Patents by Inventor Gordon B. Mills

Gordon B. Mills has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Caspase inhibitors and the use thereof
    Publication number: 20020058631
    Abstract: The present invention is directed to novel dipeptide thereof, represented by the general Formula I: 1
    Type: Application
    Filed: November 14, 2001
    Publication date: May 16, 2002
    Applicant: Cytovia, Inc.
    Inventors: Sui Xiong Cai, Eckard Weber, Yan Wang, Gordon B. Mills, Douglas R. Green
  • Caspase inhibitors and the use thereof
    Patent number: 6355618
    Abstract: The present invention is directed to novel dipeptide thereof, represented by the general Formula I: where R1-R3, X and Y are defined herein. The present invention also relates to the discovery that compounds having Formula I are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: March 12, 2002
    Assignee: Cytovia, Inc.
    Inventors: Sui Xiong Cai, Eckard Weber, Yan Wang, Gordon B. Mills, Douglas R. Green
  • Method of detecting gynecological carcinomas
    Patent number: 5994141
    Abstract: Methods for diagnosing and screening for ovarian carcinomas in a subject are provided The methods employ the steps of preparing a plasma sample from a blood specimen from the subject, and assaying for the presence of lysophosphatidic acid in the plasma sample. The presence of lysophosphatidic acid in the plasma sample is indicative of ovarian carcinoma in the subject. In a preferred embodiment the plasma sample is prepared under conditions which minimize the release of lysophosphatidic acid from platelets in the blood specimen into the plasma.
    Type: Grant
    Filed: August 25, 1998
    Date of Patent: November 30, 1999
    Assignee: The Cleveland Clinic Foundation
    Inventors: Yan Xu, Graham Casey, Douglas C. Gaudette, Bruce J. Holub, Gordon B. Mills