Patents by Inventor Ferdinando F. Bruno
Ferdinando F. Bruno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11123590Abstract: The disclosed subject matter relates to a method of treating of asbestos or asbestos-containing material, comprising applying to the asbestos or asbestos-containing material a composition including a treatment compound comprising at least one of hexafluoro titanium di-ammonium, potassium hexafluoro zirconate. ammonium hexafluoro phosphate. ammonium hexafluoro stannate, ammonium hexafluoro germanate, ammonium tetrafluoro borate or ammonium heptafluoro tantalite; and a fluorine scavenger compound.Type: GrantFiled: July 12, 2019Date of Patent: September 21, 2021Assignee: U.S. Government as Represented by the Secretary of the ArmyInventors: Ferdinando F Bruno, Manuele Bernabei, LTC Andrea Chiappa, David Ziegler, Nicole F Farhadi
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Patent number: 8932468Abstract: Disclosed is a process for the separation of one or more fractions from a resulting reaction mixture of an enzymatically catalyzed polymerization of flavonoid using HPLC with a varying concentration of organic solvent in the mobile phase. The isolated fractions can be used in numerous applications including as an antioxidant.Type: GrantFiled: January 12, 2010Date of Patent: January 13, 2015Assignee: The United States of America as Represented by the Secretary of the ArmyInventors: Nicole Favreau, Ferdinando F. Bruno
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Patent number: 8143308Abstract: A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.Type: GrantFiled: October 29, 2007Date of Patent: March 27, 2012Assignees: University of Massachusetts Lowell, The United States of America, as represented by the Secretary of the ArmyInventors: Ferdinando F. Bruno, Jayant Kumar, Subhalakshmi Nagarajan, Susan J. Braunhut, Ramaswamy Nagarajan, Lynne A. Samuelson, Donna McIntosh, Klaudia Foley
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Patent number: 8134020Abstract: The present invention provides a method of producing polyhydroxytyrosol comprising the step of reacting hydroxytyrosol monomers or derivative thereof in a mixed solution comprising an enzyme, hydrogen peroxide, and an aqueous solvent.Type: GrantFiled: December 10, 2009Date of Patent: March 13, 2012Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Ferdinando F. Bruno, Nicole Favreau
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Patent number: 8030432Abstract: The present invention provides a method of producing a copolymer of hydroxytyrosol, or its derivative, and at least one flavonoid comprising reacting hydroxytyrosol monomers or derivative with at least one flavonoid in the presence of an enzyme and hydrogen peroxide in an aqueous solution.Type: GrantFiled: December 10, 2009Date of Patent: October 4, 2011Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Ferdinando F. Bruno, Nicole Favreau
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Publication number: 20110218252Abstract: Disclosed is a separated fraction of a reaction product of an enzymatically catalyzed polymerization of a flavonoid. The separated fraction is highly resistant to oxidation and is useful in numerous applications such as an antioxidant in food products and medical applications.Type: ApplicationFiled: March 8, 2010Publication date: September 8, 2011Applicant: USA as represented by the Secretary of the ArmyInventors: Nicole Favreau, Ferdinando F. Bruno
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Publication number: 20110172389Abstract: Disclosed is a process for the separation of one or more fractions from a resulting reaction mixture of an enzymatically catalyzed polymerization of flavonoid using HPLC with a varying concentration of organic solvent in the mobile phase. The isolated fractions can be used in numerous applications including as an antioxidant.Type: ApplicationFiled: January 12, 2010Publication date: July 14, 2011Applicant: USA as represented by the Secretary of the ArmyInventors: Nicole Favreau, Ferdinando F. Bruno
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Publication number: 20110144370Abstract: The present invention provides a method of producing polyhydroxytyrosol comprising the step of reacting hydroxytyrosol monomers or derivative thereof in a mixed solution comprising an enzyme, hydrogen peroxide, and an aqueous solvent.Type: ApplicationFiled: December 10, 2009Publication date: June 16, 2011Applicant: USA as represented by the Secretary of the ArmyInventors: Ferdinando F. Bruno, Nicole Favreau
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Publication number: 20110144298Abstract: The present invention provides a method of producing a copolymer of hydroxytyrosol, or its derivative, and at least one flavonoid comprising reacting hydroxytyrosol monomers or derivative with at least one flavonoid in the presence of an enzyme and hydrogen peroxide in an aqueous solution.Type: ApplicationFiled: December 10, 2009Publication date: June 16, 2011Applicant: USA as represented by the Secretary of the ArmyInventors: Ferdinando F. Bruno, Nicole Favreau
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Patent number: 7754267Abstract: Antioxidant polymers of the present invention comprise repeat units that include one or both of Structural Formulas (I) and (II): wherein: R is —H or a substituted or unsubstituted alkyl, acyl or aryl group; Ring A is substituted with at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Ring B is substituted with at least one —H and at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Rings A and B are each optionally substituted with one or more groups selected from the group consisting of —OH, —NH, —SH, a substituted or unsubstituted alkyl or aryl group, and a substituted or unsubstituted alkoxycarbonyl group; n is an integer equal to or greater than 2; and p is an integer equal to or greater than 0. The invention also includes methods of using and preparing these polymers.Type: GrantFiled: February 27, 2007Date of Patent: July 13, 2010Assignees: The United States of America as represented by the Secretary of the Army, University of Massachusetts LowellInventors: Ashok L. Cholli, Vijayendra Kumar, Javant Kumar, Virinder Singh Parmar, Lynne Ann Samuelson, Ferdinando F. Bruno
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Patent number: 7727571Abstract: Antioxidant polymers of the present invention comprise repeat units that include one or both of Structural Formulas (I) and (II): wherein: R is —H or a substituted or unsubstituted alkyl, acyl or aryl group; Ring A is substituted with at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Ring B is substituted with at least one —H and at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Rings A and B are each optionally substituted with one or more groups selected from the group consisting of —OH, —NH, —SH, a substituted or unsubstituted alkyl or aryl group, and a substituted or unsubstituted alkoxycarbonyl group; n is an integer equal to or greater than 2; and p is an integer equal to or greater than 0. The invention also includes methods of using and preparing these polymers.Type: GrantFiled: February 27, 2007Date of Patent: June 1, 2010Assignees: University of Massachusetts Lowell, The United States of America as represented by the Secretary of the ArmyInventors: Ashok L. Cholli, Vijayendra Kumar, Javant Kumar, Virinder Singh Parmar, Lynne Ann Samuelson, Ferdinando F. Bruno
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Patent number: 7601378Abstract: The following is an examiner's statement of reasons for allowance: an antioxidant polymer and method of preparing, the antioxidant comprising repeat units that include one or both of Structural Formulas (I) and (II) wherein R is —H or a substituted or unsubstituted alkyl, acyl or aryl group; Ring A is substituted with at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Ring B is substituted with at least one —H and at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group is not taught nor fairly suggested by the prior art or any combination thereof.Type: GrantFiled: September 26, 2005Date of Patent: October 13, 2009Assignees: University of Massachusetts Lowell, The United States of America as represented by the Secretary of the ArmyInventors: Ashok L. Cholli, Vijayendra Kumar, Jayant Kumar, Virinder Singh Parmar, Lynne Ann Samuelson, Ferdinando F. Bruno
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Patent number: 7595074Abstract: A method of preparing a phenolic polymer comprising: a) protecting at least one hydroxyl group of a substituted or unsubstituted phenol represented by Structural Formula (XXIX), wherein: R11, R12, R13, R14 and R15 are independently —H, —OH, —NH, —SH, a substituted or unsubstituted alkyl or aryl group, a substituted or unsubstituted alkoxycarbonyl or aryloxycarbonyl group, a substituted or unsubstituted alkoxy group or a saturated or unsaturated carboxylic acid group; or R11, R12, R13, R14 or R15, in conjunction with an adjacent R11, R12, R13, R14 or R15, forms a substituted or unsubstituted alkylene dioxy group; provided that at least one of R11, R12, R13, R14 or R15 is a tert-butyl group 1-ethenyl-2-carboxylic acid or ester thereof, a substituted or unsubstituted alkylene dioxy group or a substituted or unsubstituted n-alkoxycarbonyl group, at least one of R11, R12, R13, R14 or R15 is a hydroxyl group, and at least one of R11, R12, R13, R14 and R15 is —H; with a protecting group, wherein thereby obtaining onType: GrantFiled: January 21, 2004Date of Patent: September 29, 2009Assignees: University of Massachusetts Lowell, The United States of America as represented by the Secretary of the ArmyInventors: Ashok L. Cholli, Vijayendra Kumar, Ashish Dhawan, Jayant Kumar, Virinder Singh Parmar, Lynne Ann Samuelson, Ferdinando F. Bruno
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Publication number: 20090170928Abstract: A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.Type: ApplicationFiled: October 29, 2007Publication date: July 2, 2009Inventors: Ferdinando F. Bruno, Jayant Kumar, Subhalakshmi Nagarajan, Susan J. Braunhut, Ramaswamy Nagarajan, Lynne A. Samuelson, Donna McIntosh, Klaudia Foley
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Patent number: 7507454Abstract: Antioxidant polymers of the present invention comprise repeat units that include one or both of Structural Formulas (I) and (II): wherein: R is —H or a substituted or unsubstituted alkyl, acyl or aryl group; Ring A is substituted with at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Ring B is substituted with at least one —H and at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Rings A and B are each optionally substituted with one or more groups selected from the group consisting of —OH, —NH, —SH, a substituted or unsubstituted alkyl or aryl group, and a substituted or unsubstituted alkoxycarbonyl group; n is an integer equal to or greater than 2; and p is an integer equal to or greater than 0. The invention also includes methods of using and preparing these polymers.Type: GrantFiled: February 27, 2007Date of Patent: March 24, 2009Assignees: University of Massachusetts Lowell, United States of America as represented by the Secretary of the ArmyInventors: Ashok L. Cholli, Vijayendra Kumar, Jayant Kumar, Virinder Singh Parmar, Lynne Ann Samuelson, Ferdinando F. Bruno
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Patent number: 7479329Abstract: Hematin, a hydroxyferriprotoporphyrin, is derivatized with one or more non-proteinaceous amphipathic groups. The derivatized hematin can serve as a mimic of horseradish peroxidase in polymerizing aromatic monomers, such as aromatic compounds. These derivatized hematins can also be used as catalysts in polymerizing aromatic monomers, and can exhibit significantly greater catalytic activity than underivatized hematin in acidic solutions. In one embodiment, polymerization is in the presence of a template, along which aromatic monomers align. An assembled hematin includes alternating layers of hematin and a polyelectrolyte, which are deposited on an electrically charged substrate. Assembled hematin can also be used to polymerize aromatic monomers.Type: GrantFiled: September 26, 2007Date of Patent: January 20, 2009Assignees: University of Massachusetts/Lowell, The United States of America as represented by the Secretary of the ArmyInventors: Susan Tripathy, legal representative, Lynne A. Samuelson, Ferdinando F. Bruno, Sucharita Roy, Ramaswamy Nagarajan, Jayant Kumar, Bon-Cheol Ku, Soo-Hyoung Lee, Sukant Tripathy
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Patent number: 7294686Abstract: Hematin, a hydroxyferriprotoporphyrin, is derivatized with one or more non-proteinaceous amphipathic groups. The derivatized hematin can serve as a mimic of horseradish peroxidase in polymerizing aromatic monomers, such as aromatic compounds. These derivatized hematins can also be used as catalysts in polymerizing aromatic monomers, and can exhibit significantly greater catalytic activity than underivatized hematin in acidic solutions. In one embodiment, polymerization is in the presence of a template, along which aromatic monomers align. An assembled hematin includes alternating layers of hematin and a polyelectrolyte, which are deposited on an electrically charged substrate. Assembled hematin can also be used to polymerize aromatic monomers.Type: GrantFiled: January 23, 2006Date of Patent: November 13, 2007Assignees: University of Massachusetts Lowell, United States of America as Represented by the Secretary of the ArmyInventors: Susan Tripathy, legal representative, Lynne A. Samuelson, Ferdinando F. Bruno, Sucharita Roy, Ramaswamy Nagarajan, Jayant Kumar, Bon-Cheol Ku, Soo-Hyoung Lee, Sukant Tripathy, deceased
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Patent number: 7223432Abstract: Antioxidant polymers of the present invention comprise repeat units that include one or both of Structural Formulas (I) and (II): wherein: R is —H or a substituted or unsubstituted alkyl, acyl or aryl group; Ring A is substituted with at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Ring B is substituted with at least one —H and at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Rings A and B are each optionally substituted with one or more groups selected from the group consisting of —OH, —NH, —SH, a substituted or unsubstituted alkyl or aryl group, and a substituted or unsubstituted alkoxycarbonyl group; n is an integer equal to or greater than 2; and p is an integer equal to or greater than 0. The invention also includes methods of using and preparing these polymers.Type: GrantFiled: April 4, 2003Date of Patent: May 29, 2007Assignees: University of Massachusettes Lowell, United States of America, as represented by the Secretary of the ArmyInventors: Ashok L. Cholli, Vijayendra Kumar, Jayant Kumar, Virinder Singh Parmar, Lynne Ann Samuelson, Ferdinando F. Bruno
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Publication number: 20040214935Abstract: One group of polymers comprise repeat units of Structural Formula (I) and/or (II): 1Type: ApplicationFiled: January 21, 2004Publication date: October 28, 2004Applicants: University of Massachusetts Lowell, Government of the United States, as represented by the Secretary of the ArmyInventors: Ashok L. Cholli, Vijayendra Kumar, Ashish Dhawan, Jayant Kumar, Virinder Singh Parmar, Lynne Ann Samuelson, Ferdinando F. Bruno
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Publication number: 20040198945Abstract: Hematin, a hydroxyferriprotoporphyrin, is derivatized with one or more non-proteinaceous amphipathic groups. The derivatized hematin can serve as a mimic of horseradish peroxidase in polymerizing aromatic monomers, such as aromatic compounds. These derivatized hematins can also be used as catalysts in polymerizing aromatic monomers, and can exhibit significantly greater catalytic activity than underivatized hematin in acidic solutions. In one embodiment, polymerization is in the presence of a template, along which aromatic monomers align. An assembled hematin includes alternating layers of hematin and a polyelectrolyte, which are deposited on an electrically charged substrate. Assembled hematin can also be used to polymerize aromatic monomers.Type: ApplicationFiled: April 16, 2004Publication date: October 7, 2004Applicants: University of Massachusetts, Government of the United States, as represented by the Secretary of the ArmyInventors: Sukant Tripathy, Susan Tripathy, Lynne A. Samuelson, Ferdinando F. Bruno, Sucharita Roy, Ramaswamy Nagarajan, Jayant Kumar, Bon-Cheol Ku, Soo-Hyoung Lee