Abstract: A climate control system having a housing with an air inlet, a cooling element for providing cooled air, a heating element located downstream of the cooling element, a cold air duct for directing cooled air located downstream, a bypass duct for directing cooled air located downstream of the cooling element, a hot air duct for directing heated air, a first mixing chamber for mixing cooled air from the cold air duct and heated air from the hot air duct into blended air, a second mixing chamber located downstream of the bypass duct and downstream of the first mixing chamber for mixing cooled air from the bypass duct and blended air from the first mixing chamber, an air outlet located downstream of the second mixing chamber for delivering air to a passenger compartment, and an air deflector device is located downstream of the bypass duct.

Abstract: An air-conditioning unit for air-conditioning an air flow may include a multipart housing including a first housing part and a second housing part arranged on top of the first housing part. The housing may further include an air-conditioning segment and a blower segment defining an axis of rotation. The blower segment may have a blower for driving the air flow. A suction chamber and a pressure chamber may be disposed in the blower segment, and the suction chamber and the pressure chamber may be open with respect to one another via a connecting opening. The blower may have an impeller arranged in the connecting opening. The impeller may include a suction side facing towards the suction chamber and a pressure side facing towards the pressure chamber. The housing may further include a connecting duct for fluidically connecting the blower segment to the air-conditioning segment.

Abstract: A climate control system for a vehicle interior, having a housing, a cooling device, and a heating device. At least one first flow channel, a second flow channel, and a third flow channel are disposed in the housing. A mixing chamber is disposed within the housing, which has at least one outflow opening, which is downstream of the mixing chamber in the flow direction. The flow channels are closable by a flap element, a third flow channel leads from the cooling device to the outflow opening while bypassing the mixing chamber, the flap element in the first flow channel and the flap element in the second flow channel are kinematically coupled and can be adjusted by a mutual control device. The flap element in the third flow channel is kinematically coupled to the other two flap elements or can be adjusted independently by a further control device.

Abstract: The invention relates to methods for the production of therapeutic proteins in mammalian cells. In one embodiment, the method comprises producing a therapeutic protein such as IGF-1 in a mammalian cell endogenously expressing a cognate receptor of said recombinant therapeutic protein and wherein binding of said therapeutic protein to said cognate receptor results in a low titer of the therapeutic protein, the method comprising with a mammalian cell being deficient in the expression of the cognate receptor of said therapeutic protein and being transformed with an expression vector comprising a nucleic acid molecule encoding the therapeutic protein: a. Cultivating said cell under conditions allowing the expression of the therapeutic protein; and b. Harvesting the therapeutic protein from the mammalian cell cultivated in step a, wherein said mammalian cell produces at least 1.5 fold more therapeutic protein than a cell in which the expression of the cognate receptor has not been so modified.

Abstract: The invention relates to an air-diverting element with a flow-optimized contour for an air-conditioning system, in particular of a motor vehicle, which air-diverting element extends approximately perpendicular to an air flow direction. To divert an air flow through approximately 180° and at the same time nevertheless prevent pressure losses and disadvantageous acoustic effects, one end of the air-diverting element is adjoined by an approximately parabolic elongation which is situated opposite that side of the air-diverting element which faces away from the air flow direction.