Abstract: The present invention relates to novel substituted bridged urea compounds, corresponding related analogs, pharmaceutical compositions and methods of use thereof. Sirtuin-modulating compounds of the present invention may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. The present invention also related to compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Abstract: Herein are disclosed indoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Abstract: This invention relates to novel substituted benzamides according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: A fishing line float and spool device is provided having a rounded, buoyant structure, and an arraignment that allows a length of fishing line to be independently supported from the water surface. The device comprises a first and second side having a perimeter flange and an inset channel therebetween for supporting the fishing line about the perimeter of the device. A plurality of notches is disposed through the flanges of each of the float sides. The fishing line attaches around the float and is extended therefrom, whereby the notches allow the line to be tied off such that when the line is struck by a fish the float flips over for notification purposes. The center of the float includes an aperture therethrough for assisting the user when tying off the fishing line, while also providing a support for an external hand crank reel or a lighted pole.

Abstract: Herein are disclosed azaindazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Abstract: Herein are disclosed indoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Abstract: Computer-implemented methods and systems are provided for creating web-based books simulating the experience of reading a physical book. The web-based books are directly editable by users in real-time.

Abstract: A fishing line float and spool device is provided having a rounded, buoyant structure, and an arraignment that allows a length of fishing line to be independently supported from the water surface. The device comprises a first and second side having a perimeter flange and an inset channel therebetween for supporting the fishing line about the perimeter of the device. A plurality of notches is disposed through the flanges of each of the float sides. The fishing line attaches around the float and is extended therefrom, whereby the notches allow the line to be tied off such that when the line is struck by a fish the float flips over for notification purposes. The center of the float includes an aperture therethrough for assisting the user when tying off the fishing line, while also providing a support for an external hand crank reel or a lighted pole.

Abstract: Herein are disclosed indoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.

Abstract: The present invention is a toy projectile launcher in the form of a role play accessory such as a belt. The belt assembly includes a strap, a launcher housing, and projectiles stored on the belt strap. The belt strap feeds through the launcher housing so that projectiles may be launched from the strap. In one embodiment the launcher is hand-held, and includes a handle which serves both as a means for holding the launcher during operation and as a power switch for the launcher. Projectiles may be discharged singly from the launcher or continuously in a rapid-fire mode.

Abstract: The present invention is a toy projectile launcher in the form of a role play accessory such as a belt. The belt assembly includes a strap, a launcher housing, and projectiles stored on the belt strap. The belt strap feeds through the launcher housing so that projectiles may be launched from the strap. In one embodiment the launcher is hand-held, and includes a handle which serves both as a means for holding the launcher during operation and as a power switch for the launcher. Projectiles may be discharged singly from the launcher or continuously in a rapid-fire mode.

Abstract: An ablating device has a cover which holds an interface material such as a gel. The cover contains the interface material during initial placement of the device. The ablating device may also have a removable tip or a membrane filled with fluid. In still another aspect, the ablating device may be submerged in liquid during operation.

Abstract: The present invention is a toy projectile launcher in the form of a role play accessory such as a belt. The belt assembly includes a strap, a launcher housing, and projectiles stored on the belt strap. The belt strap feeds through the launcher housing so that projectiles may be launched from the strap. In one embodiment the launcher is hand-held, and includes a handle which serves both for holding the launcher during operation and as a power switch for the launcher. Projectiles may be discharged singly from the launcher or continuously in a rapid-fire mode.

Abstract: An ablating device has a cover which holds an interface material such as a gel. The cover contains the interface material during initial placement of the device. The ablating device may also have a removable tip or a membrane filled with fluid. In still another aspect, the ablating device may be submerged in liquid during operation.

Abstract: An ablating device has a cover which holds an interface material such as a gel. The cover contains the interface material during initial placement of the device. The ablating device may also have a removable tip or a membrane filled with fluid. In still another aspect, the ablating device may be submerged in liquid during operation.

Abstract: Naphthyridine and quinoline derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.

Abstract: 2H-chromen-2-one derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.

Abstract: Naphthyridine and related derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.

Abstract: Compounds of formula (I) and derivatives thereof: compositions containing them, their preparation and their use as antibacterials.

Abstract: The invention described herein relates to certain pyridazinedione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.