Patents by Inventor Howard Stone
Howard Stone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150345049Abstract: Embodiments of the present disclosure provide magneto-spinning apparatus, methods of use, magnetospun material (e.g., a fiber such as a low- or non-magnetic fiber), and the like.Type: ApplicationFiled: May 28, 2015Publication date: December 3, 2015Inventors: Alexander Tokarev, Oleksandr Trotsenko, Sergiy Minko, Howard A. Stone, Ian Griffiths
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Publication number: 20150191765Abstract: The present invention relates to a method of measuring biofilms and/or biofilm streamers, wherein the method comprises a system that has at least one channel and a biofilm streamer promotion element, a fluid capable of moving along the channel, wherein the fluid has a flow driven by a controlled pressure; and a measuring element capable of measuring a flow rate of the fluid through the channel. Additionally, method of screening for compound(s) that promote and/or inhibit biofilm and/or biofilm streamers using this system are also contemplated. Uses of the system, methods and identified compounds are contemplated for medical and/or industrial environments.Type: ApplicationFiled: January 5, 2015Publication date: July 9, 2015Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Bonnie L. Bassler, Howard A. Stone, Martin F. Semmelhack, Knut Drescher, Yi Shen, Colleen T. O'Loughlin, Laura C. Miller
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Patent number: 8986628Abstract: A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.Type: GrantFiled: November 16, 2012Date of Patent: March 24, 2015Assignees: President and Fellows of Harvard College, The Governing Council of the Univ. of TorontoInventors: Howard A. Stone, Shelley L. Anna, Nathalie Bontoux, Darren Roy Link, David A. Weitz, Irina Gitlin, Eugenia Kumacheva, Piotr Garstecki, Willow R. Diluzio, George M. Whitesides
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Patent number: 8858917Abstract: Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as vital infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be a surfactant and, optionally, a carrier. The formulation may be administered as a powder where the particles consist basically of the material altering surface tension. The carrier may be a solution, such as an alcohol, although an aqueous solution may be utilized, or a material mixed with the material altering surface tension to form particles.Type: GrantFiled: January 9, 2009Date of Patent: October 14, 2014Assignee: President and Fellows of Harvard CollegeInventors: David A. Edwards, Howard A. Stone
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Publication number: 20140261675Abstract: A photovoltaic cell and method of making are disclosed. The photovoltaic cell includes a substrate having a surface at least partially covered in wrinkles and folds, the folds dividing the surface into a plurality of domains. A photoactive layer is formed on the substrate. At least one transparent electrode is coupled to the photoactive layer and configured to allow transmission of light into the photoactive layer. The domains may have a wrinkle periodicity of less than 2 ?m. The folds may have a fold density of less than 0.25. The transport layer may comprise PEDOT:PSS. The photoactive layer may comprise P3HT:PCBM. The photoactive layer may comprise a bulk heterojunction.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Yueh-Lin Loo, Jongbok Kim, Pilnam Kim, Howard Stone, Nicolas Pegard, Jason Fleischer
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Patent number: 8689981Abstract: Systems and methods for the manipulation of particles within channels such as microfluidic channels are provided. In one set of embodiments, magnets are positioned around a channel. As a fluid containing magnetic and non-magnetic particles flows through the channel, the magnetic field created by the magnets can be used to transport the magnetic and/or non-magnetic particles to desired locations within the channel, which may useful in some cases for causing some separation of the particles. For example, the magnetic field may be used to transport magnetic or non-magnetic particles from a core fluid to a surrounding sheath fluid. In some cases, the magnetic field is used to transport non-magnetic particles to a small volume within the channel (e.g., a single-file row within the channel).Type: GrantFiled: April 8, 2010Date of Patent: April 8, 2014Assignee: President and Fellows of Harvard CollegeInventors: Howard A. Stone, Mara G. Prentiss, Pierre Striehl, Efraim Feinstein
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Publication number: 20140037514Abstract: A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.Type: ApplicationFiled: November 16, 2012Publication date: February 6, 2014Applicants: Governing Council of the Univ. of Toronto, The MaRS Centre, President and Fellows of Harvard CollegeInventors: Howard A. Stone, Shelly L. Anna, Nathalie Bontoux, Darren Roy Link, David A. Weitz, Irina Gitlin, Eugenia Kumacheva, Piotr Garstecki, Willow R. DiLuzio, George M. Whitesides
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Patent number: 8526379Abstract: To ameliorate interference between an indoor wireless pico cell system, for example in an aircraft, and public wireless communications systems operating in a surrounding or over-flown area, frequencies of operation of the indoor system are coordinated with those used by the public wireless systems in the surrounding area. The pico cell system operates one type of service on all or a portion of a band used for a different type of service by the public system. In the aircraft example, a pico cell system might support GSM narrowband service and CDMA broadband service. The airborne GSM operations use a portion, e.g. corresponding to a guard band, of CDMA service spectrum in the terrestrial network. The airborne CDMA service uses a band used for GSM service by the terrestrial network. The pico cell system dynamically changes its frequency band(s), as the aircraft flies over different areas.Type: GrantFiled: February 2, 2011Date of Patent: September 3, 2013Assignee: Cellco PartnershipInventors: Richard Lee Harvey, Sean Patrick Haynberg, William Howard Stone, Jr.
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Patent number: 8337778Abstract: A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.Type: GrantFiled: March 17, 2010Date of Patent: December 25, 2012Assignees: President and Fellows of Harvard College, The Governing Council of the Univ. of TorontoInventors: Howard A. Stone, Shelley L. Anna, Nathalie Bontoux, Darren Roy Link, David A. Weitz, Irina Gitlin, Eugenia Kumacheva, Piotr Garstecki, Willow R. Diluzio, George M. Whitesides
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Publication number: 20120080360Abstract: Systems and methods for the manipulation of particles within channels such as microfluidic channels are provided. In one set of embodiments, magnets are positioned around a channel. As a fluid containing magnetic and non-magnetic particles flows through the channel, the magnetic field created by the magnets can be used to transport the magnetic and/or non-magnetic particles to desired locations within the channel, which may useful in some cases for causing some separation of the particles. For example, the magnetic field may be used to transport magnetic or non-magnetic particles from a core fluid to a surrounding sheath fluid. In some cases, the magnetic field is used to transport non-magnetic particles to a small volume within the channel (e.g., a single-file row within the channel).Type: ApplicationFiled: April 8, 2010Publication date: April 5, 2012Applicant: President and Fellows of Harvard CollegeInventors: Howard A. Stone, Mara G. Prentiss, Pierre Striehl, Efraim Feinstein
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Publication number: 20120033823Abstract: An apparatus for preventing hearing loss having a body made of a soft compliant material having first and second ends and a channel extending therethrough, an acoustically limp material adjacent one of the ends of the body with the acoustically limp material having a hole therein aligned with the channel extending through the body, and a component film, disc or other structure covering or sealing the opening in the acoustically limp material. The film or disc may be formed of a high-strength polymer material and may be less than 10 micrometers in thickness. Rather than having a single channel extending through the body, a plurality of channels may extend therethrough and a plurality of corresponding holes may be provided in the acoustically limp material. The film, disc or other structure covers or seals the plurality of holes in the acoustically limp material.Type: ApplicationFiled: January 10, 2007Publication date: February 9, 2012Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Rick Rogers, Brendan Clifford, Robert M. Westervelt, John W. Hutchinson, Howard A. Stone, Eben Oldmixon
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Publication number: 20110268803Abstract: The American Cancer Society estimated that in 2009, 1,479,350 new cancer cases would be diagnosed in the United States of which 219,440 would be lung and bronchus related. The standard treatments for NSCLC include surgery, chemotherapy, radiation, laser and photodynamic therapy, all with various success rates depending on the stage of the cancer. National Cancer Institute assesses, however, that results of standard treatment are generally poor with only a 15 percent 5-year survival rate for combined cancer stages. Challenges facing the current chemotherapy drugs include excessive toxicity to healthy tissues and limited ability to prevent metastases. A dual drug delivery system described herein selectively targets the lung to deliver anti-cancer drugs and inhibit the formation of metastases.Type: ApplicationFiled: April 5, 2011Publication date: November 3, 2011Applicants: Rutgers, The State University of New Jersey, THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Robert K. Prud'homme, Patrick J. Sinko, Howard A. Stone, Nathalie M. Pinkerton, Lei Shi, Jiandi Wan, Sherif Ibrahim, Dayuan Gao
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Publication number: 20110197899Abstract: An apparatus for preventing hearing loss having a body made of a soft compliant material having first and second ends and a channel extending therethrough, an acoustically limp material adjacent one of the ends of the body with the acoustically limp material having a hole therein aligned with the channel extending through the body, and a component film, disc or other structure covering or sealing the opening in the acoustically limp material. The film or disc may be formed of a high-strength polymer material and may be less than 10 micrometers in thickness. Rather than having a single channel extending through the body, a plurality of channels may extend therethrough and a plurality of corresponding holes may be provided in the acoustically limp material. The film, disc or other structure covers or seals the plurality of holes in the acoustically limp material.Type: ApplicationFiled: January 10, 2007Publication date: August 18, 2011Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Rick Rogers, Brendan Clifford, Robert M. Westervelt, John W. Hutchinson, Howard A. Stone
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Publication number: 20110134889Abstract: To ameliorate interference between an indoor wireless pico cell system, for example in an aircraft, and public wireless communications systems operating in a surrounding or over-flown area, frequencies of operation of the indoor system are coordinated with those used by the public wireless systems in the surrounding area. The pico cell system operates one type of service on all or a portion of a band used for a different type of service by the public system. In the aircraft example, a pico cell system might support GSM narrowband service and CDMA broadband service. The airborne GSM operations use a portion, e.g. corresponding to a guard band, of CDMA service spectrum in the terrestrial network. The airborne CDMA service uses a band used for GSM service by the terrestrial network. The pico cell system dynamically changes its frequency band(s), as the aircraft flies over different areas.Type: ApplicationFiled: February 2, 2011Publication date: June 9, 2011Applicant: Cellco Partnership d/b/a Verizon WirelessInventors: Richard Lee HARVEY, Sean Patrick HAYNBERG, William Howard STONE, JR.
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Publication number: 20110132871Abstract: The present invention relates to shear sensors. In particular, the present invention relates to deformable sensors for measurement of shear forces during chemical mechanical polishing.Type: ApplicationFiled: April 3, 2009Publication date: June 9, 2011Applicant: TUFTS UNIVERSITYInventors: Robert D. White, Andrew Mueller, Christopher Rogers, Vincent Manno, Howard Stone, Douglas A. Gauthier
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Patent number: 7942160Abstract: The present invention relates to microfluidic systems, including valves and pumps for microfluidic systems. The valves of the invention include check valves such as diaphragm valves and flap valves. Other valves of the invention include one-use valves. The pumps of the present invention include a reservoir and at least two check valves. The reservoir may be of variable volume. The present invention also relates to a flexible microfluidic system. The present invention additionally relates to a method of making microfluidic systems including those of the present invention. The method includes forming a microfluidic system on a master, connecting a support to the microfluidic system and removing the microfluidic system from the master. The support may remain connected to the microfluidic system or the microfluidic system may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system.Type: GrantFiled: June 14, 2004Date of Patent: May 17, 2011Assignee: President and Fellows of Harvard CollegeInventors: Noo Li Jeon, Daniel T. Chiu, Christopher J. Wargo, Insung S. Choi, Hongkai Wu, Janelle R. Anderson, George M. Whitesides, J. Cooper McDonald, Steven J. Metallo, Howard A. Stone
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Patent number: 7907578Abstract: To ameliorate interference between an indoor wireless pico cell system, for example in an aircraft, and public wireless communications systems operating in a surrounding or over-flown area, frequencies of operation of the indoor system are coordinated with those used by the public wireless systems in the surrounding area. The pico cell system operates one type of service on all or a portion of a band used for a different type of service by the public system. In the aircraft example, a pico cell system might support GSM narrowband service and CDMA broadband service. The airborne GSM operations use a portion, e.g. corresponding to a guard band, of CDMA service spectrum in the terrestrial network. The airborne CDMA service uses a band used for GSM service by the terrestrial network. The pico cell system dynamically changes its frequency band(s), as the aircraft flies over different areas.Type: GrantFiled: May 3, 2006Date of Patent: March 15, 2011Assignee: Cellco PartnershipInventors: Richard Lee Harvey, Sean Patrick Haynberg, William Howard Stone, Jr.
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Publication number: 20100172803Abstract: A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.Type: ApplicationFiled: March 17, 2010Publication date: July 8, 2010Applicants: President and Fellows of Harvard College, The Governing Council of the University of TorontoInventors: Howard A. Stone, Shelley L. Anna, Nathalie Bontoux, Darren R. Link, David A. Weitz, Irina Gitlin, Eugenia Kumacheva, Piotr Garstecki, Willow Diluzio, George M. Whitesides
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Patent number: 7708949Abstract: A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.Type: GrantFiled: December 28, 2004Date of Patent: May 4, 2010Assignees: President and Fellows of Harvard College, Governing Council of the Univ. of TorontoInventors: Howard A. Stone, Shelley L. Anna, Nathalie Bontoux, Darren R. Link, David A. Weitz, Irina Gitlin, Eugenia Kumacheva, Piotr Garstecki, Willow Diluzio, George M. Whitesides
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Publication number: 20100064780Abstract: Methods and apparatus for measuring changes in pressure in a fluidic system are described. In one aspect, an apparatus for measuring pressure as described herein includes a test channel (e.g., a first fluidic channel (120)) and a control channel (e.g., a second fluidic channel (125)) that join a measuring region (130) downstream of the test and control channels. In some embodiments, fluid flowing in the test and control channels can be laminar and form a stable fluid interface in the measuring region. A property of the fluid interface, such as the position of the fluid interface, e.g., relative to a width of the measuring region, may be measured, in some cases visually. In some embodiments, introduction of a component (e.g., a cell) into the test channel can cause a change in pressure drop in the test channel. This change in pressure drop can cause a deflection of the fluid interface.Type: ApplicationFiled: July 27, 2006Publication date: March 18, 2010Inventor: Howard A Stone