Abstract: A screen, for a vibrating screen device, has a frame and a screen surface. The frame has a periphery and a middle portion wherein the periphery is constructed of elongate material portions. The middle portion has middle supports including tubing having a cross-section of an ovular shape.

Abstract: A shipping strap assembly protects the isolator mechanism of a vibratory screening machine against exceeding its elastic limits. The isolator mechanism is pivotally connected between shafts on the machine frame and the machine basket. The protective assembly includes a distally narrowing boss on at least one of the shafts. A rigid strap has two apertures, one contoured to receive and ride on the boss and the other contoured to receive the other shaft, spaced to maintain the distance between the shaft axes within an elastic limit of the isolator mechanism. The narrowing boss provides leeway for easy manual alignment of the mechanism shafts with the strap apertures, and the narrowing boss and contour of the other aperture facilitate restoration toward its normal load length, of an elastically distorted mechanism.

Abstract: A pan for use in a shaker can have a first end and a second end with a length there between. The pan can have a bottom with a width, narrowing side portions, an upper opening, and upper sides separated by an upper transverse width. The upper transverse width can be wider than the width of the bottom and the narrowing side portions can connecting the upper sides to the bottom. The bottom can have a downward slant along the length between the first end and the second end.

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

Abstract: The present disclosure relates to an in vitro method for enhancing engraftment of isolated pancreatic cells comprising the step of contacting an isolated pancreatic cell prior to a transplantation in a subject in need thereof, with a gem-difluorinated C-glycopeptide compound of general formula I, or a pharmaceutically acceptable base, addition salt with an acid, hydrate or solvate of the compound of general formula I:

Abstract: The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

Abstract: The present disclosure provides novel macrocyclic compounds which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

Abstract: A shipping strap assembly protects the isolator mechanism of a vibratory screening machine against exceeding its elastic limits. The isolator mechanism is pivotally connected between shafts on the machine frame and the machine basket. The protective assembly includes a distally narrowing boss on at least one of the shafts. A rigid strap has two apertures, one contoured to receive and ride on the boss and the other contoured to receive the other shaft, spaced to maintain the distance between the shaft axes within an elastic limit of the isolator mechanism. The narrowing boss provides leeway for easy manual alignment of the mechanism shafts with the strap apertures, and the narrowing boss and contour of the other aperture facilitate restoration toward its normal load length, of an elastically distorted mechanism.

Abstract: The present invention provides (R)-5-(3-((2-(1,2,4-oxadiazol-3-yl)propan-2-yl)carbamoyl)phenyl)-6-(sec-butyl)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide (formula I), including pharmaceutically acceptable salts, as well as compositions and methods of using the compound. The compound has activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract: A shipping strap assembly protects the isolator mechanism of a vibratory screening machine against exceeding its elastic limits. The isolator mechanism is pivotally connected between shafts on the machine frame and the machine basket. The protective assembly includes a distally narrowing boss on at least one of the shafts. A rigid strap has two apertures, one contoured to receive and ride on the boss and the other contoured to receive the other shaft, spaced to maintain the distance between the shaft axes within an elastic limit of the isolator mechanism. The narrowing boss provides leeway for easy manual alignment of the mechanism shafts with the strap apertures, and the narrowing boss and contour of the other aperture facilitate restoration toward its normal load length, of an elastically distorted mechanism.

Abstract: The present invention provides (R)-5-(3-((2-(1,2,4-oxadiazol-3-yl)propan-2-yl)carbamoyl)phenyl)-6-(sec-butyl)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide (formula I), including pharmaceutically acceptable salts, as well as compositions and methods of using the compound. The compound has activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract: A process of separating a fluid and mill scale particles from mill slag can include: 1) Putting the mill slag onto a vibrating screen device which has a plurality of screen assemblies in a sequential configuration. Each screen assembly comprises a screen having a perforated center portion with elliptically shaped perforations with a span of no greater than 0.175 inches. 2) Vibrating each screen assembly to expedite separation of the mill scale particles and the fluid from the mill slag on each screen such that the fluid separated from the mill slag on each screen passes through the perforations and the mill scale particles convey along the screen. 3) Conveying the mill scale particles from a screen assembly that is sequentially before to a screen assembly that is sequentially after for further separating the fluid from the mill scale particles.

Abstract: The present disclosure relates to an in vitro method for enhancing engraftment of isolated pancreatic cells comprising the step of contacting an isolated pancreatic cell prior to a transplantation in a subject in need thereof, with a gem-difluorinated C-glycopeptide compound of general formula I, or a pharmaceutically acceptable base, addition salt with an acid, hydrate or solvate of the compound of general formula I:

Abstract: A shaker has a side frame member disposed on the side of the shaker and a seal disposed about the side frame member. The side frame member has a top, a side, and a bottom. The seal conforms to the shape and dimensions of the side frame member and is constructed and arranged to substantially cover the side frame member.

Abstract: A seal can have a middle portion, an upper lip, and a lower lip. The upper lip has a configuration with an upper end portion, an upper top portion, and an upper bottom portion with a void space defined in part by the upper end portion, the upper top portion, and the upper bottom portion. The lower lip can have a configuration with a lower end portion, a lower top portion, and a lower bottom portion with a void space defined in part by the lower end portion, the lower top portion, and the lower bottom portion. A middle portion connects the upper lip and the lower lip.

Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract: The disclosure provides compounds of formula I, II, III, IV, and V, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.