Abstract: A method of manufacturing a component carrier includes providing a laminated stack with at least one electrically conductive layer structure and/or at least one electrically insulating layer structure, at least partially covering a component with a transition layer having a thickness in a range from 0.5 nm to 1 ?m, and assembling the component with the stack.

Abstract: The cell encapsulation system (CES) device is a device used for dermal, subdermal, muscle, tissue, or organ implantation into an individual (host) that is capable of being loaded with and carrying and containing exogenously introduced cells (encapsulated cells) that can produce relevant biochemicals (factors) and/or therapeutic molecules that can be transported to the host tissue while simultaneously not eliciting a significant host immune response (to the implanted device or to the encapsulated cells). The CES device provides a means of local and/or systemic, prolonged delivery of single or multiple factors and/or therapeutic molecules to alleviate, treat, or cure a variety of acute and chronic pathologies and ailments.

Abstract: A system for predicting an activity of small Cas9 using deep learning, including a sequence input unit receiving input data on a guide sequence and target sequence of small Cas9, a predictive model generator generating a small Cas9 activity predictive model by performing deep learning for learning a relationship between small Cas9 activity data obtained from the input data on the guide sequence and target sequence of small Cas9 received from the sequence input unit and features that affect small Cas9 activity, a candidate target sequence input unit receiving candidate target sequence of small Cas9, and an activity predictor predicting small Cas9 activity by applying candidate target sequence input in the candidate target sequence input unit to the predictive model generated in the predictive model generator.

Abstract: According to a system for predicting the efficiency and an outcome of a base editor by using deep learning, it is possible to select a base editor from among 63 base editors with various protospacer adjacent motif (PAM) compatibilities and sgRNA for efficient base editing, without extensive experiments. Therefore, the system may be usefully used in all fields where gene editing is applied, such as disease treatment by gene editing.

Abstract: Provided is a genome editing composition for prime editing including a prime editor protein and a prime editing guide RNA, for editing a Z-type mutation of alpha-1 antitrypsin deficiency. The composition according to an aspect includes both a pegRNA sequence capable of effectively editing the SERPINA1 gene and prime editor 2 (PE 2), and thus, may effectively deliver the prime editor to a cell, and act specifically for a target sequence of the SERPINA1 gene, enabling genome editing with high accuracy, and therefore, may be useful as a SERPINA1 gene editing platform. In addition, the composition is capable of correcting the Z-type mutation of the SERPINA1 gene, and may be used for treatment or prevention of alpha-1 antitrypsin deficiency.

Abstract: A system for predicting prime editing efficiency by using deep learning, including: an information input unit that receives an input of data on prime editing efficiency of a prime editor, a predictive model generator for generating prime editing efficiency predictive models by performing deep learning to learn a relationship between features affecting prime editing efficiency and prime editing efficiency, by using the data received from the information input unit, a candidate sequence input unit that receives an input of a candidate target sequence for prime editing; and an efficiency predictor for predicting prime editing efficiency by applying the candidate target sequence input into the candidate sequence input unit to an efficiency predictive model generated in the predictive model generator.

Abstract: The disclosure relates to a method of evaluating functions of cancer mutations using base editors and guide RNAs, an evaluation system for mutations, and a computer-readable recording medium in which is recorded a program for executing the method by a computer.

Abstract: Logic elements (LE) that can provide a number of features. For example, the LE can provide efficient and flexible use of look up tables (LUTs) and input sharing. The LE may also provide for flexible use of one or more dedicated adders and include register functionality to provide various modes of operation that enable the various features of the LE.

Abstract: A programmable logic device (PLD) includes a plurality of logic array blocks (LAB's) connected by a PLD routing architecture. At least one LAB includes a logic element (LE) configurable to arithmetically combine a plurality of binary input signals in a plurality of stages. The LE comprises look-up table (LUT) logic having K inputs (a “K-LUT”). The K-LUT is configured to input the binary input signals at respective inputs of the K-LUT logic cell and to provide, at a plurality of outputs of the K-LUT logic cell, respective binary result signals indicative of at least two of the plurality of stages of the arithmetic combination of binary input signals. An input line network includes a network of input lines, the input lines configurable to receive input signals from the PLD routing architecture that represent the binary input signals and to provide the input signals to the K-LUT.

Abstract: A programmable logic device (PLD) includes a plurality of logic array blocks (LAB's) connected by a PLD routing architecture. At least one LAB includes a logic element (LE) configurable to arithmetically combine a plurality of binary input signals in a plurality of stages. The LE comprises look-up table (LUT) logic having K inputs (a “K-LUT”). The K-LUT is configured to input the binary input signals at respective inputs of the K-LUT logic cell and to provide, at a plurality of outputs of the K-LUT logic cell, respective binary result signals indicative of at least two of the plurality of stages of the arithmetic combination of binary input signals. An input line network includes a network of input lines, the input lines configurable to receive input signals from the PLD routing architecture that represent the binary input signals and to provide the input signals to the K-LUT.

Abstract: Disclosed is a logic element (LE) that can provide a number of advantageous features. For example, the LE can provide efficient and flexible use of LUTs and input sharing. The LE may also provide for flexible use of one or more dedicated adders and include register functionality.

Abstract: A riser for mounting to a rider-support surface of a recreational board and having a binding connected thereto comprises a first plate and a second plate selectively connectable to the first plate along a length of the first plate so as to define a connection location. A plurality of separate and interchangeable dampening members is connectable to each of the first plate and second plate. The plurality of dampening members is spaced along a portion of each first and second plate which is opposite the connection location of the first and second plates. The plurality of dampening members includes a first dampening member and a second dampening member, each having a differing hardness.

Abstract: A riser for mounting to a rider-support surface of a recreational board and having a binder connected thereto comprises a first plate and a second plate selectively connectable to the first plate along a length of the first plate so as to define a connection location. A plurality of separate and interchangeable dampening members is connectable to each of the first plate and second plate. The plurality of dampening members is spaced along a portion of each first and second plate which is opposite the connection location of the first and second plates. The plurality of dampening members includes a first dampening member and a second dampening member, each having a differing hardness.

Abstract: Disclosed is a logic element (LE) that can provide a number of advantageous features. For example, the LE can provide efficient and flexible use of LUTs and input sharing. The LE may also provide for flexible use of one or more dedicated adders and include register functionality.

Abstract: A programmable logic device (PLD) includes a plurality of logic array blocks (LAB's) connected by a PLD routing architecture. At least one LAB includes a logic element (LE) configurable to arithmetically combine a plurality of binary input signals in a plurality of stages. The LE comprises look-up table (LUT) logic having K inputs (a “K-LUT”). The K-LUT is configured to input the binary input signals at respective inputs of the K-LUT logic cell and to provide, at a plurality of outputs of the K-LUT logic cell, respective binary result signals indicative of at least two of the plurality of stages of the arithmetic combination of binary input signals. An input line network includes a network of input lines, the input lines configurable to receive input signals from the PLD routing architecture that represent the binary input signals and to provide the input signals to the K-LUT.

Abstract: Disclosed is a logic element (LE) that can provide a number of advantageous features. For example, the LE can be configured to implement register packing and/or a fracturable look up table.

Abstract: Disclosed is a logic element (LE) that can provide a number of advantageous features. For example, the LE can be configured to implement register packing and/or a fracturable look up table.

Abstract: A weatherstrip assembly includes a metal surface, a thin tie layer of polymeric material covering at least select portions of the metal surface, and an elastomeric material received over the thin tie layer of polymeric material and exhibiting improved bonding with the metal through the thin layer of polymeric material. Preferably, the thin tie layer is a polypropylene-based olefinic copolymer and an ethylene acrylic acid copolymer.

Abstract: Disclosed is a logic element (LE) that can provide a number of advantageous features. For example, the LE can be configured to implement register packing and/or a fracturable look up table.

Abstract: Methods for forming a composite for use as a vehicle weather strip and the products formed thereby are disclosed in which a main body member is formed from an elastomer polymer and an abrasion resistant decorative layer including a blend of a crosslinkable thermoplastic polyolefin and a thermoplastic vulcanizate is applied thereon. The crosslinkable thermoplastic polyolefin preferably includes a crosslinkable olefin homopolymer. The olefin homopolymer preferably contains grafted silane functional groups to allow the material to be crosslinked in the presence of moisture. The abrasion resistant decorative layer may be extruded or otherwise applied onto the main body either prior to or after the main body member is cured and either prior to or after the crosslinkable polyolefin of the abrasion resistant decorative layer is crosslinked. The material of the abrasion resistant decorative layer may be extruded into sheet form and laminated onto the main body member.