Patents by Inventor George B Mullen

George B Mullen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted alpha-(2-tricyclo(3.3.1.13,7)-decylidene)benzeneacetamide derivatives
    Patent number: 4745220
    Abstract: Substituted .alpha.-[2'-tricyclo[3.3.1.1.sup.3,7 ]decylidene]-benzenacetamide derivatives of the formula: ##STR1## where the R.sup.1, R.sup.2 and R.sup.3 substitutents are independently selected from hydrogen, lower alkyl, lower alkoxy, halogen and trifluoromethyl, provided that at least one of such substitutents is hydrogen, have antihypoxia, antiparkinson, and/or anticonvulsant activities.
    Type: Grant
    Filed: May 27, 1986
    Date of Patent: May 17, 1988
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen
  • Adamantane spiro-pyrrolidine derivatives
    Patent number: 4739074
    Abstract: Adamantane spiro-pyrrolidine derivatives, more specifically, spiro[pyrrolidine-5,2'-tricyclo[3.3.1.1.sup.3,7 ]decane]derivatives of the structure ##STR1## where X is oxygen or two hydrogen radicals and R is hydrogen or ##STR2## where R.sup.1 is a C.sub.1 -C.sub.18 alkyl radical, phenyl or phenylcyclopropyl, are disclosed herein. Said derivatives have been found to have activity in laboratory animal models against carrageenan-induced edema.
    Type: Grant
    Filed: January 22, 1986
    Date of Patent: April 19, 1988
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen
  • 3-(3-halophenyl-3,4-diazatetracyclo-[6.3.1.1.sup.6,10.0.sup.1,5 ]tridec-4-en-2-one compounds and use thereof to treat hypoxia
    Patent number: 4732909
    Abstract: 3-(3-Halophenyl)-3,4-diazatetracyclo-[6.3.1.1.sup.6,10.0.sup.1,5 ]tridec-4-en-2-ones are useful as anti-hypoxia agents.
    Type: Grant
    Filed: June 10, 1987
    Date of Patent: March 22, 1988
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen, Patricia A. Swift
  • 3-(Substituted phenyl)-3-(1H-1,2,4-triazol-1-yl)methyl-2-methyl-5-[(substituted phenoxy)methyl]isoxazolidine derivatives
    Patent number: 4727157
    Abstract: 3-(substituted phenyl)-3-(1H-1,2,4-triazol-1-yl)methyl-2-methyl-5-[(substituted phenoxy)methyl]isoxazolidine derivatives in which hydrogens of their phenyl rings may be replaced by halogen, lower alkyl, lower alkoxy, alkoxycarbonyl, alkanoylamino or nitro groups are useful as antifungal agents.
    Type: Grant
    Filed: August 27, 1986
    Date of Patent: February 23, 1988
    Assignee: Pennwalt Corporation
    Inventors: Vassil St. Georgiev, George B. Mullen
  • 3-(Substituted phenyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-{[(substituted phenyl)thio]me}isoxazolidine derivatives
    Patent number: 4727156
    Abstract: 3-(Substituting phenyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-{[(substituted phenyl)thio]m ethyl}isoxazolidines in which hydrogens of their phenyl rings may be replaced by halogen, lower alkoxy, lower alkyl or nitro groups, and the sulfur atom may be oxidized, are useful as antifungal agents.
    Type: Grant
    Filed: August 27, 1986
    Date of Patent: February 23, 1988
    Assignee: Pennwalt Corporation
    Inventors: Vassil St. Georgiev, George B. Mullen
  • Substituted 5-(phenoxyalkyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidi nes
    Patent number: 4723021
    Abstract: Substituted 5-(phenoxyalkyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine s, in which hydrogens of their benzene rings may be replaced by halogen, lower alkoxy, lower alkyl, nitro, acetamido and/or trifluoromethyl groups, are useful as antifungal agents.
    Type: Grant
    Filed: August 27, 1986
    Date of Patent: February 2, 1988
    Assignee: Pennwalt Corporation
    Inventors: Vassil St. Georgiev, George B. Mullen
  • Substituted 3,5-diphenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines
    Patent number: 4719306
    Abstract: Substituted 3,5-diphenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines in which hydrogens of their phenyl rings may be replaced by halogen, lower alkoxy or lower alkyl groups are useful as antifungal agents.
    Type: Grant
    Filed: August 27, 1986
    Date of Patent: January 12, 1988
    Assignee: Pennwalt Corporation
    Inventors: Vassil St. Georgiev, George B. Mullen
  • Substituted .alpha.-[2'-tricyclo[3.3.1.1.sup.3,7 ]decylidene]-benzeneacetic acid derivatives
    Patent number: 4705891
    Abstract: Substituted .alpha.-[2'-tricyclo[3.3.1.1.sup.3,7 ]decylidene]-benzeneacetic acid derivatives of the formula: ##STR1## where the R.sup.1, R.sup.2 and R.sup.3 substituents are independently selected from hydrogen, lower alkyl, lower alkoxy, halogen and trifluoromethane, provided that at least one of such substituents is hydrogen have antihypoxia, anticonvulsant and/or antiparkinson activities.
    Type: Grant
    Filed: May 27, 1986
    Date of Patent: November 10, 1987
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen
  • Adamantane-spirolactams
    Patent number: 4692515
    Abstract: Biologically active substituted spiro[azetidin-2-one-4,2'(or 3,2')adamantanes] of the formula ##STR1## where R is hydrogen, --SO.sub.2 Cl, or alkyl, and one of R.sup.1 and R.sup.2 is an adamantyl group which shares a ring carbon with the lactam group and the other is alkyl, substituted alkyl, phenyl, or substituted phenyl, are disclosed herein.
    Type: Grant
    Filed: June 16, 1986
    Date of Patent: September 8, 1987
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen
  • Adamantyl phenyl .beta.-alanines
    Patent number: 4691051
    Abstract: Adamantyl phenyl .beta.-alanines having the structure: ##STR1## wherein R is phenyl or substituted phenyl and one of R.sup.1 and R.sup.2 is NH.sub.2 and the other is CO.sub.2 H, are disclosed herein.
    Type: Grant
    Filed: June 4, 1986
    Date of Patent: September 1, 1987
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen
  • Spiro[isoxazalidine-3,2'-tricyclo[3.3.1.1.sup.3,7 ] decanes]
    Patent number: 4683311
    Abstract: The compounds are of the class of adamantanyl isoxazolidine derivatives useful as anti-inflammatory, antihypoxia, antimicrobial and anticonvulsant agents. Exempliary of a species of the compounds is 2 methyl-5-n-hexyl-spiro[isoxazolidin-3,2'-tricyclo[3.3.1.1.sup.3,7 ] decane].
    Type: Grant
    Filed: January 22, 1986
    Date of Patent: July 28, 1987
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen
  • 2-(substituted amino)-2-[2-hydroxy-2-alkyl (or phenyl)ethyl]tricyclo[3.3.1.1.sup.3,7 ]decane hydrohalides
    Patent number: 4649222
    Abstract: 2-(Substituted amino)-2-[2-hydroxy-2-alkyl (or phenyl)ethyl]tricyclo[3.3.1.1.sup.3,7 ]decane hydrohalides are described such as 2-(2-hydroxyoctyl)-2-(methylamino)-tricyclo[3.3.1.1.sup.3,7 ]decane hydrochloride. The compounds possess anti-inflammatory, analgesic, anticonvulsant and/or anti-hypoxia activity.
    Type: Grant
    Filed: January 22, 1986
    Date of Patent: March 10, 1987
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen, Patricia A. Swift
  • 1,4-oxazinone derivatives
    Patent number: 4631340
    Abstract: 1,4-oxazinone derivatives of the structure: ##STR1## wherein one of R and R.sup.1 is hydrogen and the other is --CH.sub.2 CO.sub.2 R.sup.6 (R.sup.6 .dbd.alkyl) or R and R.sup.1 together represent the group .dbd.CHCO.sub.2 R.sup.6, R.sup.2 and R.sup.3 are hydrogen, alkyl, substituted alkyl, phenyl or substituted phenyl or R.sup.2 and R.sup.3 together represent a single adamantyl group, and R.sup.4 and R.sup.5 are hydrogen, alkyl, substituted alkyl, phenyl, substituted phenyl, or benzyl, are disclosed herein.
    Type: Grant
    Filed: October 18, 1985
    Date of Patent: December 23, 1986
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen
  • Adamantyl containing 1,4-oxazinone derivatives
    Patent number: 4549014
    Abstract: Antimicrobial or anti-inflammatory 1,4-oxazinone derivatives of the structure: ##STR1## wherein one of R and R.sup.1 is hydrogen and the other is --CH.sub.2 CO.sub.2 R.sup.6 (R.sup.6 =alkyl) or R and R.sup.1 together represent the group .dbd.CHCO.sub.2 R.sup.6, R.sup.2 and R.sup.3 are hydrogen, alkyl, substituted alkyl, phenyl or substituted phenyl or R.sup.2 and R.sup.3 together represent a single adamantyl group, and R.sup.4 and R.sup.5 are hydrogen, alkyl, substituted alkyl, phenyl, substituted phenyl, or benzyl, are disclosed herein.
    Type: Grant
    Filed: September 6, 1984
    Date of Patent: October 22, 1985
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen