Abstract: The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.

Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Abstract: An automatic caching system is described herein that automatically determines user-relevant points at which to incrementally cache expensive to obtain data, resulting in faster computation of dependent results. The system can intelligently choose between caching data locally and pushing computation to a remote location collocated with the data, resulting in faster computation of results. The automatic caching system uses stable keys to uniquely refer to programmatic identifiers. The system annotates programs before execution with additional code that utilizes the keys to associate and cache intermediate programmatic results. The system can maintain the cache in a separate process or even on a separate machine to allow cached results to outlive program execution and allow subsequent execution to utilize previously computed results. Cost estimations are performed in order to choose whether utilizing cached values or remote execution would result in a faster computation of a result.

Abstract: A dynamic, lazy type system is provided for a dynamic, lazy programming language. Consequently, programs can benefit from runtime flexibility and lightweight notation in combination with benefits afforded by a substantial type system.

Abstract: The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.

Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Abstract: A tube assembly for use in a heat exchanger is made by arranging a first corrugated fin structure between one broad, flat side of a tube and a side sheet, and arranging a second corrugated fin between another broad and flat side of a tube and another side sheet. Compressive forces are applied to the opposite faces of the side sheets to place crests and troughs of the corrugated fin structures into contact with the side sheets and the broad, flat sides, and the assembly is brazed.

Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Abstract: A technique for enabling a plurality of software components to communicate in a software component matrix environment is disclosed. In one particular exemplary embodiment, the technique may be realized by a method for enabling a plurality of software components to communicate in a software component matrix environment comprising the steps of encoding a request at a client side; communicating the request to a server at a server side via a communication interface; comparing the request to a plurality of operations supported at the server side; determining whether a function match exists at the server side; and returning a response comprising the function match to the client side in response to the request via the communication interface wherein the response is mapped to a data model of a client.

Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Abstract: A dynamic, lazy type system is provided for a dynamic, lazy programming language. Consequently, programs can benefit from runtime flexibility and lightweight notation in combination with benefits afforded by a substantial type system.

Abstract: The present invention relates to a process for preparing aminocyclohexyl ether compounds of Formula I: or the pharmaceutically acceptable salts and esters thereof. In particular, the instant invention is directed towards a process for preparing (1R,2R)-2-[(3R)-Hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)-cyclohexane as well as various intermediates.

Abstract: A dynamic, lazy type system is provided for a dynamic, lazy programming language. Consequently, programs can benefit from runtime flexibility and lightweight notation in combination with benefits afforded by a substantial type system.

Abstract: Various technologies pertaining to construction of a query for execution over a cube are described. Tabular data is presented on a displayed on a display screen, where the tabular data represents at least a portion of a data cube. Input is received with respect to the tabular data, and responsive to the input being received, a query is constructed based upon the input. The query is executed over the data cube, resulting in provisioning of a new table.

Abstract: The present invention relates to a process for preparing aminocyclohexyl ether compounds of Formula I: or the pharmaceutically acceptable salts and esters thereof. In particular, the instant invention is directed towards a process for preparing (1R,2R)-2-[(3R)-Hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)-cyclohexane as well as various intermediates.

Abstract: The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.

Abstract: The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.

Abstract: The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.

Abstract: A technique for enabling a plurality of software components to communicate in a software component matrix environment is disclosed. In one particular exemplary embodiment, the technique may be realized by a method for enabling a plurality of software components to communicate in a software component matrix environment comprising the steps of encoding a request at a client side; communicating the request to a server at a server side via a communication interface; comparing the request to a plurality of operations supported at the server side; determining whether a function match exists at the server side; and returning a response comprising the function match to the client side in response to the request via the communication interface wherein the response is mapped to a data model of a client.