Abstract: A method for controlling a computer cursor involves capturing a plurality of arrays of data in a hand held device representing light entering the device from an environment in which the device resides, processing at least some of the plurality of arrays of data in the device to estimate motion of the device with respect to the environment during each of a plurality of measurement cycles, and sending a series of estimated motion signals to a computer to move a cursor display in response to motion of the device relative to the environment, each such estimated motion signal representing the estimated motion of the handheld device during more than one of the plurality of measurement cycles.

Abstract: A method for operating a hand held optical pointing device, such as an optical mouse, involves capturing a plurality of arrays of data in a hand held optical pointing device representing light reflected from irregularities on a surface, processing at least some of the plurality of arrays of data in the device to estimate movement of the device with respect to the surface during each of a plurality of measurement cycles, and sending a series of estimated movement update signals to a computer, each such estimated movement update signal representing the estimated relative movement of the handheld optical pointing device with respect to the surface during more than one of the plurality of measurement cycles.

Abstract: The invention relates to pharmaceutical compositions comprising combinations of ABT-751 and anti-cancer drugs. These combinations have additive antitumorigenesis activity. This invention also relates to methods of treatment using the combinations.

Abstract: The invention relates to pharmaceutical compositions comprising combinations of ABT-751 and anti-cancer drugs. These combinations have additive antitumorigenesis activity. This invention also relates to methods of treatment using the combinations.

Abstract: An optical mouse images as an array of pixels the spatial features of generally any micro textured or micro detailed work surface below the mouse. The photo detector responses are digitized and stored as a frame into memory. Motion produces successive frames of translated patterns of pixel information, which are compared by autocorrelation to ascertain the direction and amount of movement. A hold feature suspends the production of movement signals to the computer, allowing the mouse to be physically relocated on the work surface without disturbing the position on the screen of the pointer. This may be needed if the operator runs out of room to physically move the mouse further, but the screen pointer still needs to go further. The hold feature may be implemented with an actual button, a separate proximity detector or by detecting the presence of a characteristic condition in the digitized data, such as loss of correlation or velocity in excess of a selected limit.

Abstract: Methods of wireless communication between a gaming console and a wireless accessory using a protocol. The protocol is used in a TDMA frequency hopping spread spectrum system to enable simultaneous communication of voice and data between a plurality of wireless accessories and the gaming console. The protocol provides specific time slots for upstream and downstream transmissions, as well as a retransmission time slots to enable a robust environment with minimal latency.

Abstract: Power data is obtained from a power meter that utilizes a rotatable element (e.g., a disk) by illuminating a spot on the rotatable element, capturing image information from the surface of the rotatable element, processing the image information to track movement of the rotatable element, and converting the movement information to digital power data. Movement of the rotatable element is tracked by capturing successive frames of image information and correlating common features in the image frames to determine the magnitude of movement of the common features.

Abstract: Systems and methods for associating a wireless device to a host. The wireless device is associated to the host via a binding and discovery process. The binding process establishes the association. A unique identifier and other binding information is provided to the wireless device, which is stored in the wireless device to establish the link to the console. The binding information is retained in the wireless device. The discovery process enables the wireless device to join a session at hosted by the host. The host sends broadcast packets that are compared to the stored information in the wireless device. The broadcast packets are validated and authenticated to complete the discovery process. A visual indicator on the host and/or controller may indicate the success or failure of either the binding or discovery process.

Abstract: A hand operated pointing device for use with a computer includes a movable housing, a source of non-coherent light illuminating a work surface and circuitry in the movable housing using arrays of data related to light reflected by the illuminated work surface to produce values by processing portions of a first array with portions of a second array. One of the values may be identified to represent movement of the housing relative to the work surface. The light may illuminate surface irregularities at an angle of incidence low enough to produce suitable arrays of data for processing from highlights and shadows of the illuminated surface irregularities. The circuitry may produce additional values by processing another selected portion of the first array with portions of a third array or may select a fourth array for processing with the third array. Predictions may be derived from the values. Signal may be sent to a computer related to movement of the housing.

Abstract: Compositions comprising a cancer drug, a continuous oral dosing schedule with a drug which binds to the colchicine site of tubulin ?-subunits, and methods of treating cancer in a pediatric patient using continuous dosing schedules are disclosed.

Abstract: A robotic camera dolly has a column and a base. The base is both driven and steered through the use of two drive wheels. The drive wheels are driven at equal peripheral velocities to move the dolly in a straight line, and at different peripheral velocities to steer the dolly. The base of the dolly rotates during steering. However, a maintaining mechanism maintains the pointing direction of a camera mount despite the rotation of the base. Optionally, the camera dolly additionally has a suspension that couples two caster wheels to its base in a manner that provides a greater compliance with respect to common motion of the caster wheels than with respect to differential motion of the caster wheels. The suspension gives the dolly the rigid stance of a suspension having four points of support, with the stability of a suspension having only three points of support.

Abstract: Compositions comprising one or more cancer drugs, continuous oral dosing schedule with drugs which bind to the colchicine site of tubulin ?-subunits, and methods of treating diseases using continuous dosing schedules are disclosed.

Abstract: The present invention provides an array hybridization apparatus including a gasket slide and an array slide. The array slide is adapted to be disposed closely adjacent the gasket slide to form a hybridization chamber for retaining an analyte solution in close proximity to an array. At least one of the gasket slide and the array slide has a disassembly feature which aids in disassembling the hybridization chamber. The invention also provides a method for disassembling an array hybridization chamber.

Abstract: Movement of an optical mouse may be tracked by providing a source of non-coherent light in a movable housing for illuminating a work surface at a low angle of incidence, providing a two dimensional array of photo detectors for producing arrays of data elements responsive to light reflected from surface irregularities on the illuminated work surface and providing circuitry for capturing a first array of data elements from the two dimensional array of photo detectors at a first time, for detecting a characteristic condition in the first array, for capturing a second array of data elements at a second time, and for tracking movement of the housing relative to the work surface by comparing at least some of the data elements of the first array with at least some of the data elements of the second array if the characteristic condition is not detected in the first array.

Abstract: Movement of a hand operated pointing device may be tracked by providing a source of non-coherent light in a movable housing for illuminating a work surface and providing circuitry for producing a plurality of two dimensional arrays of data related to light reflected by surface irregularities on the illuminated work surface and for processing a first array with a second array to track movement of the housing relative to the illuminated work surface. Circuitry may be provided for processing the first array with the second array to predict further movement of the housing relative to the illuminated work surface. Circuitry may be provided for selecting a different portion of the first array in accordance with the prediction for processing with a third array to track further movement of the housing. Circuitry may be provided for determining validity of the tracked movement and sending a signal to a computer related to the tracked movement unless the tracked movement is determined not to be valid.

Abstract: An apparatus for controlling the position of a screen pointer includes a movement sensor for sensing relative movement between the apparatus and a surface, and generating corresponding movement data. The movement sensor is configured to generate compressed data representing the movement data. The apparatus includes a wireless transmitter for wirelessly transmitting the compressed data.

Abstract: A game controller operates in a wireless mode and is previously bound to a game console. To reestablish a wireless communication connection between the game controller and game console, the game console transmits its unique console identification that the game controller compares to a previously stored console identifier. The game controller in turn sends its unique controller identifier to the game console which compares it to a previously stored controller identifier. An adaptive frequency hopping technique is used to eliminate bad channels in a predetermined frequency hopping sequence.

Abstract: A game controller and game host are bound to one another by exchanging unique identification numbers that are stored in respective memories of the game controller and host. The binding allows the game controller and game console to exclusively communicate wirelessly with one another.

Abstract: A remote control for the visually impaired provides improved control over televisions and other appliances. The remote control has an input module, which may be a keypad, for receiving user inputs. The remote control further has a wireless transmitter module for sending control signals to an appliance being controlled. The remote control further has a speech module for uttering speech signals indicative of the user input. In an optional learning mode, the remote control only utters commands as they are entered, and does not transmit the commands. In another optional mode, the remote control only transmits control signals, and does not utter the corresponding speech signals. By the remote control providing both training and also feedback, blind users become better able to operate their complicated appliances independently, with fewer mistakes, and with less intervention.

Abstract: An array hybridization apparatus and method. The apparatus employs a first substrate that contacts and attaches to an array slide, a second substrate that contacts and attaches to a gasket slide, and a separation means for separating the first substrate from the second substrate. Methods of disassembly of the apparatus are also disclosed.