Patents by Inventor Haolun Jin

Haolun Jin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cytomegalovirus inhibiting compounds
    Patent number: 5945431
    Abstract: The present invention relates to heterocyclic compounds having antiviral activity. In particular, compounds of formula (I): wherein B, W, X, Y, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and n are as defined herein, are useful in the therapy and prophylaxis of cytomegalovirus (CMV) infection in mammals.
    Type: Grant
    Filed: September 4, 1997
    Date of Patent: August 31, 1999
    Assignee: Biochem Therapeutics Incorporated
    Inventors: Haolun Jin, Laval C. Chan, Wei Wang, Tomislav Stefanac, Tarek S. Mansour, Paul Nguyen-Ba, Jean-Francois Lavallee, Guy Falardeau
  • Stereoselective synthesis of nucleoside analogues using bicyclic intermediate
    Patent number: 5763606
    Abstract: The present invention relates to a process for producing predominantly pure cis nucleoside analogues of formula (I), wherein X is S, or O; Y is S, CH.sub.2, O or CH(R); wherein R is azido or halogen; and R.sub.2 is a purine or pyrimidine base; via the coupling of a silylated purine or pyrimidine base in the presence of an appropriate Lewis acid with a bicyclic intermediate of formula (III) wherein Z is S or O; followed by conversion of the resulting intermediate of formula (II) to an alkyl ester and reduction to yield a compound of formula (I).
    Type: Grant
    Filed: February 2, 1995
    Date of Patent: June 9, 1998
    Assignee: BioChem Pharma, Inc.
    Inventors: Tarek S. Mansour, Colleen A. Evans, Haolun Jin, M. Arshad Siddiqui, Allan H. L. Tse
  • Processes for the diastereoselective synthesis of nucleoside analogues
    Patent number: 5696254
    Abstract: The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity, and intermediates useful in those processes.
    Type: Grant
    Filed: June 13, 1994
    Date of Patent: December 9, 1997
    Assignee: BioChem Pharma Inc.
    Inventors: Tarek Mansour, Haolun Jin, Allan H. L. Tse, M. Arshad Siddiqui
  • Intermediates in the synthesis of 1,3-oxathiolanyl cytosine nucleoside analogues
    Patent number: 5693787
    Abstract: The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 2, 1997
    Assignee: BioChem Pharma Inc.
    Inventors: Tarek Mansour, Haolun Jin, Allan H. L. Tse, M. Arshad Siddiqui
  • Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
    Patent number: 5684164
    Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: ##STR1## wherein R.sub.2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S.dbd.O or SO.sub.2. The invention also relates to intermediates of use in the preparation of these compounds.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 4, 1997
    Assignee: BioChem Pharma Inc.
    Inventors: Bernard Belleau, deceased, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba
  • Processes for the diastereoselective separation of nucleoside analogue synthetic intermediates
    Patent number: 5663320
    Abstract: The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 2, 1997
    Assignee: BioChem Pharma, Inc.
    Inventors: Tarek Mansour, Haolun Jin, Allan H.L. Tse, M. Arshad Siddiqui
  • Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
    Patent number: 5587480
    Abstract: This invention relates to novel substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes or pharmaceutically acceptable salts and esters thereof, of the formula: ##STR1## wherein X is S, S.dbd.O, or SO.sub.2 ;Y is O, S, S.dbd.O, or SO.sub.2 ;R.sub.1 is hydrogen, trisubstituted silyl, C.sub.1-6 alkyl, aralkyl, or C.sub.1-6 acyl, and R.sub.2 is a pyrimidine base or an analogue or derivative thereof.This invention also relates to processes for preparing these compounds, intermediates useful in their preparation, to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents.
    Type: Grant
    Filed: April 20, 1994
    Date of Patent: December 24, 1996
    Assignee: BioChem Pharma, Inc.
    Inventors: Bernard Belleau, deceased, Nghe Nguyen-Ba, Laval C. C. Kong, Tarek Mansour, Haolun Jin, Livio Brasili
  • Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
    Patent number: 5466806
    Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: ##STR1## wherein R.sub.2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S.dbd.O or SO.sub.2. The invention also relates to intermediates of use in the preparation of these compounds.
    Type: Grant
    Filed: March 29, 1993
    Date of Patent: November 14, 1995
    Assignee: Biochem Pharma Inc.
    Inventors: Bernard Belleau, deceased, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba