Patents by Inventor Haiyin He

Haiyin He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibacterial lipopeptides and methods for their preparation and use
    Patent number: 10072045
    Abstract: Novel antibacterial lipopeptides, pharmaceutical compositions, and methods for their preparation and use are described.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: September 11, 2018
    Assignee: RAMAPO PHARMACEUTICALS, INC.
    Inventor: Haiyin He
  • Spliceostatin analogs and methods for their preparation
    Patent number: 9764040
    Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: September 19, 2017
    Assignee: Pfizer Inc.
    Inventors: Chakrapani Subramanyam, Frank Erich Koehn, Kenneth John Dirico, Alessandra S. Eustaquio, Michael Eric Green, Haiyin He, Min He, Christopher John O'Donnell, Sujiet Puthenveetil, Anokha Ratnayake, Jesse Alexander Teske, Hui Yu Yang
  • SPLICEOSTATIN ANALOGS AND METHOS FOR THEIR PREPARATION
    Publication number: 20170014523
    Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
    Type: Application
    Filed: September 29, 2016
    Publication date: January 19, 2017
    Inventors: Chakrapani SUBRAMANYAM, Frank Erich KOEHN, Kenneth John DIRICO, Alessandra S. EUSTAQUIO, Michael Eric GREEN, Haiyin HE, Min HE, Christopher John O'DONNELL, Sujiet PUTHENVEETIL, Anokha RATNAYAKE, Jesse Alexander TESKE, Hui Yu YANG
  • Spliceostatin analogs and methods for their preparation
    Patent number: 9504669
    Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: November 29, 2016
    Assignee: Pfizer Inc.
    Inventors: Chakrapani Subramanyam, Frank Erich Koehn, Kenneth John Dirico, Alessandra S. Eustaquio, Michael Eric Green, Haiyin He, Min He, Christopher John O'Donnell, Sujiet Puthenveetil, Anokha Ratnayake, Jesse Alexander Teske, Hui Yu Yang
  • SPLICEOSTATIN ANALOGS AND METHODS FOR THEIR PREPARATION
    Publication number: 20160022626
    Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
    Type: Application
    Filed: August 5, 2015
    Publication date: January 28, 2016
    Inventors: Chakrapani SUBRAMANYAM, Frank Erich Koehn, Kenneth John Dirico, Alessandra S. Eustaquio, Michael Eric Green, Haiyin He, Min He, Christopher John O'Donnell, Sujiet Puthenveetil, Anokha Ratnayake, Jesse Alexander Teske, Hui Yu Yang
  • Spliceostatin analogs and methods for their preparation
    Patent number: 9169264
    Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: October 27, 2015
    Assignee: Pfizer Inc.
    Inventors: Chakrapani Subramanyam, Frank Erich Koehn, Kenneth John Dirico, Alessandra S. Eustaquio, Michael Eric Green, Haiyin He, Min He, Christopher John O'Donnell, Sujiet Puthenveetil, Anokha Ratnayake, Jesse Alexander Teske, Hui Yu Yang
  • SPLICEOSTATIN ANALOGS AND METHODS FOR THEIR PREPARATION
    Publication number: 20140134193
    Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
    Type: Application
    Filed: October 31, 2013
    Publication date: May 15, 2014
    Applicant: PFIZER INC.
    Inventors: Chakrapani SUBRAMANYAM, Frank Erich KOEHN, Kenneth John DIRICO, Alessandra S. EUSTAQUIO, Michael Eric GREEN, Haiyin HE, Min HE, Christopher John O'DONNELL, Sujiet PUTHENVEETIL, Anokha RATNAYAKE, Jesse Alexander TESKE, Hui Yu YANG
  • Substantially pure glycopeptide antibiotics AC-98-1 ; AC-98-2; AC-98-3; AC-98-4 and AC-98-5
    Patent number: 7696164
    Abstract: The invention provides new substantially pure antibiotics designated AC-98-1, AC-98-2, AC-98-3, AC-98-4 and AC-98-5 derived from the microorganism Streptomyces hygroscopicus.
    Type: Grant
    Filed: December 13, 2006
    Date of Patent: April 13, 2010
    Assignee: Wyeth
    Inventors: Guy Thomas Carter, Haiyin He
  • SUBSTANTIALLY PURE GLYCOPEPTIDE ANTIBIOTICS AC-98-1; AC-98-2; AC-98-3; AC-98-4 AND AC-98-5
    Publication number: 20090209452
    Abstract: The invention provides new substantially pure antibiotics designated AC-98-1, AC-98-2, AC-98-3, AC-98-4 and AC-98-5 derived from the microorganism Streptomyces hygroscopicus.
    Type: Application
    Filed: December 13, 2006
    Publication date: August 20, 2009
    Applicant: Wyeth Holdings Corporation
    Inventors: Guy Thomas Carter, Haiyin He
  • Actinomadura Chromoprotein, Apoprotein and Gene Cluster
    Publication number: 20080274959
    Abstract: The present invention provides a chromoprotein produced by Actinomadura sp. 21G792, as well as amino acid and nucleic acid sequences of the apoprotein component of the chromoprotein and of components of the biosynthetic pathway for the chromophore. The present invention is useful for developing pharmaceutical and treating diseases such as cancer or bacterial infections.
    Type: Application
    Filed: December 16, 2005
    Publication date: November 6, 2008
    Applicant: Wyeth
    Inventors: Bradley A. Haltli, Haiyin He, Ying Huang, Sridhar Krishna Rabindran, Jiang Wu, Min He
  • Antibiotic P175-A and semisynthetic derivatives thereof
    Patent number: 7211417
    Abstract: This invention relates to a new antibiotic designated P175-A, to production of fermentation of Micromonospora echinospora NRRL 30633, to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic esters and ethers of P175-A.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: May 1, 2007
    Assignee: Wyeth Holdings Corporation
    Inventors: Haiyin He, Hui Yu Yang, Scott William Luckman, Valerie S. Bernan
  • Substantially pure glycopeptide antibiotics AC-98-1, AC-98-2, AC-98-3, AC-98-4 and AC-98-5
    Patent number: 7183253
    Abstract: The invention provides new substantially pure antibiotics designated AC-98-1, AC-98-2, AC-98-3, AC-98-4 and AC-98-5 derived from the microorganism Streptomyces hygroscopicus.
    Type: Grant
    Filed: February 4, 2004
    Date of Patent: February 27, 2007
    Assignee: Wyeth Holdings Corp.
    Inventors: Guy Thomas Carter, Haiyin He
  • Antibiotic Cyan426-A
    Patent number: 7129266
    Abstract: The invention relates to a new antibiotic designated Cyan426-A, to its production by fermentation, to methods for its recovery and concentration from the crude solutions, and to a process for its purification and to semisynthetic ethers of Cyan426-A, Cyan426-A-ethers.
    Type: Grant
    Filed: December 15, 2003
    Date of Patent: October 31, 2006
    Assignee: Wyeth Holdings Corporation
    Inventors: Haiyin He, Hui Yang, Ramunas Bigelis
  • Antibiotics Cyan-416 A, Cyan-416 B, Cyan-416 C, Cyan-416 D and Cyan-416 E, and ester derivatives of Cyan-416 B
    Patent number: 7078556
    Abstract: The invention relates to new antibiotics designated Cyan-416A, Cyan 416B, Cyan-416C, Cyan-416D and Cyan-416E to their production by fermentation of Acremonium sp. NRRL 30631 to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic ethers of Cyan-416B.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: July 18, 2006
    Assignee: Wyeth Holdings Corporation
    Inventors: Haiyin He, Ramunas Bigelis
  • ANTIBIOTICS CYAN-416 A, CYAN-416 B, CYAN-416 C, CYAN-416 D AND CYAN-416 E, AND ESTER DERIVATIVES OF CYAN-416 B
    Publication number: 20060100277
    Abstract: The invention relates to new antibiotics designated Cyan-416A, Cyan 416B, Cyan-416C, Cyan-416D and Cyan-416E to their production by fermentation of Acremonium sp. NRRL 30631 to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic ethers of Cyan-416B.
    Type: Application
    Filed: December 16, 2005
    Publication date: May 11, 2006
    Applicant: Wyeth Holdings Corporation
    Inventors: Haiyin He, Ramunas Bigelis
  • Antibiotics Cyan-416 A, Cyan-416 B, Cyan-416 C, Cyan-416 D and Cyan-416 E, and ester derivatives of Cyan-416 B
    Patent number: 7022873
    Abstract: The invention relates to new antibiotics designated Cyan-416A, Cyan 416B, Cyan-416C, Cyan-416D and Cyan-416E to their production by fermentation of Acremonium sp. NRRL 30631 to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic ethers of Cyan-416B.
    Type: Grant
    Filed: December 15, 2003
    Date of Patent: April 4, 2006
    Assignee: Wyeth Holdings Corporation
    Inventors: Haiyin He, Ramunas Bigelis
  • Glycopeptide antibiotics
    Patent number: 6964860
    Abstract: The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: November 15, 2005
    Assignee: Wyeth Holdings Corporation
    Inventors: Darren Robert Abbanat, Arthur Emery Bailey, Valerie Sue Bernan, Michael Greenstein, Jason Arnold Lotvin, Mark Edward Ruppen, Alan Gordon Sutherland, Haiyin He
  • Glycopeptide antibiotics
    Patent number: 6914045
    Abstract: The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: July 5, 2005
    Assignee: Wyeth Holdings Corporation
    Inventors: Darren Robert Abbanat, Valerie Sue Bernan, Russell George Dushin, Michael Greenstein, Haiyin He, Stanley Albert Lang, Howard Newman, Subas Sakya, Phaik-Eng Sum, Alan Gordon Sutherland, Ting-Zhong Wang, Jason Arnold Lotvin, Mark Edward Ruppen, Arthur Emergy Bailey, Ping Cai, Bo Shen, Fangming Kong
  • Reversal of multidrug resistance in human colon carcinoma cells
    Patent number: 6878737
    Abstract: The present invention describes the use of fumitremorgin A, B and C and a series of diketopiperazines of Formula (I) to resensitize multidrug resistant (MDR) cancer cells to the cytotoxic effects of chemotherapeutic drugs.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: April 12, 2005
    Assignee: Wyeth Holdings Corporation
    Inventors: Sridhar Krishna Rabindran, Haiyin He, Lee Martin Greenberger
  • Antibiotic P175-A and semisynthetic derivatives thereof
    Publication number: 20040220195
    Abstract: This invention relates to a new antibiotic designated P175-A, to production of fermentation of Micromonospora echinospora NRRL 30633, to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic esters and ethers of P175-A.
    Type: Application
    Filed: April 28, 2004
    Publication date: November 4, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Haiyin He, Hui Yu Yang, Scott William Luckman, Valerie S. Bernan