F. Bruno
  • Publication number: 20090170928
    Abstract: A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.
    Type: Application
    Filed: October 29, 2007
    Publication date: July 2, 2009
    Inventors: Ferdinando F. Bruno, Jayant Kumar, Subhalakshmi Nagarajan, Susan J. Braunhut, Ramaswamy Nagarajan, Lynne A. Samuelson, Donna McIntosh, Klaudia Foley
  • Patent number: 7507454
    Abstract: Antioxidant polymers of the present invention comprise repeat units that include one or both of Structural Formulas (I) and (II): wherein: R is —H or a substituted or unsubstituted alkyl, acyl or aryl group; Ring A is substituted with at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Ring B is substituted with at least one —H and at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Rings A and B are each optionally substituted with one or more groups selected from the group consisting of —OH, —NH, —SH, a substituted or unsubstituted alkyl or aryl group, and a substituted or unsubstituted alkoxycarbonyl group; n is an integer equal to or greater than 2; and p is an integer equal to or greater than 0. The invention also includes methods of using and preparing these polymers.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: March 24, 2009
    Assignees: University of Massachusetts Lowell, United States of America as represented by the Secretary of the Army
    Inventors: Ashok L. Cholli, Vijayendra Kumar, Jayant Kumar, Virinder Singh Parmar, Lynne Ann Samuelson, Ferdinando F. Bruno
  • Patent number: 7479329
    Abstract: Hematin, a hydroxyferriprotoporphyrin, is derivatized with one or more non-proteinaceous amphipathic groups. The derivatized hematin can serve as a mimic of horseradish peroxidase in polymerizing aromatic monomers, such as aromatic compounds. These derivatized hematins can also be used as catalysts in polymerizing aromatic monomers, and can exhibit significantly greater catalytic activity than underivatized hematin in acidic solutions. In one embodiment, polymerization is in the presence of a template, along which aromatic monomers align. An assembled hematin includes alternating layers of hematin and a polyelectrolyte, which are deposited on an electrically charged substrate. Assembled hematin can also be used to polymerize aromatic monomers.
    Type: Grant
    Filed: September 26, 2007
    Date of Patent: January 20, 2009
    Assignees: University of Massachusetts/Lowell, The United States of America as represented by the Secretary of the Army
    Inventors: Susan Tripathy, legal representative, Lynne A. Samuelson, Ferdinando F. Bruno, Sucharita Roy, Ramaswamy Nagarajan, Jayant Kumar, Bon-Cheol Ku, Soo-Hyoung Lee, Sukant Tripathy
  • Patent number: 7294686
    Abstract: Hematin, a hydroxyferriprotoporphyrin, is derivatized with one or more non-proteinaceous amphipathic groups. The derivatized hematin can serve as a mimic of horseradish peroxidase in polymerizing aromatic monomers, such as aromatic compounds. These derivatized hematins can also be used as catalysts in polymerizing aromatic monomers, and can exhibit significantly greater catalytic activity than underivatized hematin in acidic solutions. In one embodiment, polymerization is in the presence of a template, along which aromatic monomers align. An assembled hematin includes alternating layers of hematin and a polyelectrolyte, which are deposited on an electrically charged substrate. Assembled hematin can also be used to polymerize aromatic monomers.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: November 13, 2007
    Assignees: University of Massachusetts Lowell, United States of America as Represented by the Secretary of the Army
    Inventors: Susan Tripathy, legal representative, Lynne A. Samuelson, Ferdinando F. Bruno, Sucharita Roy, Ramaswamy Nagarajan, Jayant Kumar, Bon-Cheol Ku, Soo-Hyoung Lee, Sukant Tripathy, deceased
  • Patent number: 7223432
    Abstract: Antioxidant polymers of the present invention comprise repeat units that include one or both of Structural Formulas (I) and (II): wherein: R is —H or a substituted or unsubstituted alkyl, acyl or aryl group; Ring A is substituted with at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Ring B is substituted with at least one —H and at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Rings A and B are each optionally substituted with one or more groups selected from the group consisting of —OH, —NH, —SH, a substituted or unsubstituted alkyl or aryl group, and a substituted or unsubstituted alkoxycarbonyl group; n is an integer equal to or greater than 2; and p is an integer equal to or greater than 0. The invention also includes methods of using and preparing these polymers.
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: May 29, 2007
    Assignees: University of Massachusettes Lowell, United States of America, as represented by the Secretary of the Army
    Inventors: Ashok L. Cholli, Vijayendra Kumar, Jayant Kumar, Virinder Singh Parmar, Lynne Ann Samuelson, Ferdinando F. Bruno
  • Publication number: 20040214935
    Abstract: One group of polymers comprise repeat units of Structural Formula (I) and/or (II): 1
    Type: Application
    Filed: January 21, 2004
    Publication date: October 28, 2004
    Applicants: University of Massachusetts Lowell, Government of the United States, as represented by the Secretary of the Army
    Inventors: Ashok L. Cholli, Vijayendra Kumar, Ashish Dhawan, Jayant Kumar, Virinder Singh Parmar, Lynne Ann Samuelson, Ferdinando F. Bruno
  • Publication number: 20040198945
    Abstract: Hematin, a hydroxyferriprotoporphyrin, is derivatized with one or more non-proteinaceous amphipathic groups. The derivatized hematin can serve as a mimic of horseradish peroxidase in polymerizing aromatic monomers, such as aromatic compounds. These derivatized hematins can also be used as catalysts in polymerizing aromatic monomers, and can exhibit significantly greater catalytic activity than underivatized hematin in acidic solutions. In one embodiment, polymerization is in the presence of a template, along which aromatic monomers align. An assembled hematin includes alternating layers of hematin and a polyelectrolyte, which are deposited on an electrically charged substrate. Assembled hematin can also be used to polymerize aromatic monomers.
    Type: Application
    Filed: April 16, 2004
    Publication date: October 7, 2004
    Applicants: University of Massachusetts, Government of the United States, as represented by the Secretary of the Army
    Inventors: Sukant Tripathy, Susan Tripathy, Lynne A. Samuelson, Ferdinando F. Bruno, Sucharita Roy, Ramaswamy Nagarajan, Jayant Kumar, Bon-Cheol Ku, Soo-Hyoung Lee