Abstract: A hand operated pointing device for use with a computer includes a movable housing, a source of non-coherent light illuminating a work surface and circuitry in the movable housing using arrays of data related to light reflected by the illuminated work surface to produce values by processing portions of a first array with portions of a second array. One of the values may be identified to represent movement of the housing relative to the work surface. The light may illuminate surface irregularities at an angle of incidence low enough to produce suitable arrays of data for processing from highlights and shadows of the illuminated surface irregularities. The circuitry may produce additional values by processing another selected portion of the first array with portions of a third array or may select a fourth array for processing with the third array. Predictions may be derived from the values. Signal may be sent to a computer related to movement of the housing.

Abstract: The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of a matrix metalloproteinase inhibitor and an antineoplastic agent.

Abstract: A computer cursor control device includes (1) a light source generating light directed toward a stationary surface, (2) an optional phase modulator, (3) an optional function generator causing the phase modulator to periodically phase shift the light, and (4) a signal processor determining a direction in which the device is moving from a beat frequency or an asymmetry in the light intensity. Another computer cursor control device includes (1) an optical element combining reference and measurement beams to form a heterodyned beam, (2) a phase modulator located in an optical path of the reference beam or the measurement beam, (3) a function generator causing the phase modulator to phase shift the reference beam, and (4) a signal processor determining a direction in which the device is moving from a beat frequency of the heterodyned beam.

Abstract: A peripheral dongle for a console-based gaming system facilitates DVD movie playback. The dongle has a connector that plugs into a USB game port in the console. The dongle stores playback code that enables DVD movie playback. When connected to the game console, the dongle passes the playback code over the USB connection to the game console, where it is executed to adopt the gaming system for DVD playback. The dongle also has an IR (infrared) receiver to receive and decode commands entered via a remote control.

Abstract: An apparatus for controlling a position of a screen pointer for an electronic device having a display screen includes a touchpad including a touch-sensitive surface on which a pointing object may be placed. The touchpad is configured to generate position signals indicative of positions of the pointing object on the touch-sensitive surface. The apparatus includes a controller for generating a first set of movement data based on the position signals. The first set of movement data is indicative of motion of the pointing object across the touch-sensitive surface. The controller is configured to generate a second set of movement data when the pointing object is removed from the touch-sensitive surface, thereby leaving the touch-sensitive surface free from contact by a pointing object. The second set of movement data is indicative of motion of the pointing object across the touch-sensitive surface prior to removal of the pointing object.

Abstract: A peripheral dongle for a console-based gaming system facilitates DVD movie playback. The dongle has a connector that plugs into a USB game port in the console. The dongle stores playback code that enables DVD movie playback. When connected to the game console, the dongle passes the playback code over the USB connection to the game console, where it is executed to adopt the gaming system for DVD playback. The dongle also has an IR (infrared) receiver to receive and decode commands entered via a remote control.

Abstract: This invention relates to a mirror head (10) for an external vehicle mirror that comprises a load carrying structure (11) that is located within the mirror head, a connector (16) on the load carrying structure (11) that connects the mirror head (10) with respect to the vehicle, a shell (12, 13, 14) forming the external surface of the mirror head (10) within which at least a portion of the load carrying structure (11) locates, said connector (16) being positioned to enable connection with respect to the vehicle, and foam within the internal cavity of the shell (12, 13, 14), that acts to bond the load carrying structure (11) with respect to the shell components (12, 13, 14). This assembly provides a lighter mirror head (10) by comparison to conventional construction techniques while at the same time remaining rigid. It provides a means whereby loads can be transferred to the foam which are in turn transferred to the external shell components (12, 13, 14) of the mirror head (10).

Abstract: A hand-held input device provides a directional force feedback that acts on a housing of the device. The input device includes a threaded shaft that is rotatably driven by an electric motor. The motor causes a mass to move in response to a control signal received from a host computing device, such as personal computer that is executing a game or simulation. When the mass is rapidly accelerated or abruptly stopped in response to the control signal, the change in momentum of the mass imparts a directional reactive force to the housing, and an operator holding the housing feels the haptic force.

Abstract: Compositions comprising one or more cancer drugs, continuous oral dosing schedule with drugs which bind to the colchicine site of tubulin ?-subunits, and methods of treating diseases using continuous dosing schedules are disclosed.

Abstract: The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of a matrix metalloproteinase inhibitor and an antineoplastic agent.

Abstract: A minor parking mechanism for an exterior rear view mirror that rotates a mirror head to a parked position. The mechanism has a mirror mounting bracket, a mirror head pivotally connected to the mirror mounting bracket so the mirror head can rotate from a deployed position to a parked position. A detent acting between the mirror mounting bracket and the mirror head to lock and unlock the mirror head. A spring acts against and locks the detent in position. A worm drive in the mirror head moves longitudinally along a shaft and rotates about an axis to act against the spring, which in turn reduces the spring force applied to the detent to enable it to disengage whereupon continued rotation of the worm drive causes the mirror head to rotate.

Abstract: A method of using an MMP inhibitor and optionally radiation therapy, and one or more antineoplastic agents of the topoisomerase class selected from the group consisting of irinotecan and topotecan, as a combination therapy for the treatment of neoplasia is disclosed.

Abstract: The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of a cyclooxygenase-2 inhibitor and an antineoplastic agent.

Abstract: An electronic device able to detect a user in close proximity. The device may be a wireless data input device, for example, a radio frequency computer mouse. The device has power management features that do not require complex hardware or software to implement. For example, an antenna that is normally used for radio transmission is monitored. The power management features of the electronic device are able to detect a change in an operating characteristic of the antenna that is indicative of a user in close proximity thereto. For example, when the user touches a computer mouse, the resonant frequency of a circuit comprising the antenna changes due to capacitive loading of the antenna. The power management features cause the electronic device to be operated in a sleep mode or a radio transmission mode, depending on whether the user is detected.

Abstract: A hand-held input device provides a directional force feedback that acts on a housing of the device. The input device includes a threaded shaft that is rotatably driven by an electric motor. The motor causes a mass to move in response to a control signal received from a host computing device, such as personal computer that is executing a game or simulation. When the mass is rapidly accelerated or abruptly stopped in response to the control signal, the change in momentum of the mass imparts a directional reactive force to the housing, and an operator holding the housing feels the haptic force.

Abstract: The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of an integrin antagonist and an antineoplastic agent.

Abstract: The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of an integrin antagonist and an antineoplastic agent.

Abstract: Light emission methods and light emission devices are described including method and devices capable of emitting light at a plurality of controllable wavelengths. According to one aspect, a light emission method includes providing a control signal and emitting light using a laser operating in a plurality of polarization states. The polarization state of the laser is adjusted responsive to the control signal and the wavelength of the light emitted using the laser is adjusted responsive to the adjustment of the polarization state of the laser.

Abstract: A signaling device for disabled persons uses a pneumatic system comprised of a special cushion, an air bleed to ambient, and a sensitive air-pressure sensor. The cushion may also serve as a head, limb, or body support. The cushion is foam-filled and self-inflating, and is capable of supporting static loads without the need for its being pressurized. A user initiates the generation of a signal by bumping the cushion, as for example with a backwards jerk of their head or a sideways kick of a limb. The resulting momentary surge in system pressure is sensed by the air-pressure switch, which is set to trip at 1/1000 of an atmosphere. The momentary closing of the contacts of the pressure switch are used to signal other assistive appliances, such as computer software for generating text.

Abstract: This invention is a pivot assembly 10 that connects mirror head 11 and a mirror mounting bracket 12 of a rear vision mirror that comprises a spigot 17, a plate 14 with an aperture 26 that is journalled to the spigot 17. A detent is located between the plate 14 and the spigot 17 which holds these components together to in turn hold the mirror head 11 in at least one required position with respect to the mirror mounting bracket 12. The detent changes from a locked position where the plate 14 is held with respect to the spigot 17 to a disengaged position when the plate 14 is rotated with respect to the spigot 17. A spring 40 acts against the detent to hold it in its locked position. The spring 40 yields to allow the detent to move to its disengaged position as the plate 14 is rotated with respect to the spigot 17. An attachment mechanism is provided both on the spigot 17 and the plate 14 that allows the spigot 17 to be secured to either one of the mirror head 11 or mirror mounting bracket 12.