Patents by Inventor Helmut Mack

Helmut Mack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110306696
    Abstract: The invention relates to a process for the preparation of copolymers containing acid monomer structural units and polyether macromonomer structural units, which is carried out in a continuous mode of operation in a reactor which has ?) a body B rotating about an axis of rotation and having a reaction surface, ?) a metering system and ?) a device for irradiating the reaction surface, i) the components of a starting reaction composition being applied individually and/or as a mixture with the aid of the metering system in a thin film on an inner region of the reaction surface of the rotating body B so that the thin film flows over the reaction surface of the rotating body B to an outer region of the reaction surface of the rotating body B, the thin film on the reaction surface being electromagnetically irradiated by means of the device for the irradiation of the reaction surface, ii) the thin film leaving the reaction surface as a reaction composition which has copolymer containing acid monomer structural uni
    Type: Application
    Filed: October 8, 2009
    Publication date: December 15, 2011
    Inventors: Silke Flakus, Laurent Marc, Zhizhong Cai, Helmut Mack, Burkhard Walther, Jochen Mezger, Simone Klapdohr, Tobias Austermann
  • Publication number: 20110301275
    Abstract: The invention relates to a copolymer comprising i) 3 to 40 mol % of an isoprenolpolyether derivative structural unit ? ii) 3 to 40 mol % of a vinyloxypolyether derivative structural unit ? and iii) 35 to 93 mol % of an acid structural unit ?, the structural units of the copolymer which belong to the vinyloxypolyether derivative structural unit ? having longer side chains than the structural units which belong to the isoprenolpolyether derivative structural unit ?.
    Type: Application
    Filed: November 25, 2009
    Publication date: December 8, 2011
    Applicant: Construction Research & Technology GmbH
    Inventors: Silke Flakus, Klaus Lorenz, Helmut Mack, Christian Scholz, Petra Wagner, Barbara Wimmer, Angelika Hartl, Martin Winklbauer, Manfred Bichler
  • Patent number: 8044069
    Abstract: The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein Ar1, Ar2, L1, L2, n, R1, R4, X and Y are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: October 25, 2011
    Assignees: Abbott Laboratories, Abbott GmbH & Co. KG
    Inventors: Pramila A. Bhatia, George A. Doherty, Irene Drizin, Helmut Mack, Richard J. Perner, Andrew O. Stewart, Qingwei Zhang
  • Publication number: 20110232825
    Abstract: The invention provides an adhesive or sealant comprising at least (A) one compound selected from the group consisting of silylated polyurethanes, silylated polyureas, silylated polyethers, silylated polysulfides and silyl-terminated acrylates, and at least (B) one cyclohexane polycarboxylic acid derivative. The composition has enhanced extensibility with good adhesion properties and high tensile strength. A process is disclosed for preparing the adhesive or sealant, and also disclosed is the use thereof for producing material bonds between parts to be joined.
    Type: Application
    Filed: December 2, 2009
    Publication date: September 29, 2011
    Applicant: BASF SE
    Inventors: Helmut Mack, Tobias Austermann, Boris Breitscheidel, Jochen Wagner
  • Publication number: 20110152325
    Abstract: The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula I in which R1, R2, R3 R4, R5, m and n have the meanings mentioned in the claims and the description, the tautomers thereof, the hydrates thereof and the pharmaceutically suitable salts thereof.
    Type: Application
    Filed: December 20, 2010
    Publication date: June 23, 2011
    Applicants: Abbott GmbH & Co. KG, Abbott Laboratories
    Inventors: Andreas Kling, Katja Jantos, Helmut Mack, Achim Möller, Wilfried Hornberger, Gisela Backfisch, Yanbin Lao, Marjoleen Nijsen
  • Publication number: 20110152265
    Abstract: The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula I in which R1, R2, R3 R4, R5, m and n have the meanings mentioned in the claims and the description, the tautomers thereof, the hydrates thereof and the pharmaceutically suitable salts thereof.
    Type: Application
    Filed: December 20, 2010
    Publication date: June 23, 2011
    Applicants: Abbott GmbH & Co. KG, Abbott Laboratories
    Inventors: Andreas Kling, Katja Jantos, Helmut Mack, Achim Möller, Wilfried Hornberger, Gisela Backfisch, Yanbin Lao, Marjoleen Nijsen
  • Publication number: 20110144288
    Abstract: The invention relates to a process for the preparation of silylated polyurethanes and/or polyureas, comprising the steps: a) application of a component ?) containing isocyanate and of a component ?) containing polyol and/or polyamine to at least one surface of body A, which surface rotates about an axis of rotation and has a temperature between 60 and 400° C., and b) reaction of the reaction product of ?) isocyanate and ?) polyol and/or polyamine with a silylating agent.
    Type: Application
    Filed: June 16, 2009
    Publication date: June 16, 2011
    Inventors: Simone Klapdohr, Burkhard Walther, Helmut Mack, Zhizhong Cai, Laurent Marc, Jochen Mezger, Tobias Austermann, Silke Flakus
  • Publication number: 20110132144
    Abstract: The invention relates to a process for the preparation of metal nanoparticles, selected from the group consisting of lead, bismuth, zinc, antimony, indium, gold, nickel, cobalt, palladium, platinum, iridium, osmium, rhodium, ruthenium, rhenium, vanadium, chromium, manganese, niobium, molybdenum, tungsten, tantalum, cadmium, silver and/or copper, on a rotating body, characterized in that a reduction of corresponding metal salts, corresponding metal salt complexes, corresponding metal hydroxides and/or corresponding metal oxides by polyols having a number of hydroxyl groups in the polyol of 1 to 10 and a molecular weight of the polyols of 2000 to 18 000 Da is effected.
    Type: Application
    Filed: July 15, 2009
    Publication date: June 9, 2011
    Inventors: Jochen Mezger, Laurent Marc, Simone Klapdohr, Burkhard Walther, Zhizhong Cai, Tobias Austermann, Silke Flakus, Helmut Mack
  • Publication number: 20110132551
    Abstract: The present invention relates to a method for removing isocyanate from a reaction product of isocyanate with compounds reactive towards isocyanates, the reaction product being applied to the surface of a rotating body A, the reaction product flowing over the surface of the rotating body A to an outer region of the surface of the rotating body A and isocyanate which was used for the preparation of the reaction product and has not reacted evaporating from the mixture in the process.
    Type: Application
    Filed: June 16, 2009
    Publication date: June 9, 2011
    Inventors: Simone Klapdohr, Burkhard Walther, Helmut Mack, Zhizhong Cai, Laurent Marc, Jochen Mezger, Tobias Austermann, Silke Flakus
  • Publication number: 20110126421
    Abstract: The invention relates to a method for removing water from a mixture containing at least one compound having at least one group reactive towards isocyanate and containing water, the mixture being applied to the surface of a rotating body A, the mixture flowing over the surface of the rotating body A to an outer region of the surface of the rotating body A and water evaporating from the mixture. In particular, this method is suitable for removing water from alcohols and amines.
    Type: Application
    Filed: May 28, 2009
    Publication date: June 2, 2011
    Inventors: Simone Klapdohr, Burkhard Walther, Helmut Mack, Zhizhong Cai, Laurent Marc, Jochen Mezger, Tobias Austermann, Silke Flakus
  • Patent number: 7939616
    Abstract: The present Invention relates to a mixture comprising catenary, branched and for cyclic siloxanes of the general formula (I) where x is 1, 2 or 3, the substituents R are (i) organofunctional groups selected from —CH2—SH, —CH2—S—(CO)—R?, —CH2—(O—C2H4)a—OH with a=1 to 10, —CH2(O—C2H4)b—OR? with b=1 to 40, —(CH2)—NH2, —(CH2)—NHR?, —(CH2)—NR?2, —(CH2)—NH(CH2)2—NH2, —(CH2)—N[(CH2)2—NH2]2 and —(CH2)—NH(CH2)2—NH(CH2)2—NH2, In which R? is a linear, branched or cyclic alkyl group having 1 to 18 carbon atoms or an aryl group having 6 to 12 carbon atoms, (ii) hydroxyl, methoxy, ethoxy, 2-methoxyethoxy, isopropoxy, n-propoxy, isobutoxy and for n-butoxy groupe, and (iii) where appropriate, alkyl, alkenyl, isoalkyl, cycloalkyl or fluorcalkyl groups having 1 to 18 carbon atoms or aryl groups having 6 to 12 carbon atoms, whit the proviso that not more than one organofunctional group (i) is attached per silicon atom, the quotient of the molar ratio of the moiety (ii) to silicon le from I to 2, and the degree of oligornerizati
    Type: Grant
    Filed: March 18, 2004
    Date of Patent: May 10, 2011
    Assignee: Evonik Degussa GmbH
    Inventors: Dieter Barfurth, Helmut Mack
  • Publication number: 20110086879
    Abstract: The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula I in which R1, R2, R3a, R3b, R4, Q, Y, A and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula Ia and Ib in which R1, r, R2b, R3a, R3b, R4, Y and X have the meanings mentioned in the claims, including the tautomers thereof and the pharmaceutically suitable salts thereof.
    Type: Application
    Filed: November 5, 2010
    Publication date: April 14, 2011
    Applicants: Abbott GmbH & Co. KG, Abbott Laboratories
    Inventors: Helmut Mack, Andreas Kling, Katja Jantos, Achim Moeller, Wilfried Hornberger, Charles W. Hutchins
  • Publication number: 20110071285
    Abstract: The invention relates to novel amidines and quanidines, the production and use thereof and the use thereof as trypsine-type serine protease competitive inhibitors, especially thrombine and compliment proteases CIs and C1r. The invention also relates to pharmaceutical compositions which contain said compounds as active ingredients, in addition to the use of the compounds as thrombine inhibitors, anticoagulants, compliment inhibitors and anti-inflammatory agents. The novel compositions are characterised by the linkage of a serine protease inhibitor having amidine or guanidine functions with an alkyl radical having two or more hydroxyl functions, whereby said alkyl radical is derived from sugar derivates. Several sugar structural components or components derived from sugar can therefore be linked to each other. Said principle of linking sugar derivates enables oral active compounds to be obtained.
    Type: Application
    Filed: August 4, 2010
    Publication date: March 24, 2011
    Applicant: Abbott GmbH & Co. KG
    Inventors: Dieter Herr, Helmut Mack, Werner Seitz, Wilfried Hornberger
  • Publication number: 20110059968
    Abstract: The present invention relates to novel carboxamide compounds of the formula I and their use for the manufacture of a medicament. The carboxamide compounds are prodrugs of inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity.
    Type: Application
    Filed: December 29, 2008
    Publication date: March 10, 2011
    Applicant: Abbott GmbH & Co. KG
    Inventors: Wilfried Hornberger, Helmut Mack, Andreas Kling, Achim Moeller, Barbara Vogg, Jürgen Delzer, Gisela Backfisch, Armin Beyerbach
  • Publication number: 20110054083
    Abstract: The invention relates to a copolymer which is suitable as a superplasticizer for hydraulic binders and comprises 5 to 55 mol % of an isoprenol polyether derivative structural unit, 2 to 90 mol % of an acrylic acid derivative structural unit and 2 to 90 mol % of a hydroxyalkyl acrylate structural unit.
    Type: Application
    Filed: January 12, 2009
    Publication date: March 3, 2011
    Inventors: Klaus Lorenz, Gerhard Albrecht, Silke Flakus, Alexander Kraus, Helmut Mack, Petra Wagner, Christian Scholz, Barbara Wimmer, Angelika Hartl, Martin Winklbauer
  • Publication number: 20110034592
    Abstract: The invention relates to a process for the preparation of an aqueous solution comprising 30 to 95% by weight of water and 5 to 70% by weight of a copolymer dissolved in the water by free radical solution polymerizations of an isoprenol polyether derivative with an acrylic acid derivative, so that the copolymer has 20 to 45 mol % of an isoprenol polyether derivative structural unit and 55 to 80 mol % of an acrylic acid derivative structural unit. The aqueous solution is suitable as a superplasticizer for hydraulic binders.
    Type: Application
    Filed: January 12, 2009
    Publication date: February 10, 2011
    Inventors: Klaus Lorenz, Gerhard Albrecht, Silke Flakus, Alexander Kraus, Helmut Mack, Petra Wagner, Barbara Wimmer, Christian Scholz, Angelika Hartl, Martin Winklbauer
  • Publication number: 20110009529
    Abstract: The invention relates to a copolymer which can be used as a superplasticizer for hydraulic binders and comprises 30 to 47 mol % of a (meth)allyl alcohol polyether derivative structural unit and 53 to 70 mol % of a maleic acid derivative structural unit.
    Type: Application
    Filed: January 12, 2009
    Publication date: January 13, 2011
    Inventors: Silke Flakus, Klaus Lorenz, Gerhard Albrecht, Helmut Mack, Angelika Hartl, Martin Winklbauer, Petra Wagner, Barbara Wimmer, Christian Scholz
  • Patent number: 7847018
    Abstract: The present invention relates to a polymer dispersion wherein the components of a physical mixture comprising (i) at least one unsaturated silane of the general formula (I): [H2C?CX(Y)n]Si(CH3)p(R)3-p in which X is a hydrogen atom or a methyl group, Y is a divalent group selected from —CH2— and —C(O)O—(CH2)3—, n is 0 or 1, R is an alkoxy group selected from methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, and 2-methoxyethoxy, and p is 0 or 1, and (ii) at least one organosilane of the general formula (II): R1Si(CH3)q(R2)3-q in which R1 is a linear, branched or cyclic alkyl group having 1 to 18 carbon atoms or is an aryl group or is a polyether group, R2 is an alkoxy group selected from methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy and 2-methoxyethoxy, and q is 0 or 1, and/or at least one silicic ester of the general formula (III): Si(R3)4, in which groups R3 are identical or different and R3 is an alkoxy group selected from methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy and isobutox
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: December 7, 2010
    Assignee: Evonik Degussa GmbH
    Inventors: Dieter Barfurth, Helmut Mack
  • Publication number: 20100298326
    Abstract: The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula I in which R1, R2, R3a, R3b, W, Y and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula I-A.a? and I-A.a? in which m, E, R1, R3a, R3b, R2, Ry, Rw and Rw6* have the meanings mentioned in the claims, n is 0, 1 or 2, the tautomers thereof and the pharmaceutically suitable salts thereof.
    Type: Application
    Filed: December 28, 2007
    Publication date: November 25, 2010
    Inventors: Andreas Kling, Wilfried Hornberger, Helmut Mack, Achim Moeller, Volker Nimmrich, Dietmar Seemann, Wilfried Lubisch
  • Publication number: 20100286146
    Abstract: The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula I in which R1, R2, R3a, R3b, R4, Q, Y, A and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula Ia and Ib in which R1, r, R2b, R3a, R3b, R4, Y and X have the meanings mentioned in the claims, including the tautomers thereof and the pharmaceutically suitable salts thereof.
    Type: Application
    Filed: April 27, 2010
    Publication date: November 11, 2010
    Applicant: Abbott GmbH & Co. KG
    Inventors: Helmut Mack, Andreas Kling, Katja Jantos, Achim Moeller, Wilfried Hornberger