Patents by Inventor Haolun Jin

Haolun Jin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Integrase inhibitors
    Publication number: 20080058315
    Abstract: Tricyclic compounds, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
    Type: Application
    Filed: May 16, 2007
    Publication date: March 6, 2008
    Inventors: Zhenhong Cai, Salman Jabri, Haolun Jin, Rachael Lansdown, Samuel Metobo, Michael Mish, Richard Pastor
  • Aza-quinolinol phosphonate integrase inhibitor compounds
    Publication number: 20070185007
    Abstract: Aza-quinolinol phosphonate compounds and methods for inhibition of HIV-integrase are disclosed. Formula (I). Ar is aryl or heteroaryl connecting R6 to L. L is a bond or a linker connecting a ring atom of Ar to N. The ring atoms, X1-X5 may be N, substituted nitrogen, or substituted carbon, and form rings. The compounds include at least one phosphonate group covalently attached at any site.
    Type: Application
    Filed: September 17, 2004
    Publication date: August 9, 2007
    Inventors: Haolun Jin, Choung Kim, Peter Nelson
  • Pre-organized tricyclic integrase inhibitor compounds
    Patent number: 7253180
    Abstract: Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. A1 and A2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl. Q is N, +NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: August 7, 2007
    Assignee: Gilead Sciences, Inc.
    Inventors: James M. Chen, Xiaowu Chen, Maria Fardis, Haolun Jin, Choung U. Kim, Laura N. Schacherer
  • Integrase inhibitor compounds
    Publication number: 20070072831
    Abstract: Tricyclic compounds, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
    Type: Application
    Filed: May 16, 2006
    Publication date: March 29, 2007
    Inventors: Zhenhong Cai, Salman Jabri, Haolun Jin, Choung Kim, Rachael Lansdown, Samuel Metobo, Michael Mish, Richard Pastor
  • Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds
    Publication number: 20070010489
    Abstract: Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit 5 HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
    Type: Application
    Filed: April 25, 2003
    Publication date: January 11, 2007
    Inventors: Murty Arimilli, Mark Becker, Clifford Bryant, James Chen, Xiaowu Chen, Azar Dastgah, Maria Fardis, Gong-Xin He, Haolun Jin, Choung Kim, William Lee, Christopher Lee, Kuei-Ying Lin, Hongtao Liu, Richard Mackman, Michael Mitchell, Peter Nelson, Hyung-Jung Pyun, Tanisha Rowe, Mark Sparacino, Sundaramoorthi Swaminathan, James Tario, Jianying Wang, Matthew Wiliams, Lianhong Xu, Zheng-Yu Yang, Richard Yu, Jiancun Zhang, Lijun Zhang
  • Therapeutic phosphonate compounds
    Publication number: 20060264404
    Abstract: The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.
    Type: Application
    Filed: October 25, 2005
    Publication date: November 23, 2006
    Inventors: Constantine Boojamra, Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Manoj Desai, Maria Fardis, Craig Gibbs, Ralph Hirschmann, Alan Huang, Haolun Jin, Choung Kim, Thorsten Kirschberg, Steven Krawczyk, Christopher Lee, William Lee, Kuei-Ying Lin, Richard Mackman, David Markevitch, Peter Nelson, David Oare, Vidya Prasad, Hyung-Jung Pyun, Adrian Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William Watkins, Jennifer Zhang, Lijun Zhang
  • Pre-organized tricyclic integrase inhibitor compounds
    Publication number: 20060217410
    Abstract: Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. Formula (I). A1 and A2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl. Q is N, +NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.
    Type: Application
    Filed: October 16, 2003
    Publication date: September 28, 2006
    Inventors: James Chen, Xiaowu Chen, Maria Fardis, Haolun Jin, Choung Kim, Laura Schacherer
  • Phosphonate analogs of HIV integrase inhibitor compounds
    Publication number: 20060116356
    Abstract: Novel HIV integrase inhibitor compounds having at least one phosphonate group, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
    Type: Application
    Filed: April 14, 2005
    Publication date: June 1, 2006
    Inventors: Zhenhong Cai, Xiaowu Chen, Maria Fardis, Salman Jabri, Haolun Jin, Choung Kim, Samuel Metobo, Michael Mish, Richard Pastor
  • Pyrimidyl phosphonate antiviral compounds and methods of use
    Publication number: 20050282839
    Abstract: Pyrimidine I and pyrimidinone II phosphonate compounds and methods for viral inhibition are disclosed. The compounds include at least one phosphonate group covalently attached at any site.
    Type: Application
    Filed: January 11, 2005
    Publication date: December 22, 2005
    Inventors: Haolun Jin, Choung Kim
  • Method and compositions for identifying anti-HIV therapeutic compounds
    Publication number: 20050239054
    Abstract: Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
    Type: Application
    Filed: December 22, 2003
    Publication date: October 27, 2005
    Inventors: Murty Arimilli, Mark Becker, Gabriel Birkus, Clifford Bryant, James Chen, Xiaowu Chen, Tomas Cihlar, Azar Dastgah, Eugene Eisenberg, Maria Fardis, Marcos Hatada, Gong-Xin He, Haolun Jin, Choung Kim, William Lee, Christopher Lee, Kuei-Ying Lin, Hongtao Liu, Richard MacKman, Martin McDermott, Michael Mitchell, Peter Nelson, Hyung-Jung Pyun, Tanisha Rowe, Mark Sparacino, Sundaramoorthi Swaminathan, James Tario, Jianying Wang, Matthew Williams, Lianhong Xu, Zheng-Yu Yang, Richard Yu, Jiancun Zhang, Lijun Zhang
  • Antiviral phosphonate analogs
    Publication number: 20050215513
    Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: April 26, 2004
    Publication date: September 29, 2005
    Inventors: Constantine Boojamra, Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Maria Fardis, Haolun Jin, Ralph Hirschmann, Alan Huang, Choung Kim, Thorsten Kirschberg, Christopher Lee, William Lee, Richard MacKman, David Markevitch, David Oare, Vidya Prasad, Hyung-Jung Pyun, Adrian Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William Watkins, Jennifer Zhang
  • Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds
    Publication number: 20050209197
    Abstract: Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
    Type: Application
    Filed: April 25, 2003
    Publication date: September 22, 2005
    Inventors: Murty Arimilli, Mark Becker, Clifford Bryant, James Chen, Xiaowu Chen, Azar Dastgah, Maria Fardis, Gong-Xin He, Haolun Jin, Choung Kim, William Lee, Christopher Lee, Kuei-Ying Lin, Hongtao Liu, Richard Mackman, Michael Mitchell, Peter Nelson, Hyung-Jung Pyun, Tanisha Rowe, Mark Sparacino, Sundaramoorthi Swaminathan, James Tario, Jianying Wang, Matthew Williams, Lianhong Xu, Zheng-Yu Yang, Richard Yu, Jiancun Zhang, Lijun Zhang
  • Aza-quinolinol phosphonate integrase inhibitor compounds
    Publication number: 20050137199
    Abstract: Aza-quinolinol phosphonate compounds and methods for inhibition of HIV-integrase are disclosed. Ar is aryl or heteroaryl connecting R6 to L. L is a bond or a linker connecting a ring atom of Ar to N. The ring atoms, X1-X5 may be N, substituted nitrogen, or substituted carbon, and form rings. The compounds include at least one phosphonate group covalently attached at any site.
    Type: Application
    Filed: September 17, 2004
    Publication date: June 23, 2005
    Inventors: Haolun Jin, Choung Kim, Peter Nelson
  • Processes for preparing substituted 1, 3-oxathiolanes with antiviral properties
    Patent number: 6831174
    Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: wherein R2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S═O or SO2. The invention also relates to intermediates of use in the preparation of these compounds.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: December 14, 2004
    Assignee: Shire BioChem Inc.
    Inventors: Bernard Belleau, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba
  • Pre-organized tricyclic integrase inhibitor compounds
    Publication number: 20040167124
    Abstract: Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
    Type: Application
    Filed: October 16, 2003
    Publication date: August 26, 2004
    Applicant: GILEAD SCIENCES, INC.
    Inventors: James M. Chen, Xiaowu Chen, Maria Fardis, Haolun Jin, Choung U. Kim, Laura N. Schacherer
  • Pre-organized tricyclic integrase inhibitor compounds
    Publication number: 20040157804
    Abstract: Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
    Type: Application
    Filed: October 15, 2003
    Publication date: August 12, 2004
    Applicant: GILEAD SCIENCES, INC.
    Inventors: James M. Chen, Xiaowu Chen, Maria Fardis, Haolun Jin, Choung U. Kim, Laura N. Schacherer
  • Substituted 1,3-oxathiolanes with antiviral properties
    Patent number: 6369066
    Abstract: This invention relates to single enantiomers of novel cis-substituted 1,3-oxathiolanes, of the formula (I): wherein; R1 is hydrogen, and R2 is cytosine or 5-fluorocytosine; and pharmaceutically acceptable salts and esters thereof. This invention also relates to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents, particularly in combination therapy.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: April 9, 2002
    Assignee: BioChem Pharma, Inc.
    Inventors: Tarek S. Mansour, Haolun Jin
  • Processes for preparing substituted 1, 3-oxathiolanes with antiviral properties
    Publication number: 20010041797
    Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: 1
    Type: Application
    Filed: January 16, 2001
    Publication date: November 15, 2001
    Applicant: BioChem Pharma Inc.
    Inventors: Bernard Belleau, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba
  • Substituted 1,3-oxathiolanes with antiviral properties
    Patent number: 6228860
    Abstract: This invention relates to single enantiomers of novel cis-substituted 1,3-oxathiolanes, of the formula (I): wherein; R1 is hydrogen, and R2 is cytosine or 5-fluorocytosine, and pharmaceutically acceptable salts and esters thereof. This invention also relates to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents, particularly in combination therapy.
    Type: Grant
    Filed: November 26, 1996
    Date of Patent: May 8, 2001
    Assignee: Biochem Pharma Inc.
    Inventors: Tarek S. Mansour, Haolun Jin
  • Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
    Patent number: 6175008
    Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: wherein R2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S═O or SO2. The invention also relates to intermediates of use in the preparation of these compounds.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 16, 2001
    Assignee: BioChem Pharma Inc.
    Inventors: Bernard Belleau, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba