Abstract: Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as vital infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be a surfactant and, optionally, a carrier. The formulation may be administered as a powder where the particles consist basically of the material altering surface tension. The carrier may be a solution, such as an alcohol, although an aqueous solution may be utilized, or a material mixed with the material altering surface tension to form particles.

Abstract: The present invention includes a microfluidic filter and concentrator that can separate a filtrate from a fluid containing components, e.g. a suspension of particles, to be removed from the fluid at least to some extent. The filter may employ principals of tangential flow filtration, also known as cross-flow filtration. In one aspect, a microfluidic filter described herein includes at least a first, main channel and one or more secondary, filtering channels that connect to the main channel. Filtration occurs when a fluid portion of a sample that is flowed through the main channel enters one or more of the filtering channels and at least some of the components in the sample do not enter or do not flow through the secondary, filtering channels. The secondary channels may be dimensioned to inhibit flow of components through them, and/or a porous material such as a layer may be positioned to inhibit flow of components through the secondary channels.

Abstract: The present invention generally relates to systems and methods for forming fluidic droplets comprising particles such as colloidal particles, which may be distributed on the surfaces of the fluidic droplets in some cases, thereby encapsulating the fluidic droplets. The particles at least partially surrounding the fluidic droplet may be colloidal particles in some cases, i.e., forming a “colloidal capsule.” In one set of embodiments, the particles may be positioned on the surface of a fluidic droplet such that the fluidic droplet is able to maintain a shape that, when left undisturbed, is not achievable by an undisturbed fluidic droplet free of discrete particles, for example, elongated or prolate ellipsoid fluidic droplets. Such fluidic droplets may also exhibit unusual properties, for example, plasticity, isolation from electromagnetic fields, certain electrical and/or magnetic properties, and/or mechanical resistance.

Abstract: Impression devices are provided for making an impression of a desired feature. The impression devices include: a flexible bladder having a cavity formed therein, the flexible bladder being capable of conforming to the details of the desired feature; a rheological material, such as a magnetorheological fluid, disposed in the cavity of the flexible bladder; and an activator for applying an external stimulus to the rheological material to change the state of the rheological material and thereby capture an impression of the desired feature.

Abstract: The present invention generally relates to systems and methods of forming particles and, in certain aspects, to systems and methods of forming particles that are substantially monodisperse. Microfluidic systems and techniques for forming such particles are provided, for instance, particles may be formed using gellation, solidification, and/or chemical reactions such as cross-linking, polymerization, and/or interfacial polymerization reactions. In one aspect, the present invention is directed to a plurality of particles having an average dimension of less than about 500 micrometers and a distribution of dimensions such that no more than about 5% of the particles have a dimension greater than about 10% of the average dimension, which can be made via microfluidic systems. In one set of embodiments, at least some of the particles may comprise a metal, and in certain embodiments, at least some of the particles may comprise a magnetizable material.

Abstract: A surgical kit including a surgical guide system for drilling bones at a joint, a surgical implant for attachment to the bones at the joint, and a surgical implant for attachment to the bones at the joint.

Abstract: Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be a surfactant and, optionally, a carrier. The formulation may be administered as a powder where the particles consist basically of the material altering surface tension. The carrier may be a solution, such as an alcohol, although an aqueous solution may be utilized, or a material mixed with the material altering surface tension to form particles.

Abstract: A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.

Abstract: A multi-stage vacuum pump comprises a first piston in a first cylinder defining a first stage pumping chamber and a second piston in a second cylinder defining a second stage pumping chamber. The pump has a spool valve between the first and second cylinders for controlling flow from the first stage pumping chamber to the second stage pumping chamber. Either the first cylinder and the first piston or the second cylinder and the second piston being stepped so as to define a third stage pumping chamber. The spool valve is arranged to control the flow from the second stage pumping chamber to the third stage pumping chamber.

Abstract: A mixing apparatus is used to effect mixing between one or more fluid streams. The mixing apparatus generally functions by creating a transverse flow component in the fluid flowing within a channel without the use of moving mixing elements. The transverse or helical flow component of the flowing fluid or fluids can be created by weak modulations of the shape of the walls of the channel. Transverse or helical flow component can be created by grooves features defined on the channel wall. Specifically, the present invention can be used in laminarly flowing fluids. The mixing apparatus and methods thereof can effect mixing of a fluid or fluids flowing with a Reynolds number of less than about 100. Thus, the present invention can be used to mix a fluid flowing in the micro-regime. The mixing apparatus can be used to mix a fluid in a microfluidic system to significantly reduce the Taylor dispersion along the principal direction.

Abstract: The present invention relates to microfluidic systems, including valves and pumps for microfluidic systems. The valves of the invention include check valves such as diaphragm valves and flap valves. Other valves of the invention include one-use valves. The pumps of the present invention include a reservoir and at least two check valves. The reservoir may be of variable volume. The present invention also relates to a flexible microfluidic system. The present invention additionally relates to a method of making microfluidic systems including those of the present invention. The method includes forming a microfluidic system on a master, connecting a support to the microfluidic system and removing the microfluidic system from the master. The support may remain connected to the microfluidic system or the microfluidic system may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system.

Abstract: The present invention relates to microfluidic systems, including valves and pumps for microfluidic systems. The valves of the invention include check valves such as diaphragm valves and flap valves. Other valves of the invention include one-use valves. The pumps of the present invention include a reservoir and at least two check valves. The reservoir may be of variable volume. The present invention also relates to a flexible microfluidic system. The present invention additionally relates to a method of making microfluidic systems including those of the present invention. The method includes forming a microfluidic system on a master, connecting a support to the microfluidic system and removing the microfluidic system from the master. The support may remain connected to the microfluidic system or the microfluidic system may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system.

Abstract: Impression devices are provided for making an impression of a desired feature. The impression devices include: a flexible bladder having a cavity formed therein, the flexible bladder being capable of conforming to the details of the desired feature; a rheological material, such as a magnetorheological fluid, disposed in the cavity of the flexible bladder; and an activator for applying an external stimulus to the rheological material to change the state of the rheological material and thereby capture an impression of the desired feature.

Abstract: The present invention relates to microfluidic systems, including valves and pumps for microfluidic systems. The valves of the invention include check valves such as diaphragm valves and flap valves. Other valves of the invention include one-use valves. The pumps of the present invention include a reservoir and at least two check valves. The reservoir may be of variable volume. The present invention also relates to a flexible microfluidic system. The present invention additionally relates to a method of making microfluidic systems including those of the present invention. The method includes forming a microfluidic system on a master, connecting a support to the microfluidic system and removing the microfluidic system from the master. The support may remain connected to the microfluidic system or the microfluidic system may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system.