Abstract: A method for controlling an electric amplifier is provided. The method includes monitoring a closed-loop control signal of a regulator, which triggers an end stage of the amplifier; adjusting the closed-loop control signal as a function of an output signal of the end stage; comparing the closed-loop control signal with a reference signal; triggering the end stage when an amplitude limit value and a period length limit value are exceeded or undershot by the amplitude value and period length value, respectively, of the closed-loop control signal; and blocking an input side and/or the regulator when the end stage is triggered.

Abstract: A method for generating at least one modulator input signal from at least one regulator signal is provided. The method comprising: generating at least one dither signal based on the periodic output of elements of a discrete dither sequence of the basic form DF=0, 1, 2 . . . 2(m?n)?1; and adding the at least one dither signal to the regulator signal. The regulator signal comprises a digital regulator signal with a length of m bits, and the modulator input signal comprises a digital modulator input signal with a length of n bits, where m>n.

Abstract: The use of polyalkylene oxide modified reagents is disclosed in a method for the detection of an analyte or in suitable reagent kits for such methods.

Abstract: An electrical amplifier comprising an output stage that can be supplied by an electrical energy source, is connected to a control device on the input side, the control signal of the control device controlling an output signal of the output stage dependent on a parameter value of the energy source. The amplifier is has a compensation device that is connected to the energy source and the control device, and is used to modify the control signal according to the parameter value of the energy source which can be, for example, the network voltage of the energy source. A method for controlling an electrical amplifier comprising an output stage supplied by an electrical energy source includes, determining parameter value of the energy source, deriving a compensation signal therefrom, and a control signal for the output stage is generated according to the compensation signal. The amplifier and method can be used in a gradient amplifier for a magnetic resonance appliance.

Abstract: The present invention relates to the field of therapeutic antibodies. The invention especially relates to a method of detecting the target antigen of a therapeutic antibody in a sample comprising the steps of a) providing the sample to be analyzed, b) incubating said sample with said therapeutic antibody under conditions appropriate for binding of said therapeutic antibody to said target antigen, whereby a target antigen-therapeutic antibody-complex is formed, and c) detecting the complex formed in (b).

Abstract: A stabilization circuit wherein voltages of the secondary winding of a transformer are stabilized with respect to mains voltage fluctuations and load fluctuations, an auxiliary voltage is derived either from a secondary winding of the transformer or an auxiliary transformer. Together with the mains voltage portion of this auxiliary voltage acquired by pulse-width modulation forms the primary voltage of the transformer such that the desired stabilization is achieved.

Abstract: The invention concerns a method for determining antigen-specific antibodies of a particular immunoglobulin class in a sample by means of an immunoassay in an array format in which various binding partners Bnx are bound on different discrete areas on a support where Bnx in each case contain the various antigens that are able to specifically bind to the antibodies to be detected, by incubating the support with the sample and a binding partner B2 which carries a label and subsequently detecting the label on the respective discrete areas wherein B2 specifically binds antibodies of a certain immunoglobulin class that have been bound in an antigen-specific manner.

Abstract: By deglycosylating an enzyme derived from a eukaryotic organism prior to forming a conjugate, i.e. prior to attaching the enzyme to a molecule capable of binding to a target molecule, the sensitivity of an assay for detecting the presence or determining the quantity of a target molecule, in which the conjugate is used as a labelled component, can be increased. The present invention provides conjugates, methods for providing the same, use of such conjugates as well as kits containing the conjugates.

Abstract: A solid phase with at least one test area is described which contains reagents for the detection of at least one analyte in a sample, wherein the solid phase additionally comprises at least one control area for the detection of interfering reactions.

Abstract: A power amplifier, particularly a gradient amplifier of a magnetic resonance tomography apparatus, has at least one switched output stage containing a power bridge circuit formed by a number of switch elements and connected to a floating intermediate circuit voltage, as well as at least one digital pulse width modulator that generates pulse-width-modulated control signals for all switch elements from a digital input signal in order to generate at least one output stage voltage according to an output stage switch clock. The digital pulse width modulator is preceded by a pre-modulator for forming the digital input signals, with at least one of the digital input signals containing an offset, preferably corresponding to half an LBS.

Abstract: A power amplifier, particularly a gradient amplifier of a nuclear magnetic resonance tomography apparatus, has at least one switched output stage containing a power bridge circuit formed by a number of switch elements, the bridge circuit being connected to a floating intermediate circuit voltage, as well as at least one digital pulse width modulator that generates pulse-width-modulated control signals for all switch elements of the power bridge circuit from digital input signals in order to generate at least one output stage voltage according to an output stage switching clock.

Abstract: The invention concerns a method for the purification of a target substance from a biological sample by immobilizing the target substance on a solid phase by means of a high affinity binding pair and subsequently eluting it by adding a partner of the binding pair in a free form. In addition reagent kits for carrying out the method are disclosed.

Abstract: A stabilization circuit wherein voltages of the secondary winding of a transformer are stabilized with respect to mains voltage fluctuations and load fluctuations, an auxiliary voltage is derived either from a secondary winding of the transformer or an auxiliary transformer. Together with the mains voltage portion of this auxiliary voltage acquired by pulse-width modulation forms the primary voltage of the transformer such that the desired stabilization is achieved.

Abstract: A solid phase with at least one test area is described which contains reagents for the detection of at least one analyte in a sample, wherein the solid phase additionally comprises at least one control area for the detection of interfering reactions.

Abstract: Gradient amplifier for an MR tomography apparatus has a controller for current control that is connected to a modulator stage upstream before an output stage. The output stage supplies a voltage to a gradient coil connected thereto, thereby producing a coil current in the gradient coil. The controller has a comparator for comparing a reference value of the coil current to the actual value of the coil current, and a P control branch connected downstream from the comparator and an I control branch situated at the output of the P control branch. The outputs of the control branches are fed to an adder via scaling resistors. An output of a differential control stage is fed to the adder. The differential control stage emits an output voltage that relieves the controller, the output voltage being proportional to the slope of a pulse edge of the gradient coil current.

Abstract: The use of polyalkylene oxide modified reagents is disclosed in a method for the detection of an analyte or in suitable reagent kits for such methods.

Abstract: The invention concerns an immunological process for the detection of an analyte in a sample, in particular of tumor markers wherein for the reduction of interference substances containing a peptide sequence derived from the framework regions of the variable domain of the antibodies to be detected or the antibodies used for immune therapy or scintigraphy are added to the test preparation. Furthermore, the invention concerns the use of such substances for the reduction of interference of immunoassays, a suppressive agent and a process for the reduction of interference of immunoassays by the substances mentioned.

Abstract: In order to extend the measuring range and to reduce the Hook effect in an immunological method of determination of an antigen based on the principle of a sandwich assay it is preferable to use a method which is characterized in that the labelled detection molecule is an oligomer of a binding molecule selected from antibody or/and antibody fragment.

Abstract: A method or apparatus for the simulation of electrical stimulations in an examination subject which are generated by rapidly switched gradient fields of an MR device, and wherein aborting of the executed measuring sequence occurs given the crossing of a threshold value in an online monitoring, wherein the crossing of the threshold value is signaled prior to the execution of the measuring sequence in a look-ahead monitoring, at least one gradient signal G(t) is determined which is defined by the time characteristic of the gradient pulses, at least one first filtered gradient signal GF1(t) is formed by filtering the gradient signal G(t) with a first filtering function fF1(t) a stimulation signal Stim(t) is formed which describes the stimulation of the examination subject, from the first filtered gradient signal GF1(t), and the stimulation signal Stim(t) is compared to a definable stimulation threshold value Stimlim. If Stimlim is exceeded an indicator indicating that a stimulation has occurred is emitted.

Abstract: The invention concerns the use of peptides which are comprised essentially of D-amino acids to eliminate interference in diagnostic methods, a method for eliminating interference in diagnostic methods by peptides which are comprised essentially of D-amino acids as well as a reagent that eliminates interference containing at least one peptide which is comprised essentially of D-amino acids.