Patents by Inventor Haiyin He

Haiyin He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibiotic cytosporacin
    Patent number: 6784204
    Abstract: This disclosure describes new antibiotic Cytosporacin having the structure: The invention relates to a new antibiotic designated Cytosporacin, to its production by fermentation, to methods for its recovery and concentration from the crude solutions, and to process for its purification. The invention includes within its scope the agent in dilute form, as a crude concentrate, and in pure form. The invention also relates to the use of the compound according to the invention in antimicrobial compositions and as antiseptics or disinfectants.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: August 31, 2004
    Assignee: Wyeth Holdings Corporation, Five Giralda Farms
    Inventors: Haiyin He, Jeffrey Edwin Janso
  • Substantially pure glycopeptide antibiotics AC-98-1, AC-98-2, AC-98-3, AC-98-4 and AC-98-5
    Publication number: 20040158035
    Abstract: The invention provides new substantially pure antibiotics designated AC-98-1, AC-98-2, AC-98-3, AC-98-4 and AC-98-5 derived from the microorganism Streptomyces hygroscopicus.
    Type: Application
    Filed: February 4, 2004
    Publication date: August 12, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Guy Thomas Carter, Haiyin He
  • Antibiotics Cyan-416 A, Cyan-416 B, Cyan-416 C, Cyan-416 D, and Cyan-416 E, and ester derivatives of Cyan-416 B
    Publication number: 20040132812
    Abstract: The invention relates to new antibiotics designated Cyan-416A, Cyan 416B, Cyan-416C, Cyan-416D and Cyan-416E to their production by fermentation of Acremonium sp. NRRL 30631 to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic ethers of Cyan-416B.
    Type: Application
    Filed: December 15, 2003
    Publication date: July 8, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Haiyin He, Ramunas Bigelis
  • Antibiotic Cyan426-A
    Publication number: 20040127540
    Abstract: The invention relates to a new antibiotic designated Cyan426-A, to its production by fermentation, to methods for its recovery and concentration from the crude solutions, and to a process for its purification and to semisynthetic ethers of Cyan426-A, Cyan426-A-ethers.
    Type: Application
    Filed: December 15, 2003
    Publication date: July 1, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Haiyin He, Hui Yang, Ramunas Bigelis
  • Antibiotic cytosporacin
    Publication number: 20040082648
    Abstract: This disclosure describes new antibiotic Cytosporacin having the structure: 1
    Type: Application
    Filed: October 14, 2003
    Publication date: April 29, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Haiyin He, Jeffrey Edwin Janso
  • Substantially pure glycopeptide antibiotics AC-98-1; AC-98-2; AC-98-3; AC-98-4 and AC-98-5
    Patent number: 6713448
    Abstract: The invention provides new substantially pure antibiotics designated AC-98-1, AC-98-2, AC-98-3, AC-98-4 and AC-98-5 derived from the microorganism Streptomyces hygroscopicus.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: March 30, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Guy Thomas Carter, Haiyin He
  • Glycopeptide antibiotics
    Publication number: 20030092610
    Abstract: The invention provides compounds of formula 1
    Type: Application
    Filed: April 25, 2002
    Publication date: May 15, 2003
    Applicant: American Cyanamid Company
    Inventors: Darren Robert Abbanat, Arthur Emery Bailey, Valerie Sue Bernan, Michael Greenstein, Jason Arnold Lotvin, Mark Edward Ruppen, Alan Gordon Sutherland, Haiyin He
  • Glycopeptide antibiotics
    Publication number: 20030087812
    Abstract: The invention provides compounds of formula 1
    Type: Application
    Filed: April 25, 2002
    Publication date: May 8, 2003
    Applicant: American Cyanamid Company
    Inventors: Darren Robert Abbanat, Valerie Sue Bernan, Russell George Dushin, Michael Greenstein, Haiyin He, Stanley Albert Lang, Howard Newman, Subas Sakya, Phaik-Eng Sum, Alan Gordon Sutherland, Ting-Zhong Wang, Jason Arnold Lotvin, Mark Edward Ruppen, Arthur Emery Bailey, Ping Cai, Bo Shen, Fangming Kong
  • Reversal of multidrug resistance in human colon carcinoma cells
    Publication number: 20030083230
    Abstract: The present invention describes the use of fumitremorgin A, B and C and a series of diketopiperazines of Formula (I) to resensitize multidrug resistant (MDR) cancer cells to the cytotoxic effects of chemotherapeutic drugs.
    Type: Application
    Filed: February 28, 2002
    Publication date: May 1, 2003
    Applicant: American Cyanamid Company
    Inventors: Sridhar Krishna Rabindran, Haiyin He, Lee Martin Greenberger
  • Reversal of multidrug resistance in human colon carcinoma cells
    Patent number: 6537964
    Abstract: The present invention describes the use of fumitremorgin A, B and C and a series of diketopiperazines of Formula (I) to resensitize multidrug resistant (MDR) cancer cells to the cytotoxic effects of chemotherapeutic drugs.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: March 25, 2003
    Assignee: Wyeth Holdings Corporation
    Inventors: Haiyin He, Lee Martin Greenberger
  • Substantially pure glycopeptide antibotics AC-98-1; AC-98-2; AC-98-3; AC-98-4 AND AC-98-5
    Publication number: 20030054508
    Abstract: The invention provides new substantially pure antibiotics designated AC-98-1, AC-98-2, AC-98-3, AC-98-4 and AC-98-5 derived from the microorganism Streptomyces hygroscopicus.
    Type: Application
    Filed: April 25, 2002
    Publication date: March 20, 2003
    Applicant: American Cyanamid Company
    Inventors: Guy Thomas Carter, Haiyin He
  • Reversal of multidrug resistance in human colon carcinoma cells
    Publication number: 20020169111
    Abstract: The present invention describes the use of fumitremorgin A, B and C and a series of diketopiperazines of Formula (I) to resensitize multidrug resistant (MDR) cancer cells to the cytotoxic effects of chemotherapeutic drugs.
    Type: Application
    Filed: February 28, 2002
    Publication date: November 14, 2002
    Applicant: American Cyanamid Comany
    Inventors: Haiyin He, Lee Martin Greenberger
  • Reversal of multidrug resistance in human colon carcinoma cells
    Publication number: 20020156015
    Abstract: The present invention describes the use of fumitremorgin A, B and C and a series of diketopiperazines of Formula (I) to resensitize multidrug resistant (MDR) cancer cells to the cytotoxic effects of chemotherapeutic drugs.
    Type: Application
    Filed: February 28, 2002
    Publication date: October 24, 2002
    Applicant: American Cyanamid Company
    Inventors: Sridhar Krishna Rabindran, Haiyin He, Maya Prakash Singh, Lee Martin Greenberger
  • Reversal of multidrug resistance in human colon carcinoma cells
    Patent number: 6372775
    Abstract: The present invention describes the use of fumitremorgin A, B and C and a series of diketopiperazines of Formula (I) to resensitize multidrug resistant (MDR) cancer cells to the cytotoxic effects of chemotherapeutic drugs.
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: April 16, 2002
    Assignee: American Cyanamid Company
    Inventors: Sridhar Krishna Rabindran, Haiyin He, Lee Martin Greenberger
  • Fungicidal toxins from biocontrol bacteria
    Patent number: 6034124
    Abstract: A biocontrol bacteria, Bacillus cereus ATCC 53522, has been found to naturally synthesize two antibiotics, here designated zwittermicin A and antibiotic B. Zwittermicin A is a 396 dalton linear aminopolyol, a class of metabolite previously unknown in B. cereus. Antibiotic B is an aminoglycoside. Both antibiotics exhibit inhibitory activity on many fungal and bacterial pathogens.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: March 7, 2000
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jo Handelsman, Laura Silo-Suh, Jon Clardy, Haiyin He
  • Fungicidal toxins from biocontrol bacteria
    Patent number: 5852054
    Abstract: A biocontrol bacteria, Bacillus cereus ATCC 53522, has been found to naturally synthesize two antibiotics, here designated zwittermicin A and antibiotic B. Zwittermicin A is a 396 dalton linear aminopolyol, a class of metabolite previously unknown in B. cereus. Antibiotic B is an aminoglycoside. Both antibiotics exhibit inhibitory activity on many fungal and bacterial pathogens.
    Type: Grant
    Filed: March 8, 1994
    Date of Patent: December 22, 1998
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jo Handelsman, Laura Silo-Suh, Jon Clardy, Haiyin He
  • Biologically active amides containing a bicyclo moiety
    Patent number: 5476953
    Abstract: Cytotoxic metabolites are isolated by extraction and chromatography from a marine sponge of the same species as that deposited in the Zoological Museum of the University of Amsterdam under reg. no. ZMA POR. 10883. The isolated compounds belong to the genus of compounds having the structure: ##STR1## wherein R is C.sub.6 -C.sub.12 alkyl or C.sub.6 -C.sub.12 alkenyl having 1 or 2 double bonds, which may be interrupted with one or more imino groups and which may be substituted with one or more substituents selected from the group consisting of amino, carboxyl, hydroxy, imino and oxo.
    Type: Grant
    Filed: August 3, 1994
    Date of Patent: December 19, 1995
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Jon Clardy, Haiyin He