Patents by Inventor Howard Stone

Howard Stone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150345049
    Abstract: Embodiments of the present disclosure provide magneto-spinning apparatus, methods of use, magnetospun material (e.g., a fiber such as a low- or non-magnetic fiber), and the like.
    Type: Application
    Filed: May 28, 2015
    Publication date: December 3, 2015
    Inventors: Alexander Tokarev, Oleksandr Trotsenko, Sergiy Minko, Howard A. Stone, Ian Griffiths
  • Publication number: 20150191765
    Abstract: The present invention relates to a method of measuring biofilms and/or biofilm streamers, wherein the method comprises a system that has at least one channel and a biofilm streamer promotion element, a fluid capable of moving along the channel, wherein the fluid has a flow driven by a controlled pressure; and a measuring element capable of measuring a flow rate of the fluid through the channel. Additionally, method of screening for compound(s) that promote and/or inhibit biofilm and/or biofilm streamers using this system are also contemplated. Uses of the system, methods and identified compounds are contemplated for medical and/or industrial environments.
    Type: Application
    Filed: January 5, 2015
    Publication date: July 9, 2015
    Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Bonnie L. Bassler, Howard A. Stone, Martin F. Semmelhack, Knut Drescher, Yi Shen, Colleen T. O'Loughlin, Laura C. Miller
  • Patent number: 8986628
    Abstract: A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: March 24, 2015
    Assignees: President and Fellows of Harvard College, The Governing Council of the Univ. of Toronto
    Inventors: Howard A. Stone, Shelley L. Anna, Nathalie Bontoux, Darren Roy Link, David A. Weitz, Irina Gitlin, Eugenia Kumacheva, Piotr Garstecki, Willow R. Diluzio, George M. Whitesides
  • Patent number: 8858917
    Abstract: Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as vital infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be a surfactant and, optionally, a carrier. The formulation may be administered as a powder where the particles consist basically of the material altering surface tension. The carrier may be a solution, such as an alcohol, although an aqueous solution may be utilized, or a material mixed with the material altering surface tension to form particles.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: October 14, 2014
    Assignee: President and Fellows of Harvard College
    Inventors: David A. Edwards, Howard A. Stone
  • Publication number: 20140261675
    Abstract: A photovoltaic cell and method of making are disclosed. The photovoltaic cell includes a substrate having a surface at least partially covered in wrinkles and folds, the folds dividing the surface into a plurality of domains. A photoactive layer is formed on the substrate. At least one transparent electrode is coupled to the photoactive layer and configured to allow transmission of light into the photoactive layer. The domains may have a wrinkle periodicity of less than 2 ?m. The folds may have a fold density of less than 0.25. The transport layer may comprise PEDOT:PSS. The photoactive layer may comprise P3HT:PCBM. The photoactive layer may comprise a bulk heterojunction.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Yueh-Lin Loo, Jongbok Kim, Pilnam Kim, Howard Stone, Nicolas Pegard, Jason Fleischer
  • Patent number: 8689981
    Abstract: Systems and methods for the manipulation of particles within channels such as microfluidic channels are provided. In one set of embodiments, magnets are positioned around a channel. As a fluid containing magnetic and non-magnetic particles flows through the channel, the magnetic field created by the magnets can be used to transport the magnetic and/or non-magnetic particles to desired locations within the channel, which may useful in some cases for causing some separation of the particles. For example, the magnetic field may be used to transport magnetic or non-magnetic particles from a core fluid to a surrounding sheath fluid. In some cases, the magnetic field is used to transport non-magnetic particles to a small volume within the channel (e.g., a single-file row within the channel).
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: April 8, 2014
    Assignee: President and Fellows of Harvard College
    Inventors: Howard A. Stone, Mara G. Prentiss, Pierre Striehl, Efraim Feinstein
  • Publication number: 20140037514
    Abstract: A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
    Type: Application
    Filed: November 16, 2012
    Publication date: February 6, 2014
    Applicants: Governing Council of the Univ. of Toronto, The MaRS Centre, President and Fellows of Harvard College
    Inventors: Howard A. Stone, Shelly L. Anna, Nathalie Bontoux, Darren Roy Link, David A. Weitz, Irina Gitlin, Eugenia Kumacheva, Piotr Garstecki, Willow R. DiLuzio, George M. Whitesides
  • Patent number: 8526379
    Abstract: To ameliorate interference between an indoor wireless pico cell system, for example in an aircraft, and public wireless communications systems operating in a surrounding or over-flown area, frequencies of operation of the indoor system are coordinated with those used by the public wireless systems in the surrounding area. The pico cell system operates one type of service on all or a portion of a band used for a different type of service by the public system. In the aircraft example, a pico cell system might support GSM narrowband service and CDMA broadband service. The airborne GSM operations use a portion, e.g. corresponding to a guard band, of CDMA service spectrum in the terrestrial network. The airborne CDMA service uses a band used for GSM service by the terrestrial network. The pico cell system dynamically changes its frequency band(s), as the aircraft flies over different areas.
    Type: Grant
    Filed: February 2, 2011
    Date of Patent: September 3, 2013
    Assignee: Cellco Partnership
    Inventors: Richard Lee Harvey, Sean Patrick Haynberg, William Howard Stone, Jr.
  • Patent number: 8337778
    Abstract: A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
    Type: Grant
    Filed: March 17, 2010
    Date of Patent: December 25, 2012
    Assignees: President and Fellows of Harvard College, The Governing Council of the Univ. of Toronto
    Inventors: Howard A. Stone, Shelley L. Anna, Nathalie Bontoux, Darren Roy Link, David A. Weitz, Irina Gitlin, Eugenia Kumacheva, Piotr Garstecki, Willow R. Diluzio, George M. Whitesides
  • Publication number: 20120080360
    Abstract: Systems and methods for the manipulation of particles within channels such as microfluidic channels are provided. In one set of embodiments, magnets are positioned around a channel. As a fluid containing magnetic and non-magnetic particles flows through the channel, the magnetic field created by the magnets can be used to transport the magnetic and/or non-magnetic particles to desired locations within the channel, which may useful in some cases for causing some separation of the particles. For example, the magnetic field may be used to transport magnetic or non-magnetic particles from a core fluid to a surrounding sheath fluid. In some cases, the magnetic field is used to transport non-magnetic particles to a small volume within the channel (e.g., a single-file row within the channel).
    Type: Application
    Filed: April 8, 2010
    Publication date: April 5, 2012
    Applicant: President and Fellows of Harvard College
    Inventors: Howard A. Stone, Mara G. Prentiss, Pierre Striehl, Efraim Feinstein
  • Publication number: 20120033823
    Abstract: An apparatus for preventing hearing loss having a body made of a soft compliant material having first and second ends and a channel extending therethrough, an acoustically limp material adjacent one of the ends of the body with the acoustically limp material having a hole therein aligned with the channel extending through the body, and a component film, disc or other structure covering or sealing the opening in the acoustically limp material. The film or disc may be formed of a high-strength polymer material and may be less than 10 micrometers in thickness. Rather than having a single channel extending through the body, a plurality of channels may extend therethrough and a plurality of corresponding holes may be provided in the acoustically limp material. The film, disc or other structure covers or seals the plurality of holes in the acoustically limp material.
    Type: Application
    Filed: January 10, 2007
    Publication date: February 9, 2012
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Rick Rogers, Brendan Clifford, Robert M. Westervelt, John W. Hutchinson, Howard A. Stone, Eben Oldmixon
  • Publication number: 20110268803
    Abstract: The American Cancer Society estimated that in 2009, 1,479,350 new cancer cases would be diagnosed in the United States of which 219,440 would be lung and bronchus related. The standard treatments for NSCLC include surgery, chemotherapy, radiation, laser and photodynamic therapy, all with various success rates depending on the stage of the cancer. National Cancer Institute assesses, however, that results of standard treatment are generally poor with only a 15 percent 5-year survival rate for combined cancer stages. Challenges facing the current chemotherapy drugs include excessive toxicity to healthy tissues and limited ability to prevent metastases. A dual drug delivery system described herein selectively targets the lung to deliver anti-cancer drugs and inhibit the formation of metastases.
    Type: Application
    Filed: April 5, 2011
    Publication date: November 3, 2011
    Applicants: Rutgers, The State University of New Jersey, THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Robert K. Prud'homme, Patrick J. Sinko, Howard A. Stone, Nathalie M. Pinkerton, Lei Shi, Jiandi Wan, Sherif Ibrahim, Dayuan Gao
  • Publication number: 20110197899
    Abstract: An apparatus for preventing hearing loss having a body made of a soft compliant material having first and second ends and a channel extending therethrough, an acoustically limp material adjacent one of the ends of the body with the acoustically limp material having a hole therein aligned with the channel extending through the body, and a component film, disc or other structure covering or sealing the opening in the acoustically limp material. The film or disc may be formed of a high-strength polymer material and may be less than 10 micrometers in thickness. Rather than having a single channel extending through the body, a plurality of channels may extend therethrough and a plurality of corresponding holes may be provided in the acoustically limp material. The film, disc or other structure covers or seals the plurality of holes in the acoustically limp material.
    Type: Application
    Filed: January 10, 2007
    Publication date: August 18, 2011
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Rick Rogers, Brendan Clifford, Robert M. Westervelt, John W. Hutchinson, Howard A. Stone
  • Publication number: 20110134889
    Abstract: To ameliorate interference between an indoor wireless pico cell system, for example in an aircraft, and public wireless communications systems operating in a surrounding or over-flown area, frequencies of operation of the indoor system are coordinated with those used by the public wireless systems in the surrounding area. The pico cell system operates one type of service on all or a portion of a band used for a different type of service by the public system. In the aircraft example, a pico cell system might support GSM narrowband service and CDMA broadband service. The airborne GSM operations use a portion, e.g. corresponding to a guard band, of CDMA service spectrum in the terrestrial network. The airborne CDMA service uses a band used for GSM service by the terrestrial network. The pico cell system dynamically changes its frequency band(s), as the aircraft flies over different areas.
    Type: Application
    Filed: February 2, 2011
    Publication date: June 9, 2011
    Applicant: Cellco Partnership d/b/a Verizon Wireless
    Inventors: Richard Lee HARVEY, Sean Patrick HAYNBERG, William Howard STONE, JR.
  • Publication number: 20110132871
    Abstract: The present invention relates to shear sensors. In particular, the present invention relates to deformable sensors for measurement of shear forces during chemical mechanical polishing.
    Type: Application
    Filed: April 3, 2009
    Publication date: June 9, 2011
    Applicant: TUFTS UNIVERSITY
    Inventors: Robert D. White, Andrew Mueller, Christopher Rogers, Vincent Manno, Howard Stone, Douglas A. Gauthier
  • Patent number: 7942160
    Abstract: The present invention relates to microfluidic systems, including valves and pumps for microfluidic systems. The valves of the invention include check valves such as diaphragm valves and flap valves. Other valves of the invention include one-use valves. The pumps of the present invention include a reservoir and at least two check valves. The reservoir may be of variable volume. The present invention also relates to a flexible microfluidic system. The present invention additionally relates to a method of making microfluidic systems including those of the present invention. The method includes forming a microfluidic system on a master, connecting a support to the microfluidic system and removing the microfluidic system from the master. The support may remain connected to the microfluidic system or the microfluidic system may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: May 17, 2011
    Assignee: President and Fellows of Harvard College
    Inventors: Noo Li Jeon, Daniel T. Chiu, Christopher J. Wargo, Insung S. Choi, Hongkai Wu, Janelle R. Anderson, George M. Whitesides, J. Cooper McDonald, Steven J. Metallo, Howard A. Stone
  • Patent number: 7907578
    Abstract: To ameliorate interference between an indoor wireless pico cell system, for example in an aircraft, and public wireless communications systems operating in a surrounding or over-flown area, frequencies of operation of the indoor system are coordinated with those used by the public wireless systems in the surrounding area. The pico cell system operates one type of service on all or a portion of a band used for a different type of service by the public system. In the aircraft example, a pico cell system might support GSM narrowband service and CDMA broadband service. The airborne GSM operations use a portion, e.g. corresponding to a guard band, of CDMA service spectrum in the terrestrial network. The airborne CDMA service uses a band used for GSM service by the terrestrial network. The pico cell system dynamically changes its frequency band(s), as the aircraft flies over different areas.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: March 15, 2011
    Assignee: Cellco Partnership
    Inventors: Richard Lee Harvey, Sean Patrick Haynberg, William Howard Stone, Jr.
  • Publication number: 20100172803
    Abstract: A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
    Type: Application
    Filed: March 17, 2010
    Publication date: July 8, 2010
    Applicants: President and Fellows of Harvard College, The Governing Council of the University of Toronto
    Inventors: Howard A. Stone, Shelley L. Anna, Nathalie Bontoux, Darren R. Link, David A. Weitz, Irina Gitlin, Eugenia Kumacheva, Piotr Garstecki, Willow Diluzio, George M. Whitesides
  • Patent number: 7708949
    Abstract: A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
    Type: Grant
    Filed: December 28, 2004
    Date of Patent: May 4, 2010
    Assignees: President and Fellows of Harvard College, Governing Council of the Univ. of Toronto
    Inventors: Howard A. Stone, Shelley L. Anna, Nathalie Bontoux, Darren R. Link, David A. Weitz, Irina Gitlin, Eugenia Kumacheva, Piotr Garstecki, Willow Diluzio, George M. Whitesides
  • Publication number: 20100064780
    Abstract: Methods and apparatus for measuring changes in pressure in a fluidic system are described. In one aspect, an apparatus for measuring pressure as described herein includes a test channel (e.g., a first fluidic channel (120)) and a control channel (e.g., a second fluidic channel (125)) that join a measuring region (130) downstream of the test and control channels. In some embodiments, fluid flowing in the test and control channels can be laminar and form a stable fluid interface in the measuring region. A property of the fluid interface, such as the position of the fluid interface, e.g., relative to a width of the measuring region, may be measured, in some cases visually. In some embodiments, introduction of a component (e.g., a cell) into the test channel can cause a change in pressure drop in the test channel. This change in pressure drop can cause a deflection of the fluid interface.
    Type: Application
    Filed: July 27, 2006
    Publication date: March 18, 2010
    Inventor: Howard A Stone