Abstract: The present invention relates to prodrugs of pharmacologically active five-membered heterocyclic amidines from which are produced in vivo compounds which are competitive inhibitors of trypsin-like serine proteases, in particular thrombin and kininogenases such as kallikrein, to the preparation thereof and to the use thereof as medicines. The invention also relates to pharmaceutical compositions which comprise the prodrugs of the active compounds as ingredients, and to the use of the compounds as thrombin inhibitors, anticoagulants and as antiinflammatory agents.

Abstract: A composition containing an alkoxysiloxane including a catenate alkoxysilane of formula I and/or a cyclic siloxane of formula II, and a crosslinkable polymer compound and the use thereof as a water scavenger, dryer or precuring retarder R3Si—O—[SiR2—O—]mSiR3??(I)

Abstract: The invention relates to novel compounds which bind to integrin receptors, and to the preparation thereof and the use thereof as drugs.

Abstract: The invention relates to 3,4-dihydro-thieno[2,3-d]pyrimidin-4-one derivatives which are substituted in position 3 by 5-membered heteroaryl which may be fused to an aryl or heteroaryl radical, where the heteroaryl and, if appropriate, the fused aryl or heteroaryl radical may have 1, 2 or 3 substituents selected independently of one another from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halo-C1-5-alkyl, halo-C1-5-alkoxy, hydroxy, —NH2, —N(R6)2, —NH(R6), aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl, where the substituents aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl may have 1, 2 or 3 substituents selected independently of one another from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halo-C1-5-alkyl, halo-C1-5-alkoxy, hydroxy, —NH2, —N(R6)2 and —NH(R6). The preparation and use of these derivatives, especially for therapeutic purposes, e.g. for the treatment of depressions, are likewise described.

Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.

Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R1, R2, A, B, C and D have the meanings described in the specification.

Abstract: A compound having at least one H—Si group is reacted with an unsaturated aliphatic compound in the presence of a platinum catalyst and at least one organic additive component. The combination of platinum catalyst and additive component is one of: (i) a solution of a Pt(0) complex catalyst in a solvent, with at least one organic amide, or (ii) a solution of a Pt(0) complex catalyst in a solvent, with at least one organic amine, or (iii) a solution of a Pt(0) complex catalyst, in a solvent, with at least one organic nitrite.

Abstract: An oligomer mixture of n-propylethoxysiloxanes, containing from 80 to 100% by weight of n-propylethoxysiloxanes having a degree of oligomerization ranging from 2 to 6.

Abstract: A metal-free, in particular tin-free, silane-terminated polyurethane which is useful in adhesives or sealant compositions is obtained by reacting at least one aliphatic secondary aminoalkylalkoxysilane of formula (Ia) R—NH—(CH2)3Si(R1)x(OR2)(3-X)  (Ia) or at least one aliphatic secondary aminoalkylalkoxysilane of formula (Ib) R—NH—CH2—CH(R1)—CH2—Si(R1)x(OR2)(3-X)  (Ib) wherein in the formulae (Ia) and (Ib), R is a linear or branched alkyl group having 1 to 18 C atoms, R1 is a methyl group, R2 is a methyl or ethyl group and x is 0 or 1, with a polyurethane prepolymer having at least one terminal isocyanate group in the absence of a metal catalyst.

Abstract: The present invention provides a process for preparing a mixture, which mixture includes catenate and cyclic siloxanes of formula I R3Si—O—(SiR2—O—)mSiR3   (I) and cyclic siloxanes of formula II wherein m is an integer from 0 to 40 and n is an integer from 2 to 40, wherein R2 and R3 are each independently an organic functional group selected from the group including alkyl, aryl, vinyl, and alkoxy groups, and wherein there is not more than one vinyl group or aryl group per silicon atom, said process including a controlled hydrolysis, condensation or cocondensation reaction of at least one monomeric silane in alcoholic solution in the presence of an acidic catalyst, which reaction includes contacting alcohol, water, and at least one chlorosilane component selected from the group including (i), (ii), (iii): (i) at least one arylchlorosilane; (ii) at least one admixture selected from the group including alkylchlorosilane and arylchlorosilane, arylchlorosi

Abstract: A siloxane mixture where the siloxanes carry aminoalkyl and alkoxy groups and, where appropriate, hydrocarbon groups and also where appropriate, hydroxyl groups.

Abstract: Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, and use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory agents.

Abstract: A composition containing an alkoxysiloxane including a catenate alkoxysilane of formula I and/or a cyclic siloxane of formula II, and a crosslinkable polymer compound and the use thereof as a water scavenger, dryer or precuring retarder.

Abstract: The invention relates to novel amidines and quanidines, the production and use thereof and the use thereof as trypsine-type serine protease competitive inhibitors, especially thrombine and compliment proteases CIs and C1r. The invention also relates to pharmaceutical compositions which contain said compounds as active ingredients, in addition to the use of the compounds as thrombine inhibitors, anticoagulants, compliment inhibitors and anti-inflammatory agents. The novel compositions are characterised by the linkage of a serine protease inhibitor having amidine or quanidine functions with an alkyl radical having two or more hydroxyl functions, whereby said alkyl radical is derived from sugar derivates.Several sugar structural components or components derived from sugar can therefore be linked to each other. Said principle of linking sugar derivates enables oral active compounds to be obtained.

Abstract: Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are described.

Abstract: The present invention provides a process for preparing a mixture, which mixture includes catenate and cyclic siloxanes of formula I

Abstract: Compositions comprising at least one liquid or carrier-bound, unsaturated organosilane, at least one free-radical generator (FRG), an optional crosslinking catalyst, a thermoplastic base polymer and a reinforcing, extending, or flame-retardant mineral filler provide moisture-crosslinked, filled cable compounds having superior properties compared to conventional cable compounds.

Abstract: A compound having at least one H—Si group is reacted with an unsaturated aliphatic compound in the presence of a platinum catalyst and at least one organic additive component.

Abstract: A siloxane mixture where the siloxanes carry aminoalkyl and alkoxy groups and, where appropriate, hydrocarbon groups and also where appropriate, hydroxyl groups.

Abstract: A composition which comprises a mixture of water-soluble, amino-functional silicon compounds which are essentially free from alkoxy groups, water, optionally a content of alcohol and optionally a content of acid, the composition comprising silicon compounds of the general formula I: NH2[CH2)2NH]x(CH2)3SiO1.5  (I) in which x is 0, 1 or 2, and of the general formula II: (SiO1.5(CH2)3[NH(CH2)2]yNH[(CH2)2NH]x(CH2)3Si)1.5  (II) in which y and z are 0, 1 or 2 and are identical or different. The compositions are obtainable by mixing corresponding aminoalkoxy silanes, hydrolyzing the mixture and removing the hydrolysis alcohol formed as a result. The invention furthermore relates to a process for the preparation of the compositions and to their use in a wide variety of applications.