Abstract: An air conditioner for air conditioning a vehicle interior of a motor vehicle, comprising a coolant connection, a refrigerant connection, a condensed water connection, and an air supply channel connection which are each arranged in a front coupling plate and are surrounded by a circumferential seal.

Abstract: An air-conditioning system for air-conditioning a vehicle interior is disclosed. The air-conditioning system includes a blower for generating an air flow, a heating device for heating the air flow, and a ducting system that divides the air flow downstream of the heating device over at least two part air flows and supplies the at least two part air flows via associated ducts to associated air outlets, through which the part air flows exit into the vehicle interior. The heating device includes at least two separate regions each with at least one electric heating element that is separately controllable via a control device. The at least two separate regions are each permanently assigned one of the associated ducts of the ducting system.

Abstract: A ventilation device may include first and second supply ducts, a mixing section having a mixing duct into which the first and second supply ducts may lead, the first and second supply ducts arranged in the mixing section adjacent one another in a transverse direction, and first and second guides in the mixing section each running in the transverse direction and being located opposite one another in a longitudinal direction running transversely to the transverse direction, each guide having two guide walls running in the transverse direction and located opposite one another in a height direction running transversely to the transverse direction and longitudinal direction, at least one of the guide walls sloping away from the other guide wall at a slope angle with respect to the longitudinal direction.

Abstract: A shaft-bearing bush assembly for a valve arrangement for an air-conditioning system is disclosed. The shaft-bearing bush assembly includes a shaft drive-connectable to a valve of the valve arrangement and a bearing bush, in which the shaft is rotatably received relative to the bearing bush between a first rotary position and a second rotary position about an axis of rotation extending along the axial direction. A bush projection is non-rotatably arranged on the bearing bush relative to the bearing bush and a shaft projection is non-rotatably arranged on the shaft relative to the shaft. The bush projection and the shaft projection are matched to one another such that the bush projection provides a rotary stop for the shaft projection for limiting the rotary movement of the shaft between the first rotary position and the second rotary position.

Abstract: A method for operating an air conditioning system, which may include a heating device, to condition air in a vehicle interior of a motor vehicle. At least one first air path and at least one second air path may each fluidically communicate with the air conditioning system and each open out into the vehicle interior. The method may include guiding the air from the vehicle interior via one of (i) the at least one first air path and (ii) the at least one second air path to the air conditioning system as a function of an operating state set in the air conditioning system. The method may also include guiding the air from the air conditioning system via the other of the one of (i) the at least one first air path and (ii) the at least one second air path into the vehicle interior.

Abstract: An air-conditioning system for a motor vehicle may include at least two indirect heat exchangers through each of which both water and air is flowable. The water and the air may be fluidically separated from one another such that heat is transferable therebetween. The system may also include a warm water supply, a cold water supply, and at least two temperature-control devices each including a respective indirect heat exchanger of the at least two indirect heat exchangers. The warm and/or cold water supply may be in fluid communication with the at least two indirect heat exchangers. At least one indirect heat exchanger of the at least two indirect heat exchangers may communicate with the warm water supply and the cold water supply via an adjustable and controllable valve device such that a mixing ratio of a mixture of the warm water and the cold water introduced therein is adjustable.

Abstract: A motor vehicle air conditioning unit, having a housing with at least one air channel arranged therein and with at least one heat exchanger for conditioning the air in the at least one air channel, the housing having at least one first air outlet and one second air outlet, a first air outlet channel being assigned to the first air outlet and conducting air to the first air outlet, and a second air outlet channel being assigned to the second air outlet and conducting air to the second air outlet, a first vane valve and a second vane valve being provided. The first vane valve assigned to the first air outlet channel, and the second vane valve assigned to the second air outlet channel, the first vane valve and the second vane valve being rotatably fixedly connected to a shaft and being rotatable by an actuator driving the shaft.

Abstract: A HVAC system for a motor vehicle having a housing, wherein the housing has an air inlet for admitting air and a cold air path in which cold air flows is provided in the housing and a warm air path in which warm air flows is provided in the housing, wherein the warm air path and the cold air path open into a mixing chamber, wherein a mixing flap is provided for controlling the proportion of cold air flowing into the mixing chamber and the proportion of warm air flowing into the mixing chamber, wherein the mixing flap is arranged rotatable about an axis and is driven by a flap actuator which has a drive shaft, wherein a gear with a nonlinear translation characteristic is provided between the mixing flap and the drive shaft.

Abstract: An air-conditioning system for a motor vehicle includes an evaporator, a heating device arranged downstream of the evaporator, an evaporator bypass duct arranged below the evaporator, and at least one air guiding duct. The at least one air guiding duct has an inlet end that is communicatingly connected to the evaporator bypass duct and an outlet side that opens or ends between the evaporator and the heating device. The at least one air guiding duct is structured and arranged such that outside air flowing through the evaporator bypass duct and the air guiding duct(s) enters the heating device. The at least one air guiding duct includes a lateral collar extending outwardly therefrom, structured and arranged to facilitate discharging condensate from the evaporator into a condensate pan.

Abstract: An air conditioner for air conditioning a vehicle interior of a motor vehicle, comprising a coolant connection, a refrigerant connection, a condensed water connection, and an air supply channel connection which are each arranged in a front coupling plate and are surrounded by a circumferential seal.

Abstract: This invention relates to cytomegalovirus (CMV) proteins suitable for vaccine uses. Provided herein are mammalian host cells, in particular CHO cells, in which the sequence(s) encoding CMV proteins gH, gL, pUL128, pUL130, pUL131 (or a complex-forming fragment thereof) are stably integrated into the genome.

Abstract: The invention relates to methods for the production of therapeutic proteins in mammalian cells. In one embodiment, the method comprises producing a therapeutic protein such as IGF-1 in a mammalian cell endogenously expressing a cognate receptor of said recombinant therapeutic protein and wherein binding of said therapeutic protein to said cognate receptor results in a low titer of the therapeutic protein, the method comprising with a mammalian cell being deficient in the expression of the cognate receptor of said therapeutic protein and being transformed with an expression vector comprising a nucleic acid molecule encoding the therapeutic protein: a. Cultivating said cell under conditions allowing the expression of the therapeutic protein; and b. Harvesting the therapeutic protein from the mammalian cell cultivated in step a, wherein said mammalian cell produces at least 1.5 fold more therapeutic protein than a cell in which the expression of the cognate receptor has not been so modified.

Abstract: A climate control system for a vehicle interior, having a housing, a cooling device, and a heating device. At least one first flow channel, a second flow channel, and a third flow channel are disposed in the housing. A mixing chamber is disposed within the housing, which has at least one outflow opening, which is downstream of the mixing chamber in the flow direction. The flow channels are closable by a flap element, a third flow channel leads from the cooling device to the outflow opening while bypassing the mixing chamber, the flap element in the first flow channel and the flap element in the second flow channel are kinematically coupled and can be adjusted by a mutual control device. The flap element in the third flow channel is kinematically coupled to the other two flap elements or can be adjusted independently by a further control device.

Abstract: A climate control system having a housing with an air inlet, a cooling element for providing cooled air, a heating element located downstream of the cooling element, a cold air duct for directing cooled air located downstream, a bypass duct for directing cooled air located downstream of the cooling element, a hot air duct for directing heated air, a first mixing chamber for mixing cooled air from the cold air duct and heated air from the hot air duct into blended air, a second mixing chamber located downstream of the bypass duct and downstream of the first mixing chamber for mixing cooled air from the bypass duct and blended air from the first mixing chamber, an air outlet located downstream of the second mixing chamber for delivering air to a passenger compartment, and an air deflector device is located downstream of the bypass duct.

Abstract: This invention relates to cytomegalovirus (CMV) proteins suitable for vaccine uses. Provided herein are mammalian host cells, in particular CHO cells, in which the sequence(s) encoding CMV proteins gH, gL, pUL128, pUL130, pUL131 (or a complex-forming fragment thereof) are stably integrated into the genome.

Abstract: The disclosure pertains to novel eukaryotic cell suitable for recombinant production of a product of interest, wherein the genome of the host cell is altered so that the effect of protein FAM60A is impaired in said cell, e.g. by reducing or eliminating functional expression of gene FAM60A thereby improving the stability characteristics. Furthermore, the present disclosure provides associated technologies wherein such host cells are used in recombinant production technologies.

Abstract: An air-conditioning unit for air-conditioning an air flow may include a multipart housing including a first housing part and a second housing part arranged on top of the first housing part. The housing may further include an air-conditioning segment and a blower segment defining an axis of rotation. The blower segment may have a blower for driving the air flow. A suction chamber and a pressure chamber may be disposed in the blower segment, and the suction chamber and the pressure chamber may be open with respect to one another via a connecting opening. The blower may have an impeller arranged in the connecting opening. The impeller may include a suction side facing towards the suction chamber and a pressure side facing towards the pressure chamber. The housing may further include a connecting duct for fluidically connecting the blower segment to the air-conditioning segment.

Abstract: The present application pertains inter alia to an isolated vertebrate cell suitable for recombinant expression of a polypeptide of interest, wherein the vertebrate cell is altered to impair the function of the endogenous protease matriptase and wherein said cell comprises at least one heterologous polynucleotide encoding a polypeptide of interest and wherein the polypeptide of interest is secreted by the cell. It was found that using respective vertebrate cells for producing a recombinant polypeptide of interest significantly reduces clipping of the polypeptide of interest that is secreted into the cell culture medium. Also provided are improved production and screening methods.

Abstract: The disclosure pertains to novel eukaryotic cell suitable for recombinant production of a product of interest, wherein the effect of the expression product of an endogenous gene C12orf35 is impaired in said cell, thereby increasing their productivity when recombinantly expressing a polypeptide of interest. Furthermore, the present disclosure provides associated technologies wherein such host cells are used in recombinant production technologies.

Abstract: The invention relates to an air-diverting element with a flow-optimized contour for an air-conditioning system, in particular of a motor vehicle, which air-diverting element extends approximately perpendicular to an air flow direction. To divert an air flow through approximately 180° and at the same time nevertheless prevent pressure losses and disadvantageous acoustic effects, one end of the air-diverting element is adjoined by an approximately parabolic elongation which is situated opposite that side of the air-diverting element which faces away from the air flow direction.