Abstract: A method is provided herein for neutralizing biotin interference in a binding assay for detection of an analyte in a sample, wherein the binding assay comprises contacting the sample at least with a biotinylated component and with a biotin-binding component, wherein the sample is contacted with an adsorbent substance before or during the contacting with the biotinylated component and with the biotin-binding component. A coated solid-phase system for neutralizing biotin interference in a binding assay for detection of analyte in a sample is also provided herein.

Abstract: A method and kit are provided herein for determining the ADAMTS-13 activity in a sample. The method comprises contacting the sample with a von Willebrand factor (VWF) polypeptide which has been coupled to a reporter enzyme, such as glucose-6-phosphate dehydrogenase (G6PDH).

Abstract: The present disclosure is in the field of in vitro diagnostics and relates to an easily automatable binding assay for establishing a heparin-induced thrombocytopenia, which binding assay uses Fc?RIIa protein-coated particles.

Abstract: The present invention relates to a functional, easily automatable assay for establishing a heparin-induced thrombocytopenia (HIT). What is measured is the secretion of PF4 (platelet factor 4) from activated thrombocytes.

Abstract: Methods for detection and quantitative measurement of proteins with a Coomassie Brilliant Blue Assay with improved sensitivity and maintaining high linearity over a broad measuring range are provided herein. In particular, a method of detecting a protein in a protein-containing sample is provided. The method includes providing a sample including a protein, a reagent including Coomassie Brilliant Blue and having a pH between 0.85 and 1.1, combining the sample and the reagent, and determining absorption at first and second wavelength to determine the amount of protein in the sample. The ratio of the absorption value at the first wavelength between about 580 to 620 nm to the absorption value at the second wavelength between about 520 to 370 nm is used in the spectral photometric determination of the amount of protein.

Abstract: The present invention relates to the detection and quantitative measurement of proteins with the Coomassie Brilliant Blue Assay with improved sensitivity and maintaining high linearity over a broad measuring range. In particular the present invention relates to a method of detecting a protein in a protein-containing sample, comprising providing a sample comprising a protein, a reagent comprising Coomassie Brilliant Blue, combining the sample and the reagent and determining of the absorption to determine the amount of protein in the sample, wherein the pH-value of the reagent is between pH-value 0.85 and pH-value 1.1, and the ratio of the absorption value at a first wavelength of between about 580 to 620 nm to the one at a second wavelength of between about 520 to 370 nm is used in the spectral photometric determination of the amount of protein.

Abstract: The present disclosure is in the field of in vitro diagnostics and relates to an easily automatable binding assay for establishing a heparin-induced thrombocytopenia, which binding assay uses Fc?RIIa protein-coated particles.

Abstract: The present invention relates to a functional, easily automatable assay for establishing a heparin-induced thrombocytopenia (HIT). What is measured is the secretion of PF4 (platelet factor 4) from activated thrombocytes.

Abstract: A tube connection arrangement includes a tube having a cutout configured such that a part-tube portion adjoins a full-tube portion of the tube. An insert has a first portion for being received in the full-tube portion of the tube and has an external circumference adapted to the internal circumference of the full-tube portion, and a second portion for being received in the part-tube portion of the tube. The second portion has a curved contour adapted to the internal contour of the part-tube portion, an opposite abutment side. In the inserted state of the insert, the abutment side of the second portion is directed towards the cutout and through-openings in the part-tube portion and in the second portion of the insert are aligned in order to enable a fastening element to be fed through.

Abstract: The present invention relates to a method for optically determining at least one analyte in a sample, in which a deviation from a reference value or the reference curve is evaluated as an indication that the optical determination of the at least one analyte is corrupted by measurement artifacts.

Abstract: A transportation device for easy fixing to a vehicle frame element that includes at least two parallel struts. The transportation device includes a luggage accommodating region, at least one side part, and at least one first supporting element which is fixed to the side part. The transportation device also includes at least one second supporting element which is fixed to the side part, wherein, in a closed position of the second supporting element, at least one locking unit has a closed position configured to lock a latching member in a closed position of the second supporting element.

Abstract: There is disclosed a method of treating cancer comprising administering an agonist of CD137 ligand (CD137L) to a subject in need thereof.

Abstract: A transportation device for easy fixing to a vehicle frame element that includes at least two parallel struts. The transportation device includes a luggage accommodating region, at least one side part, and at least one first supporting element which is fixed to the side pad. The transportation device also includes at least one second supporting element which is fixed to the side part, wherein, in a closed position of the second supporting element, at least one locking unit has a closed position configured to lock a latching member in a closed position of the second supporting element.