Abstract: A system and method for managing the access of individuals to an information infrastructure is described. The metaphor for the user interface may be “myIntranet”, suggesting that the functions are similar to that of a browser of a client connected to the world-wide-web (WWW) through the Internet. The home page of “myIntranet” may be customized at a plurality of organizational levels within a medical facility, so as to provide rapid access to information that a person needs to perform a particular job responsibility. Each person may have a unique home page, or the home page may be customized, in part, by the user. Other portions of the home page may be customized by the department, the information technology organization, or other user with the appropriate permission. The configuration of the home page is associated with the individual user through a log-on procedure.

Abstract: An apparatus and a method for automatic detection of particles, in particular, biological particles such as micro-organisms. The apparatus has a device for binding the particles to separating particles which can be bound selectively to the particles. The apparatus further includes a separating device for extraction of the separating particles with bound particles from a collecting fluid, and a detection unit for detecting a number and/or concentration of the particles separated in this manner. The device for binding the particles to the separating particles includes a collecting device for collecting a collecting fluid including the separating particles and the particles that are provided by a particle-fluid mixture.

Abstract: The invention relates to a descaling device which can be operated in an optimal manner with respect to the efficiency, descaling quality, energy and water consumption and is readily available. The aim of the invention is achieved such that the spray nozzles (12), which are instrumental in descaling the steel material (2) in the descaling device (8), are designed as static nozzles and as dynamic or rotating nozzles. The static nozzles form, together with the spray bars, pairs of spray bars (13) and the dynamic or rotating nozzles form, together with spray units, rows of pairs of spray units (23).

Abstract: The invention relates to benzothiazol-2-one derivatives of general formula (I) with the meanings indicated in the description, the pharmaceutically usable salts thereof, and the use thereof as medicinal substances.

Abstract: The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the addition and/or substitution of negatively and positively charged amino acid residues and by an amidation of the C-terminal carboxy group of the B chain and histidine in position 8 of the insulin A chain. The invention also relates to the production and use thereof.

Abstract: The present invention relates to indazole derivatives of the general formulae I or II having the meanings indicated in the description, to the pharmaceutically useful salts thereof and the use thereof as drugs.

Abstract: Disclosed are compounds of Formula I wherein X is and R2, R1, A, B, D, E, R9 are as defined herein useful for treating cancers.

Abstract: The invention relates to carbamoylbenzotriazole derivatives of general formula (I), which are defined as cited in the description, to their pharmaceutically applicable salts and to their use as medicaments.

Abstract: The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end consists of an amidated basic amino acid residue such as lysine or arginine amide; b) the N-terminal amino acid residue of the insulin A chain is a lysine or arginine radical; c) the amino acid position A8 is occupied by a histidine radical; d) the amino acid position A21 is occupied by a glycine radical; and e) one or more substitutions and/or additions of negatively charged amino acid residues are carried out in the positions A5, A15, A18, B-1, B0, B1, B2, B3 and B4.

Abstract: The invention relates to carbamoylbenzotriazole derivatives of general formula (I), which are defined as cited in the description, to their pharmaceutically applicable salts and to their use as medicaments.

Abstract: The present invention relates to imidazopyridin-2-one derivatives of the formula I with the definitions specified in the description, to their pharmaceutically usable salts and to their use as medicaments.

Abstract: The present invention provides compounds which have an inhibitory effect on hormone-sensitive lipase or endothelial lipase. The compounds of the invention are azolopyridin-2-one derivatives of the general formula I wherein the substituents are as defined herein. The compounds of formula I wherein R2 is hydrogen are distinguished by favorable effects on disorders of lipid metabolism. They beneficially influence the HDL to LDL ratio and increase in particular the HDL level and are suitable for the prevention and treatment of dyslipidemias and metabolic syndrome and their diverse sequelae such as atherosclerosis, coronary heart disease, heart failure, obesity and diabetes. The compounds of formula I wherein R1 and R2 together form a ring system are distinguished by favorable effects on metabolic disorders.

Abstract: A cooling device is disclosed for a radiation detector including a detector surface and a plurality of collimator plates arranged in the direction of X-radiation before the detector surface. In order to produce the cooling device of at least one embodiment, the collimator plates are designed and/or the cooling device includes a ventilation device which is designed, so that the space between the collimator plates is at least partially exposed to a cooling air flow in order to cool the radiation detector. A corresponding method for cooling an X-radiation detector is furthermore described in at least one additional embodiment.

Abstract: The present invention provides compounds which have an inhibitory effect on hormone-sensitive lipase or endothelial lipase. The compounds of the invention are azolopyridin-2-one derivatives of the general formula I wherein the substituents are as defined herein. The compounds of formula I wherein R2 is hydrogen are distinguished by favorable effects on disorders of lipid metabolism. They beneficially influence the HDL to LDL ratio and increase in particular the HDL level and are suitable for the prevention and treatment of dyslipidemias and metabolic syndrome and their diverse sequelae such as atherosclerosis, coronary heart disease, heart failure, obesity and diabetes. The compounds of formula I wherein R1 and R2 together form a ring system are distinguished by favorable effects on metabolic disorders.

Abstract: The invention relates to diacyl indazole derivatives of general formulae (I) or (II) and to the pharmaceutically acceptable salts thereof: Wherein X, R1 and R2 are as defined herein. The invention also relates to the use of these compounds as pharmaceutical products.

Abstract: The present invention discloses trapping devices for biting (e.g. mosquitoes, sand flies, black flies, and biting midges) and nuisance flies (e.g. houseflies, filth flies, and fruit flies). The outdoor solution for biting flies includes a solar panel, a housing, a bag, and a ventilator located in the housing. The ventilator creates a capture zone having an airflow toward the bag. A CO2 generator, chemical attractants, a heat source, and a UV light attract mosquitoes to the capture zone. The chemical attractants are released continuously, the CO2 is released in pulses, and the ventilator and UV are operated in independent programmable intervals. The device is efficient in energy consumption and CO2 production. Other trapping devices are disclosed having a combination of insect-attracting mechanisms including a ventilator. Novel insect zappers including a ventilator are disclosed as well. Indoor and outdoor solutions for insects including biting and nuisance flies.

Abstract: The invention relates to diacyl indazole derivatives of general formulae (I) or (II) and to the pharmaceutically acceptable salts thereof: Wherein X, R1 and R2 are as defined herein. The invention also relates to the use of these compounds to treat diabetes mellitus, dyslipidemia and atherosclerotic disorders.

Abstract: The invention relates to triazolopyridine derivatives of general formula (I), which are defined as cited in the description, to their pharmaceutically applicable salts and to their use as medicaments.

Abstract: Disclosed are compounds of the general formula (I), where the definition of the substituents A, B, D, E, R1 and R2 are detailed in the description, and the physiologically tolerated salts thereof, a process for the preparation of these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2).

Abstract: The invention relates to benzooxazol-2-one derivatives of general formula (I) with the meanings indicated in the description, the pharmaceutically usable salts thereof, and the use thereof as medicinal substances.