Abstract: A Squalene Hopene Cyclase (SHC) isolated from Gluconobacter morbifer is provided as are variants and a method for using the G. morbifer SHC to biocatalytically convert homofarnesol to ambroxan.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for reinforcement learning. One of the methods includes selecting an action to be performed by the agent using both a slow updating recurrent neural network and a fast updating recurrent neural network that receives a fast updating input that includes the hidden state of the slow updating recurrent neural network.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as HMC compounds) that are useful, for example, in the treatment of disorders (e.g.

Abstract: Systems and methods associated for providing haptic feedback are provided. For instance, data indicative of a feedback scheme associated with an input mechanism can be accessed. The feedback scheme includes one or more feedback points associated with a position of a moveable portion of the input mechanism. The input mechanism is configured to change positions responsive to an actuation of the input mechanism by a user. One or more positions of the moveable portion of the input mechanism can be determined as the input mechanism is actuated by the user. Operation of one or more feedback motors can be controlled to provide feedback to the user in accordance with the feedback scheme based at least in part on the determined one or more positions of the input mechanism.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as HMC compounds) that are useful, for example, in the treatment of disorders (e.g.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as HMC compounds) that are useful, for example, in the treatment of disorders (e.g.

Abstract: Systems and methods associated with modular computing environments are provided. For instance, a modular computing environment can include a control entity including one or more processing devices. The modular computing environment can include one or more modular components directly or indirectly coupled to the control entity. The one or more modular components can be configured to receive a module specifying one or more instructions to be performed by an external device. The one or more modular components include one or more processing devices. Each modular component is configured to determine state data associated with the modular component based at least in part on the received module and to provide the state data to the control entity. The state data includes an identification signature of the received module and a configuration context of the modular component within the modular computing environment.

Abstract: Systems and methods associated for providing haptic feedback are provided. For instance, data indicative of a feedback scheme associated with an input mechanism can be accessed. The feedback scheme includes one or more feedback points associated with a position of a moveable portion of the input mechanism. The input mechanism is configured to change positions responsive to an actuation of the input mechanism by a user. One or more positions of the moveable portion of the input mechanism can be determined as the input mechanism is actuated by the user. Operation of one or more feedback motors can be controlled to provide feedback to the user in accordance with the feedback scheme based at least in part on the determined one or more positions of the input mechanism.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as HMC compounds) that are useful, for example, in the treatment of disorders (e.g.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as HMC compounds) that are useful, for example, in the treatment of disorders (e.g.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as HMC compounds) that are useful, for example, in the treatment of disorders (e.g.

Abstract: Systems and methods associated with modular computing environments are provided. For instance, a modular computing environment can include a control entity including one or more processing devices. The modular computing environment can include one or more modular components directly or indirectly coupled to the control entity. The one or more modular components can be configured to receive a module specifying one or more instructions to be performed by an external device. The one or more modular components include one or more processing devices. Each modular component is configured to determine state data associated with the modular component based at least in part on the received module and to provide the state data to the control entity. The state data includes an identification signature of the received module and a configuration context of the modular component within the modular computing environment.

Abstract: Systems and methods associated for providing haptic feedback are provided. For instance, data indicative of a feedback scheme associated with an input mechanism can be accessed. The feedback scheme includes one or more feedback points associated with a position of a moveable portion of the input mechanism. The input mechanism is configured to change positions responsive to an actuation of the input mechanism by a user. One or more positions of the moveable portion of the input mechanism can be determined as the input mechanism is actuated by the user. Operation of one or more feedback motors can be controlled to provide feedback to the user in accordance with the feedback scheme based at least in part on the determined one or more positions of the input mechanism.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as HMC compounds) that are useful, for example, in the treatment of disorders (e.g.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as HMC compounds) that are useful, for example, in the treatment of disorders (e.g.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as HMC compounds) that are useful, for example, in the treatment of disorders (e.g.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl -cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as HMC compounds) that are useful, for example, in the treatment of disorders (e.g.

Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as “APSAC compounds”).

Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as “APSAC compounds”).