Abstract: Devices and methods for accessing a multimedia timeline are disclosed. A device may include a memory to store an access key to obtain access to a multimedia timeline. The device may also include an interface to send the access key to a multimedia device to obtain access to the multimedia timeline. The multimedia device may be configured to provide a graphical user interface to a display device for display of the multimedia timeline.

Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 2?,4?-dichloro-biphenyl-4-yl-hydroxy-ketones and related compounds (collectively referred to herein as “DCBP compounds”), and more particularly to compounds selected from compounds of the following formula and pharmaceutically acceptable salts, solvates, and hydrates thereof: wherein: n is independently 1, 2, 3, or 4; W is independently —C(?O)—, —CH(OH)—, or —C(?NOROX)—; ROX is independently —H or C1-3alkyl; J is independently: —H, —RE1, —C(?O)—RE2, —C(?O)—O—RE3, —C(?O)—O—S(?O)2ORE4, —C(?O)—(CH2)n—C(?O)ORE5, —C(?O)—(CH2)n—NRNE1RNE2, —C(?O)—(CH2)n—NRNE3—C(?O)RE6, —C(?O)—(CH2)n—C(?O)—NRNE4RNE5, or —P(?O)(ORE7)(ORE8); wherein each of RE1, RE2, RE3, RE4, RE5, RE6, and RE7 is independently: —H, C1-3alkyl, -Ph, or —CH2-Ph.

Abstract: The invention relates to a process for the preparation of compounds of formula (I) wherein Q1 is a group selected from formulae (II) & (III) and a group *-NR6-Q2-A or, if appropriate, their pharmaceutically acceptable salts and/or isomers, tautomers, solvates or isotopic variations thereof, as well as intermediates used in said process.

Abstract: The present invention pertains to certain aryl alkyl sulfonamides and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone resorption, and more particularly to compounds of the formula: wherein: Ar1 is independently C5-20aryl (e.g., biphenyl, phenanthryl, fluorenyl, or carbazolyl, most preferably biphenyl), and is optionally substituted; RN is independently —H, acyl, C5-20aryl-C1-7alkyl, C3-20heterocyclyl, or C1-7alkyl, and is optionally substituted; Ralk is a C2-10alkylene group, and is optionally substituted; and Q is independently —H or an organic group having from 1 to 30 atoms selected from carbon, nitrogen, oxygen, sulfur, phosphorus, fluorine, chlorine, bromine, and iodine (e.g., an oxy-type group, an amine-type group, etc.); and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof.

Abstract: The invention relates to a reference mark detector for use with a metrological scale or encoder (10) having a patterned reference mark rm movable relative to the reference mark detector. The detector may comprise a photodetector array (20) for detecting the patterned reference mark, the array comprising at least two sets of detector elements A and B each set being formed as a pattern which relates to the pattern of the reference mark. The two sets may be separate rows of photodectors or different elements of the same row of photodetectors. The pattern is preferably irregular.

Abstract: A medication dispensing apparatus having a manually operable plunger axially shiftable relative to the apparatus housing. The plunger is pullable relative to the housing in a proximal direction to cock the apparatus, and when the plunger is then manually pushed back toward the housing, a piston within a medicine container of the apparatus is shifted to force medication from a needle assembly at the distal end of the apparatus. The medication dispensing apparatus also includes a priming mechanism which is operated by rotating an externally accessible driver portion to prime the apparatus for use, which priming can be performed whether or not the apparatus is in a cocked state.

Abstract: A measurement scale (20) is movable in plane x relative to a mask (10) and photodetector (30). When a pattern of apertures in the mask (10) are in correlation with a pattern of apertures e.g. a reference mark in the scale (20) then light bands a b and c may propagate to the detector (30). The relative sizes of the patterns is such that the light bands converge at the detector (30). Other embodiments show light divergent and light inversion correlation of incongruent patterns.

Abstract: The invention presents compounds of formula (I), where R represents H or a suitable carboxylic acid protecting group, which are intermediates in the preparation of therapeutic fused bicyclic amino acids.

Abstract: A sintered material and a method for the production thereof is described. The material comprises an alloy selected from one of the groups having a composition comprising in weight %: either Cr 5-30/Mo 0-15/Ni 0-25/W 0-15/C 0-5/Si 0-5/Fe 0-5/Mn 0-5/others 10 max/Co balance, or Cr 10-20/Mo 0-15/Co 0-20/W 0-5/Fe 0-20/Al 0-5/Ti 0-5/others 15 max/Ni balance; said alloy having incorporated therein from 3-15 weight % of Sn; and optionally from 1-6 weight % of a solid lubricant material.

Abstract: The invention provides a method of manufacturing a laundry appliance (10) which comprises the steps of: a) manufacturing and assembling, in a first location, a laundry appliance (10) comprising an outer casing (12) in which is mounted a means for washing and/or drying laundry (102), the outer casing (12) including a fascia (20), the fascia (20) being removable from the outer casing (12); b) transporting the laundry appliance (10) to a second location; c) manufacturing at least one alternative fascia attachable to the outer casing (12) of the laundry appliance (10), the or each alternative fascia differing from the fascia (20) by colour material or finish; d) transporting the or each alternative fascia to the second location; e) selecting the or an alternative fascia; and f) replacing the fascia (20) with the selected alternative fascia so as to change the final appearance of the laundry appliance (10). The invention provides a further method of manufacturing a laundry appliance (10).

Abstract: A sintered material and a method for the production thereof is described. The material comprises an alloy selected from one of the groups having a composition comprising in weight %: either Cr 5-30/Mo 0-15/Ni 0-25/W 0-15/C 0-5/Si 0-5/Fe 0-5/Mn 0-5/others 10max/Co balance, or Cr 10-20/Mo 0-15/Co 0-20/W 0-5/Fe 0-20/Al 0-5/Ti 0-5/others 15max/Ni balance; said alloy having incorporated therein from 3-15 weight % of Sn; and optionally from 1-6 weight % of a solid lubricant material.

Abstract: A medication dispensing apparatus having a manually operable plunger axially shiftable relative to the apparatus housing. The plunger is pullable relative to the housing in a proximal direction to cock the apparatus, and when the plunger is then manually pushed back toward the housing, a piston within a medicine container of the apparatus is shifted to force medication from a needle assembly at the distal end of the apparatus. The medication dispensing apparatus also includes a priming mechanism which is operated by rotating an externally accessible driver portion to prime the apparatus for use, which priming can be performed whether or not the apparatus is in a cocked state.

Abstract: A sintered steel and a method for the manufacture thereof are described, the sintered steel being made by a method comprising the steps of providing a first pre-alloyed steel powder having a composition comprising in weight %: C 0.5-2, Cr 3.5-6, (2 Mo+W) 12-22, V 0.5-5, Co 0-12, Mn 0.1-0.5, Si 0.1-0.6, Fe balance apart from incidental impurities; providing a second pre-alloyed steel powder having a composition comprising in weight %: C 0.3-0.7, Cr 3-5.5, Mo 1-2.5, V 0.3-1.5, W 0-2, Mn 0.1-0.6, Si 0.8-1.2. Fe balance apart from incidental impurities; mixing together from 2 to 50 weight % of the first pre-alloyed steel powder with 98 to 50 weight % of the second pre-alloyed steel powder optionally up to 60 weight % of an iron powder and with carbon powder such that the final carbon content of the matrix of the sintered steel powder is a maximum of 1.1 weight %1; compacting the mixture and sintering to form the sintered steel.

Abstract: The invention presents compounds of formula (I), 1

Abstract: An absolute measurement scale 18 comprises an incremental scale 10 with light reflecting lines 12 alternating with non-light reflecting lines 14 in which absolute data, in the form of discrete codewords, is embedded in the incremental scale by removing light reflecting lines 22. The codewords are arranged such that the scale is palindromic and cyclic. A look-up table is used to determine a coarse absolute position by comparing absolute position data extracted from the scale with absolute codewords in the look-up table. The absolute position is determined by combining the coarse absolute position with the position of the start of the first codeword in the data extracted. The absolute position may be determined to within a scale pitch by combining the absolute position with the incremental position.

Abstract: The invention provides a method of manufacturing a laundry appliance (10) which comprises the steps of: a) manufacturing and assembling, in a first location, a laundry appliance (10) comprising an outer casing (12) in which is mounted a means for washing and/or drying laundry (102), the outer casing (12) including a fascia (20), the fascia (20) being removable from the outer casing (12); b) transporting the laundry appliance (10) to a second location; c) manufacturing at least one alternative fascia attachable to the outer casing (12) of the laundry appliance (10), the or each alternative fascia differing from the fascia (20) by colour, material or finish; d) transporting the or each alternative fascia to the second location; e) selecting the or an alternative fascia; and f) replacing the fascia (20) with the selected alternative fascia so as to change the final appearance of the laundry appliance (10). The invention provides a further method of manufacturing a laundry appliance (10).

Abstract: A measurement scale (20) is movable in plane x relative to a mask (10) and photodetector (30). When a pattern of apertures in the mask (10) are in correlation with a pattern of apertures e.g. a reference mark in the scale (20) then light bands a b and c may propagate to the detector (30). The relative sizes of the patterns is such that the light bands converge at the detector (30). Other embodiments show light divergent and light inversion correlation of incongruent patterns.

Abstract: A laundry appliance (10) comprises an outer casing (14) and a container (34) mounted inside the outer to permit movement of the container (34) in use. The container (34) has a door (42) for closing the opening in the container which moves with the container (34) during use of the applicance. A seal (80) is located between the outer casing (14) and the container (34). The seal (80) extends radially inwardly from the lip (85) of the opening in the outer casing (14) and lies against the front surface or the container (34). The seal has a rigid portion (81) with a channel (83) for receiving the lip (85) of the container and a flexible portion (82).

Abstract: A wheel hub (10), primarily for a wheelchair wheel, can be manually operated by rotating a cover (168) to give three different operating states for the wheel which includes the hub. In the first position, the wheel is free to rotate relative to the chair. In the second position, the wheel is locked to the chair, i.e. the chair is braked. In the third position, the wheel can turn in the direction corresponding to forward motion of the chair, but cannot rotate in the opposite direction. This prevents the wheelchair from undesired backward rolling movement.

Abstract: An apparatus for accurate temperature and pressure measurement in production processes is described. In designing the temperture pressure probe, novel features are described which include minimization of the thermal mass of the thermal probe, thermal isolation of the thermal probe from its surroundings, and generating turbulence in the vicinity of the thermal probe where it comes in contact with the fluid flow. Embodiments disclosed for the pressure sensor include a recessed position where fluid pressure transients are minimized, and a surface mounted pressure sensor that is useful where the pressure sensor of the first embodiment is likely to get clogged due to fluid composition.