Patents by Inventor Fiona A. Harding

Fiona A. Harding has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amylases producing an altered immunogenic response and methods of making and using the same
    Publication number: 20070025974
    Abstract: The present invention provides novel amylase variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that encode novel amylase variants, host cells comprising DNA encoding novel amylase variants, as well as methods for making amylases less allergenic. In addition, the present invention provides various compositions that comprise these amylase variants that are less immunogenic than the wild-type amylases.
    Type: Application
    Filed: February 26, 2003
    Publication date: February 1, 2007
    Inventor: Fiona Hardings
  • HPV CD8+ T-cell epitopes
    Patent number: 7153659
    Abstract: The present invention provides means to identify functional CD8+ T-cell epitopes in any protein of interest. The present invention further provides CD8+ T-cell epitopes of various proteins. In additional embodiments, the present invention provides epitopes suitable for use in prophylactic and/or therapeutic vaccines. In particularly preferred embodiments, the present invention provides modified epitopes suitable for use in prophylactic and/or therapeutic vaccines. In some preferred embodiments, the present invention provides means for the development of HPV vaccines, in particular multivalent vaccines for the prevention of infection with high-risk HPV strains. In particular, the present invention provides means to identify CD8+ T-cell epitopes in HPV strains such as HPV 16 and HPV 18. In additional embodiments, the present invention provides means for the development of therapeutic vaccines against high-risk HPV types that prevent the development of benign and/or malignant tumors in infected individuals.
    Type: Grant
    Filed: August 23, 2004
    Date of Patent: December 26, 2006
    Assignee: Genencor International, Inc.
    Inventors: Fiona Harding, Jeanette Marie Mucha
  • Proteins producing an altered immunogenic response and methods of making the same
    Publication number: 20060024764
    Abstract: The present invention relates to a novel methods and compositions for producing hyper and hypo allergenic compositions. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein. Alternatively, T-cell epitopes are mutated to produce increased immunogenic reactions. Moreover, naturally occurring proteins are provided.
    Type: Application
    Filed: December 22, 2004
    Publication date: February 2, 2006
    Inventors: David Estell, Fiona Harding
  • Subtilisin carlsberg proteins with reduced immunogenicity
    Publication number: 20050239043
    Abstract: The present invention provides methods for the identification of CD4+ T-cell epitopes in subtilisin Carlsberg proteins. The present invention also provides for the production of altered peptides which, when incorporated into a wild-type subtilisin Carlsberg protein produce an altered immunogenic response, preferably a low immunogenic response in humans. In particular, the present invention provides means, including methods and compositions suitable for reducing the immunogenicity of ALCALASE® enzyme.
    Type: Application
    Filed: February 26, 2003
    Publication date: October 27, 2005
    Inventor: Fiona Harding
  • Cytokines and cytokine receptors with reduced immunogenicity
    Publication number: 20050220800
    Abstract: The present invention provides methods for the identification of CD4+ T-cell epitopes in the sequences of various proteins, namely, human cytokines and cytokine receptors, as well as the production of peptides which when incorporated into the protein sequence, are no longer capable of initiating the CD4+ T-cell response. In some embodiments, the present invention provides means and compositions suitable for reducing the immunogenicity of cytokines and cytokines receptors such as interferon-?, soluble tumor necrosis factor receptor-1, erythropoietin, and thrombopoietin.
    Type: Application
    Filed: February 26, 2003
    Publication date: October 6, 2005
    Inventors: Power Scott, Fiona Harding
  • Proteins producing an altered immunogenic response and methods of making and using the same
    Publication number: 20050202551
    Abstract: The present invention relates to novel protein variants that exhibit reduced allergenicity when compared to the parental proteins. Also included are DNA molecules that encode the novel variants, host cells comprising the DNA and methods of making proteins less allergenic.
    Type: Application
    Filed: May 12, 2005
    Publication date: September 15, 2005
    Inventors: David Estell, Grant Ganshaw, Fiona Harding, Edmund Larenas, Ayrookaran Poulose, Elizabeth Sikorski, Elliott Russell
  • Proteins producing an altered immunogenic response and methods of making and using the same
    Publication number: 20050202552
    Abstract: The present invention relates to novel protein variants that exhibit reduced allergenicity when compared to the parental proteins. Also included are DNA molecules that encode the novel variants, host cells comprising the DNA and methods of making proteins less allergenic.
    Type: Application
    Filed: May 12, 2005
    Publication date: September 15, 2005
    Inventors: David Estell, Grant Ganshaw, Fiona Harding, Edmund Larenas, Ayrookaran Poulose, Elizabeth Sikorski, Elliott Russell
  • Proteins producing an altered immunogenic response and methods of making and using the same
    Patent number: 6936249
    Abstract: The present invention relates to a novel methods and compositions for producing hyper and hypo allergenic compositions. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein. Alternatively, T-cell epitopes are mutated to produce increased immunogenic reactions. Moreover, naturally occurring proteins are provided.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: August 30, 2005
    Assignee: Genencor International, Inc.
    Inventors: David A. Estell, Fiona A. Harding
  • HPV CD8+ T-cell epitopes
    Publication number: 20050181458
    Abstract: The present invention provides means to identify functional CD8+ T-cell epitopes in any protein of interest. The present invention further provides CD8+ T-cell epitopes of various proteins. In additional embodiments, the present invention provides epitopes suitable for use in prophylactic and/or therapeutic vaccines. In particularly preferred embodiments, the present invention provides modified epitopes suitable for use in prophylactic and/or therapeutic vaccines. In some preferred embodiments, the present invention provides means for the development of HPV vaccines, in particular multivalent vaccines for the prevention of infection with high-risk HPV strains. In particular, the present invention provides means to identify CD8+ T-cell epitopes in HPV strains such as HPV 16 and HPV 18. In additional embodiments, the present invention provides means for the development of therapeutic vaccines against high-risk HPV types that prevent the development of benign and/or malignant tumors in infected individuals.
    Type: Application
    Filed: August 23, 2004
    Publication date: August 18, 2005
    Inventors: Fiona Harding, Jeannette Mucha
  • Proteins producing an altered immunogenic response and methods of making and using the same
    Patent number: 6929939
    Abstract: The present invention relates to novel protein variants that exhibit reduced allergenicity when compared to the parental proteins. Also included are DNA molecules that encode the novel variants, host cells comprising the DNA and methods of making proteins less allergenic.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: August 16, 2005
    Assignees: Genencor International, Inc., The Procter & Gamble Company
    Inventors: David A. Estell, Grant C. Ganshaw, Fiona A. Harding, Edmund A. Larenas, Ayrookaran J. Poulose, Elizabeth E. Sikorski, Elliott P. Russell
  • Beta-lactamase CD4+ T-cell epitopes
    Publication number: 20050164308
    Abstract: The present invention provides beta-lactamase CD4+ T-cell epitopes, as well as novel variants that exhibit reduced immunogenic responses, as compared to the parental beta-lactamase. The present invention further provides DNA molecules that encode novel beta-lactamase variants, host cells comprising DNA encoding novel beta-lactamase variants, as well as methods for making beta-lactamases less immunogenic. In addition, the present invention provides various compositions that comprise these beta-lactamase variants that are less immunogenic than wild-type beta-lactamases.
    Type: Application
    Filed: December 14, 2004
    Publication date: July 28, 2005
    Inventors: Fiona Harding, Volker Schellenberger
  • Proteins producing an altered immunogenic response and methods of making and using the same
    Publication number: 20050164257
    Abstract: The present invention relates to a novel methods and compositions for producing hyper and hypo allergenic compositions. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein. Alternatively, T-cell epitopes are mutated to produce increased immunogenic reactions. Moreover, naturally occurring proteins are provided.
    Type: Application
    Filed: December 22, 2004
    Publication date: July 28, 2005
    Inventors: David Estell, Fiona Harding
  • Population based assessments and means to rank the relative immunogenicity of proteins
    Publication number: 20050158806
    Abstract: The present invention provides means to assess immune response profiles of populations. In particular, the present invention provides means to qualitatively assess the immune response of human populations wherein the immune response directed against any protein of interest is analyzed. The present invention further provides means to rank proteins based on their relative immunogenicity. In addition, the present invention provides means to create proteins with reduced immunogenicity for use in various applications.
    Type: Application
    Filed: February 26, 2003
    Publication date: July 21, 2005
    Inventor: Fiona Harding
  • Protease producing an altered immunogenic response and methods of making and using the same
    Publication number: 20050148059
    Abstract: The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that encode novel variants, host cells comprising DNA encoding novel variants, as well as methods for making proteins less allergenic. In addition, the present invention provides various compositions that comprise these proteins that are less immunogenic than the wild-type proteins.
    Type: Application
    Filed: December 20, 2002
    Publication date: July 7, 2005
    Inventors: David Estell, Fiona Harding
  • Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
    Publication number: 20050137112
    Abstract: The present invention relates to a novel improved protein mutant which produces low allergenic response in humans compared to the parent of that mutant. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein.
    Type: Application
    Filed: August 23, 2004
    Publication date: June 23, 2005
    Inventors: David Estell, Fiona Harding
  • Proteins producing an altered immunogenic response and methods of making and using the same
    Patent number: 6897049
    Abstract: The present invention relates to a novel methods and compositions for producing hyper and hypo allergenic compositions. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein. Alternatively, T-cell epitopes are mutated to produce increased immunogenic reactions.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: May 24, 2005
    Assignee: Genencor International, Inc.
    Inventors: David A. Estell, Fiona A. Harding
  • Proteases producing an altered immunological response and methods of making and using the same
    Publication number: 20050054843
    Abstract: The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that encode novel variants, host cells comprising DNA encoding novel variants, as well as methods for making proteins less allergenic. In addition, the present invention provides various compositions that comprise these proteins that are less immunogenic than the wild-type proteins.
    Type: Application
    Filed: December 20, 2002
    Publication date: March 10, 2005
    Inventors: David Estell, Fiona Harding, Ayrookaran Poulose
  • Proteins producing an altered immunogenic response and methods of making and using the same
    Patent number: 6838269
    Abstract: The present invention relates to a novel methods and compositions for producing hyper and hypo allergenic compositions. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein. Alternatively, T-cell epitopes are mutated to produce increased immunogenic reactions. Moreover, naturally occuring proteins are provided.
    Type: Grant
    Filed: February 8, 2000
    Date of Patent: January 4, 2005
    Assignee: Genencor International, Inc.
    Inventors: David A. Estell, Fiona A. Harding
  • Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
    Patent number: 6835550
    Abstract: The present invention relates to a novel improved protein mutant which produces low allergenic response in humans compared to the parent of that mutant. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein.
    Type: Grant
    Filed: April 15, 1998
    Date of Patent: December 28, 2004
    Assignee: Genencor International, Inc.
    Inventors: David A. Estell, Fiona A. Harding
  • Identifying and reducing the allergenicity of food proteins
    Publication number: 20040209312
    Abstract: The present invention provides methods and composition suitable for the identification and modification of allergenic proteins. More particularly, the present invention provides methods and compositions for the identification and modification of epitopes of allergenic food proteins, as well as epitopes of potentially allergenic food proteins.
    Type: Application
    Filed: April 23, 2004
    Publication date: October 21, 2004
    Inventors: Fiona A Harding, Scott D Power