Abstract: Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the disclosed compounds or compositions for treating and/or preventing diseases (e.g., inflammatory diseases, neurological diseases (e.g., Alzheimer's disease), infectious diseases (e.g., viral infections (e.g., infections caused by viral human hepatitis (e.g., hepatitis B), a flaviviridae family virus (e.g., a flavivims (e.g., Zika virus)))), and proliferative diseases (e.g., cancer (e.g., lung cancer, prostate cancer, skin cancer, thyroid cancer, pancreatic cancer, colorectal cancer, liver cancer, leukemia, or lymphoma)) in a subject. Provided are methods of inhibiting a protein kinase (e.g., MAP2K (e.g., MKK7)) in a subject. Also provided are methods of inhibiting MKK7 in a subject in need thereof.

Abstract: An image sensor array and circuit design and method employing a voltage and current detection circuit capable of quantifying a power signal, grounding signal, internal reference voltage and internal reference current. An image sensor comprising the invented circuit design may be incorporated within a digital camera.

Abstract: A portable blowing device configured for being worn around a neck of a human body, includes two arms each defining an airflow channel therein; and fans received in the arms respectively. The arm includes an inner side wall close to the neck and an outer side wall connected to the inner side wall. The arm includes an air inlet and an air outlet in communication with the airflow channel respectively. The air inlet is arranged at the inner side wall and/or the outer side wall. The fan is configured to generate an airflow passing through the air inlet, the airflow channel and the air outlet in sequence.

Abstract: A pixel array, an image sensor, and a self-checking method of the image sensor are provided. The pixel array includes a photosensitive pixel region, a first reference pixel region and/or a second reference pixel region; the photosensitive pixel region includes M rows and N columns of pixels arranged in an array; the first reference pixel region includes n columns of first reference pixels disposed corresponding to N columns of pixels of the photosensitive pixel region; the second reference pixel region includes m rows of the second reference pixels disposed corresponding to the M rows of pixels of the photosensitive pixel region. The first reference pixel region and/or the second reference pixel region can be used to implement a real-time self-checking function of the readout circuit and/or the control circuit in the image sensor, check in real time whether the image signal output by the image sensor is correct.

Abstract: Systems and methods for the automated fulfillment of orders from a fulfillment network including consumer-facing retail locations. Orders are partitioned into suborders, which are in turn assigned to retail locations based on forecasted demand for the suborder items at the retail locations. The assignment process considers operational data for each retail location such as the number of employees, the inventory of suborder items, shipping rate cards, return policies, business hours, pick decline estimations, etc.

Abstract: The present application provides a pixel driving circuit and a liquid crystal display panel. The pixel driving circuit comprises a main pixel electrode driving module, a sub-pixel electrode driving module, a first potential regulation module, and a second potential regulation module.

Abstract: The present disclosure provides a testkey structure and a monitoring method with a testkey structure, and the testkey structure includes a first diffusion region and a second diffusion region, a first gate and a second gate, a first epitaxial layer and a second epitaxial layer, and an input pad and an output pad. The first diffusion region and the second diffusion region are disposed in a substrate. The first gate and the second gate are disposed on a substrate, across the first diffusion region and the second diffusion region respectively. The first epitaxial layer and the second epitaxial layer are respectively disposed on the second diffusion region and the first diffusion region, separately disposed between the first gate and the second gate. The input pad and the output pad are electrically connected to the first epitaxial layer and the second epitaxial layer respectively.

Abstract: An ultrasound image tracking completeness system includes an ultrasound imaging probe that acquires images during an examination, an imaging probe sensor coupled to the ultrasound imaging probe and that tracks a position and an orientation of the ultrasound imaging probe, and a display to display images acquired by the ultrasound imaging probe. The system also includes a processor programmed to calculate a probe speed threshold at which the ultrasound imaging probe may be moved while acquiring images during the examination, track the position and orientation of the ultrasound imaging probe during the examination by monitoring the imaging probe sensor, determine a movement speed of the ultrasound imaging probe during the examination, and if the movement speed of the ultrasound imaging probe exceeds the probe speed threshold, issue a warning to an operator.

Abstract: A computing system is described that obtains, based at least in part on information included in at least one previous communication associated with a user of a computing device, an indication of a future location and a future time and event information associated with the future location and the future time . The computing system obtains a duration of time for the user to travel from a current location of the computing device to the future location, and, based at least in part on the duration of time, obtains a departure time at which the user is predicted to need to depart from the current location in order to arrive at the future location by an arrival time based on the event. The computing system outputs, for transmission to the computing device, an indication associated with the event and including information indicative of the departure time.

Abstract: An electronic circuit breaker is configured to provide a fail-safe mode. It comprises an overvoltage protection device, a sensing and control circuit configured to open an air gap and a differential current transformer disposed directly on a current path of the overvoltage protection device to monitor a leakage current and detect the leakage current of the overvoltage protection device and hence leave the circuit breaker in a safe mode before component failure. The differential current transformer to see a net current of IM, and trigger the sensing and control circuit to open the air gap and leave the circuit breaker in a trip position in some circuit breakers.

Abstract: A method for fabricating a semiconductor device is disclosed. A substrate having thereon at least one metal-oxide-semiconductor (MOS) transistor is provided. A stress memorization technique (SMT) process is performed. The SMT process includes steps of depositing an SMT film covering the at least one MOS transistor on the substrate, and subjecting the SMT film to a thermal process. A lithographic process and an etching process are performed to form a patterned SMT film. A silicide layer is formed on the MOS transistor. The patterned SMT film acts as a salicide block layer when forming the silicide layer.

Abstract: The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The provided compounds may be kinase (e.g., HCK, BTK, LYN) inhibitors. Also provided are pharmaceutical compositions and kits including the provided compounds. Further provided are methods of using the provided compounds, pharmaceutical compositions, and kits (e.g., for treating diseases (e.g., proliferative diseases) in a subject in need thereof).

Abstract: A solid-state circuit breaker (SSCB) comprises a breaker housing, line-in and line-out terminals and one or more solid state switching components. The SSCB further comprises an air gap disposed between the line-in and line-out terminals and coupled in series with the solid-state switching components to complete a current conducting path when closed. The air gap includes an air gap driving mechanism. The solid-state circuit breaker further comprises an air gap actuator to interact with the air gap driving mechanism. The SSCB further comprises a controller that controls the air gap actuator and is configured to: (a). send a tripping signal to the air gap actuator and the one or more solid state switching components at substantially the same time or (b). send a tripping signal to the air gap actuator a short amount of time earlier than sending the tripping signal to the one or more solid state switching components.

Abstract: Systems and methods for the automated fulfillment of orders from a fulfillment network including consumer-facing retail locations. Orders are partitioned into suborders, which are in turn assigned to retail locations based on forecasted demand for the suborder items at the retail locations. The assignment process considers operational data for each retail location such as the number of employees, the inventory of suborder items, shipping rate cards, return policies, business hours, pick decline estimations, etc.

Abstract: The present invention discloses a metamaterial-based variable capacitor structure, comprising the first substrate, the second substrate, the metamaterial dielectric layer, the metal floor layer between the first substrate and the metamaterial dielectric layer, the gaps and isolation holes periodically arranged on metal floor layer, the microstrip line between the second substrate and the metamaterial dielectric layer, the periodically loaded branches, the bias line and the choke branch on the microstrip line, and two feeding terminals on both ends of microstrip line. The capacitance value of the metamaterial-based capacitor with variable dielectric constant is adjusted by controlling the voltage applied to the said bias line, thereby realizing the time-frequency response, frequency selection, phase shift control, transmission matching, etc. based on the variable capacitor structure.

Abstract: A computing system is described that obtains, based at least in part on information included in at least one previous communication associated with a user of a computing device, an indication of a future location and a future time and event information associated with the future location and the future time. The computing system obtains a duration of time for the user to travel from a current location of the computing device to the future location, and, based at least in part on the duration of time, obtains a departure time at which the user is predicted to need to depart from the current location in order to arrive at the future location by an arrival time based on the event. The computing system outputs, for transmission to the computing device, an indication associated with the event and including information indicative of the departure time.

Abstract: A video generation method is provided. The video generation method includes receiving a generation request carrying object data from a first target device; fusing the object data with a basic avatar model in response to the generation request, to obtain fused avatar images; generating a virtual gift video based on the avatar images; and sending the virtual gift video to the first target device, where the virtual gift video is used to be displayed in a target gift tray page of the first target device.

Abstract: The present technology relates generally to compositions and methods of preventing or treating ischemic stroke. The present technology also relates to administering the anti-ASIC1a antibodies in effective amounts to treat a subject suffering from, or predisposed to, ischemic stroke.

Abstract: A television system with a network function is disclosed. The television system includes several client devices and a server device. The several client devices are configured to store and transmit the client information. The client information includes channel information and several positions of the several client devices. The server device is communicatively connected to the several client devices and is configured to receive the client information, to integrate the client information so as to generate integrated information, and to transmit the integrated information to the several client devices. The several client devices are further configured to confirm the several integrated information so as to update the several client information.

Abstract: A wearable air conditioner includes a shell for being worn around a wearing portion of a user, a fan and a temperature regulating member disposed in the shell. The shell includes a first air passage, a first accommodating chamber, at least one air outlet in communication with the first air passage, and vent holes in communication with the first accommodating chamber. The temperature regulating member is configured for generating heat energy or cold energy. The temperature regulating member is in thermal connection with a sidewall of the first accommodating chamber. An airflow generated by the fan is capable of entering the first air passage and then exiting the shell via the at least air outlet.