Abstract: Methods for the treatment of psychotic or intellectual impairment disorders with compounds of formula I, wherein A, R and R1 are as defined in the specification.

Abstract: A compound of formula I, wherein NRR1 is attached at the 5- or 6-position of the furopyridine ring; R is hydrogen, C1–C4 alkyl, or COR2; R1 is (CH2)nAr, CH2CH?CHAr, or CH2C?CAr; n is 0 to 3; A is N or NO; Ar is a 5- or 6-membered aromatic or heteroaromatic ring which contains zero to four nitrogen atoms, zero to one oxygen atoms, and zero to one sulfur atoms; or an 8-, 9- or 10-membered fused aromatic or heteroaromatic ring system containing zero to four nitrogen atoms, zero to one oxygen atoms, and zero to one sulfur, any of which may optionally be substituted with one to two substitutents independently selected from: halogen, trifluoromethyl, or C1–C4 alkyl; R2 is hydrogen, C1–C4 alkyl, C1–C4 alkoxy or phenyl ring optionally substituted with one to three of the following substituents: halogen, C1–C4 alkyl, C2–C4 alkenyl, C2–C4 alkynyl, OH; OC1–C4 alkyl, CO2R5, —CN, —NO2, —NR3R4, or —CF3; R3, R4 and R5 may be hydrogen, C1–C4 alkyl, or phenyl ring optionally substituted with one to three of the following

Abstract: .alpha.-Substituted ketonitrone derivatives containing substituents selected from hydrogen, phenyl, substituted phenyl, naphthyl, furan, thiophen, imidazolylmethyl and triazolylmethyl are useful as intermediates for the preparation of biologically active isoxazolidine compounds.

Abstract: This invention pertains generally to substituted 2-methylisoxazolines and more specifically to 3,5-diphenyl-3-[(1H-imidazol-1-ylmethyl) or (1H-1,2,4-triazol-1-yl-methyl)]-2-methyl-4-isoxazoline derivatives which are useful as antifungal agents.

Abstract: 5-alkyl(or alkenyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl) -2- methylisoxazolidines and related derivatives in which hydrogens of their phenyl rings can be replaced by halogen, lower alkyl or lower alkoxy groups are useful as antifugal agents.

Abstract: .alpha.-Substituted ketonitrone derivatives containing substitutents selected from hydrogen, phenyl, substituted phenyl, naphythyl, furan, thiopen, imidazolylmethyl and triazolylmethyl are useful as intermediates for the preparation of biologically active isoxazolidine compounds.

Abstract: 5,5-Disubstituted-3-phenyl-3-[(1H-imidazol-1-ylmethyl) or (1H-1,2,4-triazol-1-ylmethyl)]-2-methylisoxazolidine derivatives are useful as antifungal agents.

Abstract: 5-Substituted-3-(2-naphthalenyl)-3-[(1H-imidazol-1-ylmethyl or (1H-1,2,4-triazol-1-ylmethyl)]-2-methylisoxazolidines are useful as antifungal agents.

Abstract: 5-(Substituted thiomethyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine derivatives are useful as antifungal agents.

Abstract: 5-Carbonyl derivatives of 3-phenyl-3-(1-H-imidazol-1-ylmethyl)-2-methylisoxazolidines and related compounds are useful as antifungal agents.

Abstract: 5-(phenyl or phenoxymethyl)-3-(2-furanyl)-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolid ine and related derivatives in which one or more hydrogens on the phenyl ring are replaced by halogen, lower alkyl, lower alkoxy, nitro and combinations thereof are useful as antifungal agents.

Abstract: Substituted 3,5-diphenyl-3-[(1H-1,2,4-triazol-1-yl) methyl]-2-methylisoxazolidines in which hydrogens of their phenyl rings may be replaced by halogen, lower alkoxy, lower alkyl or nitro groups are useful as antifungal agents.

Abstract: 5-(Phenyl or phenoxymethyl)-3-(2-thienyl)-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolid ines and related derivatives in which one or more hydrogens on the 5-phenyl or phenoxy rings are replaced by halogen, lower alkyl, lower alkoxy, nitro and combinations thereof are useful as antifungal agents.

Abstract: Alkyl and aryl ester compounds, 5-(acyloxyalkyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine s in which hydrogens of their phenyl rings may be replaced by halogen, lower alkyl, lower alkoxy or nitro groups are useful as antifungal agents.

Abstract: 3-Phenyl-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-[(phenylamino)methyl]isoxazo lidine and related derivatives in which hydrogens of their phenyl rings may be replaced by one or more halogen, lower alkoxy, lower alkyl and nitro groups are useful as antifungal agents.

Abstract: 3-Phenyl-3-(1H-1,2,4-triazol-1-methyl)-2-methyl-5-alkylisoxazolidines and related derivatives in which hydrogens in the phenyl ring are replaced by halogen, lower alkyl or lower alkoxy groups are useful as antifungal agents.

Abstract: 5-(Hydroxy or alkoxyalkyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines and related derivatives in which hydrogens of the phenyl ring are replaced by halogen, lower alkyl or lower alkoxy groups are useful as antifungal agents.

Abstract: 5-{[Naphthyl(or 2-oxo-1,3-benzoxathiol-6-yl)oxy]methyl}-3-phenyl-3-(1H-imidazol-1-ylmethyl )-2-methylisoxazolidines are useful as antifungal agents.

Abstract: 5-Substituted-3-phenyl-3-[1H-imidazol-1-ylmethyl) or (1H-1,2,4-triazol-1-ylmethyl)]-2-benzylisoxazolidines are useful as antifungal agents.

Abstract: Substituted .alpha.-[2'-tricyclo[3.3.1.1.sup.3,7 ]decylidene]benzeneacetonitrile derivatives having antihypoxia and anti-inflammatory activities of the formula: ##STR1## where the R.sup.1, R.sup.2 and R.sup.3 substituents are independently selected from hydrogen, lower alkyl, lower alkoxy, halogen and trifluoromethane, provided that at least one of such substituents is hydrogen.