Abstract: A method for amplifying a target nucleic acid is disclosed, which includes: (a) fragmenting a nucleic acid sample to create a target fragment comprising a target nucleic acid and two probe-complementary portions; (b) contacting said fragmented nucleic acid sample with a probe comprising two target fragment-complementary portions complementary to the probe-complementary portions of the target fragment; (c) rendering the fragmented nucleic acid sample single-stranded; (d) allowing the probe-complementary portions to hybridise with the target-fragment complementary portions; (e) if the probe in step (b) is not immobilised, immobilising the probe-target fragment hybrid on a solid phase via immobilisation moiety; (f) separating non-immobilised nucleic acid fragments from the solid phase; (g) contacting the solid phase with a ligase to ligate ligatable 5? and 3? ends of the target fragment whereby the target fragment is circularized; and (h) amplifying said circularized target fragment.

Abstract: The present invention provides a method for detecting or enriching for a target deoxyribonucleic acid (DNA) present in a nucleic acid sample, said method comprising: (a) fragmenting a nucleic acid sample to generate nucleic acid fragments including a target fragment containing said target DNA; (b) rendering said fragments, including said target fragment, at least partially single-stranded, wherein the single-stranded portion includes an end portion and wherein the length of said single-stranded portion is sufficient to allow hybridisation of at least part of the single-stranded portion of said target fragment to the probe of step (c); (c) contacting the at least partially single-stranded fragments of step (b) with oligonucleotides A and B of a single target-specific nucleic acid probe, wherein: (i) oligonucleotide A is a single-stranded oligonucleotide comprising at one end a first target-specific part comprising at least 10 nucleotides complementary in sequence to at least part of said single-stranded portio

Abstract: The present invention concerns a closure for mounting on a reagent vessel, the closure including a main body, a top wall attached by its edges to the top edges of the main body, at least one incision dividing the top wall into at least two parts, a flange attached to and extending outwards from the top edge of the top wall, and a hinge area connecting the top edge of the main body to the flange and the top wall.

Abstract: A method and a device for supervising the sensitivity of a protection function in an electrical power system including a metering device for measuring values of a feature, said protection function being configured to initialize an action based on a test value and a threshold value for the feature, wherein said test value is either a measured value or derived from the said measured values, the device includes a computing unit configured to receive the test values and, repeatedly during the operation of the protection function, to calculate a mean value and a deviation of the test values, to determine the probability of a false action based on the calculated mean value, the threshold value and the calculated deviation, and to indicate that the sensitivity is too high when the probability of a false action exceeds a first limit value for the probability of a false action.

Abstract: A gyratory crusher including a crusher head on which a first crushing shell is mounted, a frame on which a second crushing shell is mounted, the first and second crushing shells forming a crushing aperture. A drive device is adapted to rotate an eccentric to which the crusher head is so connected as to be caused, during rotation of the eccentric, to perform a gyratory movement for crushing of material which is introduced into the crushing aperture. A dust seal is adapted to seal a gap between the frame and a fastening portion situated close to the crusher head. The dust seal includes a seal bellows and a seal slide ring. The seal slide ring is connected sealingly to a lower portion of the seal bellows and has a lower slide surface adapted to slide along, and to sealingly abut, with a substantially vertical abutment pressure determined by the inherent weight of the seal slide ring and by the influence of the seal bellows, against an upper slide surface provided on the frame.

Abstract: Systems and methods for organizational purchasing are disclosed herein. More specifically, in certain embodiments a campaign corresponding to a product may be created and potential buyers informed of the campaign. These potential buyers may then themselves purchase the product in association with the campaign. In this manner not only are potential buyers informed that a product is being offered to one or more other buyers but the purchases of the individual buyers in association with the campaign may be aggregated to, for example, achieve a lower purchasing cost for each buyer relative to what the buyer would have paid if he had purchased only the quantity of product he desired.

Abstract: A method of distributing a content object (C) using a publication server in a content delivery system, which in addition to the publication server comprises a plurality of interconnected user nodes adapted to cache content object packages and to perform on-demand playback of content objects, includes: receiving a content object; defining a partition of the content object into at least two packages; defining an initial distribution plan (IDP) identifying a collection of user nodes which are to cache the content object and package to be cached by the nodes; and transmitting the initial distribution plan to each node in the collection, enabling the user node to cache the at least one package to be cached.

Abstract: The present invention relates to a system for intracellular delivery of a cargo comprising at least one component A chosen from aliphatic linear or branched moieties with at least 4 carbon atoms and/or cyclic ring systems comprising 2-4 rings which may contain several hetero atoms chosen from N, S, O and P, wherein component(s) A is (are) attached to a cell penetrating peptide B and/or a non-peptide analogue thereof. It also relates to methods of using the system in diagnosis of diseases, as research tool and as a targeting system, a composition comprising the system and especially a pharmaceutical composition a material covered with the system and a material having the delivery systems into the material. Finally it relates to novel peptides.

Abstract: The invention relates to a method for introducing common and/or individual sequence elements in a target nucleic acid molecule in a sample containing sample nucleic acid molecules, comprising the steps: i) denaturing the sample nucleic acid molecules, if the sample nucleic acid molecules are double-stranded, to obtain single stranded sample nucleic acid molecules; ii) bringing the sample nucleic acid molecules in contact with primary, secondary and tertiary probe nucleic acid molecules, wherein the 3?-end of the tertiary probe comprise a part complementary to the primary probe and the 5?-end of the tertiary probe comprise a part complementary to a 5?-part of the target nucleic acid molecule; the 3?-end of the secondary probe is complementary to a 3?-part of the target nucleic acid molecule and the 5?-end of the secondary probe is not complementary to the target nucleic acid molecule; wherein said primary, secondary and tertiary probes comprise said common and/or individual sequence elements; iii) ligating the

Abstract: A method for controlling the dispensation of a liquid volume sample when metering amounts of liquid by sucking into a tube, probe or tip a volume of a liquid to be displaced and ejecting the sample to a different vessel. According to the method the metering act is performed normally and the liquid to be metered is displaced thereafter in a desired vessel. During the metering act and after a desired amount of liquid is sucked into the metering line, a supplementary suction step is performed wherefrom the success of the metering act can be deduced. The pressure function of the supplementary suction step is measured and this function is compared with a calibration function.

Abstract: The invention concerns a method for detecting the amounts of substances that may disturb chemical analysis performed by an analyzer for clinical chemistry. The presence and concentration of hemoglobin, bilirubin and lipemia are detected by measuring the absorbance or reflectance on at least two, preferably six, different wavelengths over the measured spectrum. The measurements are performed at two wavelengths for each substance, preferably on the absorbance peaks of the specific substance and on the root of the specific peaks. Since the three substances mentioned above each have at least one peak in the spectrum, the measurement is done on three peaks and three root positions respectively when three substances have to be measured.

Abstract: The invention provides compounds of general formula wherein A, B, p, w, x, y, and z are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract: Systems and methods for organizational purchasing are disclosed herein. More specifically, in certain embodiments a campaign corresponding to a product may be created and potential buyers informed of the campaign. These potential buyers may then themselves purchase the product in association with the campaign. In this manner not only are potential buyers informed that a product is being offered to one or more other buyers but the purchases of the individual buyers in association with the campaign may be aggregated to, for example, achieve a lower purchasing cost for each buyer relative to what the buyer would have paid if he had purchased only the quantity of product he desired.

Abstract: Systems and methods for organizational purchasing are disclosed herein. More specifically, in certain embodiments a campaign corresponding to a product may be created and potential buyers informed of the campaign. These potential buyers may then themselves purchase the product in association with the campaign. In this manner not only are potential buyers informed that a product is being offered to one or more other buyers but the purchases of the individual buyers in association with the campaign may be aggregated to, for example, achieve a lower purchasing cost for each buyer relative to what the buyer would have paid if he had purchased only the quantity of product he desired.

Abstract: The invention concerns a method for detecting the amounts of substances that may disturb chemical analysis performed by an analyzer for clinical chemistry. The presence and concentration of hemoglobin, bilirubin and lipemia are detected by measuring the absorbance or reflectance on at least two, preferably six, different wavelengths over the measured spectrum. The measurements are performed at two wavelengths for each substance, preferably on the absorbance peaks of the specific substance and on the root of the specific peaks. Since the three substances mentioned above each have at least one peak in the spectrum, the measurement is done on three peaks and three root positions respectively when three substances have to be measured.

Abstract: A method for controlling the dispensation of a liquid volume sample when metering amounts of liquid by sucking into a tube, probe or tip a volume of a liquid to be displaced and ejecting the sample to a different vessel. According to the method the metering act is performed normally and the liquid to be metered is, displaced thereafter in a desired vessel. During the metering act and after a desired amount of liquid is sucked into the metering line, a supplementary suction step is performed wherefrom the success of the metering act can be deduced. The pressure function of the supplementary suction step is measured and this function is compared with a calibration function.

Abstract: The use of compounds of formula (I) wherein R1, R3, R10, m and Ar are as defined in the Specification and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment or prophylaxis of diseases or conditions in which inhibition of kinase Itk activity is beneficial is disclosed.

Abstract: A device for identifying information on a remote video display is disclosed. The device includes a remote control having a housing with a first side and a second side, the second side defining at least one opening therein, at least one functional control located on the first side of the housing, and a camera/light module positioned inside the housing adjacent the second side, said camera/light module oriented so as to align a camera lens with, and project a light source through, the at least one opening away from the second side of the housing. A method for identifying information on a remote video display is also disclosed.