Abstract: The invention relates to a cryoapparatus for freezing and/or thawing a sample (1), especially in the cryopreservation of a biological sample (1), with a coolable cooling space (3) and with a sample container (10) arranged in the cooling space (3) for temporarily receiving the sample (1) when freezing or thawing the sample (1). It is suggested that the sample container (10) can be tempered separately from the cooling space. Furthermore, the invention includes an associated operating method.

Abstract: The invention relates to an aquarium with a water tank (2), filled with water (3) when in operation and containing objects for investigation (4, 19), in particularly biological organisms, said water tank (2) being at least partly located below ground in the earth (5). According to the invention, the water tank (2) runs so deep into the earth (5) that, at least the bottom of the water tank (2) is at the pressure of the deep sea. The invention further relates to a corresponding method of operation.

Abstract: A device for producing a crosslinked substance, e.g., of crosslinked microcapsules (1) of a crosslinkable capsule substance, in particular crosslinked alginates, is described, having a first dispensing device (2) for dispensing a jet of the crosslinkable capsule substance and a crosslinking device for applying a crosslinking agent to the capsule substance, whereby the crosslinking device has a second dispensing device (5) which directs a jet (9, 13) of the crosslinking agent at the jet or at a layer of the capsule substance.

Abstract: The invention relates to an electric hand-held power tool appliance, comprising a first housing part (14), in particular for accommodating a transmission and/or a drive motor for a tool, and comprising a second housing part (16), for constituting a handle (18) for guiding the electric hand-held power tool appliance (10), the first (14) and the second (16) housing part being connectable to one another, but being able to be vibrationally decoupled from one another, at least partially, in that at least one spring and damping element is arranged between the housing parts (14, 16) at at least one joining point (20, 22), there being provided, as a spring and damping element, a helical compression spring (24) having at least one rubber or rubber-elastic damping element (28) succeeding in an axial direction as viewed from a tool side.

Abstract: Substrates (100) are described for receiving a plurality of samples, especially for the preservation of biological samples at cryotemperatures comprising a plurality of substrate plates (11, 12, 13) arranged on top of one another as a stack (10) and comprising an anchoring axis (20) to which the substrate plates (11, 12, 13) are connected. Processes for the preservation of biological samples at cryotemperatures are also described.

Abstract: The invention relates to a device and method for handling a probe, in particular, for treating, examining, inserting or extracting a cryoprobe. According to the invention, said probe is surrounded by an ambient gas, during handling, and an air-conditioning device (33) cools, dries and/or at least partially replaces the ambient gas by a protective gas, in order to prevent deterioration of the probe by the ambient gas during handling.

Abstract: A sample support (100, 101, 102, . . . ), in particular for cryopreservation of biological samples, is described and includes: a holder part (10) with a sample receiving chamber (11), a retaining device (12, 13) on which a sample can be disposed, and support connecting elements (14, 15) which are directed at opposite holder part ends (16, 17) and are formed to fit together so that a plurality of holder parts (16) can be put together. A sample store (200), which includes an assemblage of a large number of such sample supports, and a method for the cryopreservation of biological samples, are also described.

Abstract: A cryopreservation storage device (100), in particular for cryopreservation of biological samples, comprises a plurality of multi sample modules (20) being adapted for accommodating the biological samples and sample memories, a module control device (30) controlling an access to sample memories accommodated by the multi sample modules (20), and a data interface (41) for accessing to the module control device (30), wherein the module control device (30) includes a data management processor (31), which can be controlled via the data interface (41). Furthermore, a cryopreservation apparatus including at least one cryopreservation storage device (100) and a method for cryopreservation of biological samples are described.

Abstract: The invention relates to a sample receiving device (100), particularly for the cryoconservation of at least one sample, including a bundle (10) consisting of a plurality of hose-shaped flexible sample chambers (11, 12, . . . ) and a holding device (20) with which the bundle (10) of the sample chambers is joined. The holding device (20) has a plurality of holding frames (21, 22, . . . ) which are arranged in a longitudinal direction of the bundle (10).

Abstract: The invention relates to sample supports and methods for cryoconservation, especially the cryoconservation of biological materials, comprising at least one sample reservoir used to receive a biological sample. A support body is disposed in the sample reservoir, made of a material having a volume structure, consisting of a plurality of open, inner cavities which can be filled with the sample. The invention also relates to the use of motor vehicle catalyst-structure or biomorphic ceramics for producing support bodies used to receive samples for cryoconservation.

Abstract: A cell transfer method is described, in which transfer of at least one biological cell (21) describing a natural cell locomotion between a carrier (80) and a probe (10) is provided, and whereby positioning the probe (10) and the carrier (80) relative to one another in a transfer arrangement is provided, in which transfer of the cell (21) takes place due to the natural cell locomotion. Probes and cell manipulators for transferring biological cells are also described.

Abstract: The invention relates to a cryoapparatus for freezing and/or thawing a sample (1), especially in the cryopreservation of a biological sample (1), with a coolable cooling space (3) and with a sample container (10) arranged in the cooling space (3) for temporarily receiving the sample (1) when freezing or thawing the sample (1). It is suggested that the sample container (10) can be tempered separately from the cooling space. Furthermore, the invention comprises an associated operating method.

Abstract: The invention relates to a cooling device (1) for cooling an item to be cooled, especially for use in the examination, handling and processing of cryogenic samples. The device includes a cooling compartment (3) for receiving the item to be cooled, an inner wall defining the cooling compartment (3), an outer wall, a space between the outer wall and the inner wall, and a coolant feed line (11) for feeding a coolant. According to the invention, the coolant feed line (11) leads into the space between the inner wall and the outer wall and feeds the coolant into the space, the inner wall being permeable for the coolant.

Abstract: The invention relates to a cooling apparatus, especially for cryogenically preserving biological samples, comprising a duct (5) for delivering a coolant (3) to a cooling chamber (1), a heater (6) that has an adjustable first heating performance (P2) for heating the coolant (3) delivered to the cooling chamber (1), a first temperature sensor (8-10) for measuring the temperature (T2-T4) in the cooling chamber (1), a second temperature sensor (7) for measuring the temperature (T1) of the coolant (3) delivered to the cooling chamber (1), and a regulator (11) for regulating the temperature. Said regulator (11) is embodied as a multiple regulator which detects several temperatures (T1-T4) as control variables and/or adjusts several heating performances (P1, P2) as manipulated variables. The invention further relates to a corresponding operating method.

Abstract: A method for producing cell material (20) having multiple biological cells (21), which have a predefined geometrical arrangement, includes the steps of providing a manipulation tool (10) having a tool body (11), whose surface (12, 14) at least partially contacts the cell material (20), and adjusting the manipulation tool (10) using a change of geometrical properties of the surface (12, 14) in such a way that the geometrical arrangement of the cells (21) is changed. A manipulation tool for performing a method of this type is also described.

Abstract: The invention relates to a sample holding device (100), particularly for cryopreserving at least one sample, which has a bundle (10) consisting of a multitude of tubular flexible sample compartments (11, 12,) and a retaining device (20), to which the bundle (10) of sample compartments is connected. The retaining device (20) has a multitude of retaining frames (21, 22,) that are arranged in a longitudinal direction of the bundle (10).

Abstract: The invention relates to a device and method for handling a probe, in particular, for treating, examining, inserting or extracting a cryoprobe. According to the invention, said probe is surrounded by an ambient gas, during handling, and an air-conditioning device (33) cools, dries and/or at least partially replaces the ambient gas by a protective gas, in order to prevent deterioration of the probe by the ambient gas during handling.

Abstract: Substrates (100) are described for receiving a plurality of samples, especially for the preservation of biological samples at cryotemperatures comprising a plurality of substrate plates (11, 12, 13) arranged on top of one another as a stack (10) and comprising an anchoring axis (20) to which the substrate plates (11, 12, 13) are connected. Processes for the preservation of biological samples at cryotemperatures are also described.

Abstract: A method for moving a probe (10, 91) through a cell material (20), which is formed from biological cells (21), is described, the probe (10) displacing the cells (21) without injury. A probe (10, 91) for performing the method and a cell manipulator, which is equipped with at least one probe of this type, are also described.

Abstract: A carrier (10) for at least one specimen chamber (11), in particular for cryoconservation of biological specimens is described, comprising a mounting frame (20) which is set up for positioning the specimen chamber (11) and has a first frame part (30) and a second frame part (40) which can be detachably assembled with connecting elements (50) and are in contact on the side faces (31, 41) in the assembled state, wherein the specimen chamber (11) can be secured between the side faces (31, 41).