Patents by Inventor Foe S. Tjoeng

Foe S. Tjoeng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amidino dervatives useful as nitric oxide synthase inhibitors
    Patent number: 5854234
    Abstract: The current invention discloses useful pharmaceutical compositions containing azepine derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 29, 1998
    Assignee: G. D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Mark G. Currie, E. Ann Hallinan, Kam F. Fok, Timothy J. Hagen, Arija A. Bergmanis, Steven W. Kramer, Len F. Lee, Suzanne Metz, William M. Moore, Karen B. Peterson, Barnett S. Pitzele, Dale P. Spangler, R. Keith Webber, Mihaly V. Toth, Mahima Trivedi, Foe S. Tjoeng
  • Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
    Patent number: 5837698
    Abstract: The present invention relates to a pharmaceutical composition or preparation which comprises hydroxyl containing steroidal hormones and organic nitrite/nitrate or other nitric oxide donating agents.
    Type: Grant
    Filed: May 2, 1996
    Date of Patent: November 17, 1998
    Assignee: G. D. Searle & Co.
    Inventors: Foe S. Tjoeng, Mark G. Currie, Mark E. Zupec
  • Amidino derivatives useful as nitric oxide synthase inhibitors
    Patent number: 5821267
    Abstract: The current invention discloses amidino derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: March 20, 1996
    Date of Patent: October 13, 1998
    Assignee: G.D. Searle & Co.
    Inventors: Kam F. Fok, Foe S. Tjoeng, R. Keith Webber
  • Steroid nitrite ester derivatives useful as anti-inflammatory drugs
    Patent number: 5792758
    Abstract: The present invention discloses novel steroid nitrite ester derivatives, and to their use treating inflammatory diseases.
    Type: Grant
    Filed: December 8, 1995
    Date of Patent: August 11, 1998
    Assignee: G. D. Searle & Co.
    Inventors: Foe S. Tjoeng, Mark G. Currie, Mark E. Zupec
  • N-acyl beta amino acid derivatives useful as platelet aggregation inhibitors
    Patent number: 5710166
    Abstract: Novel N-Acyl Beta Amino Acid derivatives of the formula ##STR1## are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
    Type: Grant
    Filed: August 24, 1995
    Date of Patent: January 20, 1998
    Assignee: The Monsanto Company
    Inventors: Foe S. Tjoeng, Mihaly V. Toth
  • Steroid nitrite/nitrate ester derivatives useful as anti-inflammatory drugs
    Patent number: 5707984
    Abstract: Disclosed are steroid nitrite/nitrate ester derivatives of formula I: ##STR1## wherein, the substituents are as defined in the specification and their use in the treatment of inflammatory diseases.
    Type: Grant
    Filed: December 8, 1995
    Date of Patent: January 13, 1998
    Assignee: G. D. Searle & Co.
    Inventors: Foe S. Tjoeng, Mark G. Currie, Mark E. Zupec
  • Substituted .beta.-amino acid derivatives useful as platelet aggregation inhibitors
    Patent number: 5703125
    Abstract: The invention relates to platelet aggregation inhibitors which are substituted beta amino acid derivatives of the formula: ##STR1## wherein Z, A, Z', Z", W, q, R.sup.1 and R.sup.2 are as defined in the specification.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: December 30, 1997
    Assignees: G. D. Searle & Co., The Monsanto Company
    Inventors: Philippe R. Bovy, Joseph G. Rico, Thomas E. Rogers, Foe S. Tjoeng, Jeffery A. Zablocki
  • Amidine derivatives useful as platelet aggregation inhibitors and vasodilators
    Patent number: 5674894
    Abstract: The current invention discloses novel amidine derivatives with nitric oxide donating property that can inhibit platelet aggregation and promote vasodilation in a single compound.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: October 7, 1997
    Assignee: G.D. Searle & Co.
    Inventors: Mark G. Currie, Foe S. Tjoeng, Mark E. Zupec
  • Urea derivatives useful as platelet aggregation inhibitors
    Patent number: 5624956
    Abstract: Novel urea derivatives and pharmaceutical compositions thereof are provided which inhibit platelet aggregation.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: April 29, 1997
    Assignee: The Monsanto Company
    Inventors: Foe S. Tjoeng, Mihaly V. Toth, Dudley E. McMackins, Steven P. Adams
  • Urea compounds which are useful as platelet aggregation inhibitors
    Patent number: 5614539
    Abstract: Novel urea derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: March 25, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Steven P. Adams, Foe S. Tjoeng, Mark E. Zupec
  • Urea derivatives useful as platelet aggregation inhibitors
    Patent number: 5475025
    Abstract: Novel urea compounds are provided which inhibit platelet aggregation as well as pharmaceutical compositions and methods of using said compounds.
    Type: Grant
    Filed: February 23, 1994
    Date of Patent: December 12, 1995
    Assignee: The Monsanto Company
    Inventors: Foe S. Tjoeng, Mihaly V. Toth, Dudley E. McMackins, Steven P. Adams
  • Substituted bicyclic heterocyclic compounds useful as platelet aggregation inhibitors
    Patent number: 5378727
    Abstract: Novel substituted heterocyclic derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
    Type: Grant
    Filed: July 19, 1993
    Date of Patent: January 3, 1995
    Assignee: G. D. Searle & Co.
    Inventors: Philippe R. Bovy, Joseph G. Rico, Thomas E. Rogers, Foe S. Tjoeng, Jeffery A. Zablocki
  • Platelet aggregation inhibitors
    Patent number: 5354738
    Abstract: This invention relates to compounds having the following formula ##STR1## or a pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions including the compounds, and to a method of inhibiting platelet aggregation in mammals by administering such compounds and compositions.
    Type: Grant
    Filed: September 4, 1992
    Date of Patent: October 11, 1994
    Assignees: G. D. Searle & Co., The Monsanto Company
    Inventors: Foe S. Tjoeng, Jeffery A. Zablocki
  • Platelet aggregation inhibitors
    Patent number: 5344837
    Abstract: This invention relates to compounds having the following formula ##STR1## or a pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions including the compounds, and to a method of inhibiting platelet aggregation in mammals by administering such compounds and compositions.
    Type: Grant
    Filed: September 23, 1993
    Date of Patent: September 6, 1994
    Assignees: G.D. Searle & Co., Monsanto Company
    Inventors: Foe S. Tjoeng, Jeffery A. Zablocki
  • Substituted .beta.-amino acid derivatives useful as platelet aggregation inhibitors
    Patent number: 5344957
    Abstract: Novel substituted .beta. amino acid derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
    Type: Grant
    Filed: October 6, 1992
    Date of Patent: September 6, 1994
    Assignees: G.D. Searle & Co., Monsanto Company
    Inventors: Philippe R. Bovy, Joseph G. Rico, Thomas E. Rogers, Foe S. Tjoeng, Jeffery A. Zablocki
  • Urea derivatives useful as platelet aggregation inhibitors
    Patent number: 5314902
    Abstract: Novel urea derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
    Type: Grant
    Filed: January 27, 1993
    Date of Patent: May 24, 1994
    Assignee: Monsanto Company
    Inventors: Foe S. Tjoeng, Mihaly V. Toth, Dudley E. McMackins, Steven P. Adams
  • Platelet aggregation inhibitors
    Patent number: 5272162
    Abstract: This invention relates to compounds having the following formula ##STR1## or a pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions including the compounds and to a method of inhibiting platelet aggregation in mammals by administering such compounds and compositions.
    Type: Grant
    Filed: July 2, 1992
    Date of Patent: December 21, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Foe S. Tjoeng, Jeffery A. Zablocki
  • Substituted heterocyclic derivatives useful as platelet aggregation inhibitors
    Patent number: 5254573
    Abstract: Novel substituted heterocyclic derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
    Type: Grant
    Filed: October 6, 1992
    Date of Patent: October 19, 1993
    Assignees: Monsanto Company, G. D. Searle & Co.
    Inventors: Philippe R. Bovy, Joseph G. Rico, Thomas E. Rogers, Foe S. Tjoeng, Jeffery A. Zablocki
  • Substituted .beta.-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
    Patent number: 5239113
    Abstract: Novel substituted .beta. amino acid derivatives are provided which inhibit platelet aggregation and intermediates thereof. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
    Type: Grant
    Filed: April 10, 1992
    Date of Patent: August 24, 1993
    Assignees: Monsanto Company, G. D. Searle & Co.
    Inventors: Phillipe R. Bovy, Joseph G. Rico, Thomas E. Rogers, Foe S. Tjoeng, Jeffery A. Zablocki
  • Peptide mimetic compounds useful as platelet aggregation inhibitors
    Patent number: 5220050
    Abstract: This invention relates to having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidines derivatives.
    Type: Grant
    Filed: November 12, 1991
    Date of Patent: June 15, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Philippe R. Bovy, Dudley E. McMackins, Joseph G. Rico, Foe S. Tjoeng, Mihaly V. Toth, Robert B. Garland, Masateru Miyano, Jeffery A. Zablocki