Abstract: A pubic catheter apparatus (20) for storing a urinary catheter and drawing fluid from a bladder comprises a sanitation unit (66) defining a sanitation chamber (68) for impermeably sealing a fluid outlet (42) of the catheter from the environment when the fluid outlet (42) is disposed in the sanitation chamber (68). A support (54, 72) having a retained condition for connecting and holding the sanitation unit (66) adjacent to the body of the human and a release condition for releasing and removing the sanitation unit (66) from the body of the human. The support (54, 72) can include a belt (54) and a pouch (48) disposed thereon for surrounding and storing the sanitation unit (66), and connectors (72) in the pouch (48) having the retained condition for holding the sanitation unit (66) in the pouch (48) and the release condition for removing the sanitation unit (66) from the pouch (48).

Abstract: An adapter (20) comprising a pair of rails (46) extending upwardly from a lower surface (38) and longitudinally in a direction from a long end (30) toward a short end (32) and converging to be parallel with the pair of edges (34) to define a third opening between the pair of rails (46) above the lower surface (38) for receiving the cannula (22) and stylet (24) transversely to the lower surface (38). An awning (48) positioned longitudinally between the first end and the second end and extending between and connecting the pair of rails (46) to define a first opening (42). The lower surface (38) defining a recess (50) disposed adjacent the short end (32) and extending from a second opening (44) into the channel (40) for receiving the flange (28) of the trocar (26) and defining a groove (52) for guiding the cannula (22) and the stylet (24) into the first opening (42). An indicia (54) extends from an upper surface (36) next-adjacent to the short end (32) to identify the second end for receiving the trocar (26).

Abstract: Apparatus for safely and accurately positioning the fingertip of a physician (or technician) performing a biopsy procedure, e.g., to excise a core tissue samples of the male prostate or other internal organs, to avoid injury (e.g., a needle stick) from the sharpened distal end of a biopsy needle assembly. Such apparatus comprises an open tubular member defining an elongated passageway through which a biopsy needle assembly, when actuated, can be made to pass and to extend a predetermined distance along an external path in order to effect the core sampling of a biological mass of interest. The tubular housing supports a safety flange at its distal end, such flange having a flat surface adapted to be engaged by the fingertip of the physician prior to actuation of the biopsy needle assembly.

Abstract: Herein are disclosed indoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Abstract: Soft absorbent sheets, structuring fabrics for producing soft absorbent sheets, and methods of making soft absorbent sheets. The soft absorbent sheets have a plurality of projected regions and connecting regions that connect the projected regions. The projected regions include folds that are curved relative to a machine direction of the absorbent sheet, with ends of the curved folds being on opposite sides of the projected regions, and with apexes of the curved folds being positioned downstream in the machine direction of the absorbent sheet. The absorbent sheets can be formed by structuring fabrics that have angled lines of warp yarn knuckles.

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: Soft absorbent sheets, structuring fabrics for producing soft absorbent sheets, and methods of making soft absorbent sheets. The soft absorbent sheets have a plurality of domed regions or projected regions extending from a surface of the sheets, and connecting regions form a network between domed regions. The domed and projected regions include indented bars that extend across the domed and projected regions in a substantially cross machine direction of the absorbent sheets. The absorbent sheets can be formed by structuring fabrics that have long warp yarn knuckles.

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: Herein are disclosed indoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Abstract: Herein are disclosed indoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: This invention relates to the use of cyclopropylamine derivatives for the modulation, notably the inhibition of the activity of Lysine-specific demethylase 1 (LSD1). Suitably, the present invention relates to the use of cyclopropylamines in the treatment of cancer.

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: Apparatus for safely and accurately positioning the fingertip of a physician (or technician) performing a biopsy procedure, e.g., to excise a core tissue samples of the male prostate or other internal organs, to avoid injury (e.g., a needle stick) from the sharpened distal end of a biopsy needle assembly. Such apparatus comprises an open tubular member defining an elongated passageway through which a biopsy needle assembly, when actuated, can be made to pass and to extend a predetermined distance along an external path in order to effect the core sampling of a biological mass of interest. The tubular housing supports a safety flange at its distal end, such flange having a flat surface adapted to be engaged by the fingertip of the physician prior to actuation of the biopsy needle assembly.

Abstract: Herein are disclosed indoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: Herein are disclosed indoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Abstract: Features are disclosed for proving a sequence of images scaled for substantially full screen presentation by browser applications executing on mobile computing devices. In some embodiments, a collection of story art images may be maintained. Each image may include a representation of a portion of a story, and the story may progress through the images in a predetermined sequence. A request from a mobile computing device for the next image in a sequence may be served with a copy of the next image in the sequence that has been scaled to the browser display area or the display size of the mobile device. Navigation features are disclosed for providing navigation operations without presentation of a visual indicator of the navigation operation.

Abstract: Herein are disclosed azaindazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.